GR3030253T3 - Novel substituted piperidines useful for the treatment of allergic diseases - Google Patents
Novel substituted piperidines useful for the treatment of allergic diseasesInfo
- Publication number
- GR3030253T3 GR3030253T3 GR990401346T GR990401346T GR3030253T3 GR 3030253 T3 GR3030253 T3 GR 3030253T3 GR 990401346 T GR990401346 T GR 990401346T GR 990401346 T GR990401346 T GR 990401346T GR 3030253 T3 GR3030253 T3 GR 3030253T3
- Authority
- GR
- Greece
- Prior art keywords
- treatment
- allergic diseases
- novel substituted
- useful
- substituted piperidines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29596094A | 1994-08-25 | 1994-08-25 | |
US50191495A | 1995-07-13 | 1995-07-13 | |
PCT/US1995/010640 WO1996006094A1 (en) | 1994-08-25 | 1995-08-17 | Novel substituted piperidines useful for the treatment of allergic diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3030253T3 true GR3030253T3 (en) | 1999-08-31 |
Family
ID=26969426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR990401346T GR3030253T3 (en) | 1994-08-25 | 1999-05-19 | Novel substituted piperidines useful for the treatment of allergic diseases |
Country Status (20)
Country | Link |
---|---|
US (1) | US6329392B1 (el) |
EP (1) | EP0777666B1 (el) |
JP (1) | JPH10504580A (el) |
KR (1) | KR100362620B1 (el) |
CN (1) | CN1067385C (el) |
AT (1) | ATE177095T1 (el) |
AU (1) | AU693936B2 (el) |
CA (1) | CA2198084C (el) |
DE (1) | DE69508093T2 (el) |
DK (1) | DK0777666T3 (el) |
ES (1) | ES2132709T3 (el) |
FI (1) | FI114470B (el) |
GR (1) | GR3030253T3 (el) |
HU (1) | HU221434B (el) |
IL (1) | IL115040A (el) |
MX (1) | MX9701305A (el) |
NO (1) | NO313237B1 (el) |
NZ (1) | NZ292683A (el) |
TW (1) | TW430663B (el) |
WO (1) | WO1996006094A1 (el) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0920425B1 (en) * | 1995-11-17 | 2003-02-19 | Aventis Pharmaceuticals Inc. | Substituted 4-(1h-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
US6211199B1 (en) | 1995-11-17 | 2001-04-03 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
BR9612074A (pt) * | 1995-12-20 | 1999-03-30 | Hoechst Marion Roussel Inc | Novos 4-(1h-benzimidazol-2-il)(1,4) diazepanos substituidos úteis para o tratamento de doenças alérgicas |
US6194406B1 (en) | 1995-12-20 | 2001-02-27 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease |
US6423704B2 (en) | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
ATE282609T1 (de) * | 1996-02-21 | 2004-12-15 | Aventis Pharma Inc | Neue substituierte n-methyl-n-(4-(4-(1h- benzimidazol-2-yl) (1,4)diazepan-1-yl)-2- (aryl)butyl)benzamide zur behandlung von allergischen krankheiten |
US5998439A (en) | 1996-02-21 | 1999-12-07 | Hoescht Marion Roussel, Inc. | Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases |
US5932571A (en) * | 1996-02-21 | 1999-08-03 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases |
EP0888336B1 (en) * | 1996-02-21 | 2002-08-07 | Aventis Pharmaceuticals Inc. | Novel substituted n-methyl-n-(4-(4-(1h-benzimidazol-2-yl-amino)p iperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases |
FR2755133B1 (fr) * | 1996-10-31 | 1999-01-15 | Sanofi Sa | Nouveaux derives d'amides cycliques diversement substitues antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant |
FR2759585B1 (fr) * | 1997-02-17 | 1999-06-11 | Sanofi Sa | Formulations pharmaceutiques presentees sous forme seche pour l'administration orale d'un compose ammonium quaternaire cyclique |
FR2759584B1 (fr) * | 1997-02-17 | 1999-06-11 | Sanofi Sa | Composition pharmaceutique pour l'administration orale de composes heterocycliques sous forme ammonium quaternaire |
GB9821898D0 (en) * | 1998-10-08 | 1998-12-02 | Pfizer Ltd | Heterocycles |
CA2346227A1 (en) * | 1998-10-09 | 2000-04-20 | Schering Corporation | Composition and method for treating allergic diseases |
US6103735A (en) * | 1998-10-09 | 2000-08-15 | Schering Corporation | Composition and method for treating allergic diseases |
FR2789390B3 (fr) | 1999-02-10 | 2001-03-09 | Sanofi Sa | Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant |
JP4907818B2 (ja) | 1999-11-03 | 2012-04-04 | エーエムアール テクノロジー インコーポレイテッド | アリールおよびヘテロアリール置換テトラヒドロイソキノリン、ならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを阻止するためのそれらの使用 |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
US6864219B2 (en) | 2000-01-17 | 2005-03-08 | Bayer Aktiengesellschaft | Substituted aryl ketones |
EP1299393A2 (en) | 2000-07-11 | 2003-04-09 | Bristol-Myers Squibb Pharma Company | 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
HUP0401544A2 (hu) * | 2001-03-02 | 2004-12-28 | Bristol-Myers Squibb Company | Melanokortin receptor modulátoraiként hasznos vegyületek és a vegyületeket tartalmazó gyógyszerkészítmények |
SE0302116D0 (sv) * | 2003-07-21 | 2003-07-21 | Astrazeneca Ab | Novel compounds |
GB0326407D0 (en) * | 2003-11-12 | 2003-12-17 | Glaxo Group Ltd | Chemical compounds |
CN103880827B (zh) | 2004-07-15 | 2017-01-04 | 阿尔巴尼分子研究公司 | 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用 |
ES2382814T3 (es) | 2005-05-17 | 2012-06-13 | Merck Sharp & Dohme Ltd. | Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer |
KR101589551B1 (ko) | 2005-07-15 | 2016-02-02 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
WO2007041052A2 (en) | 2005-09-29 | 2007-04-12 | Merck & Co., Inc. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US8173629B2 (en) | 2006-09-22 | 2012-05-08 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
MX2009007200A (es) | 2007-01-10 | 2009-07-15 | Angeletti P Ist Richerche Bio | Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp). |
CA2676357A1 (en) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1 |
US8106086B2 (en) | 2007-04-02 | 2012-01-31 | Msd K.K. | Indoledione derivative |
US8389553B2 (en) | 2007-06-27 | 2013-03-05 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
JP2011515343A (ja) | 2008-03-03 | 2011-05-19 | タイガー ファーマテック | チロシンキナーゼ阻害薬 |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
US8691825B2 (en) | 2009-04-01 | 2014-04-08 | Merck Sharp & Dohme Corp. | Inhibitors of AKT activity |
US7918821B2 (en) | 2009-05-05 | 2011-04-05 | Mahurkar Sakharam D | Universal safety syringe |
ES2446971T3 (es) | 2009-05-12 | 2014-03-11 | Albany Molecular Research, Inc. | Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso |
SG175420A1 (en) | 2009-05-12 | 2011-12-29 | Albany Molecular Res Inc | 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof |
ES2528404T3 (es) | 2009-05-12 | 2015-02-10 | Bristol-Myers Squibb Company | Formas cristalinas de (S)-7-([1,2,4]triazol[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y sus usos |
AU2010291834A1 (en) * | 2009-09-04 | 2012-03-15 | Zalicus Pharmaceuticals Ltd. | Substituted heterocyclic derivatives for the treatment of pain and epilepsy |
EA023838B1 (ru) | 2009-10-14 | 2016-07-29 | Мерк Шарп Энд Домэ Корп. | ЗАМЕЩЕННЫЕ ПИПЕРИДИНЫ, КОТОРЫЕ ПОВЫШАЮТ АКТИВНОСТЬ p53, И ИХ ПРИМЕНЕНИЕ |
EP2584903B1 (en) | 2010-06-24 | 2018-10-24 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
CA2805265A1 (en) | 2010-08-02 | 2012-02-09 | Merck Sharp & Dohme Corp. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
HUE044815T2 (hu) | 2010-08-17 | 2019-11-28 | Sirna Therapeutics Inc | Hepatitisz B vírus (HBV) génexpressziójának RNS-interferencia közvetített gátlása, rövid interferáló nukleinsav (SINS) alkalmazásával |
US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
WO2012030685A2 (en) | 2010-09-01 | 2012-03-08 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
WO2012036997A1 (en) | 2010-09-16 | 2012-03-22 | Schering Corporation | Fused pyrazole derivatives as novel erk inhibitors |
US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
US20140045832A1 (en) | 2011-04-21 | 2014-02-13 | Piramal Enterprises Limited | Insulin-Like Growth Factor-1 Receptor Inhibitors |
EP2770987B1 (en) | 2011-10-27 | 2018-04-04 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
US20150299696A1 (en) | 2012-05-02 | 2015-10-22 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
JP6280554B2 (ja) | 2012-09-28 | 2018-02-14 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Erk阻害剤である新規化合物 |
HUE035662T2 (en) | 2012-11-28 | 2018-05-28 | Merck Sharp & Dohme | Compositions and methods for treating cancer |
ES2707305T3 (es) | 2012-12-20 | 2019-04-03 | Merck Sharp & Dohme | Imidazopiridinas sustituidas como inhibidores de HDM2 |
WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
WO2014134306A1 (en) | 2013-03-01 | 2014-09-04 | Zalicus Pharmaceuticals, Ltd. | Heterocyclic inhibitors of the sodium channel |
WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
US11589583B2 (en) * | 2013-12-03 | 2023-02-28 | Fmc Corporation | Pyrrolidinones herbicides |
WO2018071283A1 (en) | 2016-10-12 | 2018-04-19 | Merck Sharp & Dohme Corp. | Kdm5 inhibitors |
US10676456B2 (en) * | 2017-03-12 | 2020-06-09 | Xiaodong Wang | Polycyclic amines as opioid receptor modulators |
WO2019094312A1 (en) | 2017-11-08 | 2019-05-16 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
WO2019094311A1 (en) | 2017-11-08 | 2019-05-16 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
US11981701B2 (en) | 2018-08-07 | 2024-05-14 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
US12173026B2 (en) | 2018-08-07 | 2024-12-24 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR517589A (fr) | 1920-06-22 | 1921-05-07 | Simon Et Muller | Soc de charrue |
US3282947A (en) | 1962-05-17 | 1966-11-01 | Geschickter Fund Med Res | Unsymmetrically substituted 3, 9-diazaspiro(5, 5)undecane compounds |
BE794598A (fr) | 1972-01-28 | 1973-05-16 | Richardson Merrell Inc | Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation |
JPS6157311B2 (el) | 1975-01-16 | 1986-12-06 | Robins Co Inc A H | |
US4285958A (en) | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof |
US4254130A (en) | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
US4254129A (en) | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
JPS5790018A (en) | 1980-11-27 | 1982-06-04 | Toray Ind Inc | Stabilized polyphenylene sulfide and its production |
DE3132882A1 (de) | 1981-08-20 | 1983-03-03 | Cassella Ag, 6000 Frankfurt | Neue piperazinone, ihre herstellung und verwendung |
US4666905A (en) | 1983-06-02 | 1987-05-19 | Warner-Lambert Company | Diphenylmethylene piperidines compositions and methods for their use |
GB8321157D0 (en) | 1983-08-05 | 1983-09-07 | Fordonal Sa | Piperidine derivatives |
EP0360390A1 (en) | 1988-07-25 | 1990-03-28 | Glaxo Group Limited | Spirolactam derivatives |
US4908372A (en) | 1988-10-13 | 1990-03-13 | Merrell Dow Pharmaceuticals Inc. | Antihistaminic piperidinyl benzimidazoles |
FI97540C (fi) | 1989-11-06 | 1997-01-10 | Sanofi Sa | Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi |
IL99320A (en) | 1990-09-05 | 1995-07-31 | Sanofi Sa | Arylalkylamines, their preparation and pharmaceutical compositions containing them |
WO1992006086A1 (en) | 1990-10-01 | 1992-04-16 | Janssen Pharmaceutica N.V. | Novel 4-piperidinylcarbonyl derivatives |
GB9023116D0 (en) | 1990-10-24 | 1990-12-05 | Fujisawa Pharmaceutical Co | Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same |
FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
FR2676053B1 (fr) | 1991-05-03 | 1993-08-27 | Sanofi Elf | Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
GB9113219D0 (en) | 1991-06-19 | 1991-08-07 | Fujisawa Pharmaceutical Co | Peptide compound,processes for preparation thereof and pharmaceutical composition comprising the same |
TW202432B (el) | 1991-06-21 | 1993-03-21 | Pfizer | |
AU2031692A (en) | 1991-07-22 | 1993-01-28 | Zyma S.A. | Arylalkylamine derivatives |
GB9200535D0 (en) | 1992-01-10 | 1992-02-26 | Fujisawa Pharmaceutical Co | New compound |
FR2688219B1 (fr) | 1992-03-03 | 1994-07-08 | Sanofi Elf | Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant. |
ES2048109B1 (es) | 1992-07-20 | 1994-12-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol. |
ES2110761T3 (es) | 1993-05-06 | 1998-02-16 | Merrell Pharma Inc | Pirrolidin-3-il-alquil-piperidinas sustituidas utiles como antagonistas de la taquiquinina. |
-
1995
- 1995-08-17 NZ NZ292683A patent/NZ292683A/en unknown
- 1995-08-17 MX MX9701305A patent/MX9701305A/es unknown
- 1995-08-17 AT AT95931551T patent/ATE177095T1/de not_active IP Right Cessation
- 1995-08-17 HU HU9701257A patent/HU221434B/hu not_active IP Right Cessation
- 1995-08-17 ES ES95931551T patent/ES2132709T3/es not_active Expired - Lifetime
- 1995-08-17 JP JP8508257A patent/JPH10504580A/ja not_active Ceased
- 1995-08-17 CN CN95195283A patent/CN1067385C/zh not_active Expired - Fee Related
- 1995-08-17 WO PCT/US1995/010640 patent/WO1996006094A1/en active IP Right Grant
- 1995-08-17 CA CA002198084A patent/CA2198084C/en not_active Expired - Fee Related
- 1995-08-17 KR KR1019970701189A patent/KR100362620B1/ko not_active Expired - Fee Related
- 1995-08-17 EP EP95931551A patent/EP0777666B1/en not_active Expired - Lifetime
- 1995-08-17 AU AU34928/95A patent/AU693936B2/en not_active Ceased
- 1995-08-17 DK DK95931551T patent/DK0777666T3/da active
- 1995-08-17 DE DE69508093T patent/DE69508093T2/de not_active Expired - Fee Related
- 1995-08-23 TW TW084108797A patent/TW430663B/zh not_active IP Right Cessation
- 1995-08-23 IL IL11504095A patent/IL115040A/xx not_active IP Right Cessation
-
1997
- 1997-02-24 NO NO19970831A patent/NO313237B1/no unknown
- 1997-02-24 FI FI970771A patent/FI114470B/fi not_active IP Right Cessation
-
1998
- 1998-05-15 US US09/079,924 patent/US6329392B1/en not_active Expired - Fee Related
-
1999
- 1999-05-19 GR GR990401346T patent/GR3030253T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IL115040A (en) | 2000-02-29 |
CA2198084C (en) | 2000-03-28 |
NZ292683A (en) | 1998-07-28 |
CA2198084A1 (en) | 1996-02-29 |
US6329392B1 (en) | 2001-12-11 |
HUT76644A (en) | 1997-10-28 |
KR100362620B1 (ko) | 2003-02-14 |
WO1996006094A1 (en) | 1996-02-29 |
FI970771A0 (fi) | 1997-02-24 |
CN1067385C (zh) | 2001-06-20 |
NO970831D0 (no) | 1997-02-24 |
TW430663B (en) | 2001-04-21 |
JPH10504580A (ja) | 1998-05-06 |
EP0777666A1 (en) | 1997-06-11 |
DK0777666T3 (da) | 1999-09-27 |
DE69508093D1 (de) | 1999-04-08 |
NO970831L (no) | 1997-04-18 |
IL115040A0 (en) | 1995-12-08 |
DE69508093T2 (de) | 1999-07-15 |
HU221434B (en) | 2002-10-28 |
KR970705556A (ko) | 1997-10-09 |
FI114470B (fi) | 2004-10-29 |
FI970771L (fi) | 1997-02-24 |
AU3492895A (en) | 1996-03-14 |
AU693936B2 (en) | 1998-07-09 |
NO313237B1 (no) | 2002-09-02 |
ES2132709T3 (es) | 1999-08-16 |
ATE177095T1 (de) | 1999-03-15 |
MX9701305A (es) | 1998-05-31 |
EP0777666B1 (en) | 1999-03-03 |
CN1158612A (zh) | 1997-09-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL115040A0 (en) | Novel substituted piperidines useful for the treatment of allergic diseases | |
HK1008819A1 (en) | Piperidine derivatives as neurokinin antagonists | |
NO985977L (no) | Spiro-piperidinderivater og deres anvendelse som terapeutiske midler | |
MX9707879A (es) | Derivados de piperazina sustituidos novedosos que tienen actividad antagonista de receptor de taquinina. | |
PT920425E (pt) | 4-(1h-benzimidazol-2-il-amino)piperidinas substituidas uteis para o tratamento de doencas alergicas | |
NO963731L (no) | Behandling av obsessive-kompulsive sykdommer med 5HT2-antagonister | |
MX9804991A (es) | 4-(1h-benzimidazol-2-il)(1,4) diazepanes sustituidos novedosos utiles para el tratamiento de enfermedades alergicas. | |
IL125577A0 (en) | Novel substituted n-methyl-n-(4-(piperidin-1-yl)-2-(aryl)butyl) benzamides useful for the treatment of allergic diseases | |
CA2247105A1 (en) | Novel substituted n-methyl-n-(4-(4-(1h-benzimidazol-2-yl-amino)piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic di seases | |
CA2246994A1 (en) | Novel substituted n-methyl-n-(4-(4-(1h-benzimidazol-2-yl)[1,4]diazepan-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases |