+

DK3571193T3 - Potassium Channel Modulators - Google Patents

Potassium Channel Modulators Download PDF

Info

Publication number
DK3571193T3
DK3571193T3 DK18704122.3T DK18704122T DK3571193T3 DK 3571193 T3 DK3571193 T3 DK 3571193T3 DK 18704122 T DK18704122 T DK 18704122T DK 3571193 T3 DK3571193 T3 DK 3571193T3
Authority
DK
Denmark
Prior art keywords
potassium channel
channel modulators
modulators
potassium
channel
Prior art date
Application number
DK18704122.3T
Other languages
English (en)
Inventor
Dipak Vasantrao Amrutkar
Kelly Foster
Thomas Amos Jacobsen
Martin R Jefson
Gregg F Keaney
Janus Schreiber Larsen
Karin Sandager Nielsen
Original Assignee
Cadent Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadent Therapeutics Inc filed Critical Cadent Therapeutics Inc
Application granted granted Critical
Publication of DK3571193T3 publication Critical patent/DK3571193T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355Non-condensed oxazines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
DK18704122.3T 2017-01-23 2018-01-23 Potassium Channel Modulators DK3571193T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762449270P 2017-01-23 2017-01-23
PCT/US2018/014792 WO2018136917A1 (en) 2017-01-23 2018-01-23 Potassium channel modulators

Publications (1)

Publication Number Publication Date
DK3571193T3 true DK3571193T3 (da) 2022-01-17

Family

ID=61188924

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18704122.3T DK3571193T3 (da) 2017-01-23 2018-01-23 Potassium Channel Modulators

Country Status (30)

Country Link
US (4) US9975886B1 (da)
EP (1) EP3571193B1 (da)
JP (1) JP6997197B2 (da)
KR (1) KR102664772B1 (da)
CN (1) CN110198935B (da)
AR (1) AR110770A1 (da)
BR (1) BR112019014814B1 (da)
CL (1) CL2019002031A1 (da)
CO (1) CO2019009060A2 (da)
CU (1) CU24560B1 (da)
CY (1) CY1125463T1 (da)
DK (1) DK3571193T3 (da)
EA (1) EA036668B1 (da)
ES (1) ES2906078T3 (da)
HR (1) HRP20220079T1 (da)
HU (1) HUE057710T2 (da)
IL (1) IL267954B (da)
LT (1) LT3571193T (da)
MX (1) MX376080B (da)
MY (1) MY195123A (da)
PH (1) PH12019501678A1 (da)
PL (1) PL3571193T3 (da)
PT (1) PT3571193T (da)
RS (1) RS62899B1 (da)
SG (1) SG11201905893WA (da)
SI (1) SI3571193T1 (da)
TW (1) TWI751271B (da)
UA (1) UA123810C2 (da)
WO (1) WO2018136917A1 (da)
ZA (1) ZA201904458B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10774064B2 (en) * 2016-06-02 2020-09-15 Cadent Therapeutics, Inc. Potassium channel modulators
RS62899B1 (sr) 2017-01-23 2022-03-31 Cadent Therapeutics Inc Modulatori kalijumovih kanala
JP2022508945A (ja) 2018-10-22 2022-01-19 カデント セラピューティクス,インコーポレーテッド カリウムチャネルモジュレーターの結晶形態

Family Cites Families (190)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6059883B2 (ja) 1978-05-08 1985-12-27 北興化学工業株式会社 農園芸用殺菌剤
GB2183243B (en) 1985-10-09 1990-01-24 Nippon Oil Co Ltd Process for preparing oil-soluble nitrogen-containing compounds
AU3752589A (en) 1988-05-16 1989-12-12 Georgia State University Research Foundation, Inc. Nucleic acid interacting unfused heteropolycyclic compounds
LU87304A1 (fr) 1988-07-29 1990-02-07 Oreal Nouveaux derives d'ureylene triamino-2,4,6 pyrimidine oxyde-3,leur preparation et leur utilisation en cosmetique et dermopharmacie
JPH02282251A (ja) 1989-04-24 1990-11-19 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
DE3922735A1 (de) 1989-07-11 1991-01-24 Hoechst Ag Aminopyrimidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide
DE4034762A1 (de) 1990-11-02 1992-05-07 Hoechst Ag Pyridylpyrimidine, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide
GB2263639A (en) 1992-01-28 1993-08-04 Merck & Co Inc Substituted pyrimidinones as neurotensin antagonists
HU209678B (en) 1992-06-09 1994-10-28 Richter Gedeon Vegyeszet Process for producing biologically active eburnamenin-14-carbonyl-amino derivatives and pharmaceutical compositions containing them
DK72693D0 (da) 1993-06-18 1993-06-18 Lundbeck & Co As H Compounds
CA2133355A1 (en) 1993-10-04 1995-04-05 Itaru Nitta Method for producing polypeptide
WO1998006709A1 (en) 1996-08-14 1998-02-19 Takeda Chemical Industries, Ltd. Cyclic urea compounds, their production and use as herbicides
DE19642863A1 (de) 1996-10-17 1998-04-23 Bayer Ag Amide
US6117973A (en) 1997-02-24 2000-09-12 Georgia Tech Research Corp. PNA monomers with electron donor or acceptor
JPH11158073A (ja) 1997-09-26 1999-06-15 Takeda Chem Ind Ltd アデノシンa3拮抗剤
JPH11282132A (ja) 1998-03-27 1999-10-15 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料の処理方法
JP2000072695A (ja) 1998-08-24 2000-03-07 Sumitomo Pharmaceut Co Ltd 環状化合物
JP2000075449A (ja) 1998-08-31 2000-03-14 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料の現像方法
US6878712B1 (en) 1999-09-04 2005-04-12 Astrazeneca Ab Amides as inhibitors for pyruvate dehydrogenase
WO2001032170A1 (en) 1999-09-13 2001-05-10 Swope David M Composition and method for decreasing neurologic symptomatology
US6906067B2 (en) 1999-12-28 2005-06-14 Bristol-Myers Squibb Company N-heterocyclic inhibitors of TNF-α expression
JP2004501192A (ja) 2000-06-29 2004-01-15 ニューロサーチ、アクティーゼルスカブ Kcnqカリウムチャネルモジュレーターとしての3−置換オキシインドール誘導体の使用方法
WO2002030358A2 (en) 2000-10-11 2002-04-18 Tularik Inc. Modulation of ccr4 function
KR20030059835A (ko) 2000-12-07 2003-07-10 씨브이 쎄러퓨틱스, 인코포레이티드 관상동맥 질환 또는 동맥경화증에 대한 abca-1 상승화합물로서의 1,3,5-트리아진 및 피리미딘
AU2002217742B2 (en) 2001-01-16 2008-02-21 Astrazeneca Ab Therapeutic heterocyclic compounds
WO2002055013A2 (en) 2001-01-16 2002-07-18 Astrazeneca Ab Therapeutic chromone compounds
EP1353915A2 (en) 2001-01-16 2003-10-22 AstraZeneca AB Therapeutic chroman compounds
WO2002064096A2 (en) 2001-02-16 2002-08-22 Tularik Inc. Methods of using pyrimidine-based antiviral agents
CA2444596A1 (en) * 2001-04-16 2002-10-24 Tanabe Seiyaku Co., Ltd. Large conductance calcium-activated k channel opener
EP1270551A1 (en) 2001-06-26 2003-01-02 Aventis Pharma Deutschland GmbH Urea derivatives with antiproteolytic activity
US7378432B2 (en) 2001-09-14 2008-05-27 Tel Aviv University Future Technology Development L.P. Glycogen synthase kinase-3 inhibitors
US7012077B2 (en) 2001-12-20 2006-03-14 Hoffmann-La Roche Inc. Substituted cyclohexane derivatives
WO2003075828A2 (en) 2002-03-11 2003-09-18 Zetiq Technologies Ltd. Compounds useful in the treatment of cancer
MY141867A (en) 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
AU2003245669A1 (en) 2002-06-21 2004-01-06 Cellular Genomics, Inc. Certain aromatic monocycles as kinase modulators
ATE325115T1 (de) 2002-08-19 2006-06-15 Glaxo Group Ltd Pyrimidinderivate als selektive cox-2-inhibitoren
JP2005536554A (ja) 2002-08-23 2005-12-02 ユニバーシティ オブ コネチカット 新規なビフェニル及びビフェニル様カンナビノイド
GB0311201D0 (en) 2003-05-15 2003-06-18 Merck Sharp & Dohme Therapeutic agents
US7589092B2 (en) 2003-06-20 2009-09-15 Koronis Pharmaceuticals, Incorporated Prodrugs of heteroaryl compounds
US7723344B2 (en) 2003-08-13 2010-05-25 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
EP1689722A2 (en) 2003-10-10 2006-08-16 Bayer Pharmaceuticals Corporation 4-aminopyrimidine derivatives for treatment of hyperproliferative disorders
MXPA06004191A (es) 2003-10-17 2007-01-19 Incyte Corp Hidroxamatos ciclicos sustituidos en la forma inhibidores de metaloproteinasas de matriz.
CN100554264C (zh) 2003-11-24 2009-10-28 弗·哈夫曼-拉罗切有限公司 吡唑基与咪唑基嘧啶
TW200528101A (en) 2004-02-03 2005-09-01 Astrazeneca Ab Chemical compounds
CN1976905A (zh) 2004-03-30 2007-06-06 大正制药株式会社 嘧啶衍生物以及与其应用有关的治疗方法
TWI380816B (zh) 2004-04-13 2013-01-01 Synta Pharmaceuticals Corp 抑制介白素-12(il-12)生成之二鹽抑制劑
SE0401971D0 (sv) 2004-08-02 2004-08-02 Astrazeneca Ab Piperidne derivatives
US7820654B2 (en) 2004-09-23 2010-10-26 Dr. Reddy's Laboratories Ltd. Pyrimidine compounds, process for their preparation and compositions containing them
GB0422556D0 (en) 2004-10-11 2004-11-10 Syngenta Participations Ag Novel insecticides
EP1655283A1 (en) 2004-11-08 2006-05-10 Evotec OAI AG 11beta-HSD1 Inhibitors
TW200628463A (en) 2004-11-10 2006-08-16 Synta Pharmaceuticals Corp Heteroaryl compounds
WO2006065590A2 (en) 2004-12-16 2006-06-22 Xtl Biopharmaceuticals Inc. Pyridine and pyrimidine antiviral compositions
JP5208516B2 (ja) 2004-12-30 2013-06-12 エグゼリクシス, インコーポレイテッド キナーゼモジュレーターとしてのピリミジン誘導体および使用方法
US20100197687A1 (en) 2005-01-19 2010-08-05 Benjamin Pelcman Indoles Useful in the Treatment of Inflammation
ATE501119T1 (de) 2005-01-19 2011-03-15 Biolipox Ab Entzündungshemmende indol-derivate
JP2008527028A (ja) 2005-01-19 2008-07-24 バイオリポックス エービー 炎症の治療に有用なインドール類
CA2594665A1 (en) 2005-01-19 2006-07-27 Biolipox Ab Thienopyrroles useful in the treatment of inflammation
WO2006077364A1 (en) 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflammation
US20070135437A1 (en) 2005-03-04 2007-06-14 Alsgen, Inc. Modulation of neurodegenerative diseases
US8252806B2 (en) 2005-03-14 2012-08-28 Neurosearch A/S Potassium channel modulating agents and their medical use
CN101115736A (zh) * 2005-03-14 2008-01-30 神经研究公司 钾通道调节剂和它们的医药用途
EP1863796A1 (en) * 2005-03-22 2007-12-12 NeuroSearch A/S Pyrazolyl-pyrimidines as potassium channel modulating agents and their medical use
US20060156481A1 (en) 2005-03-22 2006-07-20 The Procter & Gamble Company Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
US20090036475A1 (en) 2005-03-22 2009-02-05 Neurosearch A/S Pyrazolyl-Pyrimidines as Potassium Channel Modulating Agents and Their Medical Use
DE102005025315A1 (de) 2005-06-02 2006-12-14 Merck Patent Gmbh Ionische Flüssigkeiten mit niedriger Viskosität
US8193206B2 (en) 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
CA2612227C (en) 2005-06-14 2014-04-22 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
ATE489370T1 (de) 2005-06-14 2010-12-15 Schering Corp Herstellung und verwendung von verbindungen als aspartylproteasehemmer
EP2301928A1 (en) 2005-07-30 2011-03-30 AstraZeneca AB Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders
DE102005043165A1 (de) 2005-09-12 2007-03-22 Merck Patent Gmbh Metallkomplexe
JP2007091649A (ja) 2005-09-29 2007-04-12 Taisho Pharmaceut Co Ltd ピリミジン誘導体及びその使用に関連する治療方法
GB0520657D0 (en) 2005-10-11 2005-11-16 Ludwig Inst Cancer Res Pharmaceutical compounds
FR2892859B1 (fr) 2005-10-27 2008-06-06 Commissariat Energie Atomique Procede de greffage de molecules d'interet sur des surfaces inorganiques, surfaces obtenues et applications
WO2007062222A2 (en) 2005-11-22 2007-05-31 University Of South Florida Inhibition of cell proliferation
KR20080075909A (ko) 2005-12-12 2008-08-19 제네랩스 테크놀로지스, 인코포레이티드 N-(6-원 방향족 환)-아미도 항-바이러스 화합물
CN101331125A (zh) 2005-12-12 2008-12-24 健亚生物科技公司 N-(5-元杂芳香环)-酰胺基抗病毒化合物
WO2007071632A2 (en) 2005-12-20 2007-06-28 Neurosearch A/S 2-pyridin-2-yl-quinazoline derivatives as potassium channel modulating agents for the treatment of respiratory diseases
WO2007106816A2 (en) 2006-03-13 2007-09-20 Perkinelmer Las, Inc. Substrates and internal standards for mass spectroscopy detection
EP2012769A1 (en) 2006-05-02 2009-01-14 Rundfeldt, Chris Potassium channel activators for the prevention and treatment of dystonia and dystonia-like symptoms
CA2656290A1 (en) 2006-07-05 2008-01-10 Exelixis, Inc. Methods of using igf1r and abl kinase modulators
FR2904316B1 (fr) 2006-07-31 2008-09-05 Sanofi Aventis Sa Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique.
JP2009545588A (ja) 2006-08-03 2009-12-24 プロセンサ テクノロジーズ ビー.ブイ. 抗生物質組成物
WO2008028935A2 (en) 2006-09-07 2008-03-13 Neurosearch A/S Pyridinyl-pyrimidine derivatives useful as potassium channel modulating agents
WO2008040753A1 (en) 2006-10-03 2008-04-10 Neurosearch A/S Indazolyl derivatives useful as potassium channel modulating agents
WO2008052861A2 (de) 2006-10-10 2008-05-08 Proionic Production Of Ionic Substances Gmbh & Co Keg Verfahren zur herstellung von 1,3 -hetero-aromatischen carbonaten
EP2099778A2 (en) 2006-11-21 2009-09-16 Smithkline Beecham Corporation Amido anti-viral compounds
EP2121662A1 (en) 2006-12-04 2009-11-25 Neurocrine Biosciences, Inc. Substituted pyrimidines as adenosine receptor antagonists
GB0701426D0 (en) 2007-01-25 2007-03-07 Univ Sheffield Compounds and their use
ES2381895T3 (es) 2007-02-06 2012-06-01 Novartis Ag Inhibidores de PI 3-quinasa y métodos para su uso
EP2125735B1 (en) 2007-02-28 2012-06-27 Advinus Therapeutics Private Limited 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application
WO2008110891A2 (en) 2007-03-09 2008-09-18 Orchid Research Laboratories Limited, New heterocyclic compounds
WO2008116911A1 (en) 2007-03-28 2008-10-02 Neurosearch A/S Purinyl derivatives and their use as potassium channel modulators
CN101646669B (zh) 2007-03-28 2013-09-04 神经研究公司 嘌呤基衍生物及其作为钾通道调节剂的用途
WO2008125811A1 (en) 2007-04-11 2008-10-23 Astrazeneca Ab N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS
US8633186B2 (en) 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
WO2009017838A2 (en) 2007-08-01 2009-02-05 Exelixis, Inc. Combinations of jak-2 inhibitors and other agents
JP5111039B2 (ja) 2007-09-27 2012-12-26 富士フイルム株式会社 重合性化合物、重合開始剤、および染料を含有する光硬化性組成物
US9089572B2 (en) 2008-01-17 2015-07-28 California Institute Of Technology Inhibitors of p97
JP4592820B2 (ja) 2008-02-08 2010-12-08 株式会社資生堂 美白剤及び皮膚外用剤
CA2717110A1 (en) 2008-02-28 2009-09-03 Saint Mary's University Compounds, complexes and uses thereof
EP2276750A2 (en) 2008-03-27 2011-01-26 Auckland Uniservices Limited Substituted pyrimidines and triazines and their use in cancer therapy
WO2009125870A1 (en) 2008-04-09 2009-10-15 Mitsubishi Tanabe Pharma Corporation Pyrimidine, pyridine and triazine derivatives as maxi-k channel openers.
US8642778B2 (en) 2008-05-28 2014-02-04 Merck Patent Gmbh Ionic liquids
BRPI0915101A2 (pt) 2008-06-11 2017-03-21 Astrazeneca Ab composto, uso do mesmo, método para tratar câncer em um animal de sangue quente, composição farmacêutica, e, processo para preparar um composto
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
DE102008031480A1 (de) 2008-07-03 2010-01-07 Merck Patent Gmbh Salze enthaltend ein Pyrimidincarbonsäure-Derivat
GB0815369D0 (en) 2008-08-22 2008-10-01 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
WO2010026087A1 (en) 2008-09-02 2010-03-11 Neurosearch A/S Pyrazolyl-pyrimidine derivatives and their use as potassium channel modulators
CN101684098A (zh) 2008-09-24 2010-03-31 中国科学院上海药物研究所 一类5-脂氧酶抑制剂及其制备方法、药物组合物和应用
WO2010034707A1 (en) 2008-09-26 2010-04-01 Neurosearch A/S Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators
WO2010048149A2 (en) 2008-10-20 2010-04-29 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
GB2465405A (en) 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
US8513242B2 (en) 2008-12-12 2013-08-20 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimidine compounds and methods of making and using same
AR074870A1 (es) 2008-12-24 2011-02-16 Palau Pharma Sa Derivados de pirazolo (1,5-a ) piridina
WO2010120994A2 (en) 2009-04-17 2010-10-21 Wyeth Llc Ureidoaryl-and carbamoylaryl-morpholino- pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their synthesis
WO2010129053A2 (en) 2009-05-05 2010-11-11 Dana Farber Cancer Institute Egfr inhibitors and methods of treating disorders
ES2885698T3 (es) 2009-06-25 2021-12-15 Alkermes Pharma Ireland Ltd Profármacos de compuestos nh-ácidos
WO2010151797A2 (en) 2009-06-26 2010-12-29 University Of Massachusetts Compounds for modulating rna binding proteins and uses therefor
HUE027263T2 (en) 2009-07-08 2016-10-28 Baltic Bio Ab 1,2,4-thiazolidin-3-one derivatives and their use in the treatment of cancer
WO2011008931A2 (en) 2009-07-15 2011-01-20 Cystic Fibrosis Foundation Therapeutics, Inc. Arylpyrimidine compounds and combination therapy comprising same for treating cystic fibrosis & related disorders
AR077999A1 (es) 2009-09-02 2011-10-05 Vifor Int Ag Antagonistas de pirimidin y triazin-hepcidina
CA2772790C (en) 2009-09-04 2017-06-27 Benjamin Bader Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors
WO2011029832A1 (de) 2009-09-09 2011-03-17 Vifor (International) Ag Neue thiazol- und oxazol-hepcidin-antagonisten
US9181414B2 (en) 2009-11-13 2015-11-10 Plastipak Packaging, Inc. Oxygen scavengers, compositions comprising the scavengers, and articles made from the compositions
FR2954317B1 (fr) 2009-12-23 2012-01-27 Galderma Res & Dev Nouveaux derives phenoliques, et leur utilisation pharmaceutique ou cosmetique
AT509266B1 (de) 2009-12-28 2014-07-15 Univ Wien Tech Substituierte pyridine und pyrimidine
EP2542081A4 (en) 2010-03-01 2013-07-31 Gtx Inc COMPOSITIONS FOR CANCER TREATMENT
US8957073B2 (en) 2010-05-13 2015-02-17 Amgen Inc. Unsaturated nitrogen heterocyclic compounds useful as PDE10 inhibitors
WO2012009258A2 (en) 2010-07-13 2012-01-19 Edward Roberts Peptidomimetic galanin receptor modulators
KR20120018236A (ko) 2010-07-23 2012-03-02 현대약품 주식회사 치환된 피리미디닐 유도체 및 이의 제조방법
WO2012016133A2 (en) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Ros1 kinase inhibitors for the treatment of glioblastoma and other p53-deficient cancers
US20120046301A1 (en) 2010-08-20 2012-02-23 Gruenenthal Gmbh Substituted Cyclic Carboxamide and Urea Derivatives as Ligands of the Vanilloid Receptor
TWI552750B (zh) * 2010-08-27 2016-10-11 歌林達股份有限公司 作為kcnq2/3鉀離子通道調節劑之經取代之2-氧基-及2-硫基-二氫喹啉-3-羧醯胺
JP2013542562A (ja) 2010-09-30 2013-11-21 ビーエーエスエフ ソシエタス・ヨーロピア 電解質用添加剤
US9394290B2 (en) 2010-10-21 2016-07-19 Universitaet Des Saarlandes Campus Saarbruecken Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases
ES2553610T3 (es) 2010-12-14 2015-12-10 Electrophoretics Limited Inhibidores de la caseína cinasa 1 delta (CK1delta)
EP2655334B1 (en) 2010-12-22 2018-10-03 Eutropics Pharmaceuticals, Inc. Compositions and methods useful for treating diseases
WO2012109343A2 (en) 2011-02-08 2012-08-16 President And Fellows Of Harvard College Iron complexes and methods for polymerization
US9464065B2 (en) 2011-03-24 2016-10-11 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
CN102731492B (zh) 2011-03-30 2016-06-29 江苏恒瑞医药股份有限公司 环己烷类衍生物、其制备方法及其在医药上的应用
WO2012154880A1 (en) 2011-05-09 2012-11-15 Proteostasis Therapeutics, Inc. Proteostasis regulators for treating cystic fibrosis and other protein misfolding diseases
PL2707101T3 (pl) 2011-05-12 2019-10-31 Proteostasis Therapeutics Inc Regulatory proteostazy
EP2714698B1 (en) 2011-05-31 2016-11-09 Merck Patent GmbH Compounds containing hydrido-tricyano-borate anions
WO2012167171A2 (en) 2011-06-03 2012-12-06 Massachusetts Institute Of Technology Z-selective ring-closing metathesis reactions
US9321727B2 (en) 2011-06-10 2016-04-26 Hoffmann-La Roche Inc. Pyridine derivatives as agonists of the CB2 receptor
JP2013020223A (ja) 2011-06-17 2013-01-31 Fujifilm Corp 高分子フィルム、セルロースエステルフィルム、偏光板、及び液晶表示装置
EP2750505A4 (en) 2011-08-29 2015-08-05 Ptc Therapeutics Inc ANTIBACTERIAL COMPOUNDS AND METHODS FOR THEIR USE
JP5741850B2 (ja) 2011-09-13 2015-07-01 コニカミノルタ株式会社 光学フィルム、それを含む偏光板および液晶表示装置
JP5857713B2 (ja) 2011-12-15 2016-02-10 コニカミノルタ株式会社 光学フィルム、偏光板、及び液晶表示装置
WO2013120040A1 (en) 2012-02-10 2013-08-15 Children's Medical Center Corporation Targeted pathway inhibition to improve muscle structure, function and activity in muscular dystrophy
DE102012006896A1 (de) 2012-04-05 2013-10-10 Merck Patent Gmbh Silikate mit organischen Kationen
US9013997B2 (en) 2012-06-01 2015-04-21 Broadcom Corporation System for performing distributed data cut-through
FR2992317B1 (fr) 2012-06-22 2016-05-13 Diverchim Procede de preparation de peptides chiraux
RU2015104103A (ru) 2012-07-27 2016-09-20 Биал - Портела Энд К, С.А. Способ синтеза замещенных соединений мочевины
US20150246024A1 (en) 2012-08-20 2015-09-03 The University Of Chicago Methods and compositions for inhibiting gram positive bacteria
WO2014031872A2 (en) 2012-08-23 2014-02-27 The Broad Institute, Inc. Small molecule inhibitors for treating parasitic infections
CA2883210C (en) 2012-09-18 2021-06-15 Heptares Therapeutics Limited Bicyclic aza compounds as muscarinic m1 receptor agonists
DE102012021452A1 (de) 2012-10-31 2014-04-30 Merck Patent Gmbh Salze mit Trihydroperfluoralkoxybutansulfonat- oder Trihydroperfluoralkoxypropansulfonat-Anion
KR20150085064A (ko) 2012-11-16 2015-07-22 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 단백질 화학적 변형을 위한 피크테 스펭글러 결합
ES2469290B2 (es) 2012-12-17 2015-01-26 Ocupharm Diagnostics S.L. Mejora en la aplicación tópica de fármacos oculares mediante la administración de nucleótidos
US9499762B2 (en) 2012-12-21 2016-11-22 Afton Chemical Corporation Additive compositions with a friction modifier and a detergent
US9279094B2 (en) 2012-12-21 2016-03-08 Afton Chemical Corporation Friction modifiers for use in lubricating oil compositions
US9809571B2 (en) 2013-01-07 2017-11-07 University Of Southern California Deoxyuridine triphosphatase inhibitors
WO2014108487A1 (en) 2013-01-10 2014-07-17 Universite D'aix-Marseille P-stereogenic chiral precursor of chiral ligands and use thereof
US9487472B2 (en) 2013-02-26 2016-11-08 President And Fellows Of Harvard College Synthesis of acyclic and cyclic amines using iron-catalyzed nitrene group transfer
US9359380B2 (en) 2013-03-12 2016-06-07 Vertex Pharmaceuticals Incorporated DNA-PK inhibitors
AU2014247953A1 (en) 2013-04-05 2015-11-12 Mitobridge, Inc. PPAR agonists
US20160155959A1 (en) 2013-07-02 2016-06-02 Merck Patent Gmbh Organic Electroluminescent Device
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
CN105611924A (zh) 2013-07-25 2016-05-25 泰莱托恩基金会 Fapp2的抑制剂及其用途
US9701635B2 (en) 2013-07-26 2017-07-11 The Regents Of The University Of California C-H fluorination of heterocycles with silver (II) fluoride
WO2015031725A1 (en) 2013-08-30 2015-03-05 President And Fellows Of Harvard College Transition metal-catalyzed imidation of arenes
DE102013016324A1 (de) 2013-10-04 2015-04-09 Merck Patent Gmbh Perfluoralkylfluor- oder Perfluoralkylchlorgermanate
PT3060550T (pt) 2013-10-21 2019-08-27 Merck Patent Gmbh Compostos de heteroarilo como inibidores de btk e utilizações dos mesmos
WO2015069752A1 (en) 2013-11-05 2015-05-14 The Regents Of The University Of California Acetylcholine binding protein ligands, cooperative nachr modulators and methods for making and using
CN103626741A (zh) 2013-11-26 2014-03-12 苏州大学 具有腺苷受体拮抗剂活性的杂环氨基嘧啶化合物
WO2015079028A1 (de) 2013-11-29 2015-06-04 Vtu Holding Gmbh Verrfahren zum aushärten eines klebstoffs mittels mikrowellenbestrahlung
EP3076789A4 (en) 2013-12-04 2017-11-22 The Scripps Research Institute Novel compounds as jnk kinase inhibitors
PT3126352T (pt) 2014-04-04 2018-12-27 Syros Pharmaceuticals Inc Inibidores da quinase dependente de ciclina 7 (cdk7)
US10308648B2 (en) 2014-10-16 2019-06-04 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
US10227333B2 (en) 2015-02-11 2019-03-12 Curtana Pharmaceuticals, Inc. Inhibition of OLIG2 activity
GB201502412D0 (en) 2015-02-13 2015-04-01 Canbex Therapeutics Ltd Therapeutic use
US10980755B2 (en) 2015-09-10 2021-04-20 The Regents Of The University Of California LRH-1 modulators
US20170299609A1 (en) 2016-04-18 2017-10-19 Wright State University Treatment of amyotrophic lateral sclerosis with sk channel activators
US10774064B2 (en) 2016-06-02 2020-09-15 Cadent Therapeutics, Inc. Potassium channel modulators
US20170355708A1 (en) 2016-06-09 2017-12-14 Cadent Therapeutics, Inc. Potassium channel modulators
US20180207138A1 (en) 2017-01-23 2018-07-26 Cadent Therapeutics, Inc. Methods for the treatment of tremors by positive modulation of sk channels
RS62899B1 (sr) * 2017-01-23 2022-03-31 Cadent Therapeutics Inc Modulatori kalijumovih kanala

Also Published As

Publication number Publication date
CY1125463T1 (el) 2024-02-16
BR112019014814A2 (pt) 2020-02-27
WO2018136917A1 (en) 2018-07-26
MX2019008682A (es) 2019-09-18
EP3571193A1 (en) 2019-11-27
CN110198935B (zh) 2022-05-31
MY195123A (en) 2023-01-11
SG11201905893WA (en) 2019-08-27
CU24560B1 (es) 2021-12-08
TW201838985A (zh) 2018-11-01
HRP20220079T1 (hr) 2022-04-15
US10717728B2 (en) 2020-07-21
EP3571193B1 (en) 2021-12-01
PT3571193T (pt) 2022-03-25
CO2019009060A2 (es) 2019-08-30
CL2019002031A1 (es) 2019-10-04
KR102664772B1 (ko) 2024-05-10
AR110770A1 (es) 2019-05-02
IL267954A (en) 2019-09-26
UA123810C2 (uk) 2021-06-02
US10351553B2 (en) 2019-07-16
SI3571193T1 (sl) 2022-04-29
JP6997197B2 (ja) 2022-01-17
LT3571193T (lt) 2022-02-10
US20190352293A1 (en) 2019-11-21
PH12019501678A1 (en) 2020-06-01
RS62899B1 (sr) 2022-03-31
ZA201904458B (en) 2023-04-26
BR112019014814B1 (pt) 2024-03-12
HUE057710T2 (hu) 2022-05-28
ES2906078T3 (es) 2022-04-13
JP2020504165A (ja) 2020-02-06
TWI751271B (zh) 2022-01-01
US9975886B1 (en) 2018-05-22
IL267954B (en) 2022-02-01
EA201991488A1 (ru) 2019-12-30
KR20190110572A (ko) 2019-09-30
CU20190066A7 (es) 2020-03-04
US20210380571A1 (en) 2021-12-09
MX376080B (es) 2025-03-07
US20180215746A1 (en) 2018-08-02
CN110198935A (zh) 2019-09-03
EA036668B1 (ru) 2020-12-07
PL3571193T3 (pl) 2022-04-25

Similar Documents

Publication Publication Date Title
MA50014A (fr) Modulateurs de k-ras
HK1256599A1 (zh) ROR-γ的調節劑
EP3183346C0 (en) CHANNEL MODULATORS
MA53943A (fr) Modulateurs de ror-gamma
EP3684368A4 (en) SELECTIVE P2X3 MODULATORS
MA55328A (fr) Modulateurs de ror-gamma
DK3743406T3 (da) Tmem16a modulatorer
DE202018003363U8 (de) Handgelenkssphygmomanometer
CL2018000524S1 (es) Golilla
DK3710726T3 (da) Transmission
HUE062866T2 (hu) TREX-1 modulátorok
EP3428388A4 (en) TUNNEL DRILL
EP3662710A4 (en) MULTI-TID A-MPDU TRANSMISSION
DK3488158T3 (da) Kanalpanel
EP3724498A4 (en) NARROW CHANNEL HALL EFFECT THRUSTER
EP3704466A4 (en) ANALYTE DETECTION PROCESS
IL267954B (en) potassium channel modulators
FR3050757B1 (fr) Tunnelier
EP3667136A4 (en) SEGMENT SEAL
DK3453806T3 (da) Tætningselement
EP3854876A4 (en) MODIFIED CHANNEL RHODOPSIN
EP3638587A4 (en) FINNED EJECTOR CONFIGURATIONS
EP3521070A4 (en) ÉMETTTEUR
EP3501859A4 (en) Transmitter
FR3046312B1 (fr) Emulateur de canal de transmission
点击 这是indexloc提供的php浏览器服务,不要输入任何密码和下载