DK2193118T3 - Piperidin- og piperazinderivater til behandling af tumorer - Google Patents

Piperidin- og piperazinderivater til behandling af tumorer

Info

Publication number: DK2193118T3
Authority: DK; Denmark
Prior art keywords: piperidine; tumors; treatment; piperazine derivatives; piperazine
Prior art date: 2007-10-05

Application number

DK08802402.1T

Other languages

English (en)

Inventor

Kai Schiemann

Melanie Schultz

Andree Blaukat

Ingo Kober

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-05

Filing date

2008-09-19

Publication date

2012-10-22

2008-09-19 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2012-10-22 Application granted granted Critical

2012-10-22 Publication of DK2193118T3 publication Critical patent/DK2193118T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Hematology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK08802402.1T 2007-10-05 2008-09-19 Piperidin- og piperazinderivater til behandling af tumorer DK2193118T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102007047737A DE102007047737A1 (de)	2007-10-05	2007-10-05	Piperidin- und Piperazinderivate
PCT/EP2008/007893 WO2009046841A2 (de)	2007-10-05	2008-09-19	Piperidin- und piperazinderivate zur behandlung von tumoren

Publications (1)

Publication Number	Publication Date
DK2193118T3 true DK2193118T3 (da)	2012-10-22

Family

ID=40089983

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK11007349.1T DK2426106T3 (da)	2007-10-05	2008-09-19	Piperidin- og piperazinderivat til behandling af tumorer
DK08802402.1T DK2193118T3 (da)	2007-10-05	2008-09-19	Piperidin- og piperazinderivater til behandling af tumorer

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK11007349.1T DK2426106T3 (da)	2007-10-05	2008-09-19	Piperidin- og piperazinderivat til behandling af tumorer

Country Status (22)

Country	Link
US (2)	US8791111B2 (da)
EP (2)	EP2426106B1 (da)
JP (2)	JP5597538B2 (da)
KR (1)	KR20100075601A (da)
CN (1)	CN101808988A (da)
AR (1)	AR068657A1 (da)
AU (1)	AU2008310067B2 (da)
BR (1)	BRPI0817644A2 (da)
CA (1)	CA2701519C (da)
CY (2)	CY1113757T1 (da)
DE (1)	DE102007047737A1 (da)
DK (2)	DK2426106T3 (da)
EA (1)	EA017787B1 (da)
ES (2)	ES2392475T3 (da)
HR (2)	HRP20120802T1 (da)
IL (1)	IL204562A0 (da)
MX (1)	MX2010003366A (da)
PL (2)	PL2193118T3 (da)
PT (2)	PT2193118E (da)
SI (2)	SI2426106T1 (da)
WO (1)	WO2009046841A2 (da)
ZA (1)	ZA201003124B (da)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102007047737A1 (de) *	2007-10-05	2009-04-30	Merck Patent Gmbh	Piperidin- und Piperazinderivate
AU2010230646B2 (en) *	2009-04-02	2015-11-26	Merck Patent Gmbh	Heterocyclic compounds as autotaxin inhibitors
DE102009049211A1 (de)	2009-10-13	2011-04-28	Merck Patent Gmbh	Sulfoxide
EP2687531B1 (en)	2011-03-18	2016-07-13	ONO Pharmaceutical Co., Ltd.	Tetrahydrocarboline derivative
US8828874B2 (en) *	2011-03-28	2014-09-09	Sinmat, Inc.	Chemical mechanical polishing of group III-nitride surfaces
CN103958481B (zh) *	2011-10-28	2017-06-30	因西必泰克新有限公司	可用于治疗的哒嗪衍生物
WO2013070879A1 (en)	2011-11-10	2013-05-16	Bristol-Myers Squibb Company	Methods for treating spinal cord injury with lpa receptor antagonists
IL296199B2 (en) *	2012-04-13	2024-12-01	Eisai R&D Man Co Ltd	Salt form of a human hi stone methyltransf erase ezh2 inhibitor
KR20150023373A (ko) *	2012-06-13	2015-03-05	에프. 호프만-라 로슈 아게	신규한 다이아자스피로사이클로알칸 및 아자스피로사이클로알칸
AU2013322838B2 (en) *	2012-09-25	2018-02-01	F. Hoffmann-La Roche Ag	New bicyclic derivatives
CN104968656B (zh) *	2012-12-19	2017-08-11	诺华股份有限公司	自分泌运动因子抑制剂
US9409895B2 (en)	2012-12-19	2016-08-09	Novartis Ag	Autotaxin inhibitors
AR095079A1 (es)	2013-03-12	2015-09-16	Hoffmann La Roche	Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
JP2016530209A (ja)	2013-09-17	2016-09-29	ファーマケア，インク．	ビニルオートタキシン阻害剤化合物
WO2015042052A1 (en)	2013-09-17	2015-03-26	Pharmakea, Inc.	Heterocyclic vinyl autotaxin inhibitor compounds
US9850203B2 (en)	2013-09-26	2017-12-26	Pharmakea, Inc.	Autotaxin inhibitor compounds
CN104557739B (zh) *	2013-10-25	2016-11-09	山东先达农化股份有限公司	三酮类化合物及其制备方法和应用
CN105764903B (zh)	2013-11-22	2018-09-18	法玛克亚公司	四环自分泌运动因子抑制剂
JP6501367B2 (ja)	2013-11-22	2019-04-17	ファーマケア，インク．	オートタキシン阻害剤化合物
DK3074400T3 (da)	2013-11-26	2018-01-15	Hoffmann La Roche	Octahydro-cyclobuta[1,2-c;3,4-c']dipyrrol derivater som autotaxin inhibitorer
SG11201607845RA (en)	2014-03-26	2016-10-28	Hoffmann La Roche	Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
MA50635A (fr)	2014-03-26	2020-08-12	Hoffmann La Roche	Nouveaux composés bicycliques comme inhibiteurs de la production d'autotaxin (atx) et de l'acide lysophosphatidique
EP3134398A1 (en)	2014-04-24	2017-03-01	Novartis Ag	Autotaxin inhibitors
US9783522B2 (en)	2014-04-24	2017-10-10	Mitsubishi Tanabe Pharma Corporation	2-amino-pyridine and 2-amino-pyrimidine derivatives and medicinal use thereof
US9051320B1 (en)	2014-08-18	2015-06-09	Pharmakea, Inc.	Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor
GB201501870D0 (en)	2015-02-04	2015-03-18	Cancer Rec Tech Ltd	Autotaxin inhibitors
GB201502020D0 (en)	2015-02-06	2015-03-25	Cancer Rec Tech Ltd	Autotaxin inhibitory compounds
CN104758286B (zh) *	2015-03-05	2016-09-14	南京工业大学	1-苄基-4-(2,4-二氯苯乙胺基)哌啶在制备抗肿瘤药物中的应用
MA41898A (fr)	2015-04-10	2018-02-13	Hoffmann La Roche	Dérivés de quinazolinone bicyclique
US10632104B2 (en)	2015-05-27	2020-04-28	Sabre Therapeutics Llc	Autotaxin inhibitors and uses thereof
EP3302465A1 (en)	2015-06-05	2018-04-11	Vertex Pharmaceuticals Incorporated	Triazoles for the treatment of demyelinating diseases
EP3344619B1 (en)	2015-09-04	2020-10-28	H. Hoffnabb-La Roche Ag	Phenoxymethyl derivatives
AU2016328365B2 (en)	2015-09-24	2020-04-23	F. Hoffmann-La Roche Ag	New bicyclic compounds as dual ATX/CA inhibitors
JP6877413B2 (ja)	2015-09-24	2021-05-26	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	二重ａｔｘ／ｃａ阻害剤としての新規な二環式化合物
MA42919A (fr)	2015-09-24	2018-08-01	Hoffmann La Roche	Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
EP3353180B1 (en)	2015-09-24	2022-03-16	F. Hoffmann-La Roche AG	Bicyclic compounds as atx inhibitors
WO2018106643A1 (en)	2016-12-06	2018-06-14	Vertex Pharmaceuticals Incorporated	Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106646A1 (en)	2016-12-06	2018-06-14	Vertex Pharmaceuticals Incorporated	Aminotriazoles for the treatment of demyelinating diseases
WO2018106641A1 (en)	2016-12-06	2018-06-14	Vertex Pharmaceuticals Incorporated	Pyrazoles for the treatment of demyelinating diseases
JP7090099B2 (ja)	2017-03-16	2022-06-23	エフ．ホフマン－ラロシュアーゲー	Ａｔｘインヒビターとしての新規二環式化合物
KR20190129924A (ko)	2017-03-16	2019-11-20	에프. 호프만-라 로슈 아게	이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물
KR101798840B1 (ko)	2017-05-17	2017-11-17	주식회사 레고켐 바이오사이언스	신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
US10961242B2 (en)	2017-05-17	2021-03-30	Legochem Biosciences, Inc.	Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
CN107266356B (zh) *	2017-07-25	2020-06-26	山西省生物研究院有限公司	一种作为自分泌运动因子抑制剂的咔唑类化合物及其制备方法和应用
PT3831812T (pt)	2018-07-27	2023-07-10	Mitsubishi Tanabe Pharma Corp	Novos derivados de piridina 3,5-dissubstituída e de piridazina 3,5-dissubstituída e utilização farmacêutica dos mesmos
CN112028903A (zh) *	2020-01-17	2020-12-04	平顶山学院	四氢萘并呋喃酮螺吡咯烷酮化合物及其制备方法
CN113461640B (zh) *	2021-06-17	2023-08-11	中央民族大学	Lpar1抑制剂、医药用途及其制备方法
CN117980300A (zh) *	2021-09-21	2024-05-03	明斯特大学	自分泌运动因子抑制剂
CN114378108B (zh) *	2022-03-24	2022-07-22	神美科技有限公司	一种重金属螯合剂及其在去除生活垃圾中重金属中的用途

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2491066A1 (fr)	1980-09-29	1982-04-02	Cerm Cent Europ Rech Mauvernay	Benzoxazolinones substituees en 6 par une chaine aminoalcool ou aminocetone, leur preparation et leur application en therapeutique
JPS60130573A (ja) *	1983-12-15	1985-07-12	Otsuka Pharmaceut Co Ltd	ベンゾチアゾ−ル誘導体
JPS6122069A (ja) *	1984-07-06	1986-01-30	Otsuka Pharmaceut Co Ltd	オキシインド−ル誘導体
FR2637286A1 (fr) *	1988-10-04	1990-04-06	Adir	Nouveaux derives benzoxazolinoniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2643634A1 (fr)	1989-02-28	1990-08-31	Adir	Nouveaux derives benzoxazolinoniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US5053411A (en)	1989-04-20	1991-10-01	Anaquest, Inc.	N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
US5747469A (en)	1991-03-06	1998-05-05	Board Of Regents, The University Of Texas System	Methods and compositions comprising DNA damaging agents and p53
EP0567090B1 (en) *	1992-04-24	2000-07-26	Takeda Chemical Industries, Ltd.	Benzoxazepine derivatives as cholinesterase inhibitors
DK0709384T3 (da)	1994-10-31	1999-08-23	Merck Patent Gmbh	Benzylpiperidinderivater med høj affinitet til aminosyrereceptorers bindingssteder
US6214994B1 (en) *	1997-04-21	2001-04-10	Molecular Geriatrics Corporation	Certain substituted 1-aryl-3-piperazin-1′-yl propanones
DE19643790A1 (de)	1996-10-30	1998-05-07	Merck Patent Gmbh	Benzoxazol-Derivat
US6969711B2 (en) *	1997-05-26	2005-11-29	Kowa Company, Ltd.	Cyclic diamine compounds and medicine containing the same
GB9725541D0 (en) *	1997-12-02	1998-02-04	Pharmacia & Upjohn Spa	Amino-benzothiazole derivatives
PE20000728A1 (es) *	1998-06-26	2000-08-21	Cocensys Inc	Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda
EP1002535A1 (en)	1998-10-28	2000-05-24	Hrissanthi Ikonomidou	New use of glutamate antagonists for the treatment of cancer
GB9904387D0 (en)	1999-02-25	1999-04-21	Pharmacia & Upjohn Spa	Antitumour synergistic composition
WO2000061186A1 (en)	1999-04-08	2000-10-19	Arch Development Corporation	Use of anti-vegf antibody to enhance radiation in cancer therapy
HUP0300203A3 (en) *	2000-02-29	2006-01-30	Mitsubishi Pharma Corp	Novel cyclic amide derivatives, and pharmaceutical compositions containing same
DE10050236A1 (de)	2000-10-11	2002-04-25	Merck Patent Gmbh	Verwendung bestimmter Substanzen, die an den Sigma-Rezeptor binden, zur Behandlung von Sarkomen und Karzinomen
CA2381630A1 (en) *	2001-04-23	2002-10-23	Leonard Theodore Meltzer	Method for preventing dyskinesias
DE10120159A1 (de)	2001-04-25	2002-10-31	Merck Patent Gmbh	NMDA-Antagonisten und NMDA-Agonisten zur Behandlung von Suchterkrankungen
KR100890676B1 (ko) *	2001-07-24	2009-03-26	리히데 게데온 베기에스제티 기아르 알티	신규한 카르복시산 아미드 화합물
GB0320244D0 (en) *	2003-05-06	2003-10-01	Aventis Pharma Inc	Pyrazoles as inhibitors of tumour necrosis factor
EP1736474A4 (en)	2004-04-07	2010-04-21	Kyowa Hakko Kirin Co Ltd	piperidine
US7777037B2 (en) *	2004-10-27	2010-08-17	Dr. Reddy's Laboratories Limited	Ziprasidone process
TWI415845B (zh) *	2006-10-03	2013-11-21	Arena Pharm Inc	用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
DE102007047737A1 (de) *	2007-10-05	2009-04-30	Merck Patent Gmbh	Piperidin- und Piperazinderivate

2007
- 2007-10-05 DE DE102007047737A patent/DE102007047737A1/de not_active Withdrawn
2008
- 2008-09-19 SI SI200831052T patent/SI2426106T1/sl unknown
- 2008-09-19 KR KR1020107009776A patent/KR20100075601A/ko not_active Ceased
- 2008-09-19 AU AU2008310067A patent/AU2008310067B2/en not_active Ceased
- 2008-09-19 DK DK11007349.1T patent/DK2426106T3/da active
- 2008-09-19 US US12/681,440 patent/US8791111B2/en not_active Expired - Fee Related
- 2008-09-19 PT PT08802402T patent/PT2193118E/pt unknown
- 2008-09-19 BR BRPI0817644 patent/BRPI0817644A2/pt not_active IP Right Cessation
- 2008-09-19 MX MX2010003366A patent/MX2010003366A/es not_active Application Discontinuation
- 2008-09-19 ES ES08802402T patent/ES2392475T3/es active Active
- 2008-09-19 WO PCT/EP2008/007893 patent/WO2009046841A2/de active Application Filing
- 2008-09-19 EP EP11007349.1A patent/EP2426106B1/de not_active Not-in-force
- 2008-09-19 DK DK08802402.1T patent/DK2193118T3/da active
- 2008-09-19 PT PT110073491T patent/PT2426106E/pt unknown
- 2008-09-19 ES ES11007349T patent/ES2429843T3/es active Active
- 2008-09-19 JP JP2010527349A patent/JP5597538B2/ja not_active Expired - Fee Related
- 2008-09-19 PL PL08802402T patent/PL2193118T3/pl unknown
- 2008-09-19 CN CN200880109583A patent/CN101808988A/zh active Pending
- 2008-09-19 SI SI200830792T patent/SI2193118T1/sl unknown
- 2008-09-19 PL PL11007349T patent/PL2426106T3/pl unknown
- 2008-09-19 CA CA2701519A patent/CA2701519C/en not_active Expired - Fee Related
- 2008-09-19 EA EA201000549A patent/EA017787B1/ru not_active IP Right Cessation
- 2008-09-19 EP EP08802402A patent/EP2193118B1/de not_active Not-in-force
- 2008-10-03 AR ARP080104328A patent/AR068657A1/es unknown
2010
- 2010-03-16 IL IL204562A patent/IL204562A0/en active IP Right Grant
- 2010-05-04 ZA ZA2010/03124A patent/ZA201003124B/en unknown
2012
- 2012-08-22 US US13/591,765 patent/US8754097B2/en not_active Expired - Fee Related
- 2012-10-05 HR HRP20120802AT patent/HRP20120802T1/hr unknown
- 2012-10-17 CY CY20121100967T patent/CY1113757T1/el unknown
2013
- 2013-10-03 HR HRP20130929AT patent/HRP20130929T1/hr unknown
- 2013-10-25 CY CY20131100944T patent/CY1114574T1/el unknown
2014
- 2014-04-09 JP JP2014079895A patent/JP5847226B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EA201000549A1 (ru)	2010-10-29
EA017787B1 (ru)	2013-03-29
DK2426106T3 (da)	2013-11-04
WO2009046841A2 (de)	2009-04-16
ZA201003124B (en)	2011-04-28
EP2426106A1 (de)	2012-03-07
US8754097B2 (en)	2014-06-17
EP2193118A2 (de)	2010-06-09
DE102007047737A1 (de)	2009-04-30
KR20100075601A (ko)	2010-07-02
SI2193118T1 (sl)	2012-12-31
PL2426106T3 (pl)	2013-11-29
MX2010003366A (es)	2010-04-30
US20120316162A1 (en)	2012-12-13
JP2010540579A (ja)	2010-12-24
IL204562A0 (en)	2010-11-30
JP2014129427A (ja)	2014-07-10
CA2701519C (en)	2017-07-11
PT2193118E (pt)	2012-11-02
CY1114574T1 (el)	2016-10-05
CN101808988A (zh)	2010-08-18
ES2392475T3 (es)	2012-12-11
AU2008310067B2 (en)	2013-09-26
HRP20120802T1 (hr)	2012-11-30
US20100222341A1 (en)	2010-09-02
US8791111B2 (en)	2014-07-29
ES2429843T3 (es)	2013-11-18
AU2008310067A1 (en)	2009-04-16
PL2193118T3 (pl)	2013-01-31
HRP20130929T1 (hr)	2013-11-08
BRPI0817644A2 (pt)	2015-03-31
PT2426106E (pt)	2013-11-07
WO2009046841A3 (de)	2009-06-18
EP2426106B1 (de)	2013-07-31
EP2193118B1 (de)	2012-08-22
CY1113757T1 (el)	2016-07-27
CA2701519A1 (en)	2009-04-16
AR068657A1 (es)	2009-11-25
JP5847226B2 (ja)	2016-01-20
JP5597538B2 (ja)	2014-10-01
WO2009046841A8 (de)	2010-01-21
SI2426106T1 (sl)	2013-10-30

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