ES2424943T3 - Un proceso rentable para la preparación de hierro sacarosa - Google Patents

Un proceso rentable para la preparación de hierro sacarosa Download PDF

Info

Publication number: ES2424943T3
Authority: ES; Spain
Prior art keywords: sucrose; process according; temperature; iron; ferric
Prior art date: 2004-12-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES05817906T

Other languages

English (en)

Spanish (es)

Inventor

Milind Moreshwar Gharpure

Baburao Manikrao Bhawal

Rajiv Pandurag Sutar

Satish Ramanlal Mehta

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Emcure Pharmaceuticals Ltd

Original Assignee

Emcure Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-06

Filing date

2005-12-02

Publication date

2013-10-10

2005-12-02 Application filed by Emcure Pharmaceuticals Ltd filed Critical Emcure Pharmaceuticals Ltd

2013-10-10 Application granted granted Critical

2013-10-10 Publication of ES2424943T3 publication Critical patent/ES2424943T3/es

Status Active legal-status Critical Current

2025-12-02 Anticipated expiration legal-status Critical

Links

229930006000 Sucrose Natural products 0.000 title claims abstract description 101
239000005720 sucrose Substances 0.000 title claims abstract description 100
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 title claims abstract description 68
238000000034 method Methods 0.000 title claims abstract description 52
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title description 63
229910052742 iron Inorganic materials 0.000 title description 29
238000002360 preparation method Methods 0.000 title description 29
-1 sucrose iron complex Chemical class 0.000 claims abstract description 34
IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 claims abstract description 22
239000003960 organic solvent Substances 0.000 claims abstract description 21
229910021519 iron(III) oxide-hydroxide Inorganic materials 0.000 claims abstract description 17
239000011541 reaction mixture Substances 0.000 claims abstract description 17
150000003839 salts Chemical class 0.000 claims abstract description 12
238000010438 heat treatment Methods 0.000 claims abstract description 7
239000002904 solvent Substances 0.000 claims abstract description 6
239000012736 aqueous medium Substances 0.000 claims abstract description 5
229910001415 sodium ion Inorganic materials 0.000 claims abstract description 5
239000012141 concentrate Substances 0.000 claims abstract description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 36
239000000203 mixture Substances 0.000 claims description 23
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 8
ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims description 8
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 8
238000006243 chemical reaction Methods 0.000 claims description 7
238000003756 stirring Methods 0.000 claims description 3
238000012545 processing Methods 0.000 claims description 2
229960004793 sucrose Drugs 0.000 description 83
239000000243 solution Substances 0.000 description 17
150000007529 inorganic bases Chemical class 0.000 description 16
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 13
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
239000007864 aqueous solution Substances 0.000 description 9
FWZTTZUKDVJDCM-CEJAUHOTSA-M disodium;(2r,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;iron(3+);oxygen(2-);hydroxide;trihydrate Chemical compound O.O.O.[OH-].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[Na+].[Na+].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 FWZTTZUKDVJDCM-CEJAUHOTSA-M 0.000 description 9
UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 9
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
229910021578 Iron(III) chloride Inorganic materials 0.000 description 6
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
VCJMYUPGQJHHFU-UHFFFAOYSA-N iron(3+);trinitrate Chemical compound [Fe+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O VCJMYUPGQJHHFU-UHFFFAOYSA-N 0.000 description 6
229910052708 sodium Inorganic materials 0.000 description 6
239000011734 sodium Substances 0.000 description 6
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
229960004887 ferric hydroxide Drugs 0.000 description 5
230000001105 regulatory effect Effects 0.000 description 5
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
150000001408 amides Chemical class 0.000 description 4
239000002585 base Substances 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
229910052791 calcium Inorganic materials 0.000 description 4
239000011575 calcium Substances 0.000 description 4
150000001720 carbohydrates Chemical class 0.000 description 4
235000014633 carbohydrates Nutrition 0.000 description 4
150000002576 ketones Chemical class 0.000 description 4
238000004519 manufacturing process Methods 0.000 description 4
239000000047 product Substances 0.000 description 4
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 4
229940081974 saccharin Drugs 0.000 description 4
235000019204 saccharin Nutrition 0.000 description 4
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 4
229910000029 sodium carbonate Inorganic materials 0.000 description 4
239000000725 suspension Substances 0.000 description 4
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
150000002170 ethers Chemical class 0.000 description 3
238000004108 freeze drying Methods 0.000 description 3
235000014413 iron hydroxide Nutrition 0.000 description 3
229940032961 iron sucrose Drugs 0.000 description 3
NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 description 3
238000001556 precipitation Methods 0.000 description 3
150000003462 sulfoxides Chemical class 0.000 description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
CZNVSLGYWMSMKE-OPDGVEILSA-K Ferric gluconate Chemical compound [Fe+3].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O CZNVSLGYWMSMKE-OPDGVEILSA-K 0.000 description 2
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
229930091371 Fructose Natural products 0.000 description 2
239000005715 Fructose Substances 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
229910052784 alkaline earth metal Inorganic materials 0.000 description 2
150000001342 alkaline earth metals Chemical class 0.000 description 2
229910052788 barium Inorganic materials 0.000 description 2
DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 2
239000003610 charcoal Substances 0.000 description 2
230000007547 defect Effects 0.000 description 2
239000008103 glucose Substances 0.000 description 2
150000002505 iron Chemical class 0.000 description 2
MVZXTUSAYBWAAM-UHFFFAOYSA-N iron;sulfuric acid Chemical compound [Fe].OS(O)(=O)=O MVZXTUSAYBWAAM-UHFFFAOYSA-N 0.000 description 2
238000002955 isolation Methods 0.000 description 2
229910052700 potassium Inorganic materials 0.000 description 2
239000011591 potassium Substances 0.000 description 2
235000000346 sugar Nutrition 0.000 description 2
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
102000003951 Erythropoietin Human genes 0.000 description 1
108090000394 Erythropoietin Proteins 0.000 description 1
206010022971 Iron Deficiencies Diseases 0.000 description 1
NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
229910001854 alkali hydroxide Inorganic materials 0.000 description 1
229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
150000008041 alkali metal carbonates Chemical class 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
239000000908 ammonium hydroxide Substances 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
239000004568 cement Substances 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
235000008504 concentrate Nutrition 0.000 description 1
230000001276 controlling effect Effects 0.000 description 1
235000013681 dietary sucrose Nutrition 0.000 description 1
235000015872 dietary supplement Nutrition 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
229940105423 erythropoietin Drugs 0.000 description 1
229960002413 ferric citrate Drugs 0.000 description 1
IMBKASBLAKCLEM-UHFFFAOYSA-L ferrous ammonium sulfate (anhydrous) Chemical compound [NH4+].[NH4+].[Fe+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O IMBKASBLAKCLEM-UHFFFAOYSA-L 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000012467 final product Substances 0.000 description 1
238000007429 general method Methods 0.000 description 1
238000001631 haemodialysis Methods 0.000 description 1
230000000322 hemodialysis Effects 0.000 description 1
150000004679 hydroxides Chemical class 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000011835 investigation Methods 0.000 description 1
150000004698 iron complex Chemical class 0.000 description 1
RUTXIHLAWFEWGM-UHFFFAOYSA-H iron(3+) sulfate Chemical compound [Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O RUTXIHLAWFEWGM-UHFFFAOYSA-H 0.000 description 1
PVFSDGKDKFSOTB-UHFFFAOYSA-K iron(3+);triacetate Chemical compound [Fe+3].CC([O-])=O.CC([O-])=O.CC([O-])=O PVFSDGKDKFSOTB-UHFFFAOYSA-K 0.000 description 1
HEJPGFRXUXOTGM-UHFFFAOYSA-K iron(3+);triiodide Chemical compound [Fe+3].[I-].[I-].[I-] HEJPGFRXUXOTGM-UHFFFAOYSA-K 0.000 description 1
NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 description 1
229910000360 iron(III) sulfate Inorganic materials 0.000 description 1
238000012792 lyophilization process Methods 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
229910000000 metal hydroxide Inorganic materials 0.000 description 1
150000004692 metal hydroxides Chemical class 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
238000002156 mixing Methods 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000012958 reprocessing Methods 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
229940062350 sodium ferric gluconate complex Drugs 0.000 description 1
239000000176 sodium gluconate Substances 0.000 description 1
235000012207 sodium gluconate Nutrition 0.000 description 1
229940005574 sodium gluconate Drugs 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
FEONEKOZSGPOFN-UHFFFAOYSA-K tribromoiron Chemical compound Br[Fe](Br)Br FEONEKOZSGPOFN-UHFFFAOYSA-K 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES05817906T 2004-12-06 2005-12-02 Un proceso rentable para la preparación de hierro sacarosa Active ES2424943T3 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IN1298MU2004		2004-12-06
INMU12982004		2004-12-06
PCT/IB2005/003629 WO2006061685A1 (fr)	2004-12-06	2005-12-02	Procede economique de preparation de complexes sucrose/fer

Publications (1)

Publication Number	Publication Date
ES2424943T3 true ES2424943T3 (es)	2013-10-10

Family

ID=35839026

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES05817906T Active ES2424943T3 (es)	2004-12-06	2005-12-02	Un proceso rentable para la preparación de hierro sacarosa

Country Status (4)

Country	Link
US (1)	US8030480B2 (fr)
EP (1)	EP1819720B1 (fr)
ES (1)	ES2424943T3 (fr)
WO (1)	WO2006061685A1 (fr)

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US20080132465A1 (en) *	2006-12-05	2008-06-05	Vincent Windisch	Apparatus and method for isolating iron components from serum
US9370202B2 (en)	2013-03-15	2016-06-21	LG Bionano, LLC	Encapsulated metal ion nanoclusters
CN104558064A (zh) *	2013-10-29	2015-04-29	北京京卫信康医药科技发展有限公司	蔗糖铁的制备方法
IN2013CH05383A (fr) *	2013-11-21	2015-08-28	Reddy’S Lab Ltd Dr
US20180147238A1 (en) *	2015-05-29	2018-05-31	Sun Pharmaceutical Industries Ltd.	Composition of iron sucrose and process for its preparation
CN106243177B (zh) *	2016-08-01	2019-01-22	南宁市泽威尔饲料有限责任公司	蔗糖钙络合物的制备方法
CN106243176B (zh) *	2016-08-01	2019-01-22	南宁市泽威尔饲料有限责任公司	蔗糖铜络合物的制备方法
CN106188200B (zh) *	2016-08-01	2019-01-18	南宁市泽威尔饲料有限责任公司	蔗糖锌络合物的制备方法
CN106220691B (zh) *	2016-08-01	2019-01-18	南宁市泽威尔饲料有限责任公司	蔗糖锰络合物的制备方法
CN106243162B (zh) *	2016-08-01	2019-01-25	南宁市泽威尔饲料有限责任公司	蔗糖铁络合物的制备方法
SMT202300276T1 (it)	2019-02-28	2023-11-13	Renibus Therapeutics Inc	Nuove composizioni a base di ferro e metodi di realizzazione e uso delle stesse
CN118103047A (zh)	2021-08-27	2024-05-28	美国瑞根特有限公司	铁组合物及其制备和使用方法

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US3821192A (en) *	1971-08-18	1974-06-28	Central Pharmacal Co	Process for preparing an iron-saccharide complex
DE3422249A1 (de)	1984-06-15	1985-12-19	Pfeifer & Langen, 5000 Köln	Wasserloesliches eisendextran und verfahren zu seiner herstellung
IT1186787B (it) *	1985-11-06	1987-12-16	Mediolanum Farmaceutici Srl	Ferro-derivati della globina e dell'acetilglobina dotati di elevata biodisponibilita',processo di preparazione e composizioni farmaceutiche
US4994283A (en) *	1987-07-02	1991-02-19	The Procter & Gamble Company	Iron-calcium mineral supplements with enhanced bioavailability
IN187116B (fr)	2000-01-31	2002-02-09	Alkem Lab
US6693211B2 (en)	2002-05-15	2004-02-17	Geneva Pharmaceuticals, Inc.	Chemical process
PT1540338E (pt) *	2002-08-26	2008-12-04	Vifor Int Ag	Teste de bioequivalência para formulações contendo ferro
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US7964568B2 (en) *	2003-05-30	2011-06-21	Chromaceutical Advanced Technologies, Inc.	Synthesis of high molecular weight iron-saccharidic complexes
ES2394312T3 (es) *	2004-03-16	2013-01-30	Navinta Llc	Complejos de hierro sacarosa y método de producción de los mismos

2005
- 2005-12-02 US US11/720,900 patent/US8030480B2/en active Active
- 2005-12-02 ES ES05817906T patent/ES2424943T3/es active Active
- 2005-12-02 EP EP05817906.0A patent/EP1819720B1/fr active Active
- 2005-12-02 WO PCT/IB2005/003629 patent/WO2006061685A1/fr active Application Filing

Also Published As

Publication number	Publication date
EP1819720B1 (fr)	2013-05-15
US20090299052A1 (en)	2009-12-03
EP1819720A1 (fr)	2007-08-22
WO2006061685A1 (fr)	2006-06-15
US8030480B2 (en)	2011-10-04

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