IL127516A0 - A cytokine production inhibitor - Google Patents
A cytokine production inhibitorInfo
- Publication number
- IL127516A0 IL127516A0 IL12751697A IL12751697A IL127516A0 IL 127516 A0 IL127516 A0 IL 127516A0 IL 12751697 A IL12751697 A IL 12751697A IL 12751697 A IL12751697 A IL 12751697A IL 127516 A0 IL127516 A0 IL 127516A0
- Authority
- IL
- Israel
- Prior art keywords
- cytokine production
- production inhibitor
- inhibitor
- cytokine
- production
- Prior art date
Links
- 230000016396 cytokine production Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17426896 | 1996-06-12 | ||
| JP9523797 | 1997-03-28 | ||
| PCT/JP1997/002016 WO1997047622A1 (fr) | 1996-06-12 | 1997-06-11 | Inhibiteurs de production de cytokines, composes triazepine et intermediaires correspondants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL127516A0 true IL127516A0 (en) | 1999-10-28 |
Family
ID=26436510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12751697A IL127516A0 (en) | 1996-06-12 | 1997-06-11 | A cytokine production inhibitor |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0934940A1 (xx) |
| CN (1) | CN1227555A (xx) |
| AU (1) | AU3106197A (xx) |
| BR (1) | BR9710453A (xx) |
| CA (1) | CA2258053A1 (xx) |
| IL (1) | IL127516A0 (xx) |
| NO (1) | NO985820L (xx) |
| PL (1) | PL330635A1 (xx) |
| WO (1) | WO1997047622A1 (xx) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1375465A4 (en) * | 2001-04-03 | 2006-01-11 | Eisai Co Ltd | CYCLOOCTANON DERIVATIVE AND CYCLODECANON DERIVATIVE AND THEIR USE |
| JPWO2005089800A1 (ja) * | 2004-03-17 | 2008-01-31 | 株式会社ロコモジェン | ｈｓＨＲＤ３を含む医薬組成物 |
| GB0919426D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| AU2015203454B2 (en) * | 2009-11-05 | 2017-02-23 | Glaxosmithkline Llc | Benzodiazepine bromodomain inhibitor |
| WO2011054851A1 (en) * | 2009-11-05 | 2011-05-12 | Glaxosmithkline Llc | Novel process |
| KR101424989B1 (ko) * | 2009-11-05 | 2014-07-31 | 글락소스미스클라인 엘엘씨 | 벤조디아제핀 브로모도메인 억제제 |
| JP5702396B2 (ja) * | 2009-11-05 | 2015-04-15 | グラクソスミスクライン エルエルシー | ベンゾジアゼピンブロモドメイン阻害剤 |
| EP2571875A4 (en) | 2010-05-14 | 2013-10-30 | Dana Farber Cancer Inst Inc | CONTRACEPTIVE COMPOSITIONS FOR MEN AND METHODS OF USE THEREOF |
| CA2799403C (en) | 2010-05-14 | 2020-01-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
| JP5715241B2 (ja) * | 2010-05-14 | 2015-05-07 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法 |
| AU2015201727B2 (en) * | 2010-05-14 | 2018-03-08 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating neoplasia, inflammatory disease and other disorders |
| MX362384B (es) * | 2010-05-14 | 2019-01-15 | Dana Farber Cancer Inst Inc | Composiciones y metodos para tratar neoplasias, enfermedades inflamatorias y otros trastornos. |
| WO2011161031A1 (en) | 2010-06-22 | 2011-12-29 | Glaxosmithkline Llc | Benzotriazolodiazepine compounds inhibitors of bromodomains |
| TWI583689B (zh) * | 2010-08-04 | 2017-05-21 | 達納 法柏癌症學院有限公司 | 治療腫瘤形成、發炎疾病及其他病症之組成物及方法 |
| US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2012151512A2 (en) | 2011-05-04 | 2012-11-08 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| EP2721031B1 (en) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| DE102011082013A1 (de) | 2011-09-01 | 2013-03-07 | Bayer Pharma AG | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine |
| CN102603743B (zh) * | 2012-02-24 | 2014-05-28 | 南京天易生物科技有限公司 | 抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途 |
| WO2013184878A1 (en) | 2012-06-06 | 2013-12-12 | Constellation Pharmaceuticals, Inc. | Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| US9890147B2 (en) | 2012-08-16 | 2018-02-13 | Bayer Pharma Aktiengesellshaft | 2,3-benzodiazepines |
| CN104781259B (zh) | 2012-09-28 | 2018-06-01 | 拜耳制药股份公司 | 抑制bet蛋白的5-芳基三唑并氮杂* |
| RU2016105108A (ru) | 2013-07-25 | 2017-08-30 | Дана-Фарбер Кэнсер Инститьют, Инк. | Ингибиторы факторов транскрипции и их применение |
| CA2929652A1 (en) | 2013-11-08 | 2015-05-14 | Dana-Farber Cancer Institute, Inc. | Combination therapy for cancer using bromodomain and extra-terminal (bet) protein inhibitors |
| EP3099677A4 (en) | 2014-01-31 | 2017-07-26 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| EP3099693A4 (en) | 2014-01-31 | 2017-08-16 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| SG11201607108XA (en) | 2014-02-28 | 2016-09-29 | Tensha Therapeutics Inc | Treatment of conditions associated with hyperinsulinaemia |
| PL3157928T3 (pl) | 2014-06-20 | 2019-07-31 | Constellation Pharmaceuticals, Inc. | Krystaliczne postacie 2-((4S)-6-(4-chlorofenylo)-1-metylo-4H-benzo[ c]izoksazolo-[4,5-e]azepin-4-ylo)acetamidu |
| JP2017526741A (ja) | 2014-08-08 | 2017-09-14 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | ジアゼパン誘導体およびその使用 |
| RU2017104898A (ru) | 2014-08-08 | 2018-09-10 | Дана-Фарбер Кэнсер Инститьют, Инк. | Дигидроптеридиноновые производные и их применения |
| JP2017530155A (ja) * | 2014-10-02 | 2017-10-12 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | 化合物 |
| PE20171042A1 (es) | 2014-10-27 | 2017-07-19 | Tensha Therapeutics Inc | Inhibidores del bromodominio |
| US10702527B2 (en) | 2015-06-12 | 2020-07-07 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| JP2018526421A (ja) | 2015-09-11 | 2018-09-13 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | シアノチエノトリアゾロジアゼピンおよびこれらの使用 |
| KR20180051576A (ko) | 2015-09-11 | 2018-05-16 | 다나-파버 캔서 인스티튜트 인크. | 아세트아미드 티에노트리아졸로디아제핀 및 그의 용도 |
| PE20181298A1 (es) | 2015-11-25 | 2018-08-07 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos |
| JP7252125B2 (ja) | 2016-10-03 | 2023-04-04 | ザ チルドレンズ メディカル センター コーポレーション | 糖尿病性腎症の予防および処置 |
| CA3064845A1 (en) | 2017-05-31 | 2018-12-06 | Ayumi Pharmaceutical Corporation | 6h-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivatives |
| WO2019238557A1 (en) * | 2018-06-13 | 2019-12-19 | Dybly Ag | Preparation of condensed triazepine derivatives and their use as bet inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1489980A (en) * | 1975-01-20 | 1977-10-26 | Upjohn Co | Reaction products of 3-amino-3,4-dihydro-4-hydroxy-4-phenylquinazolines |
| US4144233A (en) * | 1977-02-16 | 1979-03-13 | The Dow Chemical Company | Method for preparing benzo-(1,3,4)-benzotriazepines |
| CN1171788A (zh) * | 1994-11-18 | 1998-01-28 | 日本烟草产业株式会社 | 骨质疏松症治疗药及三氮杂䓬化合物 |
| JP2622673B2 (ja) * | 1994-11-18 | 1997-06-18 | 日本たばこ産業株式会社 | 骨粗鬆症治療薬およびトリアゼピン化合物 |
-
1997
- 1997-06-11 BR BR9710453A patent/BR9710453A/pt unknown
- 1997-06-11 CN CN97197090.4A patent/CN1227555A/zh active Pending
- 1997-06-11 IL IL12751697A patent/IL127516A0/xx unknown
- 1997-06-11 PL PL97330635A patent/PL330635A1/xx unknown
- 1997-06-11 AU AU31061/97A patent/AU3106197A/en not_active Abandoned
- 1997-06-11 EP EP97926224A patent/EP0934940A1/en not_active Withdrawn
- 1997-06-11 WO PCT/JP1997/002016 patent/WO1997047622A1/ja not_active Application Discontinuation
- 1997-06-11 CA CA002258053A patent/CA2258053A1/en not_active Abandoned
-
1998
- 1998-12-11 NO NO985820A patent/NO985820L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9710453A (pt) | 1999-08-17 |
| CA2258053A1 (en) | 1997-12-18 |
| PL330635A1 (en) | 1999-05-24 |
| NO985820D0 (no) | 1998-12-11 |
| WO1997047622A1 (fr) | 1997-12-18 |
| CN1227555A (zh) | 1999-09-01 |
| AU3106197A (en) | 1998-01-07 |
| EP0934940A1 (en) | 1999-08-11 |
| NO985820L (no) | 1999-02-01 |
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