DK3008168T3 - Sc-celler og sammensætninger og fremgangsmåde til dannelse deraf - Google Patents
Sc-celler og sammensætninger og fremgangsmåde til dannelse deraf Download PDFInfo
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- DK3008168T3 DK3008168T3 DK14819763.5T DK14819763T DK3008168T3 DK 3008168 T3 DK3008168 T3 DK 3008168T3 DK 14819763 T DK14819763 T DK 14819763T DK 3008168 T3 DK3008168 T3 DK 3008168T3
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/375—Thyroid stimulating hormone [TSH]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/395—Thyroid hormones
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
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- C12N2501/727—Kinases (EC 2.7.)
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Transplantation (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Physiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361833898P | 2013-06-11 | 2013-06-11 | |
US201461972212P | 2014-03-28 | 2014-03-28 | |
PCT/US2014/041988 WO2015002724A2 (en) | 2013-06-11 | 2014-06-11 | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3008168T3 true DK3008168T3 (da) | 2020-05-04 |
Family
ID=52022750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14819763.5T DK3008168T3 (da) | 2013-06-11 | 2014-06-11 | Sc-celler og sammensætninger og fremgangsmåde til dannelse deraf |
Country Status (17)
Country | Link |
---|---|
US (16) | US20170029778A1 (da) |
EP (4) | EP4461806A3 (da) |
JP (8) | JP6514689B2 (da) |
KR (12) | KR102773841B1 (da) |
CN (4) | CN106414718A (da) |
AU (6) | AU2014284677B2 (da) |
BR (2) | BR112015030972A8 (da) |
CA (2) | CA2915088A1 (da) |
DE (2) | DE112014002780B4 (da) |
DK (1) | DK3008168T3 (da) |
GB (3) | GB2531952C (da) |
HK (1) | HK1257187B (da) |
MX (2) | MX2015017103A (da) |
PH (1) | PH12015502767A1 (da) |
RU (2) | RU2016100219A (da) |
SG (3) | SG10201710218RA (da) |
WO (2) | WO2014201167A1 (da) |
Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2610336A1 (en) | 2007-07-31 | 2013-07-03 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
US9062290B2 (en) | 2007-11-27 | 2015-06-23 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
AU2012355698B2 (en) | 2011-12-22 | 2018-11-29 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
EP2938723B1 (en) | 2012-12-31 | 2023-02-01 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators |
US10092627B2 (en) * | 2013-04-08 | 2018-10-09 | President And Fellows Of Harvard College | Methods and compositions for rejuvenating skeletal muscle stem cells |
EP4461806A3 (en) | 2013-06-11 | 2025-02-12 | President and Fellows of Harvard College | Sc-b cells and compositions and methods for generating the same |
BR112016026626A2 (pt) | 2014-05-16 | 2017-08-15 | Janssen Biotech Inc | Uso de moléculas pequenas para melhorar a expressão de mafa em células pancreáticas endócrinas |
US10443042B2 (en) | 2014-12-18 | 2019-10-15 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof |
WO2016100921A1 (en) * | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
DK3234110T3 (da) | 2014-12-18 | 2024-05-13 | Harvard College | FREMGANGSMÅDER TIL GENERERING AF STAMCELLE-AFLEDTE ß-CELLER OG ANVENDELSER DERAF |
WO2016100930A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived b cells and methods of use thereof |
US10196613B2 (en) | 2014-12-19 | 2019-02-05 | Regeneron Pharmaceuticals, Inc. | Stem cells for modeling type 2 diabetes |
WO2016172564A1 (en) * | 2015-04-23 | 2016-10-27 | The Regents Of The University Of California | Controlled induction of human pancreatic progenitors produces functional beta-like cells |
PT3286300T (pt) * | 2015-04-24 | 2020-12-28 | Univ Copenhagen | Isolamento de células progenitoras pancreáticas genuínas |
EP3285572B1 (en) * | 2015-04-24 | 2020-12-02 | University of Copenhagen | Method for production of insulin-producing cells |
US11332716B2 (en) | 2015-07-27 | 2022-05-17 | The Regents Of The University Of California | Methods and compositions for producing pancreatic beta cells |
WO2017073740A1 (ja) * | 2015-10-29 | 2017-05-04 | 学校法人埼玉医科大学 | 膵内分泌細胞の製造方法、及び分化転換剤 |
EP3932414A1 (en) | 2015-11-10 | 2022-01-05 | City of Hope | Conditioning regimens and methods for inducing mixed chimerism |
US20190000889A1 (en) * | 2015-12-31 | 2019-01-03 | City Of Hope | Methods for treating diabetes |
CN109310742B (zh) * | 2016-01-06 | 2022-12-02 | 哈佛学院校长同事会 | 使用gdf11的治疗防止体重增加、提高葡萄糖耐量并减轻脂肪肝 |
WO2017123806A1 (en) | 2016-01-12 | 2017-07-20 | Cedars-Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
AU2017213795A1 (en) | 2016-02-01 | 2018-08-16 | Cedars-Sinai Medical Center | Systems and methods for growth of intestinal cells in microfluidic devices |
MA45747A (fr) * | 2016-02-24 | 2019-01-02 | Novo Nordisk As | Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines |
US20190060371A1 (en) * | 2016-03-02 | 2019-02-28 | Frequency Therapeutics, Inc. | Methods for controlled proliferation of vestibular stem cells / generating inner ear hair cells using wnt and tgfbeta-inhibition |
US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
MA45329A (fr) | 2016-04-08 | 2019-02-13 | Univ California | Production de cellules bêta matures pleinement fonctionnelles à partir de progénitrices pancréatiques humaines |
US20190151371A1 (en) * | 2016-06-09 | 2019-05-23 | Georgetown University | Process for continuous cell culture of islet cells |
MA45502A (fr) * | 2016-06-21 | 2019-04-24 | Janssen Biotech Inc | Génération de cellules bêta fonctionnelles dérivées de cellules souches pluripotentes humaines ayant une respiration mitochondriale glucose-dépendante et une réponse en sécrétion d'insuline en deux phases |
IL266478B2 (en) * | 2016-11-16 | 2025-02-01 | Allele Biotechnology & Pharmaceuticals Inc | Induction of pancreatic beta cells through stem cell differentiation with RNA |
WO2018140647A1 (en) | 2017-01-25 | 2018-08-02 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
KR101745297B1 (ko) * | 2017-02-02 | 2017-06-09 | 경북대학교 산학협력단 | 비만 진단용 조성물 및 이의 용도 |
US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
US11414648B2 (en) | 2017-03-24 | 2022-08-16 | Cedars-Sinai Medical Center | Methods and compositions for production of fallopian tube epithelium |
US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
IL271195B2 (en) | 2017-06-14 | 2024-04-01 | Semma Therapeutics Inc | Devices and methods for drug administration |
WO2019005871A1 (en) * | 2017-06-26 | 2019-01-03 | City Of Hope | METHODS FOR CULTURE OF CELLS OF THE ISLANDS OF LANGERHANS |
US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
JP2020527956A (ja) * | 2017-07-21 | 2020-09-17 | センマ・セラピューティクス・インコーポレーテッド | 幹細胞由来の膵臓ベータ細胞の再凝集 |
CA2983845C (en) | 2017-10-26 | 2024-01-30 | University Of Copenhagen | Generation of glucose-responsive beta cells |
IL312134A (en) * | 2017-11-15 | 2024-06-01 | Vertex Pharma | Islet cell manufacturing compositions and methods of use |
IL316168A (en) * | 2018-03-02 | 2024-12-01 | Vertex Pharma | Methods of enhancing stem cell differentiation into beta cells |
EP3768823A4 (en) * | 2018-03-23 | 2022-03-09 | Cedars-Sinai Medical Center | METHOD OF USING ISLET CELLS |
WO2019195800A1 (en) | 2018-04-06 | 2019-10-10 | Cedars-Sinai Medical Center | Novel differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells |
US12241085B2 (en) | 2018-04-06 | 2025-03-04 | Cedars-Sinai Medical Center | Human pluripotent stem cell derived neurodegenerative disease models on a microfluidic chip |
EP3790956A4 (en) * | 2018-05-11 | 2022-03-16 | Cornell University | METHOD FOR INDUCING DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS INTO MONOHORMONAL CELLS |
WO2020033879A1 (en) | 2018-08-10 | 2020-02-13 | Semma Therapeutics, Inc. | Stem cell derived islet differentiation |
CA3109647A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by upregulating jag-1 |
EP3837351A1 (en) | 2018-08-17 | 2021-06-23 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating foxo |
US20210230554A1 (en) * | 2018-08-30 | 2021-07-29 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
US20200080107A1 (en) | 2018-09-07 | 2020-03-12 | Crispr Therapeutics Ag | Universal donor cells |
CA3113676A1 (en) | 2018-09-21 | 2020-03-26 | President And Fellows Of Harvard College | Methods and compositions for treating diabetes, and methods for enriching mrna coding for secreted proteins |
WO2020069515A1 (en) * | 2018-09-28 | 2020-04-02 | Memorial Sloan-Kettering Cancer Center | Stem cell-derived human microglial cells, methods of making and methods of use |
JPWO2020080550A1 (ja) * | 2018-10-15 | 2021-10-14 | エヴィア ライフ サイエンシズ インコーポレイテッド | 低分子化合物による内胚葉組織又は器官由来細胞からの幹/前駆細胞の作製方法 |
KR102115960B1 (ko) * | 2018-11-28 | 2020-05-27 | 송미연 | 인간 중간엽 줄기세포를 갑상선 호르몬 분비세포로 분화 방법 |
US20220175848A1 (en) | 2019-04-01 | 2022-06-09 | The Broad Institute, Inc. | Methods and compositions for cell therapy |
CN113728090B (zh) * | 2019-04-08 | 2024-04-05 | 诺和诺德股份有限公司 | 从干细胞衍生的定形内胚层生成胰腺内胚层 |
US20220411759A1 (en) | 2019-05-21 | 2022-12-29 | President And Fellows Of Harvard College | Endocrine differentiation-inducing molecule |
KR102167257B1 (ko) * | 2019-05-28 | 2020-10-19 | 부산대학교 산학협력단 | 토마티딘 처리를 통한 줄기세포의 성숙화된 심근세포로의 분화유도 촉진 방법 |
WO2020243668A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
WO2020243665A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
US20220234006A1 (en) | 2019-05-31 | 2022-07-28 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
JP2022535239A (ja) | 2019-05-31 | 2022-08-05 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | 生体適合性メンブレン複合体 |
EP3980535A4 (en) * | 2019-06-06 | 2023-06-21 | President and Fellows of Harvard College | Compositions and methods for maturing stem cell-derived beta cells |
CA3144948A1 (en) | 2019-06-25 | 2020-12-30 | Vertex Pharmaceuticals Incorporated | Enhanced differentiation of beta cells |
WO2021030424A1 (en) * | 2019-08-13 | 2021-02-18 | Semma Therapeutics, Inc. | Pancreatic differentiation |
US10740609B1 (en) * | 2019-08-30 | 2020-08-11 | Numerica Corporation | System and method for space object detection in daytime sky images |
JP2022547505A (ja) | 2019-09-05 | 2022-11-14 | クリスパー セラピューティクス アクチェンゲゼルシャフト | ユニバーサルドナー細胞 |
US11116797B2 (en) | 2019-09-05 | 2021-09-14 | Crispr Therapeutics Ag | Universal donor cells |
JP2022550918A (ja) * | 2019-10-10 | 2022-12-05 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイト | 成熟幹細胞由来インスリン生産細胞の識別、単離及び改善のためのentpd3の使用 |
US20230014430A1 (en) * | 2019-11-20 | 2023-01-19 | Washington University | Methods and Compositions for Generating Functionally Mature Beta Cells and Uses Thereof |
AU2021223336A1 (en) | 2020-02-19 | 2022-10-06 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing TGFB antagonist prodrugs useful in the treatment of cancer and methods thereof |
CN111269875B (zh) * | 2020-03-24 | 2022-04-08 | 山东兴瑞生物科技有限公司 | 一种利用自体免疫细胞定向分化为胰岛细胞的方法 |
US20230392124A1 (en) * | 2020-04-16 | 2023-12-07 | Washington University | Methods and compositions for improving sc-beta cells or enhancing their utility |
US20220010282A1 (en) * | 2020-06-16 | 2022-01-13 | The Broad Institute, Inc. | Three-dimensional cell culture, devices, and use thereof |
AU2021319209A1 (en) | 2020-07-31 | 2023-03-02 | Vertex Pharmaceuticals Incorporated | Differentiation of pancreatic endocrine cells |
EP4189066A4 (en) * | 2020-07-31 | 2024-10-23 | Vertex Pharmaceuticals Incorporated | IN VITRO DIFFERENTIATION OF ENDOCRINE PANCREAS CELLS |
EP4271795A1 (en) | 2020-12-31 | 2023-11-08 | CRISPR Therapeutics AG | Universal donor cells |
CN112980771B (zh) * | 2021-03-05 | 2023-12-19 | 贝康医学科技有限公司 | 一种制备胰腺beta细胞的方法及其应用 |
CN113046299B (zh) * | 2021-03-19 | 2024-06-28 | 上海爱萨尔生物科技有限公司 | 一种诱导多能干细胞定向分化制备胰岛β细胞的添加剂 |
CN112980774B (zh) * | 2021-03-19 | 2022-04-01 | 上海爱萨尔生物科技有限公司 | 一种诱导多能干细胞定向分化制备胰岛β细胞的培养方法 |
CN112961823B (zh) * | 2021-03-19 | 2024-01-23 | 上海爱萨尔生物科技有限公司 | 一种诱导多能干细胞定向分化制备胰岛β细胞的培养液 |
CN113234664B (zh) * | 2021-05-11 | 2024-05-10 | 澳门大学 | 一种胰腺祖细胞的制备方法及其应用 |
US20220403340A1 (en) * | 2021-06-11 | 2022-12-22 | Washington University | Media for cryopreserved cells and methods of making and using same |
WO2023278382A1 (en) | 2021-06-29 | 2023-01-05 | Staffan Holmin | Endoluminal delivery cannula |
WO2023048182A1 (en) | 2021-09-21 | 2023-03-30 | Okinawa Institute Of Science And Technology School Corporation | Platforms for drug tests against synucleinopathy using human brain organoids |
WO2023070019A1 (en) | 2021-10-21 | 2023-04-27 | Vertex Pharmaceuticals Incorporated | Hypoimmune cells |
WO2023072170A1 (en) * | 2021-10-28 | 2023-05-04 | Sunshine Lake Pharma Co., Ltd. | A METHOD FOR PROMOTING THE DIFFERENTIATION OF STEM CELLS INTO FUNCTIONALLY MATURE ISLET β CELLS AND USE THEREOF |
JP2024542041A (ja) | 2021-11-01 | 2024-11-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | 幹細胞由来の膵臓島分化 |
WO2023097513A1 (en) * | 2021-11-30 | 2023-06-08 | Hangzhou Reprogenix Bioscience, Inc. | Method of generating functional islets from pluripotent stem cells |
IL313628A (en) * | 2022-02-01 | 2024-08-01 | Vertex Pharma | Cell therapy for diabetes |
EP4507701A1 (en) | 2022-04-15 | 2025-02-19 | SmartCella Solutions AB | Compositions and methods for exosome-mediated delivery of mrna agents |
EP4531873A1 (en) * | 2022-06-03 | 2025-04-09 | Cornell University | Derivation of glucose-responsive insulin-secreting cells and organoids from human stomach cells and their use to treat diabetes |
WO2024091676A1 (en) * | 2022-10-28 | 2024-05-02 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for accelerated production of thymic cells from pluripotent stem cells |
WO2024151541A1 (en) * | 2023-01-09 | 2024-07-18 | Sana Biotechnology, Inc. | Type-1 diabetes autoimmune mouse |
WO2024151804A2 (en) * | 2023-01-11 | 2024-07-18 | Mayo Foundation For Medical Education And Research | Methods and materials for generating stem cell-derived endocrine cell types |
WO2024173283A1 (en) | 2023-02-14 | 2024-08-22 | Vertex Pharmaceuticals Incorporated | Macroencapsulation devices including immunomodulatory compounds |
WO2024243236A2 (en) | 2023-05-22 | 2024-11-28 | Sana Biotechnology, Inc. | Methods of delivery of islet cells and related methods |
WO2025029671A1 (en) * | 2023-07-28 | 2025-02-06 | Vertex Pharmaceuticals Incorporated | Cell therapy for diabetes |
CN117672411B (zh) * | 2023-12-05 | 2024-05-14 | 首都医科大学附属北京世纪坛医院 | 一种中药成分的Hormesis效应研究方法及中药成分小檗碱的应用 |
Family Cites Families (169)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US130A (en) | 1837-02-16 | Improvement in metallic solutions for the preservation of timber | ||
US6774A (en) | 1849-10-09 | Improved jointed center-board | ||
US3270960A (en) | 1964-09-11 | 1966-09-06 | Sperry Rand Corp | Fluid sensor |
DE1570610C3 (de) | 1965-10-01 | 1974-08-01 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Poly-N-oxyden |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4391909A (en) | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
US4378016A (en) | 1981-07-15 | 1983-03-29 | Biotek, Inc. | Artificial endocrine gland containing hormone-producing cells |
US5425764A (en) | 1992-07-30 | 1995-06-20 | The University Of Toledo | Bioartificial pancreas |
US6469017B1 (en) | 1998-01-16 | 2002-10-22 | Cell Therapeutics, Inc. | Method of inhibiting interleukin-12 signaling |
US7018419B2 (en) | 1994-05-20 | 2006-03-28 | Spielberg Theodore E | Microporous encapsulated endocrine cell disks, biconcave disks and multidimpled chambers for hormonal replacement |
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
AU720662B2 (en) | 1995-04-07 | 2000-06-08 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant B-cell and uses thereof |
US6187991B1 (en) | 1995-05-23 | 2001-02-13 | Pfizer Inc | Transgenic animal models for type II diabetes mellitus |
EP0822857A1 (en) | 1996-02-23 | 1998-02-11 | Circe Biomedical, Inc. | Novel artificial pancreas |
US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
IL129222A0 (en) | 1996-10-01 | 2000-02-17 | Geron Corp | Telomerase reverse transcriptase |
CA2277278A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
US6090622A (en) | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
US6800480B1 (en) | 1997-10-23 | 2004-10-05 | Geron Corporation | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
CA2397292A1 (en) | 2000-01-14 | 2001-07-19 | Bresagen Limited | Cell production |
GB0005251D0 (en) | 2000-03-03 | 2000-04-26 | Merck Sharp & Dohme | Therapeutic compounds |
US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
AU2001263199B2 (en) | 2000-05-17 | 2004-09-16 | Asterias Biotherapeutics, Inc. | Neural progenitor cell populations |
US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
US6906810B2 (en) | 2000-07-13 | 2005-06-14 | Morgan Guaranty Trust Company | Method and system for allowing an on-line user to selectively customize a document for printing in a single batch process |
US7163918B2 (en) | 2000-08-22 | 2007-01-16 | New River Pharmaceuticals Inc. | Iodothyronine compositions |
WO2002031135A1 (en) | 2000-10-12 | 2002-04-18 | Institute Of Materials Research And Engineering | Non-disruptive three-dimensional culture and harvest system for anchorage-dependent cells |
CA2425356C (en) | 2000-10-13 | 2015-10-06 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
US6576464B2 (en) | 2000-11-27 | 2003-06-10 | Geron Corporation | Methods for providing differentiated stem cells |
EP1366148A2 (en) | 2001-01-24 | 2003-12-03 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES | Differentiation of stem cells to pancreatic endocrine cells |
EP1393066A4 (en) | 2001-05-15 | 2006-01-25 | Rappaport Family Inst For Res | INSULIN-PRODUCING CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS |
US7432104B2 (en) | 2001-08-06 | 2008-10-07 | Bresgen Inc. | Methods for the culture of human embryonic stem cells on human feeder cells |
US20030054331A1 (en) | 2001-09-14 | 2003-03-20 | Stemsource, Inc. | Preservation of non embryonic cells from non hematopoietic tissues |
CA2463914A1 (en) | 2001-10-18 | 2003-04-24 | Ixion Biotechnology, Inc. | Conversion of liver stem and progenitor cells to pancreatic functional cells |
US20030077256A1 (en) | 2001-10-19 | 2003-04-24 | Paul Czernichow | Pancreas regeneration using embryonic pancreatic cells |
US7157278B2 (en) | 2001-12-04 | 2007-01-02 | Organogenesis, Inc. | Cultured cells from pancreatic islets |
JP4666567B2 (ja) | 2001-12-07 | 2011-04-06 | ジェロン・コーポレーション | ヒト胚幹細胞由来の膵島細胞 |
EP2305276A3 (en) | 2001-12-07 | 2011-09-21 | Cytori Therapeutics, Inc. | Processed lipoaspirate cells for use in therapy |
CA2469483C (en) | 2001-12-07 | 2017-07-25 | Geron Corporation | Hematopoietic cells from human embryonic stem cells |
US20060003446A1 (en) | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
AU2003240810A1 (en) * | 2002-05-28 | 2003-12-12 | Becton, Dickinson And Company | Methods, compositions, and growth and differentiation factors for insulin-producing cells |
EP1578925A4 (en) | 2002-05-28 | 2006-10-11 | Becton Dickinson Co | METHOD FOR IN VITRO EXPANSION AND TRANSDIFFERENCING HUMAN PANCREATIC AZINUS CELLS FOR INSULIN-PRODUCING CELLS |
US20060040385A1 (en) | 2002-12-05 | 2006-02-23 | Technion Research & Development Foundation Ltd. | Cultured human pancreatic islets, and uses thereof |
WO2004058764A1 (en) | 2002-12-27 | 2004-07-15 | Bayer Healthcare Ag | 4-phenyl-pyrimido [4,5-b] indole derivatives |
US7172682B2 (en) | 2003-01-24 | 2007-02-06 | Rensselaer Polytechnic Institute | Enzyme immobilization for electroosmotic flow |
US20030224411A1 (en) | 2003-03-13 | 2003-12-04 | Stanton Lawrence W. | Genes that are up- or down-regulated during differentiation of human embryonic stem cells |
US7084246B2 (en) | 2003-04-17 | 2006-08-01 | Molecular Logix, Inc. | Epidermal growth factor agonists |
US7625753B2 (en) | 2003-12-23 | 2009-12-01 | Cythera, Inc. | Expansion of definitive endoderm cells |
US7510876B2 (en) | 2003-12-23 | 2009-03-31 | Cythera, Inc. | Definitive endoderm |
US7985585B2 (en) | 2004-07-09 | 2011-07-26 | Viacyte, Inc. | Preprimitive streak and mesendoderm cells |
WO2007059007A2 (en) | 2005-11-14 | 2007-05-24 | Cythera, Inc. | Markers of definitive endoderm |
US7541185B2 (en) | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
US8647873B2 (en) | 2004-04-27 | 2014-02-11 | Viacyte, Inc. | PDX1 expressing endoderm |
US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
CA2558486A1 (en) | 2004-03-10 | 2005-09-22 | Alberto Hayek | Compositions and methods for growth of embryonic stem cells |
EP1740532A4 (en) | 2004-03-30 | 2009-06-10 | Univ California | CFTR INHIBITOR COMPOUNDS CONTAINING HYDRAZIDS AND USES THEREOF |
GB2427874B (en) | 2004-04-01 | 2008-09-10 | Wisconsin Alumni Res Found | Differentiation of stem cells to endoderm and pancreatic lineage |
EP2377922B1 (en) | 2004-04-27 | 2020-04-08 | Viacyte, Inc. | PDX1 expressing endoderm |
CA2573437C (en) | 2004-07-13 | 2016-04-05 | Geron Corporation | Medium for growing human embryonic stem cells |
US8187878B2 (en) | 2004-08-13 | 2012-05-29 | University Of Georgia Research Foundation, Inc. | Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors |
US7517870B2 (en) | 2004-12-03 | 2009-04-14 | Fondazione Telethon | Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization |
EP1676574A3 (en) | 2004-12-30 | 2006-07-26 | Johnson & Johnson Vision Care, Inc. | Methods for promoting survival of transplanted tissues and cells |
AU2006210955A1 (en) | 2005-01-31 | 2006-08-10 | Es Cell International Pte Ltd. | Directed differentiation of embryonic stem cells and uses thereof |
CN103361302A (zh) | 2005-03-31 | 2013-10-23 | 斯丹姆涅恩有限公司 | 从高度纯化来自羊膜的细胞群获得的细胞裂解产物的组合物 |
KR20080030039A (ko) | 2005-06-22 | 2008-04-03 | 제론 코포레이션 | 인간 배아 줄기 세포의 현탁 배양 |
GB2441718B (en) | 2005-06-22 | 2010-10-06 | Geron Corp | Differentiation of human embryonic stem cells to cardiomyocyte-lineage cells |
US20070078111A1 (en) | 2005-07-19 | 2007-04-05 | Gabor Tigyi | LPA2 receptor agonist inhibitors of CFTR |
US20070122905A1 (en) | 2005-10-27 | 2007-05-31 | D Amour Kevin A | PDX1-expressing dorsal and ventral foregut endoderm |
WO2007070866A2 (en) | 2005-12-16 | 2007-06-21 | Alcon, Inc. | Control of intraocular pressure using alk5 modulation agents |
WO2007075807A2 (en) | 2005-12-20 | 2007-07-05 | Es Cell International Pte Ltd. | Methods for the directed differentiation of embryonic stem cell |
CA2637843C (en) | 2006-01-20 | 2014-12-30 | Reneuron, Inc. | Method of improving cell proliferation of pancreatic progenitor cells in a pancreatic cell culture |
WO2007088651A1 (ja) | 2006-02-01 | 2007-08-09 | The University Of Tokyo | TGF-βシグナル阻害剤と抗腫瘍剤の組み合せ使用 |
CA2646140C (en) | 2006-02-13 | 2015-04-28 | The Board Of Trustees Of The Leland Stanford Junior University | Blockade of gamma-secretase activity to promote myelination by oligodendrocytes |
EP2420565B1 (en) | 2006-02-23 | 2017-08-30 | ViaCyte, Inc. | Compositions and methods useful for culturing differentiable cells |
US7695965B2 (en) | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
EP1999253B1 (en) | 2006-03-02 | 2019-05-22 | Viacyte, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
US8247531B2 (en) | 2006-03-20 | 2012-08-21 | Cochran Jennifer R | Mutant epidermal growth factor polypeptides, nucleic acids, and uses therefor |
CA2650812C (en) | 2006-04-28 | 2017-12-12 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
WO2007139929A2 (en) | 2006-05-25 | 2007-12-06 | The Burnham Institute For Medical Research | Methods for culture and production of single cell populations of human embryonic stem cells |
CA2654196A1 (en) * | 2006-06-02 | 2007-12-13 | University Of Georgia Research Foundation, Inc. | Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems |
WO2007149182A2 (en) | 2006-06-19 | 2007-12-27 | Geron Corporation | Differentiation and enrichment of islet-like cells from human pluripotent stem cells |
AU2007277364B2 (en) | 2006-07-26 | 2010-08-12 | Viacyte, Inc. | Methods of producing pancreatic hormones |
EP2056759B1 (en) | 2006-08-29 | 2015-01-14 | The University of Akron | Implantable devices for producing insulin |
EP2118309B1 (en) * | 2006-12-29 | 2015-01-28 | The Regents of the University of Colorado, a body corporate | Diagnostic and therapeutic target for autoimmune diseases and uses thereof |
US10167450B2 (en) * | 2007-02-21 | 2019-01-01 | Sarl Endocells | Human pancreatic beta cell lines for diagnostic of diabetes |
KR20100016073A (ko) | 2007-04-02 | 2010-02-12 | 인스티튜트 포 원월드 헬스 | Cftr 억제제 화합물 및 이의 용도 |
BRPI0814425A2 (pt) * | 2007-07-18 | 2014-10-21 | Lifescan Inc | Diferenciação de células-tronco embrionárias humanas |
EP2610336A1 (en) | 2007-07-31 | 2013-07-03 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
EA017495B1 (ru) | 2007-08-09 | 2012-12-28 | Кабусики Кайся Якулт Хонса | ИНГИБИТОРЫ γ-СЕКРЕТАЗЫ |
US7695963B2 (en) | 2007-09-24 | 2010-04-13 | Cythera, Inc. | Methods for increasing definitive endoderm production |
US8623650B2 (en) | 2007-10-19 | 2014-01-07 | Viacyte, Inc. | Methods and compositions for feeder-free pluripotent stem cell media containing human serum |
US9062290B2 (en) | 2007-11-27 | 2015-06-23 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
SG154367A1 (en) * | 2008-01-31 | 2009-08-28 | Es Cell Int Pte Ltd | Method of differentiating stem cells |
WO2009114180A1 (en) | 2008-03-13 | 2009-09-17 | The General Hospital Corporation | Inhibitors of the bmp signaling pathway |
EP2283117B1 (en) | 2008-04-21 | 2013-10-23 | Viacyte, Inc. | Methods for purifying pancreatic endoderm cells derived from human embryonic stem cells |
US8338170B2 (en) | 2008-04-21 | 2012-12-25 | Viacyte, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
WO2009132083A2 (en) | 2008-04-22 | 2009-10-29 | President And Fellows Of Harvard College | Compositions and methods for promoting the generation of pdx1+ pancreatic cells |
US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
US20090298178A1 (en) * | 2008-06-03 | 2009-12-03 | D Amour Kevin Allen | Growth factors for production of definitive endoderm |
CN102159703B (zh) | 2008-06-30 | 2015-11-25 | 森托科尔奥索生物科技公司 | 多能干细胞的分化 |
US9683215B2 (en) * | 2008-08-22 | 2017-06-20 | President And Fellows Of Harvard College | Methods of reprogramming cells |
US20120021519A1 (en) | 2008-09-19 | 2012-01-26 | Presidents And Fellows Of Harvard College | Efficient induction of pluripotent stem cells using small molecule compounds |
EP2350265B1 (en) * | 2008-10-31 | 2019-04-17 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
AU2009308967C1 (en) | 2008-10-31 | 2017-04-20 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
US8008075B2 (en) | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
PL2356227T3 (pl) | 2008-11-14 | 2018-07-31 | Viacyte, Inc. | Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych |
MX2011005289A (es) | 2008-11-20 | 2011-06-01 | Centocor Ortho Biotech Inc | Metodos y composiciones para union y cultivo celular sobre sustratos planares. |
GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
WO2010091241A2 (en) | 2009-02-06 | 2010-08-12 | President And Fellows Of Harvard College | Compositions and methods for promoting the generation of definitive endoderm |
US20100267731A1 (en) | 2009-04-17 | 2010-10-21 | Summa Health Systems, LLC | Use of transforming growth factor-b receptor inhibitors to suppress ocular scarring |
US9109245B2 (en) | 2009-04-22 | 2015-08-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
DK2421957T3 (da) * | 2009-04-22 | 2021-01-25 | Viacyte Inc | Cellesammensætninger afledt af dedifferentierede omprogrammerede celler |
US8685726B2 (en) | 2009-04-27 | 2014-04-01 | Viacyte, Inc. | Small molecules supporting pluripotent cell growth and methods thereof |
US9328331B2 (en) * | 2009-05-21 | 2016-05-03 | Joslin Diabetes Center, Inc. | Compositions and methods for promoting beta cell maturity |
BR112012001557A2 (pt) * | 2009-07-20 | 2016-03-08 | Janssen Biotech Inc | diferenciação de células-tronco embrionárias humanas. |
WO2011011349A2 (en) | 2009-07-20 | 2011-01-27 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells |
KR101861584B1 (ko) * | 2009-10-29 | 2018-05-28 | 얀센 바이오테크 인코포레이티드 | 만능 줄기 세포 |
CA2784415C (en) | 2009-12-23 | 2019-06-18 | Jean Xu | Differentiation of human embryonic stem cells |
US8932853B2 (en) * | 2009-12-29 | 2015-01-13 | Takeda Pharmaceutical Company Limited | Method for manufacturing pancreatic-hormone-producing cells |
WO2011109279A2 (en) * | 2010-03-01 | 2011-09-09 | Centocor Ortho Biotech Inc. | Methods for purifying cells derived from pluripotent stem cells |
JP5909482B2 (ja) | 2010-03-31 | 2016-04-26 | ザ スクリプス リサーチ インスティテュート | 細胞の再プログラム |
WO2011128897A1 (en) | 2010-04-12 | 2011-10-20 | Technion Research & Development Foundation Ltd. | Populations of pancreatic progenitor cells and methods of isolating and using same |
EP2563908B1 (en) | 2010-04-25 | 2019-01-09 | Icahn School of Medicine at Mount Sinai | Generation of anterior foregut endoderm from pluripotent cells |
CA2800610C (en) | 2010-05-12 | 2019-09-24 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
EP2604685B1 (en) * | 2010-08-09 | 2017-03-15 | Takeda Pharmaceutical Company Limited | Method of producing pancreatic hormone-producing cells |
US20120039955A1 (en) * | 2010-08-12 | 2012-02-16 | Janssen Biotech, Inc. | Treatment of Diabetes with Pancreatic Endocrine Precursor Cells |
GB201014169D0 (en) | 2010-08-25 | 2010-10-06 | Cambridge Entpr Ltd | In vitro hepatic differentiation |
US9181528B2 (en) | 2010-08-31 | 2015-11-10 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
CN108517310B (zh) | 2010-08-31 | 2022-02-15 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
KR101851956B1 (ko) | 2010-08-31 | 2018-04-25 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
WO2012044486A1 (en) | 2010-09-28 | 2012-04-05 | Baylor Research Institute | Induction of pancreatic stem cells by transient overexpression of reprogramming factors and pdxi selection |
EP2508607A1 (en) | 2011-04-07 | 2012-10-10 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for liver regeneration and for treatment of liver failure |
US20120270890A1 (en) | 2011-04-22 | 2012-10-25 | Cheng-Ho Chung | Methods of Pancreatic Beta Cell Regeneration |
WO2013000084A1 (en) | 2011-06-27 | 2013-01-03 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
WO2013000085A1 (en) | 2011-06-27 | 2013-01-03 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
WO2013018851A1 (ja) | 2011-08-02 | 2013-02-07 | 独立行政法人国立がん研究センター | 誘導肝幹細胞から肝分化誘導する方法及び誘導肝前駆細胞 |
US20140243374A1 (en) | 2011-10-04 | 2014-08-28 | The Brigham And Women's Hospital, Inc. | Novel Sulfonamides |
EP2768948B1 (en) * | 2011-10-18 | 2017-06-07 | Univercell Biosolutions | Production of a human beta cell line from an early post natal pancreas |
CA2855932A1 (en) | 2011-11-13 | 2013-05-16 | Blanchette Rockefeller Neurosciences Institute | Pkc activators and combinations thereof |
AU2012355698B2 (en) * | 2011-12-22 | 2018-11-29 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
WO2013169769A1 (en) | 2012-05-07 | 2013-11-14 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endoderm |
RU2707292C2 (ru) | 2012-05-08 | 2019-11-26 | Мерк Шарп И Доум Корп. | Проницаемые ингибиторы гликозидазы и их применения |
WO2013166654A1 (en) | 2012-05-08 | 2013-11-14 | Merck Sharp & Dohme Corp. | Permeable glycosidase inhibitors and uses thereof |
KR102114209B1 (ko) | 2012-06-08 | 2020-05-25 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 췌장 내분비 세포로의 분화 |
MX2014015419A (es) | 2012-06-14 | 2015-07-14 | Janssen Biotech Inc | Tratamiento de celulas pluripotentes. |
US20150247123A1 (en) | 2012-09-03 | 2015-09-03 | Novo Nordisk A/S | Generation of pancreatic endoderm from Pluripotent Stem cells using small molecules |
RU2658488C2 (ru) * | 2012-12-31 | 2018-06-21 | Янссен Байотек, Инк. | Способ получения клеток, экспрессирующих маркеры, характерные для панкреатических эндокринных клеток |
EP2938723B1 (en) * | 2012-12-31 | 2023-02-01 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators |
JP6529440B2 (ja) | 2012-12-31 | 2019-06-12 | ヤンセン バイオテツク,インコーポレーテツド | 膵内分泌細胞への分化のためのヒト多能性細胞の懸濁及びクラスタリング |
WO2014130887A1 (en) | 2013-02-22 | 2014-08-28 | Cedars-Sinai Medical Center | Pancreatic insulin-producing beta-cell lines derived from human pluripotent stem cells |
US20140287944A1 (en) | 2013-02-26 | 2014-09-25 | President And Fellows Of Harvard College | Markers for functionally mature beta-cells and methods of using the same |
WO2014151871A2 (en) | 2013-03-14 | 2014-09-25 | Tolero Pharmaceuticals, Inc. | Jak2 and alk2 inhibitors and methods for their use |
US8859286B2 (en) | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
US20140329704A1 (en) | 2013-03-28 | 2014-11-06 | President And Fellows Of Harvard College | Markers for mature beta-cells and methods of using the same |
EP4461806A3 (en) | 2013-06-11 | 2025-02-12 | President and Fellows of Harvard College | Sc-b cells and compositions and methods for generating the same |
JP6636427B2 (ja) | 2013-08-30 | 2020-01-29 | ノヴォ ノルディスク アー/エス | 小分子を用いるヒト多能性幹細胞からの内分泌始原細胞の作製 |
BR112016026626A2 (pt) * | 2014-05-16 | 2017-08-15 | Janssen Biotech Inc | Uso de moléculas pequenas para melhorar a expressão de mafa em células pancreáticas endócrinas |
AU2015267148B2 (en) | 2014-05-28 | 2021-07-29 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
JP6678107B2 (ja) | 2014-08-04 | 2020-04-08 | 武田薬品工業株式会社 | 膵前駆細胞の増殖方法 |
US20160177268A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating augmented stem cell-derived beta cells and uses thereof |
DK3234110T3 (da) | 2014-12-18 | 2024-05-13 | Harvard College | FREMGANGSMÅDER TIL GENERERING AF STAMCELLE-AFLEDTE ß-CELLER OG ANVENDELSER DERAF |
US10443042B2 (en) | 2014-12-18 | 2019-10-15 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof |
WO2016100930A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived b cells and methods of use thereof |
WO2016100921A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
US9974784B2 (en) | 2015-01-21 | 2018-05-22 | The Texas A&M University System | Inhibitors of activin-like receptor kinases |
MA45747A (fr) | 2016-02-24 | 2019-01-02 | Novo Nordisk As | Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines |
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