DK1636375T3 - Fremgangsmåde til screening for substanser hvilke er i stand til modulation af phosphoryleringen af tau protein - Google Patents
Fremgangsmåde til screening for substanser hvilke er i stand til modulation af phosphoryleringen af tau proteinInfo
- Publication number
- DK1636375T3 DK1636375T3 DK04743090T DK04743090T DK1636375T3 DK 1636375 T3 DK1636375 T3 DK 1636375T3 DK 04743090 T DK04743090 T DK 04743090T DK 04743090 T DK04743090 T DK 04743090T DK 1636375 T3 DK1636375 T3 DK 1636375T3
- Authority
- DK
- Denmark
- Prior art keywords
- tau protein
- screening
- fyn
- candidate
- phosphatase
- Prior art date
Links
- 102000013498 tau Proteins Human genes 0.000 title abstract 9
- 108010026424 tau Proteins Proteins 0.000 title abstract 9
- 239000000126 substance Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 238000012216 screening Methods 0.000 title abstract 3
- 230000026731 phosphorylation Effects 0.000 title 1
- 238000006366 phosphorylation reaction Methods 0.000 title 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 abstract 3
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000030609 dephosphorylation Effects 0.000 abstract 3
- 238000006209 dephosphorylation reaction Methods 0.000 abstract 3
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 230000000865 phosphorylative effect Effects 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0314943.2A GB0314943D0 (en) | 2003-06-25 | 2003-06-25 | Screening methods |
PCT/GB2004/002739 WO2005001114A2 (fr) | 2003-06-25 | 2004-06-25 | Procedes de criblage |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1636375T3 true DK1636375T3 (da) | 2008-12-15 |
Family
ID=27637418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04743090T DK1636375T3 (da) | 2003-06-25 | 2004-06-25 | Fremgangsmåde til screening for substanser hvilke er i stand til modulation af phosphoryleringen af tau protein |
Country Status (11)
Country | Link |
---|---|
US (2) | US8822171B1 (fr) |
EP (1) | EP1636375B1 (fr) |
JP (2) | JP5688747B2 (fr) |
AT (1) | ATE404692T1 (fr) |
AU (1) | AU2004252273B2 (fr) |
CA (2) | CA2527437C (fr) |
DE (1) | DE602004015791D1 (fr) |
DK (1) | DK1636375T3 (fr) |
ES (1) | ES2313032T3 (fr) |
GB (1) | GB0314943D0 (fr) |
WO (1) | WO2005001114A2 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0314943D0 (en) * | 2003-06-25 | 2003-07-30 | Proteome Sciences Plc | Screening methods |
EP2441847B1 (fr) * | 2004-06-21 | 2015-09-23 | Proteome Sciences Plc | Methodes de criblage utilisant syk en combinaison avec la proteine tau |
JP4522910B2 (ja) * | 2005-05-30 | 2010-08-11 | 株式会社日立ハイテクノロジーズ | 質量分析方法及び質量分析装置 |
ES2425179T3 (es) | 2006-10-25 | 2013-10-11 | The Rockefeller University | Métodos para el tratamiento de trastornos relacionados con beta-amiloide y composiciones para los mismos |
WO2009101942A1 (fr) * | 2008-02-12 | 2009-08-20 | Takeda Pharmaceutical Company Limited | Procédé de criblage |
GB0903913D0 (en) * | 2009-03-06 | 2009-04-22 | Medical Res Council | Compositions and methods |
ES2553610T3 (es) | 2010-12-14 | 2015-12-10 | Electrophoretics Limited | Inhibidores de la caseína cinasa 1 delta (CK1delta) |
WO2014055413A2 (fr) * | 2012-10-02 | 2014-04-10 | Bloodcenter Research Foundation | Procédé permettant de fournir une thérapie cellulaire à l'aide de cellules tueuses naturelles modifiées ou de lymphocytes t |
KR20160101197A (ko) | 2014-01-09 | 2016-08-24 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
MX390815B (es) | 2016-03-11 | 2025-03-21 | Apple Inc | Estabilizacion de imagenes opticas con motor de bobina de voz para mover el sensor de imagenes. |
US11956544B2 (en) | 2016-03-11 | 2024-04-09 | Apple Inc. | Optical image stabilization with voice coil motor for moving image sensor |
US10437023B2 (en) | 2016-03-28 | 2019-10-08 | Apple Inc. | Folded lens system with three refractive lenses |
US10890734B1 (en) | 2017-03-29 | 2021-01-12 | Apple Inc. | Camera actuator for lens and sensor shifting |
US10863094B2 (en) | 2017-07-17 | 2020-12-08 | Apple Inc. | Camera with image sensor shifting |
US11122205B1 (en) | 2018-09-14 | 2021-09-14 | Apple Inc. | Camera actuator assembly with sensor shift flexure arrangement |
US11575835B2 (en) | 2020-09-24 | 2023-02-07 | Apple Inc. | Multi-axis image sensor shifting system |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9316727D0 (en) * | 1993-08-12 | 1993-09-29 | Inst Of Psychiatry | Models of alzheimers's disease |
WO1995019178A1 (fr) * | 1994-01-13 | 1995-07-20 | Research Foundation For Mental Hygiene, Inc. | Procedes et compositions de traitement et de diagnostic de la maladie d'alzheimer et d'autres troubles |
US6057117A (en) | 1996-04-04 | 2000-05-02 | Chiron Corporation | Identification and use of selective inhibitors of glycogen synthase kinase 3 |
US6593512B1 (en) * | 1999-03-03 | 2003-07-15 | Cognosci, Inc. | Transgenic mouse expressing human tau gene |
AU6722300A (en) * | 1999-08-31 | 2001-03-26 | Ramot University Authority For Applied Research And Industrial Development Ltd. | Peptides and substances, methods and devices using same for diagnosing and treating neurodegenerative disorders |
US6503914B1 (en) * | 2000-10-23 | 2003-01-07 | Board Of Regents, The University Of Texas System | Thienopyrimidine-based inhibitors of the Src family |
US20020172990A1 (en) * | 2002-02-19 | 2002-11-21 | Thomas Curran | Cyclin dependent kinase 5 phosphorylation of disabled 1 protein |
GB0314943D0 (en) * | 2003-06-25 | 2003-07-30 | Proteome Sciences Plc | Screening methods |
-
2003
- 2003-06-25 GB GBGB0314943.2A patent/GB0314943D0/en not_active Ceased
-
2004
- 2004-06-25 JP JP2006516474A patent/JP5688747B2/ja not_active Expired - Fee Related
- 2004-06-25 CA CA2527437A patent/CA2527437C/fr not_active Expired - Fee Related
- 2004-06-25 WO PCT/GB2004/002739 patent/WO2005001114A2/fr active IP Right Grant
- 2004-06-25 AU AU2004252273A patent/AU2004252273B2/en not_active Ceased
- 2004-06-25 DK DK04743090T patent/DK1636375T3/da active
- 2004-06-25 ES ES04743090T patent/ES2313032T3/es not_active Expired - Lifetime
- 2004-06-25 DE DE602004015791T patent/DE602004015791D1/de not_active Expired - Lifetime
- 2004-06-25 EP EP04743090A patent/EP1636375B1/fr not_active Expired - Lifetime
- 2004-06-25 AT AT04743090T patent/ATE404692T1/de active
- 2004-06-25 US US10/562,951 patent/US8822171B1/en active Active
- 2004-06-25 CA CA2848433A patent/CA2848433C/fr not_active Expired - Fee Related
-
2011
- 2011-11-25 JP JP2011257692A patent/JP2012045002A/ja not_active Withdrawn
-
2014
- 2014-07-24 US US14/339,538 patent/US20150051097A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2005001114A2 (fr) | 2005-01-06 |
WO2005001114A3 (fr) | 2005-03-31 |
ATE404692T1 (de) | 2008-08-15 |
CA2848433C (fr) | 2017-01-10 |
JP2012045002A (ja) | 2012-03-08 |
CA2848433A1 (fr) | 2005-01-06 |
JP2007527210A (ja) | 2007-09-27 |
EP1636375A2 (fr) | 2006-03-22 |
US8822171B1 (en) | 2014-09-02 |
CA2527437A1 (fr) | 2005-01-06 |
DE602004015791D1 (de) | 2008-09-25 |
ES2313032T3 (es) | 2009-03-01 |
AU2004252273A1 (en) | 2005-01-06 |
AU2004252273B2 (en) | 2011-04-28 |
US20150051097A1 (en) | 2015-02-19 |
EP1636375B1 (fr) | 2008-08-13 |
JP5688747B2 (ja) | 2015-03-25 |
CA2527437C (fr) | 2016-08-02 |
GB0314943D0 (en) | 2003-07-30 |
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