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ES2055867T3 - DIBENZOTIAZEPINE DERIVATIVES USEFUL AS ANTIESPASMODIC AGENTS. - Google Patents

DIBENZOTIAZEPINE DERIVATIVES USEFUL AS ANTIESPASMODIC AGENTS.

Info

Publication number
ES2055867T3
ES2055867T3 ES90305718T ES90305718T ES2055867T3 ES 2055867 T3 ES2055867 T3 ES 2055867T3 ES 90305718 T ES90305718 T ES 90305718T ES 90305718 T ES90305718 T ES 90305718T ES 2055867 T3 ES2055867 T3 ES 2055867T3
Authority
ES
Spain
Prior art keywords
dibenzotiazepine
antiespasmodic
agents
derivatives useful
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90305718T
Other languages
Spanish (es)
Inventor
David Dr Alker
Robert J Dr Bass
Peter Edward Dr Cross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2055867T3 publication Critical patent/ES2055867T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

The invention provides compounds of the formula:- <CHEM> wherein k is 1, 2 or 3; m is 1, 2 or 3; n is 1, 2 or 3; p is 0, 1 or 2; X is O, S or a direct link, with the proviso that when X is O or S, n is 2 or 3; R<1> is H or C1-C4 alkyl; and R<2> is an optionally substituted phenyl or heteroaryl group; and pharmaceutically acceptable salts thereof. These compounds are useful for the treatment of motility disorders, particularly those of the gut such as irritable bowel syndrome.
ES90305718T 1989-05-27 1990-05-25 DIBENZOTIAZEPINE DERIVATIVES USEFUL AS ANTIESPASMODIC AGENTS. Expired - Lifetime ES2055867T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898912303A GB8912303D0 (en) 1989-05-27 1989-05-27 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2055867T3 true ES2055867T3 (en) 1994-09-01

Family

ID=10657526

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90305718T Expired - Lifetime ES2055867T3 (en) 1989-05-27 1990-05-25 DIBENZOTIAZEPINE DERIVATIVES USEFUL AS ANTIESPASMODIC AGENTS.

Country Status (20)

Country Link
US (1) US5071844A (en)
EP (1) EP0404359B1 (en)
JP (1) JPH0317079A (en)
KR (1) KR900018091A (en)
CN (1) CN1047673A (en)
AT (1) ATE107927T1 (en)
AU (1) AU5595490A (en)
CA (1) CA2017535C (en)
DD (1) DD294718A5 (en)
DE (1) DE69010285T2 (en)
DK (1) DK0404359T3 (en)
ES (1) ES2055867T3 (en)
FI (1) FI96950C (en)
GB (1) GB8912303D0 (en)
HU (1) HUT58329A (en)
IE (1) IE64196B1 (en)
IL (1) IL94457A0 (en)
NO (1) NO902336L (en)
PL (1) PL285350A1 (en)
PT (1) PT94151B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94295A0 (en) * 1989-05-25 1991-03-10 Fujisawa Pharmaceutical Co Thiazepine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IT1247509B (en) * 1991-04-19 1994-12-17 Univ Cagliari SYNTHESIS COMPOUNDS FOR USE IN THE TREATMENT OF RHINOVIRUS INFECTIONS
US5437291A (en) * 1993-08-26 1995-08-01 Univ Johns Hopkins Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction
TW479057B (en) * 1996-03-11 2002-03-11 Ajinomoto Kk 5,11-dihydrobenzo[b,e] [1,4]oxazepine derivatives and pharmaceutical composition containing the same
CN1137120C (en) * 1997-09-10 2004-02-04 味之素株式会社 5,11-Dihydrodibenz [b,e] [1,4] oxazepine derivaties and medicinal composition containing the same
EP0915088B1 (en) * 1997-10-31 2002-09-18 F. Hoffmann-La Roche Ag D-Proline derivatives
US6541479B1 (en) * 1997-12-02 2003-04-01 Massachusetts College Of Pharmacy Calcium channel blockers
US7459473B2 (en) 1998-06-03 2008-12-02 Glia Med, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
AU1892700A (en) 1999-01-08 2000-07-24 Ajinomoto Co., Inc. Oxazepine derivatives and drugs containing the same
EP1219611A4 (en) * 1999-09-03 2003-03-19 Ajinomoto Kk Novel processes for preparing oxazepine derivatives
EP1403258A4 (en) 2001-05-30 2005-06-08 Ajinomoto Kk Dihydrodiaryloxazepine derivative and medicinal composition containing the derivative
JP2005343791A (en) * 2002-05-31 2005-12-15 Ajinomoto Co Inc Medicinal composition for treating digestive tract disease
JP2005343790A (en) * 2002-05-31 2005-12-15 Ajinomoto Co Inc Medicinal composition containing calcium channel antagonist
WO2011016576A1 (en) 2009-08-04 2011-02-10 Takeda Pharmaceutical Company Limited Alanine derivatives as inhibitors of apoptosis proteins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB988008A (en) * 1900-01-01
GB774883A (en) * 1954-06-21 1957-05-15 Rhone Poulenc Sa Phenthiazine derivatives
GB975705A (en) * 1960-04-14 1964-11-18 Westminster Bank Ltd Improvements in or relating to the preparation of 3-alkylmercapto phenothiazines and intermediates formed in the process
CH407127A (en) * 1962-02-19 1966-02-15 Geigy Ag J R Process for the preparation of N-heterocyclic compounds
US3188322A (en) * 1962-08-08 1965-06-08 Olin Mathieson Dihydrodibenzothiazepines

Also Published As

Publication number Publication date
ATE107927T1 (en) 1994-07-15
EP0404359A1 (en) 1990-12-27
DK0404359T3 (en) 1994-07-25
EP0404359B1 (en) 1994-06-29
NO902336D0 (en) 1990-05-25
US5071844A (en) 1991-12-10
AU5595490A (en) 1990-11-29
PT94151B (en) 1996-12-31
DE69010285T2 (en) 1994-10-13
JPH0317079A (en) 1991-01-25
IE901883L (en) 1990-11-27
GB8912303D0 (en) 1989-07-12
FI96950C (en) 1996-09-25
HU903197D0 (en) 1990-10-28
IE64196B1 (en) 1995-07-12
PT94151A (en) 1991-01-08
PL285350A1 (en) 1991-05-20
DD294718A5 (en) 1991-10-10
FI96950B (en) 1996-06-14
CA2017535A1 (en) 1990-11-27
NO902336L (en) 1990-11-28
JPH057389B2 (en) 1993-01-28
CA2017535C (en) 2000-02-29
CN1047673A (en) 1990-12-12
FI902632A0 (en) 1990-05-25
KR900018091A (en) 1990-12-20
DE69010285D1 (en) 1994-08-04
IL94457A0 (en) 1991-06-10
HUT58329A (en) 1992-02-28

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