IN2014KN02324A - - Google Patents
Info
- Publication number
- IN2014KN02324A IN2014KN02324A IN2324KON2014A IN2014KN02324A IN 2014KN02324 A IN2014KN02324 A IN 2014KN02324A IN 2324KON2014 A IN2324KON2014 A IN 2324KON2014A IN 2014KN02324 A IN2014KN02324 A IN 2014KN02324A
- Authority
- IN
- India
- Prior art keywords
- masp
- inhibitory agent
- subject
- amount
- mas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Medicinal Preparation (AREA)
Abstract
Provided are methods and compositions for inhibiting MASP-3-dependent complement activation in a subject suffering from paroxysmal nocturnal hemoglobinuria by administering to the subject a composition comprising an amount of a MASP-3 inhibitory agent in an amount effective to inhibit MAS P-3-depencien! complement activation. Also provided are methods and compositions for increasing the survival of red blood cells in a subject suffering from paroxysmal nocturnal hemoglobinuria by administering to the subject a composition comprising an amount of at least one of a MASP-1 inhibitory agent and/or a MAS P-3 inhibitory agent effective to increase the survival of red blood cells. The subject may be administered a MASP-2 inhibitory agent and a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent, administered, a MASP-3 inhibitory agent and a MASP-1 inhibitory agent, or a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261621461P | 2012-04-06 | 2012-04-06 | |
| PCT/US2013/035488 WO2013180834A2 (en) | 2012-04-06 | 2013-04-05 | Compositions and methods of inhibting masp-1 and/or masp-3 for the treatment of paroxysmal nocturnal hemoglobinuria |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014KN02324A true IN2014KN02324A (en) | 2015-05-01 |
Family
ID=49325295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2324KON2014 IN2014KN02324A (en) | 2012-04-06 | 2013-04-05 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US20130273053A1 (en) |
| EP (2) | EP2833907B1 (en) |
| JP (3) | JP6366571B2 (en) |
| KR (2) | KR102318623B1 (en) |
| CN (1) | CN104661676A (en) |
| AU (3) | AU2013267909B2 (en) |
| BR (1) | BR112014024793A2 (en) |
| CA (2) | CA3087933A1 (en) |
| CL (1) | CL2014002694A1 (en) |
| CY (1) | CY1120736T1 (en) |
| DK (2) | DK2833907T3 (en) |
| ES (2) | ES2894944T3 (en) |
| HR (1) | HRP20180671T1 (en) |
| HU (1) | HUE036930T2 (en) |
| IL (2) | IL234991B (en) |
| IN (1) | IN2014KN02324A (en) |
| LT (1) | LT2833907T (en) |
| MX (2) | MX388278B (en) |
| NO (1) | NO2881536T3 (en) |
| NZ (2) | NZ781091A (en) |
| PL (2) | PL2833907T3 (en) |
| PT (1) | PT2833907T (en) |
| RS (1) | RS57266B1 (en) |
| RU (2) | RU2655299C2 (en) |
| SI (1) | SI2833907T1 (en) |
| SM (1) | SMT201800253T1 (en) |
| TR (1) | TR201806939T4 (en) |
| WO (1) | WO2013180834A2 (en) |
| ZA (1) | ZA201408100B (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2636038C2 (en) * | 2011-05-04 | 2017-11-17 | Омерос Корпорейшн | Compositions for inhibition of masp-2-dependent complement activation |
| CN118924900A (en) * | 2012-06-18 | 2024-11-12 | 奥默罗斯公司 | Compositions and methods for inhibiting MASP-1 and/or MASP-2 and/or MASP-3 |
| CA2906096C (en) | 2013-03-15 | 2022-03-15 | Omeros Corporation | Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same |
| US20140363433A1 (en) | 2013-03-15 | 2014-12-11 | Omeros Corporation | Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same |
| JOP20170154B1 (en) * | 2016-08-01 | 2023-03-28 | Omeros Corp | Compositions and methods of inhibiting masp-3 for the treatment of various diseases and disorders |
| CN110214151A (en) | 2016-11-28 | 2019-09-06 | 中外制药株式会社 | Ligand binding molecules with adjustable ligand-binding activity |
| KR102630923B1 (en) * | 2016-11-28 | 2024-01-30 | 추가이 세이야쿠 가부시키가이샤 | Polypeptide containing an antigen-binding domain and a transport portion |
| WO2018186322A1 (en) * | 2017-04-03 | 2018-10-11 | Chugai Seiyaku Kabushiki Kaisha | Anti-masp-1 antibodies and methods of use |
| CA3083259A1 (en) | 2017-11-28 | 2019-06-06 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide including antigen-binding domain and carrying section |
| KR20200089312A (en) | 2017-11-28 | 2020-07-24 | 추가이 세이야쿠 가부시키가이샤 | Ligand binding molecule capable of modulating ligand binding activity |
| IL311042A (en) * | 2018-05-29 | 2024-04-01 | Omeros Corp | Masp-2 inhibitors and methods of use |
| US12077577B2 (en) | 2018-05-30 | 2024-09-03 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide comprising aggrecan binding domain and carrying moiety |
| JOP20220011A1 (en) * | 2019-07-31 | 2023-01-30 | Biocryst Pharm Inc | Dosing regimens for oral complement factor d inhibitors |
| IL293588A (en) | 2019-12-04 | 2022-08-01 | Omeros Corp | 2-masp inhibitor compounds, preparations containing them and their uses |
| US12030853B2 (en) | 2019-12-04 | 2024-07-09 | Omeros Corporation | MASP-2 inhibitors and methods of use |
| KR20220110530A (en) | 2019-12-04 | 2022-08-08 | 오메로스 코포레이션 | MASP-2 Inhibitors and Methods of Use |
| CA3189666A1 (en) | 2020-08-18 | 2022-02-24 | William Jason Cummings | Monoclonal antibodies, compositions and methods for detecting complement factor d |
| CN114295594B (en) * | 2021-12-06 | 2023-09-19 | 贵州理工学院 | A "turn on" fluorescent sensor based on molecular beacons for screening triple-helix DNA intercalators |
| JP2024546109A (en) * | 2021-12-10 | 2024-12-17 | オメロス コーポレーション | Therapeutic antibodies that bind to the serine protease domain of MASP-2 and uses thereof |
| WO2024251199A1 (en) * | 2023-06-09 | 2024-12-12 | 舒泰神（北京）生物制药股份有限公司 | Antibody specifically binding to masp3, and multi-specific antibody specifically binding to masp3 and masp2 |
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| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
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| US5211657A (en) | 1988-11-07 | 1993-05-18 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides |
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| US20030186419A1 (en) * | 1999-12-02 | 2003-10-02 | Jensenius Jens Christian | Masp-3, a complement-fixing enzyme, and uses for it |
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| US7043719B2 (en) * | 2001-07-23 | 2006-05-09 | Intel Corporation | Method and system for automatically prioritizing and analyzing performance data for one or more, system configurations |
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| WO2005075665A2 (en) * | 2004-02-03 | 2005-08-18 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with plasma kallikrein (klkb1) |
| US20050169921A1 (en) * | 2004-02-03 | 2005-08-04 | Leonard Bell | Method of treating hemolytic disease |
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| US8840893B2 (en) * | 2004-06-10 | 2014-09-23 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| US7919094B2 (en) * | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| EP2495257A3 (en) | 2005-08-19 | 2012-10-17 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
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| EP2152861B1 (en) | 2007-05-31 | 2017-03-22 | University of Washington | Inducible mutagenesis of target genes |
| EP2342231A1 (en) * | 2008-09-26 | 2011-07-13 | Roche Glycart AG | Bispecific anti-egfr/anti-igf-1r antibodies |
| CN102307594A (en) * | 2009-01-06 | 2012-01-04 | 戴埃克斯有限公司 | Treatment of mucositis with kallikrein inhibitors |
| JP2012519555A (en) * | 2009-03-05 | 2012-08-30 | スミス アンド ネフュー インコーポレーテッド | System, method and apparatus for positioning a femoral neck guidewire |
| CN107513103A (en) * | 2009-07-17 | 2017-12-26 | 丹麦国家医院 | MASP isotypes as the inhibitor of complement activation |
| EP2496259B1 (en) * | 2009-11-05 | 2017-02-22 | Alexion Pharmaceuticals, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria |
| US8795973B2 (en) * | 2010-11-29 | 2014-08-05 | University of Leceister | Methods for identifying inhibitors of mannan-binding lectin associated serine protease (MASP) proteins and uses thereof |
| NZ709997A (en) * | 2011-04-08 | 2016-03-31 | Univ Leicester | Methods for treating conditions associated with masp-2 dependent complement activation |
-
2013
- 2013-04-05 PL PL13798222T patent/PL2833907T3/en unknown
- 2013-04-05 BR BR112014024793A patent/BR112014024793A2/en not_active Application Discontinuation
- 2013-04-05 MX MX2018008658A patent/MX388278B/en unknown
- 2013-04-05 NZ NZ781091A patent/NZ781091A/en unknown
- 2013-04-05 AU AU2013267909A patent/AU2013267909B2/en active Active
- 2013-04-05 RS RS20180586A patent/RS57266B1/en unknown
- 2013-04-05 SI SI201331032T patent/SI2833907T1/en unknown
- 2013-04-05 US US13/857,391 patent/US20130273053A1/en not_active Abandoned
- 2013-04-05 HR HRP20180671TT patent/HRP20180671T1/en unknown
- 2013-04-05 HU HUE13798222A patent/HUE036930T2/en unknown
- 2013-04-05 EP EP13798222.9A patent/EP2833907B1/en active Active
- 2013-04-05 ES ES18158799T patent/ES2894944T3/en active Active
- 2013-04-05 RU RU2014144621A patent/RU2655299C2/en active
- 2013-04-05 MX MX2014012045A patent/MX357540B/en active IP Right Grant
- 2013-04-05 CA CA3087933A patent/CA3087933A1/en active Pending
- 2013-04-05 LT LTEP13798222.9T patent/LT2833907T/en unknown
- 2013-04-05 DK DK13798222.9T patent/DK2833907T3/en active
- 2013-04-05 KR KR1020207022397A patent/KR102318623B1/en active Active
- 2013-04-05 PL PL18158799T patent/PL3366307T3/en unknown
- 2013-04-05 KR KR1020147030787A patent/KR102142508B1/en active Active
- 2013-04-05 EP EP18158799.9A patent/EP3366307B1/en active Active
- 2013-04-05 CA CA2869326A patent/CA2869326C/en active Active
- 2013-04-05 WO PCT/US2013/035488 patent/WO2013180834A2/en active Application Filing
- 2013-04-05 RU RU2018114903A patent/RU2018114903A/en unknown
- 2013-04-05 IN IN2324KON2014 patent/IN2014KN02324A/en unknown
- 2013-04-05 DK DK18158799.9T patent/DK3366307T3/en active
- 2013-04-05 NZ NZ629675A patent/NZ629675A/en unknown
- 2013-04-05 SM SM20180253T patent/SMT201800253T1/en unknown
- 2013-04-05 TR TR2018/06939T patent/TR201806939T4/en unknown
- 2013-04-05 CN CN201380029994.3A patent/CN104661676A/en active Pending
- 2013-04-05 JP JP2015504751A patent/JP6366571B2/en active Active
- 2013-04-05 ES ES13798222.9T patent/ES2670668T3/en active Active
- 2013-04-05 PT PT137982229T patent/PT2833907T/en unknown
-
2014
- 2014-10-05 IL IL234991A patent/IL234991B/en active IP Right Grant
- 2014-10-06 CL CL2014002694A patent/CL2014002694A1/en unknown
- 2014-11-05 ZA ZA2014/08100A patent/ZA201408100B/en unknown
- 2014-12-04 NO NO14196403A patent/NO2881536T3/no unknown
-
2018
- 2018-01-31 AU AU2018200721A patent/AU2018200721B2/en active Active
- 2018-05-23 CY CY181100540T patent/CY1120736T1/en unknown
- 2018-07-03 JP JP2018126460A patent/JP6815355B2/en active Active
-
2019
- 2019-02-26 US US16/285,741 patent/US20190382505A1/en not_active Abandoned
-
2020
- 2020-05-17 IL IL274721A patent/IL274721B/en unknown
- 2020-06-22 AU AU2020204163A patent/AU2020204163A1/en not_active Abandoned
- 2020-09-17 JP JP2020156216A patent/JP2021001199A/en active Pending
-
2021
- 2021-10-11 US US17/498,521 patent/US20220242972A1/en active Pending
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