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EP2323725A4 - An extracorporeal cell-based therapeutic device and delivery system - Google Patents

An extracorporeal cell-based therapeutic device and delivery system

Info

Publication number
EP2323725A4
EP2323725A4 EP09807211.9A EP09807211A EP2323725A4 EP 2323725 A4 EP2323725 A4 EP 2323725A4 EP 09807211 A EP09807211 A EP 09807211A EP 2323725 A4 EP2323725 A4 EP 2323725A4
Authority
EP
European Patent Office
Prior art keywords
cells
grown
wafer
deliver
embodiment includes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09807211.9A
Other languages
German (de)
French (fr)
Other versions
EP2323725A2 (en
Inventor
H David Humes
Deborah Buffington
Gretchen Hageman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innovative Biotherapies Inc
Original Assignee
Innovative Biotherapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovative Biotherapies Inc filed Critical Innovative Biotherapies Inc
Publication of EP2323725A2 publication Critical patent/EP2323725A2/en
Publication of EP2323725A4 publication Critical patent/EP2323725A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • A61M1/3689—Chemical treatment by biological cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • External Artificial Organs (AREA)

Abstract

Extracorporeal cell-based therapeutic devices and delivery systems are disclosed which provide a method for therapeutic delivery of biologically active molecules produced by living cells in response to a dynamic physiologic environment. One embodiment includes long hollow fibers in which a layer of cells are grown within the intraluminal volume or within a double hollow-filled chamber. Another embodiment includes a wafer or a series of wafers providing a substrate onto which cells are grown. The wafer(s) are inserted into a device. A device may deliver a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation and/or may deliver a member of different cell products. The device is adapted to secure viable cells which produce and secrete the pre-selected molecule into blood or fluid. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel or body cavity the device of the invention.
EP09807211.9A 2008-08-15 2009-08-12 An extracorporeal cell-based therapeutic device and delivery system Withdrawn EP2323725A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18911908P 2008-08-15 2008-08-15
PCT/US2009/053516 WO2010019643A2 (en) 2008-08-15 2009-08-12 An extracorporeal cell-based therapeutic device and delivery system

Publications (2)

Publication Number Publication Date
EP2323725A2 EP2323725A2 (en) 2011-05-25
EP2323725A4 true EP2323725A4 (en) 2014-01-29

Family

ID=41669637

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09807211.9A Withdrawn EP2323725A4 (en) 2008-08-15 2009-08-12 An extracorporeal cell-based therapeutic device and delivery system

Country Status (4)

Country Link
US (1) US20110190679A1 (en)
EP (1) EP2323725A4 (en)
CA (1) CA2734200A1 (en)
WO (1) WO2010019643A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090081296A1 (en) * 2006-02-02 2009-03-26 Humes H David Extracorporeal cell-based therapeutic device and delivery system
WO2007092735A2 (en) 2006-02-02 2007-08-16 Innovative Bio Therapies An extracorporeal cell-based therapeutic device and delivery system
US9029144B2 (en) 2008-06-18 2015-05-12 Innovative Bio Therapies, Inc. Methods for enhanced propagation of cells
JP2014500735A (en) 2010-10-15 2014-01-16 サイトフェリックス インコーポレイテッド Cytopheresis cartridge and its use
US8574309B2 (en) * 2011-02-10 2013-11-05 Vivonics, Inc. Two-stage system and method for oxygenating and removing carbon dioxide from a physiological fluid
EP4194024A1 (en) 2012-01-09 2023-06-14 SeaStar Medical, Inc. Cartridge and method for increasing myocardial function
US20150352229A1 (en) * 2012-12-28 2015-12-10 Glusense, Ltd. Apparatus for facilitating cell growth in an implantable sensor
US9861726B2 (en) 2014-09-15 2018-01-09 Covidien Lp Coupling a body conduit to tissue
CN106999118B (en) 2014-10-13 2020-07-17 葡萄糖传感器公司 Analyte sensing device
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US10871487B2 (en) 2016-04-20 2020-12-22 Glusense Ltd. FRET-based glucose-detection molecules
US10767164B2 (en) * 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
GB201708729D0 (en) * 2017-06-01 2017-07-19 Ucl Business Plc Cryopreservation
WO2019070507A1 (en) 2017-10-05 2019-04-11 Fresenius Medical Care Holdings, Inc. Polysulfone-urethane copolymer, membranes and products incorporating same, and methods for making and using same
WO2019159149A1 (en) * 2018-02-19 2019-08-22 National Research Council Of Canada A microfluidic device for culturing cells comprising a biowall, a bead bed and a biointerface and methods of modelling said biointerface thereof
CN108403254B (en) * 2018-03-19 2024-03-29 内蒙古工业大学 A new type of retrievable vena cava filter
DE102019106651A1 (en) * 2019-03-15 2020-09-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Treatment device and method for extracorporeal, immune tolerance-increasing blood treatment
US11995833B2 (en) * 2020-07-31 2024-05-28 The Joan and Irwin Jacobs Technion-Cornell Institute System and method for on-phase microscopy
WO2022150482A1 (en) * 2021-01-08 2022-07-14 Shayne Guiliano Methods for culturing antibody secreting cells

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014496A1 (en) * 1992-12-29 1994-07-07 Hepatix, Inc. Organ support system
US6218182B1 (en) * 1996-04-23 2001-04-17 Advanced Tissue Sciences Method for culturing three-dimensional tissue in diffusion gradient bioreactor and use thereof
US6472200B1 (en) * 1999-07-23 2002-10-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Device and method for performing a biological modification of a fluid
US20040124147A1 (en) * 2002-09-11 2004-07-01 Fissell William H. Ultrafiltration membrane, device, bioartificial organ, and methods
WO2005094353A2 (en) * 2004-03-29 2005-10-13 Cytomatrix, Llc Methods for production of regulatory t cells and uses thereof
US20070269489A1 (en) * 2006-02-02 2007-11-22 Innovative Bio Therapies Extracorporeal cell-based therapeutic device and delivery system

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4878913A (en) * 1987-09-04 1989-11-07 Pfizer Hospital Products Group, Inc. Devices for neural signal transmission
DE60029606T2 (en) * 1999-09-24 2007-07-12 Cytomatrix, LLC, Woburn CELL CULTURE SPINNER BOTTLES
DE10061704A1 (en) * 2000-12-12 2002-06-20 Hans Joerg Bauer Method and device for producing biological tissue in a growth chamber

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014496A1 (en) * 1992-12-29 1994-07-07 Hepatix, Inc. Organ support system
US6218182B1 (en) * 1996-04-23 2001-04-17 Advanced Tissue Sciences Method for culturing three-dimensional tissue in diffusion gradient bioreactor and use thereof
US6472200B1 (en) * 1999-07-23 2002-10-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Device and method for performing a biological modification of a fluid
US20040124147A1 (en) * 2002-09-11 2004-07-01 Fissell William H. Ultrafiltration membrane, device, bioartificial organ, and methods
WO2005094353A2 (en) * 2004-03-29 2005-10-13 Cytomatrix, Llc Methods for production of regulatory t cells and uses thereof
US20070269489A1 (en) * 2006-02-02 2007-11-22 Innovative Bio Therapies Extracorporeal cell-based therapeutic device and delivery system

Also Published As

Publication number Publication date
CA2734200A1 (en) 2010-02-18
WO2010019643A2 (en) 2010-02-18
EP2323725A2 (en) 2011-05-25
US20110190679A1 (en) 2011-08-04
WO2010019643A9 (en) 2010-04-22
WO2010019643A3 (en) 2010-06-10

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