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ES2969366T3 - Dispositivo y métodos de administración de fármacos con microchip de dos etapas - Google Patents

Dispositivo y métodos de administración de fármacos con microchip de dos etapas Download PDF

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Publication number
ES2969366T3
ES2969366T3 ES20816665T ES20816665T ES2969366T3 ES 2969366 T3 ES2969366 T3 ES 2969366T3 ES 20816665 T ES20816665 T ES 20816665T ES 20816665 T ES20816665 T ES 20816665T ES 2969366 T3 ES2969366 T3 ES 2969366T3
Authority
ES
Spain
Prior art keywords
drug
reservoir
delivery device
drug delivery
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20816665T
Other languages
English (en)
Spanish (es)
Inventor
Robert Farra
Elizabeth Proos
Scott W James
Nicolas J Pacelli
Hong-Ren Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dare MB inc
Original Assignee
Dare MB inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dare MB inc filed Critical Dare MB inc
Application granted granted Critical
Publication of ES2969366T3 publication Critical patent/ES2969366T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/007Injectors for solid bodies, e.g. suppositories
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4836Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A61M2005/1726Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure the body parameters being measured at, or proximate to, the infusion site
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16Masculine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES20816665T 2019-11-01 2020-10-30 Dispositivo y métodos de administración de fármacos con microchip de dos etapas Active ES2969366T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962929432P 2019-11-01 2019-11-01
PCT/US2020/058240 WO2021087277A1 (fr) 2019-11-01 2020-10-30 Méthodes et dispositif d'administration de médicament à micropuces à deux étages

Publications (1)

Publication Number Publication Date
ES2969366T3 true ES2969366T3 (es) 2024-05-17

Family

ID=73646420

Family Applications (1)

Application Number Title Priority Date Filing Date
ES20816665T Active ES2969366T3 (es) 2019-11-01 2020-10-30 Dispositivo y métodos de administración de fármacos con microchip de dos etapas

Country Status (13)

Country Link
US (1) US20210128463A1 (fr)
EP (1) EP4051365B1 (fr)
JP (1) JP2022553563A (fr)
KR (1) KR20220091506A (fr)
CN (1) CN114728152A (fr)
AU (1) AU2020373091A1 (fr)
BR (1) BR112022007471A2 (fr)
CA (1) CA3153175A1 (fr)
ES (1) ES2969366T3 (fr)
IL (1) IL292471A (fr)
MX (1) MX2022005206A (fr)
WO (1) WO2021087277A1 (fr)
ZA (1) ZA202203976B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11464300B2 (en) 2016-05-12 2022-10-11 Arthur Snyder Display attachment

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070590B1 (en) 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
AU6639400A (en) 1999-08-18 2001-03-13 Microchips, Inc. Thermally-activated microchip chemical delivery devices
AU770395B2 (en) 1999-11-17 2004-02-19 Boston Scientific Limited Microfabricated devices for the delivery of molecules into a carrier fluid
AU2002326304A1 (en) * 2001-05-31 2002-12-16 Massachusetts Institute Of Technology Microchip devices with improved reservoir opening
CN1585627A (zh) * 2001-09-14 2005-02-23 弗朗西斯J·马丁 用于持续释放治疗剂的显微制作的纳米微孔装置
US6953455B2 (en) * 2002-07-30 2005-10-11 Hospira, Inc. Medicine delivery system
DE60336727D1 (de) 2002-08-16 2011-05-26 Microchips Inc Vorrichtung mit kontrollierter abgabe und verfahren
AU2003278881A1 (en) * 2002-09-23 2004-04-08 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
WO2005016558A2 (fr) * 2003-08-04 2005-02-24 Microchips, Inc. Procedes de liberation acceleree de matiere a partir d'un systeme reservoir
WO2006015299A2 (fr) * 2004-07-30 2006-02-09 Microchips, Inc. Dispositif multi-reservoir pour la delivrance de medicament transdermique et la detection
EP1791643B1 (fr) 2004-09-01 2009-03-11 Microchips, Inc. Dispositifs a reservoir dotes de plusieurs capuchons destines a la liberation controlee ou a l'exposition de contenus de reservoir
US20080076975A1 (en) * 2005-01-25 2008-03-27 Microchips, Inc. Method and implantable device with reservoir array for pre-clinical in vivo testing
WO2007041584A2 (fr) * 2005-10-03 2007-04-12 Combinatorx, Incorporated Capteurs implantables, pompes implantables et associations de medicaments empechant la formation de cicatrices
US20070275035A1 (en) * 2006-05-24 2007-11-29 Microchips, Inc. Minimally Invasive Medical Implant Devices for Controlled Drug Delivery
JP2010502346A (ja) * 2006-09-08 2010-01-28 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 所定量の物質の制御放出のための装置
CN100482293C (zh) * 2006-12-19 2009-04-29 重庆大学 缓释型遥控电子胶囊
US10427153B2 (en) 2011-08-25 2019-10-01 Microchips Biotech, Inc. Systems and methods for sealing a plurality of reservoirs of a microchip element with a sealing grid
CN103906466B (zh) * 2011-08-25 2017-02-22 微芯片生物科技公司 省空间的封闭装置及其制造方法
AU2013226076B2 (en) * 2012-02-27 2017-11-16 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administration thereof
CN104869888B (zh) * 2012-12-21 2017-12-19 微芯片生物技术公司 用于微创插入的可植入医疗装置
JP6387357B2 (ja) 2013-02-28 2018-09-05 マイクロチップス バイオテック,インコーポレイテッド 低侵襲挿入のための植え込み型医療デバイス
WO2016061509A1 (fr) * 2014-10-17 2016-04-21 The Broad Institute, Inc. Compositions et procédés de traitement de la dystrophie musculaire
US10286198B2 (en) * 2016-04-08 2019-05-14 International Business Machines Corporation Microchip medical substance delivery devices
CN110944645A (zh) * 2017-07-25 2020-03-31 塔里斯生物医药公司 治疗肿瘤转移的方法
WO2019108580A1 (fr) * 2017-11-28 2019-06-06 Massachusetts Institute Of Technology Électroniques à résidence gastrique
US12115330B2 (en) * 2019-01-03 2024-10-15 Vibrant Ltd. Device and method for delivering an ingestible medicament into the gastrointestinal tract of a user

Also Published As

Publication number Publication date
BR112022007471A2 (pt) 2022-07-12
US20210128463A1 (en) 2021-05-06
AU2020373091A1 (en) 2022-05-19
WO2021087277A1 (fr) 2021-05-06
KR20220091506A (ko) 2022-06-30
JP2022553563A (ja) 2022-12-23
CN114728152A (zh) 2022-07-08
MX2022005206A (es) 2022-08-10
CA3153175A1 (fr) 2021-05-06
EP4051365B1 (fr) 2023-10-18
ZA202203976B (en) 2023-10-25
IL292471A (en) 2022-06-01
EP4051365A1 (fr) 2022-09-07

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