ES2017088B3 - Quelatos de tecnecio a utilizar para determinar la funcion renal. - Google Patents

Quelatos de tecnecio a utilizar para determinar la funcion renal.

Info

Publication number: ES2017088B3
Authority: ES; Spain
Prior art keywords: group; atoms; chelate; atom; alkyl groups
Prior art date: 1986-05-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES87200876T

Other languages

English (en)

Inventor

Alfons M Verbruggen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mallinckrodt Inc

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-28

Filing date

1987-05-13

Publication date

1991-01-01

1987-05-13 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

1991-01-01 Application granted granted Critical

1991-01-01 Publication of ES2017088B3 publication Critical patent/ES2017088B3/es

2007-05-13 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

230000003907 kidney function Effects 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
-1 sulpho group Chemical group 0.000 abstract 3
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
239000013522 chelant Substances 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
230000009977 dual effect Effects 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052713 technetium Inorganic materials 0.000 abstract 1
229940056501 technetium 99m Drugs 0.000 abstract 1
GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Optics & Photonics (AREA)
Public Health (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
External Artificial Organs (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES87200876T 1986-05-28 1987-05-13 Quelatos de tecnecio a utilizar para determinar la funcion renal. Expired - Lifetime ES2017088B3 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL8601369		1986-05-28

Publications (1)

Publication Number	Publication Date
ES2017088B3 true ES2017088B3 (es)	1991-01-01

Family

ID=19848082

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES87200876T Expired - Lifetime ES2017088B3 (es)	1986-05-28	1987-05-13	Quelatos de tecnecio a utilizar para determinar la funcion renal.

Country Status (8)

Country	Link
US (1)	US4849511A (es)
EP (1)	EP0250013B1 (es)
JP (1)	JPS62289596A (es)
AT (1)	ATE52516T1 (es)
AU (1)	AU611854B2 (es)
CA (1)	CA1316296C (es)
DE (1)	DE3762624D1 (es)
ES (1)	ES2017088B3 (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4980147A (en) *	1984-06-25	1990-12-25	University Of Utah Research Foundation	Radiolabeled technetium chelates for use in renal function determinations
US5393512A (en) *	1985-01-14	1995-02-28	Vanderheyden; Jean-Luc	Stable therapeutic radionuclide compositions and methods for preparation thereof
US4965392A (en) *	1987-03-26	1990-10-23	Neorx Corporation	Chelating compounds for metal-radionuclide labeled proteins
US5091514A (en) *	1987-03-26	1992-02-25	Neorx Corporation	Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy
US4846187A (en) *	1987-12-01	1989-07-11	The Center For Molecular Medicine And Immunology	Dual isotope scintigraphic image enhancement
US5071636A (en) *	1987-12-29	1991-12-10	Nihon Medi-Physics Co., Ltd.	Chelating compounds and their use
US5202451A (en) *	1988-02-17	1993-04-13	Neorx Corporation	Anchimeric radiometal chelating compounds
US5218128A (en) *	1988-06-15	1993-06-08	Centocor, Inc.	Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
DE68919366T2 (de) *	1988-09-30	1995-05-18	Neorx Corp	Spaltbare linker zur reduzierung der akkumulierung von immunokonjugaten in nicht-zielorganen.
US5171563A (en) *	1988-09-30	1992-12-15	Neorx Corporation	Cleavable linkers for the reduction of non-target organ retention of immunoconjugates
US4925650A (en) *	1988-11-16	1990-05-15	Mallinckrodt, Inc.	Technetium -99m complex for examining the renal function
US5164176A (en) *	1989-06-16	1992-11-17	Neorx Corporation	Radionuclide metal chelates for the radiolabeling of proteins
US5250666A (en) *	1989-06-16	1993-10-05	Neorx Corporation	Radionuclide metal chelates for the radiolabeling of proteins
US5700444A (en) *	1992-02-20	1997-12-23	Rhomed Incorporated	Chemotactic peptide pharmaceutical applications
US5985240A (en) *	1989-08-09	1999-11-16	Rhomed Incorporated	Peptide radiopharmaceutical applications
US5759515A (en) *	1989-08-09	1998-06-02	Rhomed Incorporated	Polyvalent peptide pharmaceutical applications
US5112953A (en) *	1989-12-29	1992-05-12	Neorx Corporation	Radiolabeled proteins for diagnostic or therapeutic use
US5175257A (en) *	1989-12-29	1992-12-29	Neorx Corporation	Radiolabeled proteins for diagnostic or therapeutic use
US5268163A (en) *	1990-04-17	1993-12-07	Mallinckrodt Medical, Inc.	Method of preparing a radiolabelled technetium complex and kit for performing said method
US5684137A (en) *	1990-09-28	1997-11-04	Neorx Corporation	S3 N chelating compounds for the radiolabeling of ligands, anti-ligands or other proteins
US5252721A (en) *	1990-09-28	1993-10-12	Neorx Corporation	S3 N chelating compounds
US5037631A (en) *	1990-10-29	1991-08-06	Mallinckrodt Medical, Inc.	Technetium-99M complex for examinating the renal function
US5116598A (en) *	1990-10-29	1992-05-26	Mallinckrodt Medical, Inc.	N4 technetium-99 m complexes for use as radiopharmaceuticals
JP2860157B2 (ja) *	1990-10-31	1999-02-24	日本メジフィジックス株式会社	腎機能測定用の既放射能標識テクネチウムキレート注射剤の製造方法
EP0485664A1 (en) *	1990-11-13	1992-05-20	Mallinckrodt Diagnostica (Holland) B.V.	Method of preparing a diagnostic agent for detecting inflammations
JPH06505268A (ja) *	1991-02-14	1994-06-16	マリンクロッド・メディカル・インコーポレイテッド	放射性医薬製剤の現場合成
AU1995392A (en) *	1991-05-08	1992-12-21	Mallinckrodt Medical, Inc.	Technetium chelates to be used for determining the renal function
US5808091A (en)	1991-10-29	1998-09-15	Bracco International B.V.	Rhenium and technetium complexes containing a hypoxia localizing moiety
EP0542216A1 (de) *	1991-11-13	1993-05-19	Hoechst Aktiengesellschaft	Diaminomercapto (thio)ether als Komplexbildner für in der Nuklearmedizin einsetzbare Nuklide, Verfahren zur Herstellung der Komplexe, sowie Markierungskits, enthaltend diese Komplexe
US5738838A (en) *	1992-02-20	1998-04-14	Rhomed Incorporated	IKVAV peptide radiopharmaceutical applications
US5556609A (en) *	1992-02-20	1996-09-17	Rhomed Incorporated	YIGSR peptide radiopharmaceutical applications
DE69231586T2 (de) *	1992-01-03	2001-07-19	Rhomed, Inc.	Pharmazeutische anwendungen auf der basis von peptid-metall-ionen
US5688485A (en) *	1992-12-31	1997-11-18	The Dupont Merck Pharmaceutical Company	Radiolabelled complexes of ester-substituted diaminethiols
DE4311023C2 (de) *	1993-03-31	1996-05-02	Diagnostikforschung Inst	Bifunktionelle chalkogenatom-unterbrochene Chelatbildner von Typ XN¶1¶S¶1¶O¶1¶ für radioaktive Isotope, deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel
DE4311022C2 (de) *	1993-03-31	1996-07-11	Diagnostikforschung Inst	Bifunktionelle chalkogenatom-unterbrochene Chelatbildner vom Typ S¶3¶N¶2¶ für radioaktive Isotope und deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel
DE4310999C2 (de) *	1993-03-31	1996-07-18	Diagnostikforschung Inst	Bifunktionelle chalkogenatom-unterbrochene Chelatbildner vom Typ XN¶1¶S¶1¶X' für radioaktive Isotope und deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel
US5464934A (en) *	1993-05-14	1995-11-07	Mallinckrodt Medical, Inc.	Metal chelates as spacer compounds in biologically active peptides
US5608110A (en) *	1993-06-15	1997-03-04	Bracco International B.V.	Heteroatom-bearing ligands and metal complexes thereof
EP0710228B1 (en) *	1993-07-19	1998-01-21	Resolution Pharmaceuticals Inc.	Hydrazino-type radionuclide chelators having an n 3?s configuration
US5574140A (en) *	1993-09-03	1996-11-12	Resolution Pharmaceutical Inc.	Hydrazino-type N2 S2 chelators
US5858327A (en) *	1993-09-03	1999-01-12	Resolutions Pharmaceuticals, Inc.	Hydrazino-type N2 S2 radionuclide chelating compounds
DE4425781A1 (de) *	1994-07-14	1996-01-18	Schering Ag	Technetium-Sulfonamid-Komplexe, deren Verwendung, diese enthaltende pharmazeutische Mittel, sowie Verfahren zur Herstellung der Komplexe und Mittel
US5662885A (en) *	1994-07-22	1997-09-02	Resolution Pharmaceuticals Inc.	Peptide derived radionuclide chelators
WO1996007629A1 (en) *	1994-09-08	1996-03-14	Mallinckrodt Medical, Inc.	Technetium chelates to be used for determining the renal function
US5986074A (en) *	1996-05-06	1999-11-16	Emory University	Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof
US5955053A (en) *	1996-05-06	1999-09-21	Emory University	Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof
DE19860289C2 (de) *	1998-12-21	2003-11-13	Schering Ag	Neue Chelatoren sowie deren Tricarbonyl-Komplexe mit Technetium und Rhenium

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4980147A (en) *	1984-06-25	1990-12-25	University Of Utah Research Foundation	Radiolabeled technetium chelates for use in renal function determinations

1987
- 1987-05-13 EP EP87200876A patent/EP0250013B1/en not_active Expired - Lifetime
- 1987-05-13 AT AT87200876T patent/ATE52516T1/de not_active IP Right Cessation
- 1987-05-13 DE DE8787200876T patent/DE3762624D1/de not_active Expired - Fee Related
- 1987-05-13 ES ES87200876T patent/ES2017088B3/es not_active Expired - Lifetime
- 1987-05-25 JP JP62126068A patent/JPS62289596A/ja active Pending
- 1987-05-25 CA CA000537923A patent/CA1316296C/en not_active Expired - Fee Related
- 1987-05-26 AU AU73605/87A patent/AU611854B2/en not_active Ceased
- 1987-05-26 US US07/054,649 patent/US4849511A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE52516T1 (de)	1990-05-15
AU7360587A (en)	1988-12-01
EP0250013A1 (en)	1987-12-23
US4849511A (en)	1989-07-18
JPS62289596A (ja)	1987-12-16
CA1316296C (en)	1993-04-13
EP0250013B1 (en)	1990-05-09
DE3762624D1 (de)	1990-06-13
AU611854B2 (en)	1991-06-27

Publication	Publication Date	Title
ES2017088B3 (es)	1991-01-01	Quelatos de tecnecio a utilizar para determinar la funcion renal.
DE68928705D1 (de)	1998-07-16	Technetium-99m-komplex zur untersuchung der nierenfunktion
DK297383A (da)	1983-12-30	Fremgangsmaade til fremstilling af piperazinderivater
DK114783A (da)	1983-09-11	Hidtil ukendte forbindelser, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
JPS56154467A (en)	1981-11-30	Novel pyrimidine-2-sulfide compound
PT941082E (pt)	2004-12-31	Nova utilizacao para derivados de 1,3-propanodiol
RO100335B1 (ro)	1990-11-30	COMPOZITIE ERBICIDA PULVERULENTA PE BAZA DE COMPUSI CU FOSFOR SOLUBILA îN APA
CY1113359T1 (el)	2016-06-22	Αντι-νεοπλασιακα παραγωγα του et-743
ES529636A0 (es)	1984-11-01	Procedimiento para la preparacion de derivados de carbaciclina
ATE232528T1 (de)	2003-02-15	Pyrimidinylpyrazolderivate
YU6699A (sh)	2000-03-21	Biaromatična jedinjenja i farmaceutski i kozmetički preparati koji ih sadrže
DK161896C (da)	1992-02-03	Anvendelse af korrosionsinhibitorer i vandige systemer
LV10076A (lv)	1994-05-10	Aizvietoti beta- diketoni
HUP9901007A2 (hu)	1999-07-28	C2a, D2 és E GE2270 faktor antibiotikum-származékok
ATE246482T1 (de)	2003-08-15	Dauerwellenzusammensetzung und verfahren
YU45966B (sh)	1992-12-21	Postopek za pripravo cefemskih spojin
DK494482A (da)	1983-05-08	2-imidazolylmethyl-2-phenyl-1,3-dioxolaner, fremgangsmaade til deres fremstilling samt deres anvendelse som fungicider
GR3006821T3 (es)	1993-06-30
ES544919A0 (es)	1986-05-16	Un procedimiento para la preparacion de nuevos derivados de aminoalcoholes
ES440030A1 (es)	1977-02-16	Un procedimiento para preparar nuevos derivados de 2-ami- noindano.
DK0812838T3 (da)	2002-08-19	Pyridoncarboxylsyrederivater substitueret med bicyclisk aminogruppe, estere og salte deraf og bicyclisk amin som mellemprodukt
TR200002804T2 (tr)	2001-02-21	MRP1 inhibe etmek için yöntemler
ZA865685B (en)	1987-03-25	Substituted phenylipiperazine derivatives
DE69515302D1 (de)	2000-04-06	Aromatische aminsubstituierte liganden mit verbrückten stickstoff-und schwefeldonatoratomen für bildformung
ES454421A1 (es)	1978-10-16	Procedimiento para preparar derivados de acetamidoxina.