DK1654253T3 - Substituerede 3-pyrrolidinindolderivater - Google Patents
Substituerede 3-pyrrolidinindolderivaterInfo
- Publication number
- DK1654253T3 DK1654253T3 DK04763915T DK04763915T DK1654253T3 DK 1654253 T3 DK1654253 T3 DK 1654253T3 DK 04763915 T DK04763915 T DK 04763915T DK 04763915 T DK04763915 T DK 04763915T DK 1654253 T3 DK1654253 T3 DK 1654253T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyrrolidine
- substituted
- indole derivatives
- methods
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10337184A DE10337184A1 (de) | 2003-08-13 | 2003-08-13 | Substituierte 3-Pyrrolidin-Indol-Derivate |
| PCT/EP2004/008889 WO2005019208A1 (de) | 2003-08-13 | 2004-08-09 | Substituierte 3-pyrrolidin-indol-derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1654253T3 true DK1654253T3 (da) | 2007-04-30 |
Family
ID=34177511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04763915T DK1654253T3 (da) | 2003-08-13 | 2004-08-09 | Substituerede 3-pyrrolidinindolderivater |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7368470B2 (da) |
| EP (1) | EP1654253B1 (da) |
| JP (1) | JP4866730B2 (da) |
| AT (1) | ATE350377T1 (da) |
| CA (1) | CA2535536C (da) |
| CY (1) | CY1106386T1 (da) |
| DE (2) | DE10337184A1 (da) |
| DK (1) | DK1654253T3 (da) |
| ES (1) | ES2279421T3 (da) |
| PL (1) | PL1654253T3 (da) |
| PT (1) | PT1654253E (da) |
| WO (1) | WO2005019208A1 (da) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005066157A1 (en) * | 2004-01-02 | 2005-07-21 | Suven Life Sciences | 3-(pyrolidin-3-l) indoles as 5-ht6 receptor modulators |
| AR053710A1 (es) * | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
| MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| ES2372701T3 (es) * | 2005-07-22 | 2012-01-25 | Shionogi & Co., Ltd. | Derivado de indol que tiene actividad antagonista del receptor de pgd2. |
| EP1911759A4 (en) * | 2005-07-22 | 2010-07-21 | Shionogi & Co | AZAINDOL DERIVATIVE ANTAGONISTIC EFFECT ON PGD2 RECEPTOR |
| WO2007029629A1 (ja) * | 2005-09-06 | 2007-03-15 | Shionogi & Co., Ltd. | Ｐｇｄ２受容体アンタゴニスト活性を有するインドールカルボン酸誘導体 |
| EP2051977A2 (en) * | 2006-07-20 | 2009-04-29 | Amgen Inc. | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLbeta-HSD-1 |
| JP2010506853A (ja) * | 2006-10-12 | 2010-03-04 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 疼痛などのナトリウムチャネル媒介性の疾患の処置のための、スピロ（［３，２−フロ］ピリジン−３，３’−インドール）−２’（１’ｈ）−オン誘導体および関連化合物 |
| CN101522685A (zh) * | 2006-10-12 | 2009-09-02 | 泽农医药公司 | 三环螺-吲哚酮衍生物及其作为治疗剂的用途 |
| CL2007002950A1 (es) | 2006-10-12 | 2008-02-01 | Xenon Pharmaceuticals Inc | Uso de compuestos derivados de espiro-oxindol en el tratamiento de hipercolesterolemia, hiperplasia benigna de prostata, pruritis, cancer |
| BRPI0809193A2 (pt) | 2007-03-15 | 2014-09-23 | Novartis Ag | Compostos orgânicos e seus usos |
| JP5529743B2 (ja) * | 2007-11-05 | 2014-06-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 選択的１１−ベータ−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤としての７−アザインドール誘導体 |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| KR101286323B1 (ko) | 2008-10-17 | 2013-07-15 | 제논 파마슈티칼스 인크. | 스피로-옥스인돌 화합물 및 치료제로서의 그의 용도 |
| EP2350091B1 (en) | 2008-10-17 | 2015-06-03 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| KR20120099429A (ko) | 2009-10-14 | 2012-09-10 | 제논 파마슈티칼스 인크. | 스피로-옥스인돌 화합물의 합성 방법 |
| WO2011047173A2 (en) * | 2009-10-14 | 2011-04-21 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| PH12012501564A1 (en) | 2010-02-26 | 2019-07-17 | Xenon Pharmaceuticals Inc | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
| EP2752410B1 (en) | 2011-10-25 | 2016-08-31 | Shionogi & Co., Ltd. | Heterocycle derivative having pgd2 receptor antagonist activity |
| CN102702175B (zh) * | 2012-06-21 | 2014-08-13 | 东华大学 | 一种吲哚-3-琥珀酰亚胺的制备方法 |
| US10092574B2 (en) | 2012-09-26 | 2018-10-09 | Valorisation-Recherche, Limited Partnership | Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof |
| CN102942560A (zh) * | 2012-12-04 | 2013-02-27 | 东华大学 | 一种3-(2-甲基吲哚-3-)吡咯-2,5-二酮的制备方法 |
| MX2017005462A (es) | 2014-11-05 | 2017-07-28 | Flexus Biosciences Inc | Agentes inmunorreguladores. |
| UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| AR103636A1 (es) | 2015-02-05 | 2017-05-24 | Teva Pharmaceuticals Int Gmbh | Métodos de tratamiento de neuralgia postherpética con una formulación tópica de un compuesto de espiro-oxindol |
| KR20250044734A (ko) * | 2022-08-05 | 2025-04-01 | 마인드셋 파마 인크. | 세로토닌 관련 장애의 치료에 유용한 세로토닌 작용제로서의 3-피롤리딘-인돌 이량체 |
| TW202430151A (zh) * | 2022-11-21 | 2024-08-01 | 日商日本新藥股份有限公司 | 作為ddr1激酶抑制劑之化合物及醫藥 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3109844A (en) * | 1959-09-16 | 1963-11-05 | Bristol Myers Co | 3-(3-indolyl) pyrrolidines |
| WO1993011106A1 (en) | 1991-11-25 | 1993-06-10 | Pfizer, Inc. | Indole derivatives |
| TW251284B (da) | 1992-11-02 | 1995-07-11 | Pfizer | |
| GB9420529D0 (en) * | 1994-10-12 | 1994-11-30 | Pfizer Ltd | Indoles |
| DE19615232A1 (de) * | 1996-04-18 | 1997-10-23 | Merck Patent Gmbh | Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten |
| US5891875A (en) * | 1996-05-20 | 1999-04-06 | Eli Lilly And Company | Morpholinyl tachykinin receptor antagonists |
| US5792760A (en) * | 1997-04-23 | 1998-08-11 | Eli Lilly And Company | Bisindoles as tachykinin receptor antagonists |
| WO1999010346A1 (en) | 1997-08-22 | 1999-03-04 | Eli Lilly And Company Limited | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands |
| DE19756036A1 (de) * | 1997-12-17 | 1999-06-24 | Merck Patent Gmbh | Amid- und Harnstoffderivate |
| GB9810886D0 (en) | 1998-05-13 | 1998-07-22 | Lilly Industries Ltd | Pharmaceutical compounds |
| NL1012754C2 (nl) * | 1999-07-30 | 2001-02-01 | Presstech N V | Drukcontrole-inrichting. |
| JP2003517481A (ja) | 1999-12-17 | 2003-05-27 | ブリストルーマイヤーズ スクイブ カンパニー | 抗精神病複素環式化合物 |
| DK1309592T3 (da) | 2000-08-14 | 2006-08-21 | Ortho Mcneil Pharm Inc | Substituerede pyrazoler |
| IL156517A0 (en) * | 2000-12-22 | 2004-01-04 | Wyeth Corp | Heterocyclindazole and azaindazole compounds as 5-hydroxytryptamine-6 ligands |
| JP2004531506A (ja) * | 2001-03-29 | 2004-10-14 | ブリストル−マイヤーズ スクイブ カンパニー | 選択的なセロトニン再取り込みインヒビターとしてのシクロプロピルインドール誘導体 |
| WO2002079151A1 (en) | 2001-03-29 | 2002-10-10 | Smithkline Beecham P.L.C. | 3-substituted indoels or fused pyrroles as antagonists of the chemokine mcp-1 (ccr2b) receptor |
| GB0107907D0 (en) | 2001-03-29 | 2001-05-23 | Smithkline Beecham Plc | Novel compounds |
| WO2003097598A1 (fr) * | 2002-05-16 | 2003-11-27 | Shionogi & Co., Ltd. | Composé comprenant un antagonisme du récepteur de pdg2 |
| DE10252666A1 (de) * | 2002-11-11 | 2004-08-05 | Grünenthal GmbH | N-Piperidyl-cyclohexan-Derivate |
-
2003
- 2003-08-13 DE DE10337184A patent/DE10337184A1/de not_active Withdrawn
-
2004
- 2004-08-09 WO PCT/EP2004/008889 patent/WO2005019208A1/de active IP Right Grant
- 2004-08-09 EP EP04763915A patent/EP1654253B1/de not_active Expired - Lifetime
- 2004-08-09 DE DE502004002571T patent/DE502004002571D1/de not_active Expired - Lifetime
- 2004-08-09 ES ES04763915T patent/ES2279421T3/es not_active Expired - Lifetime
- 2004-08-09 DK DK04763915T patent/DK1654253T3/da active
- 2004-08-09 AT AT04763915T patent/ATE350377T1/de active
- 2004-08-09 JP JP2006522968A patent/JP4866730B2/ja not_active Expired - Fee Related
- 2004-08-09 PT PT04763915T patent/PT1654253E/pt unknown
- 2004-08-09 PL PL04763915T patent/PL1654253T3/pl unknown
- 2004-08-09 CA CA2535536A patent/CA2535536C/en not_active Expired - Fee Related
- 2004-08-12 US US10/916,633 patent/US7368470B2/en not_active Expired - Fee Related
-
2007
- 2007-03-15 CY CY20071100366T patent/CY1106386T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1654253T3 (pl) | 2007-05-31 |
| PT1654253E (pt) | 2007-02-28 |
| DE502004002571D1 (de) | 2007-02-15 |
| ES2279421T3 (es) | 2007-08-16 |
| EP1654253A1 (de) | 2006-05-10 |
| JP4866730B2 (ja) | 2012-02-01 |
| CA2535536C (en) | 2012-10-02 |
| US7368470B2 (en) | 2008-05-06 |
| ATE350377T1 (de) | 2007-01-15 |
| DE10337184A1 (de) | 2005-03-10 |
| CA2535536A1 (en) | 2005-03-03 |
| CY1106386T1 (el) | 2011-10-12 |
| JP2007501828A (ja) | 2007-02-01 |
| EP1654253B1 (de) | 2007-01-03 |
| WO2005019208A1 (de) | 2005-03-03 |
| US20050096376A1 (en) | 2005-05-05 |
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