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ES2076369T3 - Procedimiento para la separacion de racematos de esteres de acidos 4-aril-2-oxo-pirrolidina-3-carboxilicos. - Google Patents

Procedimiento para la separacion de racematos de esteres de acidos 4-aril-2-oxo-pirrolidina-3-carboxilicos.

Info

Publication number
ES2076369T3
ES2076369T3 ES90909039T ES90909039T ES2076369T3 ES 2076369 T3 ES2076369 T3 ES 2076369T3 ES 90909039 T ES90909039 T ES 90909039T ES 90909039 T ES90909039 T ES 90909039T ES 2076369 T3 ES2076369 T3 ES 2076369T3
Authority
ES
Spain
Prior art keywords
oxo
racemates
aryl
esters
pirrolidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90909039T
Other languages
English (en)
Inventor
Karl Petzoldt
Ralph Schmiechen
Kurt Hamp
Matthias Gottwald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2076369T3 publication Critical patent/ES2076369T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

DESCRIBIMOS UN PROCESO DE ENCIMAS PARA LA SEPARACION DE LA RACEMIZACION DE ESTERES DE ACIDOS 4-ARIL-2-OXO-PIRROLIDINE-3-CARBOXILICOS DE LA FORMULA GENERAL (I), DONDE X ES UN ENLACE CARBONO-CARBONO O UN ATOMO DE OXIGENO; R SUB 1 ES UN GRUPO HIDROCARBONO CON UN MAXIMO DE 16 ATOMOS DE CARBONO QUE PUEDEN SER SUSTITUIDOS POR GRUPOS HIDROXY, GURPOS OXO Y/O ATOMOS DE HALOGENO Y/O PUEDE INCLUIR ATOMOS DE NITROGENO EN LA CADENA; R SUB 2 ES UN GRUPO ALKIL CON UN MAXIMO DE 4 ATOMOS DE CARBONO Y R SUB 3 ES UN GRUPO ALKIL CON UN MAXIMO DE 6 ATOMOS DE CARBONO.
ES90909039T 1989-06-28 1990-06-14 Procedimiento para la separacion de racematos de esteres de acidos 4-aril-2-oxo-pirrolidina-3-carboxilicos. Expired - Lifetime ES2076369T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3921593A DE3921593A1 (de) 1989-06-28 1989-06-28 Verfahren zur racemattrennung von 4-aryl-2-oxo-pyrrolidin-3-carbonsaeure-ester

Publications (1)

Publication Number Publication Date
ES2076369T3 true ES2076369T3 (es) 1995-11-01

Family

ID=6384062

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90909039T Expired - Lifetime ES2076369T3 (es) 1989-06-28 1990-06-14 Procedimiento para la separacion de racematos de esteres de acidos 4-aril-2-oxo-pirrolidina-3-carboxilicos.

Country Status (11)

Country Link
US (1) US5539111A (es)
EP (1) EP0437555B1 (es)
AT (1) ATE127159T1 (es)
CA (1) CA2026862A1 (es)
DD (1) DD295358A5 (es)
DE (2) DE3921593A1 (es)
DK (1) DK0437555T3 (es)
ES (1) ES2076369T3 (es)
GR (1) GR900100368A (es)
IE (1) IE902338A1 (es)
WO (1) WO1991000362A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277626B1 (en) 1998-02-17 2001-08-21 G.D. Searle & Co. Process for the enzymatic resolution of lactams
KR20090080573A (ko) 2001-10-16 2009-07-24 메모리 파마슈티칼스 코포레이션 신경계 증후군의 치료를 위한 ｐｄｅ-4 억제제로서의 4-(4-알콕시-3-히드록시페닐)-2-피롤리돈 유도체
KR20060039392A (ko) * 2003-04-16 2006-05-08 메모리 파마슈티칼스 코포레이션 포스포디에스테라제 4 억제제
CN1809559B (zh) * 2003-04-18 2010-06-02 记忆药物公司 作为磷酸二酯酶4抑制剂的吡唑衍生物
US7148362B2 (en) * 2003-09-18 2006-12-12 Hoffmann-La Roche Inc. Process for the preparation of enantiopure pyrrolidin-2-one derivatives
CA2584317A1 (en) * 2004-10-15 2006-04-27 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
CN101166737A (zh) * 2004-10-20 2008-04-23 记忆药物公司 磷酸二酯酶4抑制剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2413935A1 (de) * 1974-03-20 1975-10-16 Schering Ag 4-(polyalkoxy-phenyl)-2-pyrrolidone
DE2834114A1 (de) * 1978-08-01 1980-02-14 Schering Ag Polyalkoxyphenylpyrrolidone iii, verfahren zu ihrer herstellung und ihre verwendung
JPS5931693A (ja) * 1982-08-13 1984-02-20 Kanegafuchi Chem Ind Co Ltd 光学活性オキサゾリジノン誘導体の製造方法
US4732853A (en) * 1984-11-21 1988-03-22 President And Fellows Of Harvard College Method of making chiral epoxy alcohols
EP0197474B1 (en) * 1985-04-01 1991-07-10 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for preparing optically active indoline-2-carboxylic acid
US5180671A (en) * 1986-04-16 1993-01-19 Sumitomo Chemical Company, Limited Method for producing optically active cyclopropane carboxylic acid
US4879421A (en) * 1988-08-15 1989-11-07 General Electric Company Method for preparing optically active binaphthol and spiroibiindanol
DE59205454D1 (de) * 1991-08-22 1996-04-04 Lonza Ag Verfahren zur Herstellung von optisch aktiven 4-Amino-3-hydroxycarbonsäuren

Also Published As

Publication number Publication date
ATE127159T1 (de) 1995-09-15
DE59009580D1 (de) 1995-10-05
DK0437555T3 (da) 1995-12-27
CA2026862A1 (en) 1990-12-29
EP0437555B1 (de) 1995-08-30
EP0437555A1 (de) 1991-07-24
DE3921593A1 (de) 1991-01-10
IE902338L (en) 1990-12-30
US5539111A (en) 1996-07-23
IE902338A1 (en) 1991-01-16
GR900100368A (el) 1991-11-15
DD295358A5 (de) 1991-10-31
WO1991000362A1 (de) 1991-01-10

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