JPS5728066A - Glycerol derivative of 5-fluorouracil - Google Patents
Glycerol derivative of 5-fluorouracilInfo
- Publication number
- JPS5728066A JPS5728066A JP10208880A JP10208880A JPS5728066A JP S5728066 A JPS5728066 A JP S5728066A JP 10208880 A JP10208880 A JP 10208880A JP 10208880 A JP10208880 A JP 10208880A JP S5728066 A JPS5728066 A JP S5728066A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouracil
- expressed
- glycerol derivative
- formula
- glycerol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960002949 fluorouracil Drugs 0.000 title abstract 3
- 150000002314 glycerols Chemical class 0.000 title abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- FHLNOFIKNZLHOS-UHFFFAOYSA-N 5-fluoro-2,4-dioxopyrimidine-1-carboxamide Chemical compound NC(=O)N1C=C(F)C(=O)NC1=O FHLNOFIKNZLHOS-UHFFFAOYSA-N 0.000 abstract 1
- -1 5-fluorouracil-1-yl Chemical group 0.000 abstract 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 125000005456 glyceride group Chemical group 0.000 abstract 1
- 125000003104 hexanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A glycerol derivative of 5-fluorouracil expressed by formula I (R1 is 2W20C aliphatic acyl; R2 is R1 or H; n is 1W10).
EXAMPLE: 1, 3-Didecanoyl-2-[ 6-[ ( 5-fluorouracil-1-yl )carbonylamino ]hexanoyl]glyceride.
USE: An orally admenistrable carcinostatic agent in which 5-fluorouracil is linked to the β-position of the glycerol.
PROCESS: An α,α'-diglyceride expressed by formula II is reacted with a 1-(ω-carboxyalkyl) carbamoyl-5-fluorouracil expressed by formula III in the presence of a condensing agent, e.g. N,N'-dicyclohexylcarbodiimide.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10208880A JPS5728066A (en) | 1980-07-25 | 1980-07-25 | Glycerol derivative of 5-fluorouracil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10208880A JPS5728066A (en) | 1980-07-25 | 1980-07-25 | Glycerol derivative of 5-fluorouracil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5728066A true JPS5728066A (en) | 1982-02-15 |
Family
ID=14318015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10208880A Pending JPS5728066A (en) | 1980-07-25 | 1980-07-25 | Glycerol derivative of 5-fluorouracil |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5728066A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0424720U (en) * | 1990-06-19 | 1992-02-27 |
-
1980
- 1980-07-25 JP JP10208880A patent/JPS5728066A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0424720U (en) * | 1990-06-19 | 1992-02-27 |
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