JP3194672B2 - Calcium and magnesium oral supplements and foods containing the same - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral calcium and magnesium supplement having an excellent balance between calcium and magnesium and an excellent taste, and a food containing the same.

[0002]

2. Description of the Related Art Calcium is used as a component of bones or teeth to maintain its anatomy, secretes hormones and nerves.
It also plays an important role as a regulator of muscle excitement, blood coagulation, and the activities of various enzymes. In addition, the relationship between calcium intake and osteoporosis, hypertension, colon cancer and the like has recently been clarified. However, the average daily intake in Japanese is 539 mg, which is much lower than the required daily intake of 600 mg for men and women.
(Ministry of Health and Welfare Bureau of Health, 1992 National Nutrition Survey Report).

[0003] In recent years, with the social situation facing an aging society, anxiety about osteoporosis is increasing, and various calcium preparations containing a large amount of calcium, calcium-enriched foods, and the like are sold in the market. .

[0004] However, there is hardly any of these preparations and foods in consideration of the calcium and magnesium intake balance.

[0005] Oral preparations containing calcium and magnesium (JP-A-2-212) and foods and drinks (JP-A-2-46269, JP-A-4-27369, and JP-B-4-79717) are available. Although they are disclosed, they have problems such as a small amount of minerals that can be replenished, or bitterness / astringency derived from the magnesium salt used, and poor palatability.

[0006]

SUMMARY OF THE INVENTION It is an object of the present invention to provide an oral calcium and magnesium supplement which has an excellent balance between calcium and magnesium, and which is excellent in taste quality without bitterness or astringency even when it is blended at a high concentration. , And foods containing the same.

[0007]

Means for Solving the Problems In view of the above-mentioned situation, the present inventors have conducted intensive studies and as a result, have found that a specific calcium source and a specific magnesium source are preferably dissolved in an aqueous solution at a certain ratio. The present inventors have found that a preparation obtained by solid-liquid separation of a precipitate formed by mixing can solve the above-mentioned problems, and have completed the present invention.

That is, the present invention relates to a precipitate formed by mixing a poorly water-soluble calcium salt and magnesium chloride or bitter water in an aqueous solution and containing at least 1% by weight or more of calcium as calcium per dry weight. And a calcium and magnesium oral supplement comprising a solid-liquid separated product of the above, and a supplementary food comprising the same.

First, the poorly water-soluble calcium salt used as a calcium source in the present invention is easily available commercially, and is a calcined product of a calcium compound derived from a mineral such as limestone or a digested product thereof, or a shell, eggshell, or crustacean. Shells, corals, burned products of echinoderm shells or digested products thereof are preferred. These poorly water-soluble calcium salts can be used alone or in combination.

Next, the magnesium source in the present invention may be any of those which are water-soluble per se and whose calcium salt formed upon mixing with the calcium source becomes water-soluble, such as bitter, lactic acid magnesium,
Magnesium gluconate and the like can be mentioned, and from the viewpoint of improving taste quality, magnesium chloride and bitter are preferred. Among them, magnesium chloride (especially hexahydrate) is easily available commercially, and bitter is a by-product generated in the process of salt formation from seawater, and is preferably used because it is easily available commercially. These magnesium sources also
These can be used alone or in combination.

The oral calcium and magnesium supplement of the present invention comprises a solid-liquid separation of a precipitate formed by mixing such a poorly water-soluble calcium salt with magnesium chloride or bitter solution in an aqueous solution. The precipitate contains at least 1% by weight of calcium as calcium per dry weight.

To prepare the calcium and magnesium oral supplement of the present invention, for example, a slurry is prepared by uniformly dispersing a poorly water-soluble calcium salt in water, and then magnesium chloride or bitter is added and mixed with stirring. . The stirring time is not particularly limited, but is preferably 5 minutes to 60 minutes from the viewpoint of workability. Alternatively, stirring may be performed after adding a poorly water-soluble calcium salt to an aqueous solution of magnesium chloride or bitterness.

The mixing ratio of the poorly water-soluble calcium salt to magnesium chloride or bitter is expressed by a molar ratio, and the ratio of magnesium chloride or magnesium in bitter water to calcium in the poorly water-soluble calcium salt is 0.1%. 1
It is preferably from 0.95 to 0.95, more preferably from 0.3 to 0.65. If the ratio is less than 0.1, the magnesium content in the resulting precipitate is too low, which is not preferable from the viewpoint of sufficiently replenishing magnesium.
If it exceeds 95, on the contrary, the magnesium content in the precipitate formed is too high, and the balance between calcium and magnesium to be taken is lost, so that the object of the present invention cannot be achieved.

Next, a precipitate is separated from the stirred and mixed slurry by using an appropriate solid-liquid separator, for example, a filter, a centrifuge, a thickener, or the like. As the solid-liquid separation device to be used, a device having a cake washing function is more preferable from the viewpoint of removing a water-soluble substance remaining in the separated cake and causing unpleasant taste. At this time, it has been found that it is necessary for the purpose of the present invention that the precipitate contains at least 1% by weight of calcium based on dry weight in terms of calcium.

By such solid-liquid separation, a cake-like oral calcium and magnesium supplement is obtained. This cake-like material can be appropriately adjusted to a desired mesh by a pulverizer or the like after drying as required.

The oral calcium and magnesium supplement of the present invention can be made into powders, granules, tablets, capsules, drinks and the like. Upon preparation into such a dosage form, excipients, extenders, sweeteners, sour agents,
A component such as a coloring agent can be added, and the balance between calcium and magnesium can be adjusted to a desired ratio by further adding a conventionally known calcium salt or magnesium salt.

Particularly, in order to make the calcium and magnesium oral supplement of the present invention into a liquid dosage form, a suitable paste is used.
For example, the replenisher is used in an aqueous solution using one or more of xanthan gum, locust bean gum, carrageenan, pectin, gelatin, guar gum, agar, tamarind seed polysaccharide, crystalline cellulose, gum arabic, carboxymethylcellulose, methylcellulose and the like. It is more preferable to disperse uniformly or to dissolve using one or more suitable organic acids such as lactic acid, acetic acid, gluconic acid, and ascorbic acid.

The calcium and magnesium oral supplements of the present invention can be prepared by a conventional method, for example, hard candy, tablet confectionery, gelatin jelly, biscuit, wafer,
It can be blended in sweets such as chocolate, carbonated drinks, fruitless drinks, fruit juice drinks, vegetable drinks, lactic acid bacteria drinks, coffee drinks, powdered drinks and other favorite drinks, staple foods and the like. By preparing foods in such various forms of use, calcium and magnesium supplement foods having an excellent calcium and magnesium intake balance and being useful for preventing and treating osteoporosis and circulatory system diseases and for supplementing pregnant women with minerals can be obtained.
Such foods are also within the scope of the present invention.

The calcium and magnesium supplements of the present invention may optionally contain, if necessary, additives such as excipients, extenders, sweeteners, sour agents, flavors, coloring agents and the like which are usually used in foods. be able to. When producing a liquid supplementary food, it is preferable to disperse the supplement with the paste as described above or to dissolve with the organic acid as described above.

[0020]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Test Examples, Examples and Comparative Examples, but the present invention is not limited thereto. Test Example 1 7.56 kg of white powder of slaked lime (Ca content 53.0%)
(Equivalent to 100 mol as Ca) in Shimizu
After preparing 50 kg of lime milk, as shown in Table 1, M
5 to 150 mol equivalent of MgCl ₂ .6H ₂
O was weighed and added to the lime milk and stirred for 30 minutes (Examples 1 to 6, Comparative Examples 1 to 4). Next, each of the prepared slurries was filtered through a filter press to precipitate a precipitate, and then the separated precipitate was washed with water for 1 hour to obtain a wet cake having a water content of about 60%. After drying these wet cakes with hot air of about 90 ° C., white powder of 100 mesh or less was obtained by a pulverizer.

[0021]

[Table 1]

The amounts of calcium and magnesium in the obtained white powder were measured using a high-frequency induction emission spectrum analyzer (Shimadzu ICPS-50). Table 2 shows the results.

[0023]

[Table 2]

As is clear from Table 2, MgCl ₂ .6H
_{As the} amount of added ₂ O increases, the magnesium content in the precipitate increases and the calcium content decreases. However, even if MgCl ₂ .6H ₂ O containing magnesium equal to or more than the mole number of calcium in slaked lime is added, the calcium and magnesium contents are almost constant and do not change. Also, the molar ratio of calcium and magnesium to be mixed is 1: 0.1.
It can be seen that a precipitate having an excellent balance between calcium and magnesium was formed in the range of １ ： 1: 0.95.

Example 7 Using the calcium- and magnesium-containing powder obtained in Example 3, each component was mixed according to the following formulation to prepare a tablet of 2.4 g per tablet by a conventional method. Ingredients Compounding amount Example 3 Powder 40.0 g Powdered reduced maltose starch syrup 56.85 g Corn starch 1.0 g L-tartaric acid 0.3 g Sucrose fatty acid ester 1.5 g Aspartame 0.05 g Fragrance 0.3 g

As a result of analysis in the same manner as described above, one tablet contains 294 mg of calcium and 160 mg of magnesium, and the daily intake of calcium and magnesium can be replenished by taking two tablets.

Example 8 White powder 23 of eggshell calcined calcium (Ca content 48.0% by weight) was added to 100 kg of bittern (Mg content 3.97% by weight).
After putting in kg, make up to 200L with Shimizu,
Stir for 1 hour. Subsequently, the slurry was subjected to a decanter-type centrifugal separator to dehydrate the precipitate, dried with hot air of about 90 ° C., and further obtained a white powder of 100 mesh or less by a pulverizer. 500 mg of this white powder was filled into hard capsules to obtain calcium and magnesium supplements. As a result of analysis in the same manner as described above, one capsule contained 125 mg of calcium and 118 mg of magnesium.

Example 9 10 kg of white powder of oyster shell calcined calcium (Ca content: 50.0% by weight) was dispersed in 200 L of clear water, and then MgC was added.
l of ₂ · 6H ₂ O was stirred added 10.5 kg 15 minutes.
Subsequently, this slurry was applied to a filter press, and after the precipitate was filtered, the separated precipitate was further washed with water for 2 hours to obtain a wet cake having a water content of 62% by weight. Using this wet cake,
After dissolving the wet cake with 50% by weight of L-type fermented lactic acid according to the following formulation, each component was mixed to prepare a beverage by an ordinary method. Ingredients Compounding amount Wet cake 20.0 g 50% L-type fermented lactic acid 45.0 g Fructose-glucose liquid sugar 120.0 g 1/5 concentrated plum juice 10.0 g Plum pigment 0.5 g Fragrance 1.0 g Water 803.5 g

As a result of analysis in the same manner as described above, this beverage 2
608mg of calcium and 30 of magnesium in 50g
It contains 2 mg, and a daily intake of calcium and magnesium can be supplemented by taking 250 g.

Comparative Example 5 Using white powder of oyster shell calcined calcium (Ca content: 50.0% by weight) and MgCl ₂ .6H ₂ O, Example 9 was carried out without performing the solid-liquid separation step according to the present invention. A beverage containing equal amounts of calcium and magnesium was prepared according to the following recipe.

Ingredients Blended Oyster Shell Calcium 4.8 g MgCl ₂ .6H ₂ O 10.0 g 50% L-type fermented lactic acid 28.0 g Fructose-glucose liquid sugar 120.0 g 1/5 concentrated plum juice 10.0 g Plum pigment 0 0.5g Fragrance 1.0g Water 835.7g

As a result of analysis in the same manner as described above, this beverage 2
In 50 g, 604 mg of calcium and 29 of magnesium
8 mg was contained.

Test Example 2 Using the beverages prepared in Example 9 and Comparative Example 5, a sensory test was conducted by 20 specialized panelists. The evaluation items were three items of salty taste, bitterness, and comprehensive evaluation, and the evaluation criteria were the following four levels. Salty: 1 ... strong salty 2 ... slightly salty 3 ... slightly salty 4 ... slightly salty bitterness: 1 ... strongly bittery 2 ... slightly bittery 3 ... slightly bitterness 4 ... slightly bitter ... very difficult to drink 3 ... slightly difficult to drink 4 ... easy to drink Table 3 shows the results.

[0034]

[Table 3]

As is evident from the results in Table 3, by using the calcium and magnesium oral supplement of the present invention, it is possible to obtain a food excellent in flavor and taste and capable of supplementing a considerable amount of calcium and magnesium. Became clear.

[0036]

Industrial Applicability According to the present invention, an oral calcium and magnesium supplement which is excellent in the balance of calcium and magnesium intake and excellent in taste quality, and which can supplement the required daily amount of calcium by one administration, and A formulated calcium and magnesium supplement is provided.

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-1-320969 (JP, A) JP-A-5-15319 (JP, A) JP-A-6-133738 (JP, A) JP-A-6-13737 98699 (JP, A) (58) Field surveyed (Int. Cl. ⁷ , DB name) A23L 1/29-1/308

Claims (6)

(57) [Claims] 1. Solid-liquid separation of a precipitate formed by mixing a poorly water-soluble calcium salt with magnesium chloride or bitter water in an aqueous solution and containing at least 1% by weight or more of calcium as calcium per dry weight. Calcium and magnesium oral supplements. 2. The precipitate is formed by mixing a sparingly water-soluble calcium salt containing 1 mol of calcium with magnesium chloride or bittern containing 0.1 to 0.95 mol of magnesium. 2. The calcium and magnesium oral supplement according to claim 1. 3. The sparingly water-soluble calcium salt is a calcined product of a calcium compound derived from a mineral or a digested product thereof, or a calcined product of a shell of a shell, an eggshell, a crustacean shell, a coral, an echinoderm or a digested product thereof. 3. The oral calcium and magnesium supplement according to claim 2. 4. A liquid calcium and magnesium oral supplement prepared by dispersing the oral supplement according to claim 3 with a paste or dissolving with an organic acid. 5. A food supplemented with calcium and magnesium supplemented with the oral supplement according to claim 3. 6. A liquid calcium and magnesium supplement food obtained by dispersing the oral supplement according to claim 3 with a paste or dissolving with an organic acid.