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PE20070336A1 - Compuestos de indolina como agonistas de receptores adrenergicos alfa2c funcionalmente selectivos - Google Patents

Compuestos de indolina como agonistas de receptores adrenergicos alfa2c funcionalmente selectivos

Info

Publication number
PE20070336A1
PE20070336A1 PE2006001022A PE2006001022A PE20070336A1 PE 20070336 A1 PE20070336 A1 PE 20070336A1 PE 2006001022 A PE2006001022 A PE 2006001022A PE 2006001022 A PE2006001022 A PE 2006001022A PE 20070336 A1 PE20070336 A1 PE 20070336A1
Authority
PE
Peru
Prior art keywords
alfa2c
ilmethyl
indol
imidazol
dihydro
Prior art date
Application number
PE2006001022A
Other languages
English (en)
Inventor
Kevin D Mccormick
Neng-Yang Shih
Pietro Mangiaracina
Bo Liang
Huagang Lu
Salem Fevrier
Rong-Qiang Liu
Chia-Yu Huang
Robert G Aslanian
Christopher W Boyce
Original Assignee
Schering Corp
Pharmacopeia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37401474&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070336(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp, Pharmacopeia Inc filed Critical Schering Corp
Publication of PE20070336A1 publication Critical patent/PE20070336A1/es

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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Otolaryngology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A DERIVADOS DE INDOLINA DE FORMULA (I) EN DONDE A ES UN HETEROCICLICO DE 5 MIEMBROS QUE CONTIENE AL MENOS UN N, TAL COMO IMIDAZOLILO, OPCIONALMENTE SUSTITUIDO CON R5; J1, J2 Y J3 SON INDEPENDIENTEMENTE C(R2), N, N(O); J4 ES C O N; J5 ES C(R6) O N(R6); LINEAS PUNTEADAS ES UN ENLACE SIMPLE O DOBLE; R1 ES -(CH2)qYR7, -(CH2)qNR7YR7', -(CH2)qNR7R7', -(CH2)qOYR7, ENTRE OTROS; Y ES -C(=O)-, -C(=O)NR7, -C(=O)O, -S(O)p, ENTRE OTROS; R3 ES H, ALQUILO, ALCOXI, ENTRE OTROS; R4 ES H, -CN, ALQUILO, ENTRE OTROS. SON PREFERIDOS: 1-(4H-IMIDAZOL-4-ILMETIL)-N-2,3-DIHIDRO-1H-INDOL-6-METILAMIDA, N-[1-(4H-IMIDAZOL-4-ILMETIL)-2,3-DIHIDRO-1H-INDOL-6-IL]ACETAMIDA, METIL[1-(4H-IMIDAZOL-4-ILMETIL)-3-METIL-2,3-DIHIDRO-1H-INDOL-6-IL]CARBAMATO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON AGONISTAS SELECTIVOS DE RECEPTORES ADRENERGICOS ALFA2C, POR LO QUE SON UTILES PARA TRATAMIENTO DE CONGESTION (INCLUSO NASAL), MIGRANA, INSUFICIENCIA CARDIACA CONGESTIVA, ISQUEMIA CARDIACA, GLAUCOMA, DOLOR Y TRANSTORNOS SICOTICOS
PE2006001022A 2005-08-25 2006-08-23 Compuestos de indolina como agonistas de receptores adrenergicos alfa2c funcionalmente selectivos PE20070336A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71139805P 2005-08-25 2005-08-25

Publications (1)

Publication Number Publication Date
PE20070336A1 true PE20070336A1 (es) 2007-04-16

Family

ID=37401474

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001022A PE20070336A1 (es) 2005-08-25 2006-08-23 Compuestos de indolina como agonistas de receptores adrenergicos alfa2c funcionalmente selectivos

Country Status (19)

Country Link
US (1) US7803828B2 (es)
EP (1) EP1945626B1 (es)
JP (1) JP2009506047A (es)
KR (1) KR20080039982A (es)
CN (1) CN101296920A (es)
AR (1) AR056043A1 (es)
AT (1) ATE517883T1 (es)
AU (1) AU2006283104A1 (es)
BR (1) BRPI0615307A2 (es)
CA (1) CA2620171A1 (es)
EC (1) ECSP088222A (es)
IL (1) IL189679A0 (es)
NO (1) NO20081426L (es)
PE (1) PE20070336A1 (es)
RU (1) RU2008110908A (es)
SG (1) SG165314A1 (es)
TW (1) TWI316515B (es)
WO (1) WO2007024944A1 (es)
ZA (1) ZA200802453B (es)

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US20070099872A1 (en) 2007-05-03
US7803828B2 (en) 2010-09-28
AR056043A1 (es) 2007-09-12
CA2620171A1 (en) 2007-03-01
KR20080039982A (ko) 2008-05-07
BRPI0615307A2 (pt) 2009-08-04
ZA200802453B (en) 2008-12-31
CN101296920A (zh) 2008-10-29
RU2008110908A (ru) 2009-09-27
WO2007024944A1 (en) 2007-03-01
EP1945626B1 (en) 2011-07-27
ATE517883T1 (de) 2011-08-15
SG165314A1 (en) 2010-10-28
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