FR2360560A1 - D-THREO-1-PHENYL-2-TRIFLUORACETAMIDO-1,3-PROPANE-DIOL DERIVATIVES AND THEIR APPLICATIONS AS ANTIBIOTICS - Google Patents
D-THREO-1-PHENYL-2-TRIFLUORACETAMIDO-1,3-PROPANE-DIOL DERIVATIVES AND THEIR APPLICATIONS AS ANTIBIOTICSInfo
- Publication number
- FR2360560A1 FR2360560A1 FR7724168A FR7724168A FR2360560A1 FR 2360560 A1 FR2360560 A1 FR 2360560A1 FR 7724168 A FR7724168 A FR 7724168A FR 7724168 A FR7724168 A FR 7724168A FR 2360560 A1 FR2360560 A1 FR 2360560A1
- Authority
- FR
- France
- Prior art keywords
- trifluoracetamido
- threo
- antibiotics
- propane
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229960002449 glycine Drugs 0.000 abstract 1
- 235000013905 glycine and its sodium salt Nutrition 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Ces composés répondent à la formule ci-après, dans laquelle R représente CH3 S- ou CH3 O2 S- et R1 représente un atome d'hydrogène ou même, quand R = CH3 O2 S-, un radical acyle choisi dans le groupe constitué par les radicaux d'acides aliphatiques à 15-17 atomes de carbone et de l'acide aminoacétique. Ce sont aussi les sels d'addition d'acide de ces composés. Application de ces substances à des compositions ayant un large spectre d'activité antibiotique.These compounds correspond to the formula below, in which R represents CH3 S- or CH3 O2 S- and R1 represents a hydrogen atom or even, when R = CH3 O2 S-, an acyl radical chosen from the group consisting of radicals of aliphatic acids with 15-17 carbon atoms and aminoacetic acid. These are also the acid addition salts of these compounds. Application of these substances to compositions having a broad spectrum of antibiotic activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT26042/76A IT1065143B (en) | 1976-08-05 | 1976-08-05 | D-TREO-1-FENYL-2-TRIFLUOROACETAMIDO-1,3-PROPANDIOL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2360560A1 true FR2360560A1 (en) | 1978-03-03 |
| FR2360560B1 FR2360560B1 (en) | 1981-02-06 |
Family
ID=11218484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7724168A Granted FR2360560A1 (en) | 1976-08-05 | 1977-08-05 | D-THREO-1-PHENYL-2-TRIFLUORACETAMIDO-1,3-PROPANE-DIOL DERIVATIVES AND THEIR APPLICATIONS AS ANTIBIOTICS |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5321135A (en) |
| AT (1) | AT351018B (en) |
| AU (1) | AU509278B2 (en) |
| BE (1) | BE857543A (en) |
| CA (1) | CA1087207A (en) |
| CH (1) | CH609338A5 (en) |
| DE (1) | DE2735431A1 (en) |
| ES (1) | ES461093A1 (en) |
| FR (1) | FR2360560A1 (en) |
| GB (1) | GB1534387A (en) |
| HU (1) | HU173169B (en) |
| IE (1) | IE45460B1 (en) |
| IT (1) | IT1065143B (en) |
| NL (1) | NL7708695A (en) |
| PT (1) | PT66889B (en) |
| YU (1) | YU40678B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001060344A3 (en) * | 2000-02-16 | 2002-03-28 | Zambon Spa | Use of thiamphenicol in the treatment of vancomycin-intermediates and multiresistant staphylococci infections |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5977276A (en) * | 1982-10-27 | 1984-05-02 | 松下冷機株式会社 | Ice machine |
| DE3486438T2 (en) | 1983-06-02 | 1998-08-13 | Schering Plouth Ltd | Process for the preparation of 1- (phenyl) -1-hydroxy-2-amino-3-fluoropropane derivatives |
-
1976
- 1976-08-05 IT IT26042/76A patent/IT1065143B/en active
-
1977
- 1977-07-18 YU YU1779/77A patent/YU40678B/en unknown
- 1977-07-28 ES ES461093A patent/ES461093A1/en not_active Expired
- 1977-08-04 CH CH959077A patent/CH609338A5/en not_active IP Right Cessation
- 1977-08-04 PT PT66889A patent/PT66889B/en unknown
- 1977-08-05 FR FR7724168A patent/FR2360560A1/en active Granted
- 1977-08-05 AU AU27655/77A patent/AU509278B2/en not_active Expired
- 1977-08-05 BE BE179956A patent/BE857543A/en not_active IP Right Cessation
- 1977-08-05 NL NL7708695A patent/NL7708695A/en not_active Application Discontinuation
- 1977-08-05 GB GB32845/77A patent/GB1534387A/en not_active Expired
- 1977-08-05 DE DE19772735431 patent/DE2735431A1/en not_active Withdrawn
- 1977-08-05 CA CA284,228A patent/CA1087207A/en not_active Expired
- 1977-08-05 HU HU77CE1140A patent/HU173169B/en unknown
- 1977-08-05 JP JP9345877A patent/JPS5321135A/en active Pending
- 1977-08-05 AT AT577177A patent/AT351018B/en not_active IP Right Cessation
- 1977-08-05 IE IE1643/77A patent/IE45460B1/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001060344A3 (en) * | 2000-02-16 | 2002-03-28 | Zambon Spa | Use of thiamphenicol in the treatment of vancomycin-intermediates and multiresistant staphylococci infections |
Also Published As
| Publication number | Publication date |
|---|---|
| IE45460B1 (en) | 1982-08-25 |
| ES461093A1 (en) | 1978-06-16 |
| GB1534387A (en) | 1978-12-06 |
| IT1065143B (en) | 1985-02-25 |
| AT351018B (en) | 1979-07-10 |
| AU2765577A (en) | 1979-02-08 |
| ATA577177A (en) | 1978-12-15 |
| BE857543A (en) | 1977-12-01 |
| JPS5321135A (en) | 1978-02-27 |
| AU509278B2 (en) | 1980-05-01 |
| NL7708695A (en) | 1978-02-07 |
| PT66889A (en) | 1977-09-01 |
| CH609338A5 (en) | 1979-02-28 |
| HU173169B (en) | 1979-03-28 |
| YU177977A (en) | 1982-10-31 |
| PT66889B (en) | 1979-01-25 |
| DE2735431A1 (en) | 1978-02-09 |
| YU40678B (en) | 1986-04-30 |
| IE45460L (en) | 1978-02-05 |
| FR2360560B1 (en) | 1981-02-06 |
| CA1087207A (en) | 1980-10-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property | ||
| ST | Notification of lapse |