DK1603584T3 - Aplidine til behandling af multipelt myelom - Google Patents

Aplidine til behandling af multipelt myelom

Info

Publication number: DK1603584T3
Authority: DK; Denmark
Prior art keywords: aplidine; multiple myeloma; treatment; medicament; manufacture
Prior art date: 2003-03-12

Application number

DK04720081T

Other languages

Danish (da)

English (en)

Inventor

Joseph R Bertino

Daniel Medina

Glynn Thomas Faircloth

Constantine S Mitsiades

Kenneth Anderson

Nicholas Mitsiades

Original Assignee

Dana Farber Cancer Inst Inc

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-12

Filing date

2004-03-12

Publication date

2009-01-05

2004-03-12 Application filed by Dana Farber Cancer Inst Inc, Pharma Mar Sa filed Critical Dana Farber Cancer Inst Inc

2009-01-05 Application granted granted Critical

2009-01-05 Publication of DK1603584T3 publication Critical patent/DK1603584T3/da

Links

UUSZLLQJYRSZIS-LXNNNBEUSA-N plitidepsin Chemical compound CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)=O UUSZLLQJYRSZIS-LXNNNBEUSA-N 0.000 title abstract 3
208000034578 Multiple myelomas Diseases 0.000 title abstract 2
206010035226 Plasma cell myeloma Diseases 0.000 title abstract 2
229950008499 plitidepsin Drugs 0.000 title abstract 2
108010049948 plitidepsin Proteins 0.000 title abstract 2
239000003814 drug Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK04720081T 2003-03-12 2004-03-12 Aplidine til behandling af multipelt myelom DK1603584T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US45412503P	2003-03-12	2003-03-12
US52029303P	2003-11-14	2003-11-14
PCT/GB2004/001062 WO2004080477A1 (fr)	2003-03-12	2004-03-12	Aplidine utilisee dans le traitement du myelome multiple

Publications (1)

Publication Number	Publication Date
DK1603584T3 true DK1603584T3 (da)	2009-01-05

Family

ID=32994545

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04720081T DK1603584T3 (da)	2003-03-12	2004-03-12	Aplidine til behandling af multipelt myelom

Country Status (20)

Country	Link
US (1)	US7381703B2 (fr)
EP (1)	EP1603584B1 (fr)
JP (1)	JP4584245B2 (fr)
KR (1)	KR101160320B1 (fr)
AT (1)	ATE406171T1 (fr)
AU (1)	AU2004218883B2 (fr)
CA (1)	CA2519789C (fr)
CY (1)	CY1108599T1 (fr)
DE (1)	DE602004016126D1 (fr)
DK (1)	DK1603584T3 (fr)
ES (1)	ES2312979T3 (fr)
IL (1)	IL170136A (fr)
MX (1)	MXPA05009742A (fr)
NO (1)	NO334264B1 (fr)
NZ (1)	NZ541611A (fr)
PL (1)	PL1603584T3 (fr)
PT (1)	PT1603584E (fr)
RU (1)	RU2335294C2 (fr)
SI (1)	SI1603584T1 (fr)
WO (1)	WO2004080477A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ518847A (en) *	1999-11-15	2004-02-27	Pharma Mar S	Aplidine treatment of cancers
CN1761480B (zh)	2003-03-12	2012-09-26	达纳-法伯癌症协会有限公司	用于多发性骨髓瘤的治疗的aplidine
WO2007100385A2 (fr) *	2005-10-31	2007-09-07	Genentech, Inc.	Conjugués anticorps-médicaments à base de depsipeptide macrocyclique et méthodes associées
ME02450B (fr) *	2006-02-28	2016-09-20	Pharma Mar Sa	Traitements antitumoraux perfectionnés
WO2008080956A1 (fr) *	2006-12-29	2008-07-10	Pharma Mar, S.A.	Marqueurs moléculaires de pronostic pour thérapie anticancéreuse à l'aplidine
WO2009002553A1 (fr) *	2007-06-25	2008-12-31	Prolexys Pharmaceuticals, Inc.	Procédés de traitement d'un myélome multiple et de cancers résistants
JP2011500650A (ja) *	2007-10-19	2011-01-06	ファルマ・マール・ソシエダード・アノニマ	改良された抗腫瘍治療
RU2010140888A (ru) *	2008-03-07	2012-04-20	Фарма Мар, С.А. (Es)	Улучшенные противораковые терапии
CN102065865B (zh) *	2008-05-16	2013-03-20	马尔药品公司	多发性骨髓瘤治疗
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام

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EP0048149B1 (fr)	1980-09-12	1983-11-30	University of Illinois Foundation	Antibiotiques, dérivés de ceux-ci, procédé de leur extraction et compositions contenant ceux-ci
US4950649A (en) *	1980-09-12	1990-08-21	University Of Illinois	Didemnins and nordidemnins
US4493796A (en) *	1980-09-12	1985-01-15	Board Of Trustees, Univ. Of Ill.	Didemnins A, B, C, and derivatives thereof, as antiviral agents
IT1153974B (it) *	1982-09-23	1987-01-21	Erba Farmitalia	Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
US4948791A (en)	1989-04-10	1990-08-14	The Board Of Trustees Of The University Of Illinois	Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum
GB8922026D0 (en) *	1989-09-29	1989-11-15	Pharma Mar Sa	Novel anti-viral and cytotoxic agent
DE4120327A1 (de)	1991-06-20	1992-12-24	Basf Ag	Neue peptide, ihre herstellung und verwendung
US5462726A (en) *	1993-12-17	1995-10-31	Bristol-Myers Squibb Company	Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
DE69431071T2 (de) *	1993-12-29	2003-03-20	Matrix Pharma	Zusammensetzung für lokale freigabe von zytostatika
EP0706799B1 (fr) *	1994-09-16	2001-11-14	MERCK PATENT GmbH	Immunoconjugués
US5861439A (en) *	1994-11-14	1999-01-19	Alza Corporation	Method for enhanced electrotransport agent delivery
ES2102322B1 (es)	1995-07-13	1998-03-01	Pharma Mar Sa	Procedimiento de preparacion de didemnina a.
EP0914116B1 (fr) *	1996-05-22	2000-10-11	Protarga Inc.	Compositions contenant des conjugues d'acide cis-docosahexanoique et de taxotere
US6156724A (en) *	1996-06-07	2000-12-05	Rinehart; Kenneth L.	Uses of didemnins as immunomodulating agents
EP0918694B1 (fr)	1996-07-03	2001-11-07	C G Paxton Limited	Conteneur
CA2269881A1 (fr)	1996-10-24	1998-04-30	The Board Of Trustees Of The University Of Illinois	Procedes semi-synthetiques de preparation d'analogues de didemnine
ATE245435T1 (de)	1996-10-24	2003-08-15	Univ Illinois	Totalsynthese des amino hip analogen von didemnin a
US6034058A (en) *	1997-04-15	2000-03-07	Rinehart; Kenneth L.	Semi-synthetic alanyl dilemnin analogs
JP4327260B2 (ja) *	1997-05-07	2009-09-09	フアルマ・マル・エセ・ア	Ｌ型カルシウムチャンネルエンハンサーとしてのアプリジン
GB9803448D0 (en) *	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
EP1100589B1 (fr) *	1998-07-30	2005-01-19	Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.	Utilisation de propionyle l-carnitine et d'acetyl l-carnitine dans la preparation de medicaments a action anticancereuse
US20010021380A1 (en) *	1999-04-19	2001-09-13	Pluenneke John D.	Soluble tumor necrosis factor receptor treatment of medical disorders
WO2000071135A1 (fr)	1999-05-25	2000-11-30	Point Therapeutics, Inc.	Agents anti-tumorales contenant des composes de boroproline
US6890904B1 (en) *	1999-05-25	2005-05-10	Point Therapeutics, Inc.	Anti-tumor agents
NZ518847A (en) *	1999-11-15	2004-02-27	Pharma Mar S	Aplidine treatment of cancers
BR0109958A (pt)	2000-04-07	2003-05-27	Univ Pennsylvania	Análogos de didemnina e tamandarina e métodos de preparação e uso deles
US6509315B1 (en) *	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
UA76718C2 (uk)	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
AU2002213053B2 (en) *	2000-10-05	2006-12-21	Immunex Corporation	Nectin polypeptides, polynucleotides, methods of making and use thereof
DE60111858T2 (de)	2000-10-12	2006-04-20	Pharma Mar, S.A., Tres Cantos	BEHANDLUNG VON KREBSERKRANKUNGEN mit APLIDIN IN KOMBINATION MIT CARNITIN ODER ACETYLCARNITIN
WO2002032374A2 (fr) *	2000-10-18	2002-04-25	Immunex Corporation	Methodes de traitement de troubles induits par l'il-18
EP1351678A2 (fr) *	2001-01-02	2003-10-15	Elizabeth Shanahan-Prendergast	Traitement pour inhiber des lesions neoplasiques contenant de l'incensole et/ou des furanogermacrens
US20050004012A1 (en)	2001-10-19	2005-01-06	Ramon Mangues	Use of aplidine for the treatment of pancreatic cancer
CN1761480B (zh)	2003-03-12	2012-09-26	达纳-法伯癌症协会有限公司	用于多发性骨髓瘤的治疗的aplidine

2004
- 2004-03-12 KR KR1020057016966A patent/KR101160320B1/ko not_active Expired - Lifetime
- 2004-03-12 EP EP04720081A patent/EP1603584B1/fr not_active Expired - Lifetime
- 2004-03-12 PL PL04720081T patent/PL1603584T3/pl unknown
- 2004-03-12 AT AT04720081T patent/ATE406171T1/de active
- 2004-03-12 ES ES04720081T patent/ES2312979T3/es not_active Expired - Lifetime
- 2004-03-12 MX MXPA05009742A patent/MXPA05009742A/es active IP Right Grant
- 2004-03-12 NZ NZ541611A patent/NZ541611A/en not_active IP Right Cessation
- 2004-03-12 JP JP2006505957A patent/JP4584245B2/ja not_active Expired - Lifetime
- 2004-03-12 WO PCT/GB2004/001062 patent/WO2004080477A1/fr active IP Right Grant
- 2004-03-12 CA CA2519789A patent/CA2519789C/fr not_active Expired - Lifetime
- 2004-03-12 SI SI200430878T patent/SI1603584T1/sl unknown
- 2004-03-12 DE DE602004016126T patent/DE602004016126D1/de not_active Expired - Lifetime
- 2004-03-12 DK DK04720081T patent/DK1603584T3/da active
- 2004-03-12 US US10/548,710 patent/US7381703B2/en not_active Expired - Lifetime
- 2004-03-12 AU AU2004218883A patent/AU2004218883B2/en not_active Expired
- 2004-03-12 PT PT04720081T patent/PT1603584E/pt unknown
- 2004-03-12 RU RU2005131578/15A patent/RU2335294C2/ru active
2005
- 2005-08-07 IL IL170136A patent/IL170136A/en active IP Right Grant
- 2005-10-11 NO NO20054668A patent/NO334264B1/no unknown
2008
- 2008-11-26 CY CY20081101367T patent/CY1108599T1/el unknown

Also Published As

Publication number	Publication date
US20070149445A9 (en)	2007-06-28
MXPA05009742A (es)	2006-05-25
JP2006519828A (ja)	2006-08-31
WO2004080477A1 (fr)	2004-09-23
US7381703B2 (en)	2008-06-03
CA2519789C (fr)	2012-07-03
AU2004218883A1 (en)	2004-09-23
KR101160320B1 (ko)	2012-06-26
SI1603584T1 (sl)	2009-02-28
ES2312979T3 (es)	2009-03-01
NO334264B1 (no)	2014-01-20
CA2519789A1 (fr)	2004-09-23
IL170136A (en)	2014-04-30
KR20060006779A (ko)	2006-01-19
AU2004218883B2 (en)	2009-10-01
NZ541611A (en)	2008-04-30
CY1108599T1 (el)	2014-04-09
NO20054668L (no)	2005-10-11
ATE406171T1 (de)	2008-09-15
WO2004080477A8 (fr)	2004-11-11
RU2005131578A (ru)	2006-01-27
DE602004016126D1 (de)	2008-10-09
RU2335294C2 (ru)	2008-10-10
PT1603584E (pt)	2008-11-21
EP1603584B1 (fr)	2008-08-27
JP4584245B2 (ja)	2010-11-17
PL1603584T3 (pl)	2009-02-27
US20060172926A1 (en)	2006-08-03
EP1603584A1 (fr)	2005-12-14

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CY1108599T1 (el)	2014-04-09	Η απλιδινη στην αντιμετωπιση του πολλαπλου μυελωματος
BR0309665A (pt)	2005-08-16	Tratamento de deficiência de alfa-galactosidase a
ATE461217T1 (de)	2010-04-15	Glp-1-verbindungen
DK2308507T3 (da)	2015-04-20	Fremgangsmåder til behandling af præeklampsi
RS50660B (sr)	2010-06-30	Dihidrotetrabenazini i farmaceutske kompozicije koje ih sadrže
ATE512163T1 (de)	2011-06-15	Verabreichung von mitteln zur behandlung von entzündungen
ATE474617T1 (de)	2010-08-15	Medizinproduktsysteme
CY1111622T1 (el)	2015-10-07	Ανθρωποποιημενοι ανταγωνιστες anti-cmet
ECSP056229A (es)	2006-10-10	Una composición farmacéutica que comprende formas polimórficas de 3-(4-amino-1-oxo-1.3 dyhidro-isoindol-2-il)-piperidina-2,6-diona para el tratamiento y manejo de cánceres
CY1108843T1 (el)	2014-07-02	3,11β cis διϋδροτετραβεναζινη για την θεραπεια της σχιζοφρενιας και αλλων ψυχωσεων
EP1534074A4 (fr)	2008-01-09	Polytherapie pour le traitement de l'obesite
DE60327103D1 (de)	2009-05-20	Darreichungsformen enthaltend einen protonpumphemmer, einen nsaid und einen puffer
DK1803718T3 (da)	2008-10-27	4-Tetrazolyl-4-phenylpiperidin-derivater til behandling af smerter
SE0301650D0 (sv)	2003-06-04	Novel compounds
HRP20070291T3 (en)	2007-10-31	Pharmaceutical composition comprising a zinc-hyaluronate complex for the treatment of multiple sclerosis
DK1687297T3 (da)	2014-09-22	Triazindimerer til behandling af autoimmunsygdomme
BRPI0417265A (pt)	2007-03-06	composição farmacêutica compreendendo um princìpio ativo e sulfobetaìna
DE60315490D1 (de)	2007-09-20	Therapeutische behandlung
UA88655C2 (ru)	2009-11-10	S-миртазапин для лечения прилива крови
ATE391489T1 (de)	2008-04-15	Haarbehandlungszusammensetzungen
DE60322942D1 (de)	2008-09-25	Textilbehandlung
DK1523985T3 (da)	2010-05-31	Ikke-radioaktivt strontiumholdigt middel til behandling af kræft
DK1537132T3 (da)	2006-05-08	Salt af mortin-6-glucuronid
DK1713438T3 (da)	2008-11-10	Medicinsk sæbe
DE50309647D1 (de)	2008-05-29	Ng fibrotischer erkrankungen