EE04783B1 - TNF retseptoriga seotud faktori (TRAF) modulaatorid, nende valmistamine ja kasutamine - Google Patents

TNF retseptoriga seotud faktori (TRAF) modulaatorid, nende valmistamine ja kasutamine

Info

Publication number: EE04783B1
Authority: EE; Estonia
Prior art keywords: traf; modulators; preparation; tnf receptor; related factor
Prior art date: 1996-04-02

Application number

EE9800322A

Other languages

English (en)

Other versions

EE9800322A (et

Inventor

Wallach David

Malinin Nikolai

Boldin Mark

Kovalenko Andrei

Mett Igor

Original Assignee

Yeda Research And Development Co. Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-02

Filing date

1997-04-01

Publication date

2007-02-15

1996-04-02 Priority claimed from IL11780096A external-priority patent/IL117800A0/xx

1996-08-26 Priority claimed from IL11913396A external-priority patent/IL119133A0/xx

1997-04-01 Application filed by Yeda Research And Development Co. Ltd. filed Critical Yeda Research And Development Co. Ltd.

1999-04-15 Publication of EE9800322A publication Critical patent/EE9800322A/et

2007-02-15 Publication of EE04783B1 publication Critical patent/EE04783B1/et

Links

108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 title abstract 2
102000003298 tumor necrosis factor receptor Human genes 0.000 title abstract 2
108091028043 Nucleic acid sequence Proteins 0.000 abstract 4
102000004169 proteins and genes Human genes 0.000 abstract 3
108090000623 proteins and genes Proteins 0.000 abstract 3
102000014914 Carrier Proteins Human genes 0.000 abstract 1
102000001708 Protein Isoforms Human genes 0.000 abstract 1
108010029485 Protein Isoforms Proteins 0.000 abstract 1
108091008324 binding proteins Proteins 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Biochemistry (AREA)
Immunology (AREA)
Wood Science & Technology (AREA)
Gastroenterology & Hepatology (AREA)
General Engineering & Computer Science (AREA)
Toxicology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Rheumatology (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

EE9800322A 1996-04-02 1997-04-01 TNF retseptoriga seotud faktori (TRAF) modulaatorid, nende valmistamine ja kasutamine EE04783B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IL11780096A IL117800A0 (en)	1996-04-02	1996-04-02	Modulators of TNF receptor associated factor (TRAF) their preparation and use
IL11913396A IL119133A0 (en)	1996-08-26	1996-08-26	Modulators of TNF receptor associated factor (TRAF) their preparation and use
PCT/IL1997/000117 WO1997037016A1 (en)	1996-04-02	1997-04-01	Modulators of tnf receptor associated factor (traf), their preparation and use

Publications (2)

Publication Number	Publication Date
EE9800322A EE9800322A (et)	1999-04-15
EE04783B1 true EE04783B1 (et)	2007-02-15

Family

ID=26323248

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800322A EE04783B1 (et)	1996-04-02	1997-04-01	TNF retseptoriga seotud faktori (TRAF) modulaatorid, nende valmistamine ja kasutamine

Country Status (22)

Country	Link
US (2)	US7485456B1 (et)
EP (1)	EP0894130B1 (et)
JP (1)	JP4180114B2 (et)
CN (1)	CN1197966C (et)
AT (1)	ATE380866T1 (et)
AU (1)	AU732793B2 (et)
BG (1)	BG64755B1 (et)
BR (1)	BR9708518A (et)
CA (1)	CA2250085C (et)
CZ (3)	CZ299094B6 (et)
DE (1)	DE69738370T2 (et)
DK (1)	DK0894130T3 (et)
EA (1)	EA004309B1 (et)
EE (1)	EE04783B1 (et)
ES (1)	ES2294796T3 (et)
HU (1)	HU226328B1 (et)
NO (1)	NO327054B1 (et)
NZ (1)	NZ331902A (et)
PT (1)	PT894130E (et)
SK (3)	SK287889B6 (et)
UA (1)	UA71889C2 (et)
WO (1)	WO1997037016A1 (et)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA71889C2 (uk) *	1996-04-02	2005-01-17	Йєда Рісерч Енд Дівелопмент Ко. Лтд.	Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування
US5843721A (en) *	1997-07-03	1998-12-01	Tularik Inc.	Nucleic acids encoding human NIK protein
JP2003525567A (ja) *	1997-11-07	2003-09-02	ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー	分泌蛋白およびそれらをコードするポリヌクレオチド
US6265538B1 (en) *	1998-02-27	2001-07-24	The Regents Of The University Of California	Inhibitor of the inflammatory response induced by the TNFA and IL-1
DE69928244T2 (de) *	1998-05-06	2006-08-10	Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw.	Inhibitoren der nf-kb aktivierung
AU767973B2 (en) *	1998-08-18	2003-11-27	Abbott Gmbh & Co. Kg	TPL-2/COT kinase and methods of use
IL131719A0 (en)	1999-09-02	2001-03-19	Yeda Res & Dev	Iren protein its preparation and use
GB9930616D0 (en) *	1999-12-24	2000-02-16	Mathilda & Terence Kennedy Ins	Activation and inhibition of the immune system
US20040109854A1 (en) *	2001-02-21	2004-06-10	Zang-Hee Lee	Novel traf6 inhibiting protein
CA2447249A1 (en)	2001-06-22	2003-01-03	Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw	Abin-mediated hepatitis protection
EP1499729B9 (en) *	2002-04-18	2012-03-14	Yeda Research And Development Co., Ltd.	Derivatives of the nf-kappab inducing enzyme, their preparation and use
PT1678209E (pt) *	2003-10-07	2011-06-30	Yeda Res & Dev	Anticorpos para a nik, a sua preparação e a sua utilização
IL158287A0 (en)	2003-10-07	2004-05-12	Yeda Res & Dev	Antibodies to nik, their preparation and use
WO2005051423A2 (en) *	2003-11-30	2005-06-09	Yeda Research And Development Co. Ltd	Methods and agents for immune modulation and methods for identifying immune modulators
IL173104A0 (en) *	2006-01-12	2006-06-11	Yeda Res & Dev	Siva and ubiquintination
EP3629022A1 (en)	2008-07-25	2020-04-01	Richard W. Wagner	Protein screening methods
GB201012420D0 (en)	2010-07-23	2010-09-08	Univ Erasmus Medical Ct	Foetal heamoglobin inhibitor
AU2011293294B2 (en)	2010-08-25	2016-03-24	Pangu Biopharma Limited	Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases
CN105200073B (zh) *	2010-09-01	2019-03-01	山东新时代药业有限公司	人肿瘤坏死因子受体-Fc融合基因及其产物蛋白
CA2827161A1 (en)	2011-03-16	2012-09-20	F. Hoffmann-La Roche Ag	6,5-heterocyclic propargylic alcohol compounds and uses therefor
JP6157461B2 (ja)	2011-06-30	2017-07-05	ジェンザイム・コーポレーション	Ｔ細胞活性化の阻害剤
ES2657743T3 (es)	2011-07-19	2018-03-06	Philogen S.P.A.	Terapia secuencial con anti-CTLA-4 e IL-2 dirigida
UY34317A (es)	2011-09-12	2013-02-28	Genzyme Corp	Anticuerpo antireceptor de célula T (alfa)/ß
WO2015109391A1 (en)	2014-01-24	2015-07-30	Children's Hospital Of Eastern Ontario Research Institute Inc.	Smc combination therapy for the treatment of cancer
CN105986001B (zh) *	2015-02-12	2019-12-03	上海交通大学	一种基于膜结合蛋白和荧光互补的高通量猎物拮抗剂筛选方法
CN108026172B (zh)	2015-06-26	2022-04-29	赛诺菲生物技术公司	单克隆抗il-1racp抗体
MA55529A (fr)	2019-04-03	2022-02-09	Genzyme Corp	Polypeptides de liaison anti-alpha bêta tcr à fragmentation réduite
CN120225564A (zh)	2022-09-21	2025-06-27	赛诺菲生物技术公司	人源化抗il-1r3抗体及其使用方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5641876A (en) *	1990-01-05	1997-06-24	Cornell Research Foundation, Inc.	Rice actin gene and promoter
WO1997004793A1 (en) *	1995-08-02	1997-02-13	Ingram Teresa J	Composition for administration to patients with chronic fatigue syndrome and acquired immune deficiency syndrome
AU6692996A (en) *	1995-08-08	1997-03-05	Tularik Inc.	Inhibitors of apoptosis
US5804412A (en) *	1996-04-01	1998-09-08	The Regents Of The University Of California	Nucleic acids encoding sorting nexins and methods of using same
UA71889C2 (uk) *	1996-04-02	2005-01-17	Йєда Рісерч Енд Дівелопмент Ко. Лтд.	Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування
BR9708918A (pt)	1996-05-08	1999-08-03	Henkel Corp	Tensoativo processo para fabricar o mesmo produto e composição de limpeza
US5843721A (en) *	1997-07-03	1998-12-01	Tularik Inc.	Nucleic acids encoding human NIK protein

1997
- 1997-01-04 UA UA98105743A patent/UA71889C2/uk unknown
- 1997-04-01 EE EE9800322A patent/EE04783B1/et unknown
- 1997-04-01 NZ NZ331902A patent/NZ331902A/en not_active IP Right Cessation
- 1997-04-01 AT AT97914534T patent/ATE380866T1/de active
- 1997-04-01 CN CNB971951934A patent/CN1197966C/zh not_active Expired - Lifetime
- 1997-04-01 AU AU21755/97A patent/AU732793B2/en not_active Expired
- 1997-04-01 DK DK97914534T patent/DK0894130T3/da active
- 1997-04-01 DE DE69738370T patent/DE69738370T2/de not_active Expired - Lifetime
- 1997-04-01 CA CA002250085A patent/CA2250085C/en not_active Expired - Lifetime
- 1997-04-01 SK SK50016-2007A patent/SK287889B6/sk not_active IP Right Cessation
- 1997-04-01 EP EP97914534A patent/EP0894130B1/en not_active Expired - Lifetime
- 1997-04-01 BR BR9708518A patent/BR9708518A/pt not_active Application Discontinuation
- 1997-04-01 EA EA199800885A patent/EA004309B1/ru not_active IP Right Cessation
- 1997-04-01 JP JP53509997A patent/JP4180114B2/ja not_active Expired - Lifetime
- 1997-04-01 SK SK50017-2007A patent/SK287890B6/sk not_active IP Right Cessation
- 1997-04-01 CZ CZ20060018A patent/CZ299094B6/cs not_active IP Right Cessation
- 1997-04-01 CZ CZ20060017A patent/CZ298866B6/cs not_active IP Right Cessation
- 1997-04-01 HU HU9902429A patent/HU226328B1/hu unknown
- 1997-04-01 CZ CZ0318398A patent/CZ299682B6/cs not_active IP Right Cessation
- 1997-04-01 PT PT97914534T patent/PT894130E/pt unknown
- 1997-04-01 SK SK1361-98A patent/SK287085B6/sk not_active IP Right Cessation
- 1997-04-01 ES ES97914534T patent/ES2294796T3/es not_active Expired - Lifetime
- 1997-04-01 US US09/155,676 patent/US7485456B1/en not_active Expired - Fee Related
- 1997-04-01 WO PCT/IL1997/000117 patent/WO1997037016A1/en active IP Right Grant
1998
- 1998-09-29 NO NO19984551A patent/NO327054B1/no not_active IP Right Cessation
- 1998-10-07 BG BG102817A patent/BG64755B1/bg unknown
2009
- 2009-02-03 US US12/365,136 patent/US8236507B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
UA71889C2 (uk)	2005-01-17
JP4180114B2 (ja)	2008-11-12
PT894130E (pt)	2008-01-14
SK287890B6 (sk)	2012-03-02
EP0894130A1 (en)	1999-02-03
NO984551D0 (no)	1998-09-29
SK287889B6 (sk)	2012-03-02
JP2000507826A (ja)	2000-06-27
CN1197966C (zh)	2005-04-20
CZ318398A3 (cs)	1999-05-12
DE69738370D1 (de)	2008-01-24
SK287085B6 (sk)	2009-11-05
US20090291888A1 (en)	2009-11-26
WO1997037016A1 (en)	1997-10-09
US7485456B1 (en)	2009-02-03
NO327054B1 (no)	2009-04-14
ATE380866T1 (de)	2007-12-15
EA004309B1 (ru)	2004-02-26
AU732793B2 (en)	2001-05-03
CZ299094B6 (cs)	2008-04-23
HU226328B1 (en)	2008-09-29
CA2250085C (en)	2009-10-20
BR9708518A (pt)	1999-08-03
DE69738370T2 (de)	2008-12-04
DK0894130T3 (da)	2008-01-07
HUP9902429A2 (hu)	1999-10-28
SK136198A3 (en)	1999-05-07
NO984551L (no)	1998-11-24
BG64755B1 (bg)	2006-02-28
HUP9902429A3 (en)	2001-11-28
BG102817A (en)	1999-05-31
US8236507B2 (en)	2012-08-07
CZ299682B6 (cs)	2008-10-15
AU2175597A (en)	1997-10-22
CZ298866B6 (cs)	2008-02-27
ES2294796T3 (es)	2008-04-01
HK1018910A1 (en)	2000-01-07
EE9800322A (et)	1999-04-15
CN1221449A (zh)	1999-06-30
NZ331902A (en)	2000-02-28
EA199800885A1 (ru)	1999-04-29
CA2250085A1 (en)	1997-10-09
EP0894130B1 (en)	2007-12-12

Legal Events

Date	Code	Title	Description
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231

Publication	Publication Date	Title
EE04783B1 (et)	2007-02-15	TNF retseptoriga seotud faktori (TRAF) modulaatorid, nende valmistamine ja kasutamine
DK0970213T3 (da)	2007-05-21	Dödsdomæneholdig receptor
DK0417563T3 (da)	2000-11-06	TNF-bindende proteiner
IL140938A (en)	2010-12-30	Dna sequences encoding polypeptides capable of binding to ldcam, polypeptides encoded by them, fusion proteins comprising the polypeptides and a process for the preparation of the polypeptides
DK0975754T3 (da)	2007-10-01	Osteoprotegerin bindende proteiner og receptorer
NO960767D0 (no)	1996-02-26	Protocadherinproteiner og deres anvendelse
ATE128184T1 (de)	1995-10-15	Expression des rekombinanten tumor-nekrosisfaktor-bindungsproteins i (tbp-i).
CY1108175T1 (el)	2014-02-12	ΠΟΛΥΠΕΠΤΙΔΙΟ DcR3, ΟΜΟΛΟΓΟ TNFR
IL193886A (en)	2010-12-30	Antibodies that bind to ldcam sequences
WO2002036769A3 (en)	2003-01-30	Nucleic acids encoding cd40/cd40l chimeric polypeptides, methods for their production and uses thereof
TW200716746A (en)	2007-05-01	Methods for identifying a compound modulating the binding between polypeptides
ATE342976T1 (de)	2006-11-15	Cytokinrezeptor-kette
NZ315514A (en)	1998-12-23	Tumour necrosis factor associated factor (traf) inhibitors including traf polypeptide, murine nucleotide sequence and associated assays
MY125980A (en)	2006-09-29	Highly purified cytokine activating factor and methods of use
WO2000024771A3 (en)	2000-11-09	Nucleic acids encoding osteoprotegerin-like proteins and methods of using same
AR008064A1 (es)	1999-12-09	Una proteina ligante del factor de necrosis tumoral truncada de bajo peso molecular (tnf bp), un polinucleotido codificante de dicha proteina, un vector, una celula hospedante, metodos para producir dicha proteina, una composicion farmaceutica, metodo para tratar una enfermedad mediada por tnf bp y usos de dicha proteina.
MX9605531A (es)	1998-02-28	Modulador de receptores de la superfamilia de factor de necrosis tumoral/factor de crecimiento de nervio y receptores oligomericos solubles de la superfamilia de factor de necrosis tumoral/factor de crecimiento necrotico.