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DK1611238T3 - Modulatoriske glutamattransportforbindelser og -fremgangsmåder - Google Patents

Modulatoriske glutamattransportforbindelser og -fremgangsmåder

Info

Publication number
DK1611238T3
DK1611238T3 DK04714617T DK04714617T DK1611238T3 DK 1611238 T3 DK1611238 T3 DK 1611238T3 DK 04714617 T DK04714617 T DK 04714617T DK 04714617 T DK04714617 T DK 04714617T DK 1611238 T3 DK1611238 T3 DK 1611238T3
Authority
DK
Denmark
Prior art keywords
methods
modulatory
transport compounds
glutamate transport
protein expression
Prior art date
Application number
DK04714617T
Other languages
Danish (da)
English (en)
Inventor
Jeffrey D Rothstein
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Application granted granted Critical
Publication of DK1611238T3 publication Critical patent/DK1611238T3/da

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406Neurotransmitters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70571Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2871Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
DK04714617T 2003-02-26 2004-02-25 Modulatoriske glutamattransportforbindelser og -fremgangsmåder DK1611238T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45022703P 2003-02-26 2003-02-26
PCT/US2004/005698 WO2004076675A2 (fr) 2003-02-26 2004-02-25 Composes modulant le transport du glutamate et procedes associes

Publications (1)

Publication Number Publication Date
DK1611238T3 true DK1611238T3 (da) 2009-10-26

Family

ID=32927622

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04714617T DK1611238T3 (da) 2003-02-26 2004-02-25 Modulatoriske glutamattransportforbindelser og -fremgangsmåder

Country Status (13)

Country Link
US (1) US20060121488A1 (fr)
EP (1) EP1611238B1 (fr)
JP (1) JP2006524637A (fr)
KR (1) KR20050115245A (fr)
AT (1) ATE433993T1 (fr)
AU (1) AU2004214938B2 (fr)
CA (1) CA2516619A1 (fr)
DE (1) DE602004021574D1 (fr)
DK (1) DK1611238T3 (fr)
ES (1) ES2328811T3 (fr)
MX (1) MXPA05009134A (fr)
PL (1) PL377896A1 (fr)
WO (1) WO2004076675A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004048551A2 (fr) * 2002-11-22 2004-06-10 The Johns Hopkins University Cible destinee a la therapie d'un trouble cognitif
EP1680126A4 (fr) * 2003-10-21 2009-05-13 Univ Johns Hopkins Neuroprotection par le biais de composes au beta-lactame
WO2006096404A2 (fr) * 2005-03-04 2006-09-14 Alsgen, Inc Modulation de maladies neurodegeneratives par l'intermediaire du recepteur de la progesterone
US8778979B2 (en) * 2005-04-05 2014-07-15 Yale University Glutamate agents in the treatment of mental disorders
AU2007217892A1 (en) * 2006-02-16 2007-08-30 The Mclean Hospital Corporation Methods and compositions for the treatment of Parkinson's Disease
FR2902010B1 (fr) * 2006-06-12 2008-08-22 Pierre Fabre Medicament Sa Utilisation de la 1,7 dimethylxanthine pour la fabrication d'un medicament psychoanaleptique non anxiogene destine au traitement d'un trouble neuropsychiatrique
WO2009033055A1 (fr) * 2007-09-06 2009-03-12 Rutgers, The State University Of New Jersey Procédés et kits destinés à identifier des composés anti-excitotoxiques
KR100980098B1 (ko) * 2008-01-30 2010-09-03 한국과학기술연구원 음이온 채널을 통한 신경전달물질의 방출 조절
WO2011099502A1 (fr) * 2010-02-10 2011-08-18 公立大学法人横浜市立大学 Utilisation d'un composé se liant à msin3b qui se lie, de façon spécifique, au facteur silenceur de la spécification neuronale nrsf
FR2958664B1 (fr) 2010-04-07 2012-10-26 Coatex Sas Utilisation d'un latex de styrene et de taille de 100 nm comme agent rheologique dans une sauce de couchage papetiere, sauce et son procede d'obtention
US9662347B2 (en) 2010-05-11 2017-05-30 Gachon University Of Industry-Academic Cooperation Foundation Method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of age-albumin in cells of the mononuclear phagocyte system
WO2012075408A1 (fr) * 2010-12-02 2012-06-07 Massachusetts Institute Of Technology Suppresseurs chimiques et de type arni de la neurotoxicité dans la maladie de huntington
WO2014076702A1 (fr) * 2012-11-14 2014-05-22 Ramot At Tel-Aviv University Ltd. Polythérapie pour la sclérose latérale amyotrophique (sla)
US10448861B2 (en) * 2013-09-06 2019-10-22 Covidien Lp System and method for light based lung visualization
CN104074095A (zh) * 2014-06-25 2014-10-01 宁波天源科技有限公司 流变改质剂
KR101809379B1 (ko) * 2016-10-13 2017-12-14 연세대학교 산학협력단 디오스민 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 근육 질환 예방 또는 치료용 조성물
CN111116374B (zh) * 2019-12-04 2020-12-15 北京理工大学 一种氨鲁米特与2-硝基苯甲酸合成π-π键共晶体的方法
CN110923148B (zh) * 2019-12-11 2021-05-14 华北制药股份有限公司 青霉素v钾高产菌及其在发酵生产青霉素v钾中的应用

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US4575506A (en) * 1983-11-03 1986-03-11 Zambon S.P.A. Method of treatment for inhibiting the tolerance onset while treating painful syndromes with central analgesics
US5210076A (en) 1988-09-13 1993-05-11 Berliner David L Methods of treating Parkinson's disease using melanin
ATE136461T1 (de) * 1990-08-13 1996-04-15 Searle & Co Verwendung von heterozyklischen aminoalkoholverbindungen zur herstellung eines medikaments für die behandlung von erkrankungen des zns
US5658782A (en) * 1993-10-20 1997-08-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A Non-Profit Organization Amino acid transporters and uses
US5795563A (en) * 1996-09-04 1998-08-18 Sphingomonas Research Partners, L.P. Identification of an exogenous intra-erythrocytic bacterium in patients having systemic lupus erythematosus, and treatment
US6255467B1 (en) * 1997-11-06 2001-07-03 Pathobiotek Diagnostics Inc. Human blood bacterium
US7060457B2 (en) * 1998-03-18 2006-06-13 Johns Hopkins University Aberrant glutamate transporters and methods of use
WO1999059964A1 (fr) * 1998-05-15 1999-11-25 University Of Vermont Nouveaux analogues d'acide 16-hydroxyeicosatetraenoique
US6426342B2 (en) * 1999-08-16 2002-07-30 Revaax Pharmaceuticals, Llc Use of β-lactamase inhibitors as neuroprotectants
US6489319B2 (en) * 1999-08-16 2002-12-03 Revaax Pharmaceuticals, Llc Neurotherapeutic use of carboxypeptidase inhibitors
US6627625B1 (en) * 1999-08-16 2003-09-30 Revaax Pharmaceuticals, Llc Treatment of behavioral disorders with β-lactam compounds
US20020013270A1 (en) * 2000-06-05 2002-01-31 Bolte Ellen R. Method for treating a mental disorder
US6248360B1 (en) * 2000-06-21 2001-06-19 International Health Management Associates, Inc. Complexes to improve oral absorption of poorly absorbable antibiotics
AU2001288792A1 (en) * 2000-09-06 2002-03-22 Neurotherapeutics, Llc Method of treating neurologic disorders
US6833478B2 (en) * 2001-07-13 2004-12-21 Sri International N,N-dinitramide salts as solubilizing agents for biologically active agents
EP1474434B1 (fr) * 2002-02-15 2009-01-07 The Johns Hopkins University Promoteur eaat2 et utilisations de ce promoteur
WO2004048551A2 (fr) * 2002-11-22 2004-06-10 The Johns Hopkins University Cible destinee a la therapie d'un trouble cognitif

Also Published As

Publication number Publication date
WO2004076675A3 (fr) 2005-03-17
EP1611238B1 (fr) 2009-06-17
PL377896A1 (pl) 2006-02-20
EP1611238A2 (fr) 2006-01-04
AU2004214938B2 (en) 2008-11-06
CA2516619A1 (fr) 2004-09-10
MXPA05009134A (es) 2005-12-05
ATE433993T1 (de) 2009-07-15
AU2004214938A1 (en) 2004-09-10
EP1611238A4 (fr) 2007-07-04
US20060121488A1 (en) 2006-06-08
WO2004076675A2 (fr) 2004-09-10
JP2006524637A (ja) 2006-11-02
KR20050115245A (ko) 2005-12-07
ES2328811T3 (es) 2009-11-18
DE602004021574D1 (de) 2009-07-30

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