FI95375B - Analogiamenetelmä medetomidiinin terapeuttisesti aktiivisen d-isomeerin valmistamiseksi - Google Patents

Analogiamenetelmä medetomidiinin terapeuttisesti aktiivisen d-isomeerin valmistamiseksi

Info

Publication number: FI95375B
Authority: FI; Finland
Prior art keywords: medetomidine; isomer; preparation; therapeutically active; analogous process
Prior art date: 1987-07-16

Application number

FI882819A

Other languages

English (en)

Swedish (sv)

Other versions

FI882819L (fi

FI95375C (fi

FI882819A0 (fi

Inventor

Arto Johannes Karjalainen

Raimo Einari Virtanen

Eino Juhani Savolainen

Original Assignee

Farmos Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-16

Filing date

1988-06-14

Publication date

1995-10-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10620775&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI95375(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-06-14 Application filed by Farmos Oy filed Critical Farmos Oy

1988-06-14 Publication of FI882819A0 publication Critical patent/FI882819A0/fi

1989-01-17 Publication of FI882819L publication Critical patent/FI882819L/fi

1995-10-13 Publication of FI95375B publication Critical patent/FI95375B/fi

1996-01-25 Application granted granted Critical

1996-01-25 Publication of FI95375C publication Critical patent/FI95375C/fi

Links

HRLIOXLXPOHXTA-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CN=C[N]1 HRLIOXLXPOHXTA-UHFFFAOYSA-N 0.000 title abstract 2
229960002140 medetomidine Drugs 0.000 title abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
239000000018 receptor agonist Substances 0.000 abstract 1
229940044601 receptor agonist Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Optical Record Carriers And Manufacture Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Photoreceptors In Electrophotography (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI882819A 1987-07-16 1988-06-14 Analogiamenetelmä medetomidiinin terapeuttisesti aktiivisen d-isomeerin valmistamiseksi FI95375C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8716803A GB2206880B (en)	1987-07-16	1987-07-16	Optical isomers of an imidazole derivative
GB8716803		1987-07-16

Publications (4)

Publication Number	Publication Date
FI882819A0 FI882819A0 (fi)	1988-06-14
FI882819L FI882819L (fi)	1989-01-17
FI95375B true FI95375B (fi)	1995-10-13
FI95375C FI95375C (fi)	1996-01-25

Family

ID=10620775

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI882819A FI95375C (fi)	1987-07-16	1988-06-14	Analogiamenetelmä medetomidiinin terapeuttisesti aktiivisen d-isomeerin valmistamiseksi

Country Status (29)

Country	Link
US (1)	US4910214A (fi)
EP (1)	EP0300652B1 (fi)
JP (1)	JPH0625138B2 (fi)
KR (1)	KR940007311B1 (fi)
CN (1)	CN1022323C (fi)
AT (1)	ATE71941T1 (fi)
AU (1)	AU600839B2 (fi)
BG (1)	BG60473B2 (fi)
CA (1)	CA1337659C (fi)
CY (2)	CY1787A (fi)
DD (1)	DD281807A5 (fi)
DE (2)	DE10399005I2 (fi)
DK (1)	DK165788C (fi)
ES (1)	ES2038757T3 (fi)
FI (1)	FI95375C (fi)
GB (1)	GB2206880B (fi)
GR (1)	GR3003878T3 (fi)
HK (1)	HK56094A (fi)
HU (1)	HU198693B (fi)
IE (1)	IE60456B1 (fi)
IL (1)	IL87076A0 (fi)
LU (1)	LU91010I2 (fi)
NL (1)	NL300117I2 (fi)
NO (2)	NO170579C (fi)
NZ (1)	NZ225362A (fi)
PT (1)	PT88013B (fi)
SU (1)	SU1648248A3 (fi)
UA (1)	UA5560A1 (fi)
ZA (1)	ZA885134B (fi)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2215206B (en) *	1988-02-29	1991-07-03	Farmos Oy	4-substituted imidazole derivatives useful in perioperative care
US5124157A (en) *	1989-08-18	1992-06-23	Cygnus Therapeutic Systems	Method and device for administering dexmedetomidine transdermally
US5120713A (en) *	1990-09-10	1992-06-09	Applied Research Systems Ars Holding N.V.	Treatment of obesity with an alpha-2-adrenergic agonist and a growth hormone releasing peptide
GB9111732D0 (en) *	1991-05-31	1991-07-24	Orion Yhtymae Oy	The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs
GB2281206A (en) *	1993-08-25	1995-03-01	Orion Yhtymae Oy	Use of dexmedetomidine
GB9425211D0 (en) *	1994-12-14	1995-02-15	Ucb Sa	Substituted 1H-imidazoles
IN187238B (fi) *	1995-06-30	2002-03-09	Astra Ab
GB9521680D0 (en) *	1995-10-23	1996-01-03	Orion Yhtymo Oy	New use of imidazole derivatives
US5866579A (en) *	1997-04-11	1999-02-02	Synaptic Pharmaceutical Corporation	Imidazole and imidazoline derivatives and uses thereof
US6716867B1 (en)	1998-04-01	2004-04-06	Orion Corporation	Use of dexmedetomidine for ICU sedation
AR015744A1 (es) *	1998-04-01	2001-05-16	Orion Corp	Uso de dexmedetomidina para sedacion en terapia intensiva
CA2388979C (en)	1999-10-29	2010-09-14	Orion Corporation	Treatment or prevention of hypotension and shock with use of an imidazole derivative
US6388090B2 (en) *	2000-01-14	2002-05-14	Orion Corporation	Imidazole derivatives
US7141597B2 (en) *	2003-09-12	2006-11-28	Allergan, Inc.	Nonsedating α-2 agonists
WO2007056457A2 (en)	2005-11-09	2007-05-18	Combinatorx, Incorporated	Methods, compositions, and kits for the treatment of medical conditions
CN101400343B (zh)	2006-03-16	2012-01-11	特瑞斯制药股份有限公司	含有药物-离子交换树脂复合物的经修饰释放的制剂
US7795263B2 (en) *	2008-07-08	2010-09-14	Wildlife Laboratories, Inc.	Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals
WO2010065547A1 (en) *	2008-12-01	2010-06-10	Map Pharmaceuticals, Inc.	Inhalation delivery methods and devices
US8555875B2 (en) *	2008-12-23	2013-10-15	Map Pharmaceuticals, Inc.	Inhalation devices and related methods for administration of sedative hypnotic compounds
EP3305281A1 (en) *	2009-05-15	2018-04-11	Recro Pharma, Inc.	Sublingual dexmedetomidine compositions and methods of use thereof
CN101671305A (zh) *	2009-09-29	2010-03-17	北京华禧联合科技发展有限公司	一种拆分美托咪定的左旋及右旋对映体的方法
CN102464619A (zh) *	2010-11-17	2012-05-23	桑迪亚医药技术（上海）有限责任公司	一种左旋4-[1-(2,3-二甲基苯基)乙基]-1r-咪唑消旋化方法
US20130096170A1 (en)	2011-10-14	2013-04-18	Hospira, Inc.	Methods of treating pediatric patients using dexmedetomidine
WO2013069025A1 (en)	2011-11-11	2013-05-16	Neon Laboratories Ltd.	"process for the preparation of dexmedetomidine"
US9795559B2 (en)	2011-12-11	2017-10-24	Recro Pharma, Inc.	Intranasal dexmedetomidine compositions and methods of use thereof
US8242158B1 (en)	2012-01-04	2012-08-14	Hospira, Inc.	Dexmedetomidine premix formulation
ITMI20120311A1 (it) *	2012-02-29	2013-08-30	Edmond Pharma Srl	Procedimento per la risoluzione di medetomidina e recupero dell'enantiomero indesiderato
CA2880456A1 (en)	2012-08-15	2014-02-20	Tris Pharma, Inc.	Methylphenidate extended release chewable tablet
KR102146690B1 (ko) *	2012-10-15	2020-08-24	오리온 코포레이션	수의학적 소음 혐오증 완화 방법
ES2856748T3 (es)	2013-10-07	2021-09-28	Teikoku Pharma Usa Inc	Dispositivos de administración transdérmica de dexmedetomidina y métodos para el uso de los mismos
RU2648449C2 (ru)	2013-10-07	2018-03-26	ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК.	Способы и композиции для трансдермальной доставки неседативного количества дексмедетомидина
KR101831290B1 (ko)	2013-10-07	2018-02-22	테이코쿠 팔마 유에스에이, 인코포레이티드	덱스메데토미딘 경피 조성물을 사용하여 주의력 결핍 과잉행동 장애, 불안 및 불면증을 치료하기 위한 방법 및 조성물
CN105175339B (zh) *	2015-10-09	2018-01-16	辰欣药业股份有限公司	一种制备盐酸右美托咪定的方法
US9717796B1 (en)	2016-04-20	2017-08-01	Slypharma, Llc	Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
FR3054218B1 (fr) *	2016-07-22	2020-03-06	Universite De Rouen	Procede de dedoublement de sels de baclofene
US11160791B2 (en)	2018-11-01	2021-11-02	Medefil, Inc.	Dexmedetomidine injection premix formulation in ready to use (RTU) bags
CN114671811A (zh) *	2022-04-14	2022-06-28	南京正科医药股份有限公司	一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU518569B2 (en) *	1979-08-07	1981-10-08	Farmos-Yhtyma Oy	4-benzyl- and 4-benzoyl imidazole derivatives
GB2092569B (en) *	1981-02-05	1984-09-19	Farmos Oy	Substituted imidazole derivatives and their preparation and use
GB2101114B (en) *	1981-07-10	1985-05-22	Farmos Group Ltd	Substituted imidazole derivatives and their preparation and use
FI844786A0 (fi)	1984-12-04	1984-12-04	Farmos Oy	Terapeutiskt utnyttjbar foerening.
DE3531682A1 (de) *	1985-09-05	1987-03-12	Thomae Gmbh Dr K	(+)-6-chlor-5,10-dihydro-5-((1-methyl-4- piperidinyl)acetyl)-11h-dibenzo(b,e)(1,4) diazepin-11-on, seine isolierung und verwendung als arzneimittel

1987
- 1987-07-16 GB GB8716803A patent/GB2206880B/en not_active Expired - Lifetime
1988
- 1988-06-14 FI FI882819A patent/FI95375C/fi active Protection Beyond IP Right Term
- 1988-06-28 UA UA4356076A patent/UA5560A1/uk unknown
- 1988-06-28 SU SU884356076A patent/SU1648248A3/ru active
- 1988-07-08 AT AT88306250T patent/ATE71941T1/de active
- 1988-07-08 ES ES198888306250T patent/ES2038757T3/es not_active Expired - Lifetime
- 1988-07-08 EP EP88306250A patent/EP0300652B1/en not_active Expired - Lifetime
- 1988-07-08 DE DE2003199005 patent/DE10399005I2/de active Active
- 1988-07-08 DE DE8888306250T patent/DE3867945D1/de not_active Expired - Lifetime
- 1988-07-11 DK DK386288A patent/DK165788C/da not_active IP Right Cessation
- 1988-07-11 NZ NZ225362A patent/NZ225362A/xx unknown
- 1988-07-11 AU AU18941/88A patent/AU600839B2/en not_active Expired
- 1988-07-12 IL IL87076A patent/IL87076A0/xx not_active IP Right Cessation
- 1988-07-14 DD DD88317936A patent/DD281807A5/de not_active IP Right Cessation
- 1988-07-14 CA CA000572086A patent/CA1337659C/en not_active Expired - Lifetime
- 1988-07-15 KR KR1019880008937A patent/KR940007311B1/ko not_active Expired - Lifetime
- 1988-07-15 HU HU883708A patent/HU198693B/hu unknown
- 1988-07-15 IE IE217488A patent/IE60456B1/en not_active IP Right Cessation
- 1988-07-15 NO NO883155A patent/NO170579C/no not_active IP Right Cessation
- 1988-07-15 PT PT88013A patent/PT88013B/pt not_active IP Right Cessation
- 1988-07-15 US US07/219,637 patent/US4910214A/en not_active Expired - Lifetime
- 1988-07-15 ZA ZA885134A patent/ZA885134B/xx unknown
- 1988-07-16 JP JP63177959A patent/JPH0625138B2/ja not_active Expired - Lifetime
- 1988-07-16 CN CN88104440A patent/CN1022323C/zh not_active Expired - Lifetime
1992
- 1992-02-21 GR GR920400299T patent/GR3003878T3/el unknown
1994
- 1994-01-18 BG BG098380A patent/BG60473B2/bg unknown
- 1994-05-24 HK HK56094A patent/HK56094A/en not_active IP Right Cessation
1995
- 1995-10-20 CY CY178795A patent/CY1787A/xx unknown
2003
- 2003-02-14 LU LU91010C patent/LU91010I2/fr unknown
- 2003-03-03 NL NL300117C patent/NL300117I2/nl unknown
- 2003-07-01 NO NO2003004C patent/NO2003004I2/no unknown
2004
- 2004-10-27 CY CY200400006C patent/CY2004006I2/el unknown

Also Published As

Publication number	Publication date
DE10399005I2 (de)	2012-06-06
BG60473B2 (bg)	1995-04-28
FI882819L (fi)	1989-01-17
IE60456B1 (en)	1994-07-13
NL300117I2 (nl)	2003-10-01
CY1787A (en)	1995-10-20
AU1894188A (en)	1989-01-19
LU91010I2 (fr)	2003-06-19
NO883155L (no)	1989-01-17
NO2003004I2 (no)	2005-03-21
GB2206880A (en)	1989-01-18
JPH0625138B2 (ja)	1994-04-06
NO170579C (no)	1992-11-04
NO883155D0 (no)	1988-07-15
DD281807A5 (de)	1990-08-22
DE3867945D1 (de)	1992-03-05
KR940007311B1 (ko)	1994-08-12
FI95375C (fi)	1996-01-25
UA5560A1 (uk)	1994-12-28
GB8716803D0 (en)	1987-08-19
CN1030576A (zh)	1989-01-25
DE10399005I1 (de)	2003-06-05
ATE71941T1 (de)	1992-02-15
JPS6434968A (en)	1989-02-06
PT88013A (pt)	1989-06-30
HK56094A (en)	1994-06-03
NZ225362A (en)	1990-07-26
SU1648248A3 (ru)	1991-05-07
ZA885134B (en)	1989-04-26
NL300117I1 (nl)	2003-05-01
DK386288D0 (da)	1988-07-11
ES2038757T3 (es)	1993-08-01
NO170579B (no)	1992-07-27
IE882174L (en)	1989-01-16
HUT48218A (en)	1989-05-29
US4910214A (en)	1990-03-20
KR890002030A (ko)	1989-04-07
EP0300652A1 (en)	1989-01-25
IL87076A0 (en)	1988-12-30
EP0300652B1 (en)	1992-01-22
CY2004006I1 (el)	2009-11-04
DK165788C (da)	1993-06-14
DK386288A (da)	1989-01-17
GR3003878T3 (fi)	1993-03-16
CA1337659C (en)	1995-11-28
CN1022323C (zh)	1993-10-06
FI882819A0 (fi)	1988-06-14
HU198693B (en)	1989-11-28
GB2206880B (en)	1991-04-24
PT88013B (pt)	1995-03-01
CY2004006I2 (el)	2009-11-04
AU600839B2 (en)	1990-08-23
DK165788B (da)	1993-01-18

Legal Events

Date	Code	Title	Description
1988-06-14	FG	Patent granted	Owner name: ORION-YHTYMAE OY
1995-09-18	BB	Publication of examined application
1996-01-19	GB	Transfer or assigment of application	Owner name: ORION-YHTYMAE OY
2003-02-25	SPCF	Supplementary protection certificate application filed	Spc suppl protection certif: L20030004
2004-08-31	FG	Patent granted	Owner name: ORION-YHTYMAE OY
2006-11-20	SPCG	Supplementary protection certificate granted	Spc suppl protection certif: L196 Extension date: 20130613

Publication	Publication Date	Title
FI95375B (fi)	1995-10-13	Analogiamenetelmä medetomidiinin terapeuttisesti aktiivisen d-isomeerin valmistamiseksi
FI873205A0 (fi)	1987-07-21	Menetelmä terapeuttisesti aktiivisten bentsimidatsolijohdannaisten valmistamiseksi
FI906438A0 (fi)	1990-12-28	Menetelmä uusien, terapeuttisesti käyttökelpoisten A-nor-steroidi-3-karboksyylihappojohdannaisten valmistamiseksi
FI880816A7 (fi)	1988-09-24	Menetelmä uusien terapeuttisesti käyttökelpoisten kinoksaliinijohdannaisten valmistamiseksi
LU81297A1 (fr)	1979-09-11	Procede enzymatique microbiologique pour la production d'aminoacides optiquement actifs en partant d'hydantoines et/ou de derives carbamoyle racemiques
FI89046C (fi)	1993-08-10	Foerfarande foer framstaellning av terapeutiskt aktiv bensimidazolfoerening
FI871087A0 (fi)	1987-03-12	Menetelmä terapeuttisesti aktiivisten 1,2,3,4-tetrahydro-3-karbamoyyli-2-tiokso/okso-5-pyrimidiinikarboksyylihappojohdannaisten valmistamiseksi
FI884660A0 (fi)	1988-10-11	Menetelmä terapeuttisesti aktiivisten 2,2-dimetyylikromeenijohdannaisten valmistamiseksi
FI99013B (fi)	1997-06-13	Analogiamenetelmä terapeuttisesti käyttökelpoisten bentsimidatsolijohdannaisten valmistamiseksi
FI893471A0 (fi)	1989-07-18	Menetelmä haavaumia ehkäisevien (alkyyliditio)kinoliinijohdannaisten valmistamiseksi
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