PE20061197A1 - Aminoalcoholes triciclicos, como inhibidores de la secresion de citoquina il-8 - Google Patents
Aminoalcoholes triciclicos, como inhibidores de la secresion de citoquina il-8Info
- Publication number
- PE20061197A1 PE20061197A1 PE2006000009A PE2006000009A PE20061197A1 PE 20061197 A1 PE20061197 A1 PE 20061197A1 PE 2006000009 A PE2006000009 A PE 2006000009A PE 2006000009 A PE2006000009 A PE 2006000009A PE 20061197 A1 PE20061197 A1 PE 20061197A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- inhibitors
- hexahidrobenzo
- trifluoromethyl
- cycloalkyl
- Prior art date
Links
- 108090001007 Interleukin-8 Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001414 amino alcohols Chemical class 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical group F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 239000002158 endotoxin Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 2
- UNVNVCMGCFNMQD-UHFFFAOYSA-N 2h-chromen-5-ol Chemical compound O1CC=CC2=C1C=CC=C2O UNVNVCMGCFNMQD-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004063227A DE102004063227A1 (de) | 2004-12-22 | 2004-12-22 | Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061197A1 true PE20061197A1 (es) | 2006-12-07 |
Family
ID=36250953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000009A PE20061197A1 (es) | 2004-12-22 | 2006-01-03 | Aminoalcoholes triciclicos, como inhibidores de la secresion de citoquina il-8 |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JP2008524300A (fr) |
| KR (1) | KR20070089948A (fr) |
| CN (1) | CN101087780A (fr) |
| AR (1) | AR055016A1 (fr) |
| AU (1) | AU2005318354A1 (fr) |
| BR (1) | BRPI0519710A2 (fr) |
| CA (1) | CA2586973A1 (fr) |
| DE (1) | DE102004063227A1 (fr) |
| GT (1) | GT200500385A (fr) |
| IL (1) | IL183060A0 (fr) |
| MX (1) | MX2007007420A (fr) |
| PA (1) | PA8657801A1 (fr) |
| PE (1) | PE20061197A1 (fr) |
| WO (1) | WO2006066950A2 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS20060250A (en) | 2003-10-08 | 2008-08-07 | Schering Aktiengesellschaft, | 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, method for the production thereof, and their use as antiphlogistics |
| US7662821B2 (en) | 2003-10-08 | 2010-02-16 | Bayer Schering Pharma Ag | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| US7638515B2 (en) | 2003-10-08 | 2009-12-29 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| US20080153859A1 (en) | 2004-04-05 | 2008-06-26 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| US7297700B2 (en) | 2005-03-24 | 2007-11-20 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| EP1834948A1 (fr) | 2006-03-15 | 2007-09-19 | Bayer Schering Pharma Aktiengesellschaft | Derives de tetrahydronaphtalene , procedes pour leur production et leur utilisation en tant qu'anti-inflammatoires |
| TWI464148B (zh) | 2006-03-16 | 2014-12-11 | Evotec Us Inc | 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途 |
| EP1917963A1 (fr) * | 2006-10-31 | 2008-05-07 | Bayer Schering Pharma Aktiengesellschaft | Imidazoles cycliques substitués par un groupe phényle, procédé pour leur préparation et leur utilisation comme des agents anti-inflammatoires |
| EP2072509A1 (fr) | 2007-12-18 | 2009-06-24 | Bayer Schering Pharma Aktiengesellschaft | 1-aryl-1H-quinoline-2-ones : leur procédé de fabrication et leur utilisation en tant qu'agents anti-inflammatoires |
| AU2013216935C1 (en) | 2012-02-08 | 2017-12-14 | John Emmerson Campbell | Heteroaryl compounds and methods of use thereof |
| AU2017301769B2 (en) | 2016-07-29 | 2022-07-28 | Pgi Drug Discovery Llc | Compounds and compositions and uses thereof |
| JP2019523279A (ja) | 2016-07-29 | 2019-08-22 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 化合物および組成物ならびにそれらの使用 |
| CA3070993A1 (fr) | 2017-08-02 | 2019-02-07 | Sunovion Pharmaceuticals Inc. | Composes d'isochromane et leurs utilisations |
| CA3130849A1 (fr) | 2019-03-14 | 2020-09-17 | Sunovion Pharmaceuticals Inc. | Sels d'un compose d'isochromanyle et formes cristallines, procedes de preparation, utilisations therapeutiques et compositions pharmaceutiques associees |
| KR102462991B1 (ko) * | 2020-11-02 | 2022-11-04 | 한국해양과학기술원 | 남극-유래 진균 균주 아크레모늄(Acremonium sp.) SF-7394에서 분리한 화합물 및 이를 포함하는 항염증, 항암 또는 항당뇨용 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10038639A1 (de) * | 2000-07-28 | 2002-02-21 | Schering Ag | Nichtsteroidale Entzündungshemmer |
| ES2298508T3 (es) * | 2002-03-26 | 2008-05-16 | Boehringer Ingelheim Pharmaceuticals Inc. | Mimeticos de glucocorticoides, metodos para prepararlos, composiciones farmaceuticas y sus usos. |
| DE10215316C1 (de) * | 2002-04-02 | 2003-12-18 | Schering Ag | Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer |
| RS20060250A (en) * | 2003-10-08 | 2008-08-07 | Schering Aktiengesellschaft, | 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, method for the production thereof, and their use as antiphlogistics |
| GB0418045D0 (en) * | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
| DE102004044680B3 (de) * | 2004-09-09 | 2006-06-08 | Schering Ag | Alkyliden-Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer sowie diese enthaltende pharmazeutische Präparate |
-
2004
- 2004-12-22 DE DE102004063227A patent/DE102004063227A1/de not_active Withdrawn
-
2005
- 2005-12-20 WO PCT/EP2005/013943 patent/WO2006066950A2/fr not_active Application Discontinuation
- 2005-12-20 AU AU2005318354A patent/AU2005318354A1/en not_active Abandoned
- 2005-12-20 BR BRPI0519710-4A patent/BRPI0519710A2/pt not_active Application Discontinuation
- 2005-12-20 MX MX2007007420A patent/MX2007007420A/es not_active Application Discontinuation
- 2005-12-20 KR KR1020077014116A patent/KR20070089948A/ko not_active Withdrawn
- 2005-12-20 CN CNA2005800442843A patent/CN101087780A/zh active Pending
- 2005-12-20 CA CA002586973A patent/CA2586973A1/fr not_active Abandoned
- 2005-12-20 JP JP2007547379A patent/JP2008524300A/ja active Pending
- 2005-12-22 AR ARP050105486A patent/AR055016A1/es not_active Application Discontinuation
- 2005-12-22 PA PA20058657801A patent/PA8657801A1/es unknown
- 2005-12-22 GT GT200500385A patent/GT200500385A/es unknown
-
2006
- 2006-01-03 PE PE2006000009A patent/PE20061197A1/es not_active Application Discontinuation
-
2007
- 2007-05-08 IL IL183060A patent/IL183060A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2586973A1 (fr) | 2006-06-29 |
| KR20070089948A (ko) | 2007-09-04 |
| AU2005318354A1 (en) | 2006-06-29 |
| WO2006066950A3 (fr) | 2006-08-17 |
| BRPI0519710A2 (pt) | 2009-03-10 |
| IL183060A0 (en) | 2007-09-20 |
| AR055016A1 (es) | 2007-08-01 |
| JP2008524300A (ja) | 2008-07-10 |
| GT200500385A (es) | 2006-08-03 |
| DE102004063227A1 (de) | 2006-07-06 |
| PA8657801A1 (es) | 2006-12-07 |
| WO2006066950A2 (fr) | 2006-06-29 |
| CN101087780A (zh) | 2007-12-12 |
| MX2007007420A (es) | 2007-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |