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ES2123873T3 - Pirrolocarbazol. - Google Patents

Pirrolocarbazol.

Info

Publication number
ES2123873T3
ES2123873T3 ES95111472T ES95111472T ES2123873T3 ES 2123873 T3 ES2123873 T3 ES 2123873T3 ES 95111472 T ES95111472 T ES 95111472T ES 95111472 T ES95111472 T ES 95111472T ES 2123873 T3 ES2123873 T3 ES 2123873T3
Authority
ES
Spain
Prior art keywords
sup
hydrogen
lower alkyl
pyrollocarbazole
heteroaril
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95111472T
Other languages
English (en)
Inventor
Chris Allen Broka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HOFFMANN LA ROCHE
F Hoffmann La Roche AG
Original Assignee
HOFFMANN LA ROCHE
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HOFFMANN LA ROCHE, F Hoffmann La Roche AG filed Critical HOFFMANN LA ROCHE
Application granted granted Critical
Publication of ES2123873T3 publication Critical patent/ES2123873T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LOS COMPUESTOS REPRESENTADOS POR LA FORMULA I: EN LA QUE: R{SUP,1} ES HIDROGENO O ALQUILO INFERIOR; R{SUP,2} ES HETEROARILO; Y R{SUP,3} Y R{SUP,4} SON, INDEPENDIENTEMENTE, HIDROGENO O ALQUILO INFERIOR; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, SON UTILES COMO AGENTES QUIMIOTERAPEUTICOS.
ES95111472T 1994-08-04 1995-07-21 Pirrolocarbazol. Expired - Lifetime ES2123873T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28604394A 1994-08-04 1994-08-04

Publications (1)

Publication Number Publication Date
ES2123873T3 true ES2123873T3 (es) 1999-01-16

Family

ID=23096813

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95111472T Expired - Lifetime ES2123873T3 (es) 1994-08-04 1995-07-21 Pirrolocarbazol.

Country Status (30)

Country Link
US (1) US5721267A (es)
EP (1) EP0695755B1 (es)
JP (1) JP2672290B2 (es)
KR (1) KR100326790B1 (es)
CN (1) CN1051551C (es)
AT (1) ATE172463T1 (es)
AU (1) AU692563B2 (es)
BR (1) BR9503536A (es)
CA (1) CA2155148A1 (es)
CO (1) CO4410329A1 (es)
CZ (1) CZ288583B6 (es)
DE (1) DE69505470T2 (es)
DK (1) DK0695755T3 (es)
ES (1) ES2123873T3 (es)
FI (1) FI111258B (es)
HK (1) HK1012341A1 (es)
HU (1) HU225567B1 (es)
IL (1) IL114785A (es)
MA (1) MA23639A1 (es)
MY (1) MY117092A (es)
NO (1) NO304833B1 (es)
NZ (1) NZ272687A (es)
PE (1) PE34996A1 (es)
PL (1) PL180801B1 (es)
RU (1) RU2162089C2 (es)
SA (1) SA95160203B1 (es)
TR (1) TR199500954A1 (es)
TW (1) TW403652B (es)
UY (1) UY24010A1 (es)
ZA (1) ZA956327B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1283203B1 (it) * 1996-03-07 1998-04-16 Ausimont Spa Composizioni estinguenti la fiamma
US6020298A (en) * 1997-03-05 2000-02-01 Ausimont S.P.A. Solvent cleaning agents including additives of the formula Rf -CFX-L containing perfluoroalkylenic units
DE19744257B4 (de) * 1997-10-07 2004-04-15 Zentaris Gmbh Beta-Carboline und deren Verwendung zur Behandlung von malignen und anderen, auf pathologischen Zellproliferationen beruhenden Erkrankungen
US7122679B2 (en) * 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
AU2002354499A1 (en) * 2001-12-18 2003-06-30 Kyowa Hakko Kogyo Co., Ltd. Indole derivative
US7094798B1 (en) 2002-04-26 2006-08-22 Pfizer Inc Inhibitors of checkpoint kinases (Wee1 and Chk1)
EP1501831A1 (en) * 2002-04-26 2005-02-02 Warner-Lambert Company Llc Inhibitors of checkpoint kinases (wee1 and chk1)
JP2012051804A (ja) * 2008-12-26 2012-03-15 Kyoto Univ Ｅｇ５阻害剤
BRPI1011649B1 (pt) * 2009-06-10 2021-11-30 Chugai Seiyaku Kabushiki Kaisha Compostos tetracíclicos, medicamento, composição farmacêutica, inibidor de alk e produto farmacêutico
US9365514B2 (en) 2010-08-20 2016-06-14 Chugai Seiyaku Kabushiki Kaisha Composition comprising tetracyclic compound
US10668075B2 (en) 2012-09-25 2020-06-02 Chugai Seiyaku Kabushiki Kaisha RET inhibitor
KR101577098B1 (ko) 2012-11-20 2015-12-14 주식회사 두산 유기 화합물 및 이를 포함하는 유기 전계 발광 소자
WO2015163447A1 (ja) 2014-04-25 2015-10-29 中外製薬株式会社 ４環性化合物の新規結晶
WO2015163448A1 (ja) 2014-04-25 2015-10-29 中外製薬株式会社 ４環性化合物を高用量含有する製剤
TWI803187B (zh) 2014-08-08 2023-05-21 日商中外製藥股份有限公司 包含４環性化合物的非晶質體之固體分散體及製劑
EP3246047B1 (en) 2015-01-16 2024-12-25 Chugai Seiyaku Kabushiki Kaisha Combination drug
CA3107270A1 (en) 2018-09-04 2020-03-12 Chugai Seiyaku Kabushiki Kaisha Method for producing tetracyclic compound
KR102509614B1 (ko) * 2022-08-09 2023-03-13 김학수 부직포 패널 제조방법 및 제조장치

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8611762D0 (en) * 1986-05-14 1986-06-25 Wellcome Found Polycyclic biocidal compounds
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
SK75289A3 (en) * 1988-02-10 1998-05-06 Hoffmann La Roche Substituted pyrroles, their use for producing a drug, and the drug on their base
DE3833008A1 (de) * 1988-09-29 1990-04-05 Goedecke Ag Pyrrolocarbozol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
MC2096A1 (fr) * 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
US5166204A (en) * 1989-11-01 1992-11-24 Toyama Chemical Co., Ltd. Isoindole derivatives and salts thereof and antitumor agent comprising the same
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung
AU678435B2 (en) * 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
ES2118414T3 (es) * 1993-05-28 1998-09-16 Cephalon Inc Utilizacion de derivados del indolocarbazol para el tratamiento de la prostata.

Also Published As

Publication number Publication date
HK1012341A1 (en) 1999-07-30
FI953710L (fi) 1996-02-05
PE34996A1 (es) 1996-10-01
HUT73437A (en) 1996-07-29
FI953710A0 (fi) 1995-08-03
DK0695755T3 (da) 1999-06-28
HU225567B1 (en) 2007-03-28
JP2672290B2 (ja) 1997-11-05
AU2722095A (en) 1996-02-15
NZ272687A (en) 1997-04-24
NO953052D0 (no) 1995-08-03
JPH0859666A (ja) 1996-03-05
MY117092A (en) 2004-05-31
NO304833B1 (no) 1999-02-22
CZ199795A3 (en) 1996-02-14
KR100326790B1 (ko) 2002-07-27
NO953052L (no) 1996-02-05
PL180801B1 (pl) 2001-04-30
TR199500954A1 (tr) 1996-10-21
DE69505470T2 (de) 1999-05-12
PL309874A1 (en) 1996-02-05
SA95160203B1 (ar) 2005-07-31
ZA956327B (en) 1996-02-04
CA2155148A1 (en) 1996-02-05
RU2162089C2 (ru) 2001-01-20
ATE172463T1 (de) 1998-11-15
DE69505470D1 (de) 1998-11-26
EP0695755B1 (en) 1998-10-21
EP0695755A1 (en) 1996-02-07
TW403652B (en) 2000-09-01
MA23639A1 (fr) 1996-04-01
US5721267A (en) 1998-02-24
CZ288583B6 (cs) 2001-07-11
BR9503536A (pt) 1996-06-04
CO4410329A1 (es) 1997-01-09
UY24010A1 (es) 2000-12-29
KR960007592A (ko) 1996-03-22
AU692563B2 (en) 1998-06-11
IL114785A0 (en) 1995-11-27
CN1123280A (zh) 1996-05-29
IL114785A (en) 1998-06-15
FI111258B (fi) 2003-06-30
HU9502270D0 (en) 1995-09-28
CN1051551C (zh) 2000-04-19

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