DK3364993T3 - Fremgangsmåder til behandling af angelman syndrom - Google Patents
Fremgangsmåder til behandling af angelman syndrom Download PDFInfo
- Publication number
- DK3364993T3 DK3364993T3 DK16858443.1T DK16858443T DK3364993T3 DK 3364993 T3 DK3364993 T3 DK 3364993T3 DK 16858443 T DK16858443 T DK 16858443T DK 3364993 T3 DK3364993 T3 DK 3364993T3
- Authority
- DK
- Denmark
- Prior art keywords
- approaches
- treatment
- angelman syndrome
- angelman
- syndrome
- Prior art date
Links
- 208000009575 Angelman syndrome Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Fats And Perfumes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245038P | 2015-10-22 | 2015-10-22 | |
| PCT/US2016/058487 WO2017070680A1 (en) | 2015-10-22 | 2016-10-24 | Methods for treating angelman syndrome and related disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3364993T3 true DK3364993T3 (da) | 2023-01-09 |
Family
ID=58558152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16858443.1T DK3364993T3 (da) | 2015-10-22 | 2016-10-24 | Fremgangsmåder til behandling af angelman syndrom |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11273218B2 (da) |
| EP (1) | EP3364993B1 (da) |
| JP (2) | JP6957460B2 (da) |
| AU (1) | AU2016341429B2 (da) |
| CA (1) | CA3002831C (da) |
| DK (1) | DK3364993T3 (da) |
| ES (1) | ES2936400T3 (da) |
| FI (1) | FI3364993T3 (da) |
| MX (1) | MX2018004947A (da) |
| WO (1) | WO2017070680A1 (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3364993T3 (da) | 2015-10-22 | 2023-01-09 | Cavion Inc | Fremgangsmåder til behandling af angelman syndrom |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| BR112019002538A2 (pt) | 2016-08-11 | 2019-05-21 | Ovid Therapeutics Inc. | uso de uma composição farmacêutica compreendendo um modulador alostérico, uso de uma composição farmacêutica compreendendo garboxadol ou um sal farmaceuticamente aceitável do mesmo, e composição farmacêutica para a administração parenteral |
| CN110545806A (zh) | 2017-02-15 | 2019-12-06 | 卡维昂公司 | 钙通道抑制剂 |
| JP7326159B2 (ja) * | 2017-04-26 | 2023-08-15 | カビオン・インコーポレイテッド | ドラベ症候群の処置方法 |
| MX2019012818A (es) * | 2017-04-26 | 2020-07-14 | Cavion Inc | Metodos para mejorar la memoria y la cognicion y para el tratamiento de trastornos de la memoria y cognitivos. |
| WO2018237383A1 (en) * | 2017-06-23 | 2018-12-27 | The Trustees Of Columbia University In The City Of New York | METHODS OF PREVENTING AND TREATING DISEASES CHARACTERIZED BY SYNAPTIC DYSFUNCTION AND NEURODEGENERATION, INCLUDING ALZHEIMER'S DISEASE |
| US10420773B2 (en) | 2017-09-26 | 2019-09-24 | Ovid Therapeutics Inc. | Methods of treating developmental disorders and/or seizure disorders with etifoxine |
| MA53075A (fr) * | 2018-02-02 | 2021-05-12 | Boehringer Ingelheim Int | Dérivés d'oxadiazolopyridine à substitution benzyle, (pyridin-3-yl)méthyle ou (pyridin-4-yl)méthyle utilisés en tant qu'inhibiteurs de la ghréline o-acyltransférase (goat) |
| AU2019215710A1 (en) | 2018-02-02 | 2020-07-23 | Boehringer Ingelheim International Gmbh | Triazolopyrimidine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors |
| CN108410824B (zh) * | 2018-03-14 | 2020-03-06 | 江南大学 | 一株氮哌酮单克隆抗体杂交瘤细胞株及其应用 |
| KR20210087459A (ko) * | 2018-10-03 | 2021-07-12 | 카비온, 인코포레이티드 | (r)-2-(4-이소프로필페닐)-n-(1-(5-(2,2,2-트리플루오로에톡시)피리딘-2-일)에틸)아세트아미드를 사용하는 본태성 진전 치료 |
| MX2021005291A (es) * | 2018-11-05 | 2021-06-18 | Ovid Therapeutics Inc | Uso de gaboxadol, ganaxolona y alopregnanolona para tratar trastornos del movimiento. |
| CN119868330A (zh) | 2019-03-01 | 2025-04-25 | 弗拉梅尔爱尔兰有限公司 | 在进食状态下具有改善的药代动力学的γ-羟基丁酸酯组合物 |
| TWI870475B (zh) * | 2019-10-02 | 2025-01-21 | 美商卡凡恩公司 | 用於治療神經毒性之方法及材料 |
| US20230042176A1 (en) | 2019-12-18 | 2023-02-09 | National University Of Singapore | Method for treating angelman syndrome and related disorders |
| CA3177277A1 (en) * | 2020-04-29 | 2021-11-04 | Kiran Reddy | Methods of use of t-type calcium channel modulators |
| ES2984466T3 (es) | 2020-05-22 | 2024-10-29 | Boehringer Ingelheim Int | Procedimiento de fabricación de 7-amino-5-metil-[1,2,5]oxadiazolo[3,4-b]piridín-carboxilato de alquilo |
| DK4153600T3 (da) | 2020-05-22 | 2024-10-21 | Boehringer Ingelheim Int | Kontinuerlig fremgangsmåde til fremstilling af alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-carboxylat |
| WO2022109408A1 (en) * | 2020-11-22 | 2022-05-27 | Xenon Pharmaceuticals Inc. | Flunarizine for use in treating absence seizures |
| BR112023024354A2 (pt) * | 2021-05-24 | 2024-02-06 | Cavion Inc | Método de tratamento de tremor essencial |
| EP4389892A1 (en) | 2021-08-17 | 2024-06-26 | Korea Advanced Institute of Science and Technology | Antisense oligonucleotide targeting cav3.1 gene and uses thereof |
| IT202100023651A1 (it) * | 2021-09-14 | 2023-03-14 | Edilio Lancellotti | Niaprazina per uso veterinario nel trattamento di disturbi del sistema nervoso centrale |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| WO2024197267A1 (en) * | 2023-03-22 | 2024-09-26 | The Regents Of The University Of Colorado, A Body Corporate | Inhibitors of ca 2+/calmodulin-dependent protein kinase ii (camkii) that do not inhibit long-term potentiation (ltp) induction and therapeutic uses thereof |
| WO2025022402A1 (en) * | 2023-07-25 | 2025-01-30 | Ariel Scientific Innovations Ltd. | Compositions and methods for treating behavior diseases |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK171349B1 (da) | 1986-11-14 | 1996-09-16 | Hoffmann La Roche | Tetrahydronaphthalenderivater, fremgangsmåde til fremstilling deraf, lægemidler indeholdende forbindelserne samt anvendelse af forbindelserne til fremstilling af lægemidler |
| WO1993004047A1 (en) | 1991-08-16 | 1993-03-04 | Merck & Co., Inc. | Quinazoline derivatives as inhibitors of hiv reverse transcriptase |
| TR199801581T2 (xx) | 1996-02-14 | 1998-10-21 | Isis Pharmaceuticals, Inc. | �ekerle de�i�tirilmi� bo�luklu oligon�kleotid'ler. |
| AU2001235363A1 (en) | 2000-02-25 | 2001-09-03 | Novo-Nordisk A/S | Mibefradil analogues and their use |
| EP1385421A4 (en) | 2001-04-06 | 2007-01-24 | Univ City | IDENTIFICATION, DIAGNOSIS AND TREATMENT OF NEUROPATHOLOGIES, NEUROTOXICITIES, TUMORS AND CEREBRAL AND MEDULLAION LESIONS BY MICROVOLTAMETRY USING MICRO ELECTRODES |
| IL162540A0 (en) | 2002-01-17 | 2005-11-20 | Univ British Columbia | Bispecific antisense olignucleotides that inhibit igfbp-2 and igfbp-5 and methods of using same |
| WO2004035000A2 (en) | 2002-10-17 | 2004-04-29 | Merck & Co., Inc. | Enhancement of sleep with t-type calcium channel antagonists |
| US8487002B2 (en) | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
| EP1721607A1 (en) | 2003-03-21 | 2006-11-15 | Dynogen Pharmaceuticals, Inc. | Methods for treating lower urinary tract disorders using smooth muscle modulators and alpha-2-delta subunit calcium channel modulators |
| US7157461B2 (en) | 2003-07-23 | 2007-01-02 | Bristol-Myers Squibb Co. | Substituted dihydropyrimidine inhibitors of calcium channel function |
| US7166603B2 (en) | 2003-07-23 | 2007-01-23 | Bristol-Myers Squibb Co. | Dihydropyrimidone inhibitors of calcium channel function |
| KR100610731B1 (ko) | 2004-02-24 | 2006-08-09 | 한국과학기술연구원 | Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법 |
| US7504431B2 (en) | 2004-04-16 | 2009-03-17 | Bristol-Myers Squibb Company | Sulfonyl amide inhibitors of calcium channel function |
| WO2006023883A2 (en) | 2004-08-20 | 2006-03-02 | University Of Virginia Patent Foundation | T type calcium channel inhibitors |
| CA2576186A1 (en) | 2004-08-20 | 2006-03-02 | University Of Virginia Patent Foundation | T type calcium channel blockers and the treatment of diseases |
| BRPI0608343A2 (pt) | 2005-03-09 | 2016-10-04 | Merck & Co Inc | composto, composição farmacêutica, e, métodos para tratamento ou controle de uma doença ou condição, para intensificação da qualidade do sono, para aumento de sono rem e do sono de onda lenta, para diminuição da fragmentação de padrões do sono, para intensificação de cognição, para aumento da retenção de memória, e, para tratamento, controle, melhora ou redução do risco de esquizofrenia em um paciente mamífero em necessidade destes |
| EP1896414A4 (en) | 2005-06-23 | 2009-09-09 | Merck & Co Inc | 3-FLUOR-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS |
| WO2007002884A2 (en) | 2005-06-29 | 2007-01-04 | Merck & Co., Inc. | 4-fluoro-piperidine t-type calcium channel antagonists |
| US7643104B2 (en) | 2005-07-14 | 2010-01-05 | Teijin Chemicals, Ltd. | Foamed resin sheet and liquid crystal display |
| KR100654328B1 (ko) | 2005-08-26 | 2006-12-08 | 한국과학기술연구원 | 피페라지닐알킬피라졸계 ｔ-타입 칼슘 채널 억제 화합물 및이의 제조방법 |
| US20070197523A1 (en) | 2005-12-22 | 2007-08-23 | Icagen, Inc. | Calcium channel antagonists |
| CN101466676B (zh) | 2006-04-12 | 2012-07-18 | 默沙东公司 | 吡啶基酰胺类t-型钙通道拮抗剂 |
| KR100743255B1 (ko) | 2006-05-04 | 2007-07-27 | 한국과학기술연구원 | Ｔ-형 칼슘 채널에 활성을 지닌 신규1,3-다이옥소아이소인돌 유도체 |
| KR100754325B1 (ko) | 2006-06-12 | 2007-09-05 | 한국과학기술연구원 | Ｔ-형 칼슘 채널 길항제로서의3-(4-클로로벤질)-4-옥소-2-티옥소-1,2,3,4-테트라히드로-퀴나졸린 유도체 |
| KR100749843B1 (ko) | 2006-07-13 | 2007-08-21 | 한국과학기술연구원 | Ｔ-타입 칼슘 채널에 억제 활성을 지닌 신규2,4-디옥소-퀴나졸린 유도체 및 이의 제조방법 |
| KR100969686B1 (ko) | 2006-08-07 | 2010-07-14 | 한국과학기술연구원 | 신규한 티아졸계 화합물 및 이를 함유하는 ｔ-형 칼슘 채널저해제 |
| CA2663503A1 (en) | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidinone derivatives and methods of use thereof |
| AR062790A1 (es) | 2006-09-15 | 2008-12-03 | Schering Corp | Derivados de azetidina utiles en el tratamiento del dolor, diabetes y trastornos del metabolismo de los lipidos |
| WO2008033464A2 (en) | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidinone derivatives for the treatment of disorders of the lipid metabolism |
| MX2009002919A (es) | 2006-09-15 | 2009-04-01 | Schering Corp | Derivados de azetidina y azetidona utiles en el tratamiento del dolor y trastornos del metabolismo de los lipidos. |
| KR20090066287A (ko) | 2006-09-15 | 2009-06-23 | 쉐링 코포레이션 | 통증, 당뇨병, 및 지질 대사 장애의 치료방법 |
| WO2008050200A1 (en) | 2006-10-24 | 2008-05-02 | Pfizer Products Inc. | Oxadiazole compounds as calcium channel antagonists |
| EP2073799A4 (en) | 2007-03-12 | 2009-08-19 | Vm Discovery Inc | NOVEL ACTIVE SUBSTANCES FROM CALCIUMIONAL CHANNEL MODULATORS |
| US20080227823A1 (en) | 2007-03-12 | 2008-09-18 | Hassan Pajouhesh | Amide derivatives as calcium channel blockers |
| WO2008117148A1 (en) | 2007-03-23 | 2008-10-02 | Pfizer Products Inc. | Substituted oxadiazole analogs as calcium channel antagonists |
| CA2685753A1 (en) | 2007-05-09 | 2008-11-20 | Neuromed Pharmaceuticals Ltd. | Bicyclic pyrimidine derivatives as calcium channel blockers |
| KR100863239B1 (ko) | 2007-05-23 | 2008-10-15 | 한국과학기술연구원 | 신규한 2-이미노-1,3-티아졸린계 화합물 및 이를 함유하는ｔ-형 칼슘 채널 저해제 |
| CA2692783A1 (en) | 2007-07-10 | 2009-01-15 | Merck Sharp & Dohme Corp. | Quinazolinone t-type calcium channel antagonists |
| KR101079459B1 (ko) | 2007-09-14 | 2011-11-03 | 이화여자대학교 산학협력단 | 신규한 화합물, 이의 제조방법 및 이를 포함하는 통증억제용 조성물 |
| JP5524071B2 (ja) | 2007-10-24 | 2014-06-18 | メルク・シャープ・アンド・ドーム・コーポレーション | 複素環フェニルアミドｔ型カルシウムチャネルアンタゴニスト |
| CA2703471A1 (en) | 2007-10-24 | 2009-04-30 | Merck Sharp & Dohme Corp. | Pyrazinyl amide t-type calcium channel antagonists |
| WO2009054983A1 (en) | 2007-10-24 | 2009-04-30 | Merck & Co., Inc. | Heterocycle amide t-type calcium channel antagonists |
| WO2009056934A1 (en) | 2007-10-31 | 2009-05-07 | Pfizer Products Inc. | 1,4-dihydronaphthyridine derivatives |
| KR100917037B1 (ko) | 2007-11-01 | 2009-09-10 | 한국과학기술연구원 | 피라졸릴카르복스아미도알킬피페라진 유도체 및 이의제조방법 |
| US20090270413A1 (en) | 2008-04-28 | 2009-10-29 | Galemmo Jr Robert | Di-t-butylphenyl piperazines as calcium channel blockers |
| EP3560496A1 (en) | 2008-04-29 | 2019-10-30 | Pharnext | Combination compositions for treating alzheimer disease and related disorders with zonisamide and acamprosate |
| US8377968B2 (en) | 2008-06-02 | 2013-02-19 | Zalicus Pharmaceuticals, Ltd. | N-piperidinyl acetamide derivatives as calcium channel blockers |
| US20090298834A1 (en) | 2008-06-02 | 2009-12-03 | Hassan Pajouhesh | 4-(aminomethyl)cyclohexanamine derivatives as calcium channel blockers |
| KR101014887B1 (ko) | 2008-06-26 | 2011-02-15 | 한국과학기술연구원 | 칼슘이온 채널 조절제로서 유효한 이미다졸릴알킬카르보닐유도체 및 그의 제조방법 |
| KR20100005476A (ko) | 2008-07-07 | 2010-01-15 | 한국과학기술연구원 | Ｔ-형 칼슘 채널에 활성을 지닌 신규 아이소인돌리논유도체 및 이의 제조방법 |
| US20100137403A1 (en) | 2008-07-10 | 2010-06-03 | Scott Malstrom | Method for enhancing cognition or inhibiting cognitive decline |
| KR101052620B1 (ko) | 2008-08-28 | 2011-07-29 | 한국과학기술연구원 | 신규 페닐아세테이트 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 ｔ-형 칼슘 이온 채널의 활성에 의해 유발되는 질환의 예방 또는 치료용 조성물 |
| KR101052065B1 (ko) | 2008-10-15 | 2011-07-27 | 한국과학기술연구원 | 칼슘이온 채널 조절제로서 유효한 피라졸릴메틸아민-피페라진 유도체와 이의 제조방법 |
| TW201028421A (en) | 2009-01-15 | 2010-08-01 | Abbott Lab | Novel benzenesulfonamides as calcium channel blockers |
| KR20120030112A (ko) | 2009-06-05 | 2012-03-27 | 타우 쎄라퓨틱스 엘엘씨 | 암 또는 전암성 질환을 치료하기 위한 인터레이스 방법 |
| EP2476308A2 (en) | 2009-08-12 | 2012-07-18 | Carlos Alberto Barcelo Rojas | Bioelectronic system |
| US20130036482A1 (en) | 2010-01-29 | 2013-02-07 | National University Corporation Okayama University | Method for assessment of potential for development of dravet syndrome and use thereof |
| US8575361B2 (en) | 2010-03-02 | 2013-11-05 | Concert Pharmaceuticals Inc. | Tetrahydronaphthalene derivatives |
| EP2613766A4 (en) | 2010-09-08 | 2014-04-09 | Pronova Biopharma Norge As | COMPOSITIONS COMPRISING AN OIL MIXTURE CONSISTING OF FATTY ACIDS COMPRISING EPA AND DHA AS FREE ACID, SURFACTANT AND STATIN |
| WO2012094615A2 (en) | 2011-01-07 | 2012-07-12 | Zenyaku Kogyo Kabushikikaisha | Use of cav3.1 selective t-type calcium channel antagonists |
| MX2014013599A (es) * | 2012-05-08 | 2015-05-11 | Zafgen Inc | Tratamiento de la obesidad hipotalamica con inhibidores de metap2. |
| KR20150108853A (ko) | 2013-01-10 | 2015-09-30 | 타우 쎄라퓨틱스 엘엘씨 | 암의 치료를 위한 t-타입 칼슘 채널 억제제 |
| WO2015149066A1 (en) | 2014-03-28 | 2015-10-01 | University Of Virginia Patent Foundation | General anesthetics that are not neurotoxic |
| KR101679262B1 (ko) | 2015-06-08 | 2016-11-24 | 한국과학기술연구원 | 4-이소프로필크로만-3-올 화합물 |
| GB2539472A (en) | 2015-06-17 | 2016-12-21 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
| US9351968B1 (en) | 2015-09-09 | 2016-05-31 | Ovid Therapeutics Inc | Methods of treating developmental disorders using pipradrol |
| DK3364993T3 (da) | 2015-10-22 | 2023-01-09 | Cavion Inc | Fremgangsmåder til behandling af angelman syndrom |
| JP7326159B2 (ja) | 2017-04-26 | 2023-08-15 | カビオン・インコーポレイテッド | ドラベ症候群の処置方法 |
| MX2019012818A (es) | 2017-04-26 | 2020-07-14 | Cavion Inc | Metodos para mejorar la memoria y la cognicion y para el tratamiento de trastornos de la memoria y cognitivos. |
| GB2571978A (en) | 2018-03-15 | 2019-09-18 | Andre Fisahn | Uses, compositions and methods |
| KR20210087459A (ko) | 2018-10-03 | 2021-07-12 | 카비온, 인코포레이티드 | (r)-2-(4-이소프로필페닐)-n-(1-(5-(2,2,2-트리플루오로에톡시)피리딘-2-일)에틸)아세트아미드를 사용하는 본태성 진전 치료 |
| TWI870475B (zh) | 2019-10-02 | 2025-01-21 | 美商卡凡恩公司 | 用於治療神經毒性之方法及材料 |
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2016
- 2016-10-24 DK DK16858443.1T patent/DK3364993T3/da active
- 2016-10-24 EP EP16858443.1A patent/EP3364993B1/en active Active
- 2016-10-24 FI FIEP16858443.1T patent/FI3364993T3/fi active
- 2016-10-24 JP JP2018520430A patent/JP6957460B2/ja active Active
- 2016-10-24 MX MX2018004947A patent/MX2018004947A/es unknown
- 2016-10-24 ES ES16858443T patent/ES2936400T3/es active Active
- 2016-10-24 CA CA3002831A patent/CA3002831C/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| FI3364993T3 (fi) | 2023-01-13 |
| US20180280357A1 (en) | 2018-10-04 |
| ES2936400T3 (es) | 2023-03-16 |
| US11273218B2 (en) | 2022-03-15 |
| JP2022017263A (ja) | 2022-01-25 |
| CA3002831C (en) | 2024-04-16 |
| AU2016341429B2 (en) | 2023-09-21 |
| JP6957460B2 (ja) | 2021-11-02 |
| AU2016341429A1 (en) | 2018-05-10 |
| EP3364993B1 (en) | 2022-11-09 |
| JP2018535208A (ja) | 2018-11-29 |
| EP3364993A4 (en) | 2019-08-28 |
| WO2017070680A1 (en) | 2017-04-27 |
| MX2018004947A (es) | 2018-11-09 |
| EP3364993A1 (en) | 2018-08-29 |
| CA3002831A1 (en) | 2017-04-27 |
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