DK1491553T3 - Peptider til behandling af cancer forbundet med human papillomavirus (HPV) og andre epitheliale tumorer - Google Patents

Peptider til behandling af cancer forbundet med human papillomavirus (HPV) og andre epitheliale tumorer

Info

Publication number: DK1491553T3
Authority: DK; Denmark
Prior art keywords: hpv; peptides; treatment; papilloma virus; human papilloma
Prior art date: 2001-12-20

Application number

DK02796490.7T

Other languages

English (en)

Inventor

Izaguirre Yaquela N Puchades

Soria Alejandro Moro

Rodriguez Silvio Ernesto Perea

Acosta Osvaldo Reyes

Vispo Nelson Francisco Santiago

Rodriguez Ricardo Silva

Savio Alicia Santos

Lopez Luis Javier Gonzalez

Barrios Belkis Gonzalez

Original Assignee

Ct Ingenieria Genetica Biotech

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-20

Filing date

2002-12-04

Publication date

2011-12-05

2002-12-04 Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech

2011-12-05 Application granted granted Critical

2011-12-05 Publication of DK1491553T3 publication Critical patent/DK1491553T3/da

Links

241000701806 Human papillomavirus Species 0.000 title 2
206010028980 Neoplasm Diseases 0.000 title 2
201000011510 cancer Diseases 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Biophysics (AREA)
Virology (AREA)
Wood Science & Technology (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Gastroenterology & Hepatology (AREA)
Biotechnology (AREA)
Epidemiology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK02796490.7T 2001-12-20 2002-12-04 Peptider til behandling af cancer forbundet med human papillomavirus (HPV) og andre epitheliale tumorer DK1491553T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CU20010309A CU23225A1 (es)	2001-12-20	2001-12-20	PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES
PCT/CU2002/000010 WO2003054002A1 (es)	2001-12-20	2002-12-04	Péptidos para el tratamiento del cáncer asociado al virus papiloma humano (vph) y de otros tumores epiteliales

Publications (1)

Publication Number	Publication Date
DK1491553T3 true DK1491553T3 (da)	2011-12-05

Family

ID=40091679

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02796490.7T DK1491553T3 (da)	2001-12-20	2002-12-04	Peptider til behandling af cancer forbundet med human papillomavirus (HPV) og andre epitheliale tumorer

Country Status (33)

Country	Link
US (2)	US7374767B2 (da)
EP (2)	EP1491553B1 (da)
JP (1)	JP4056476B2 (da)
KR (1)	KR100642437B1 (da)
CN (1)	CN100368431C (da)
AR (1)	AR037825A1 (da)
AT (1)	ATE520704T1 (da)
AU (1)	AU2002361922B2 (da)
BR (1)	BRPI0215213C1 (da)
CA (1)	CA2471110C (da)
CR (1)	CR7361A (da)
CU (1)	CU23225A1 (da)
DK (1)	DK1491553T3 (da)
DO (1)	DOP2002000548A (da)
ES (1)	ES2371239T3 (da)
HN (1)	HN2002000377A (da)
HR (1)	HRP20040663B1 (da)
IL (2)	IL162633A0 (da)
IS (1)	IS2906B (da)
MA (1)	MA27868A1 (da)
MX (1)	MXPA04005832A (da)
MY (1)	MY133530A (da)
NO (1)	NO333259B1 (da)
NZ (1)	NZ534170A (da)
PE (1)	PE20030861A1 (da)
PT (1)	PT1491553E (da)
RU (1)	RU2290410C2 (da)
SI (1)	SI1491553T1 (da)
TN (1)	TNSN04114A1 (da)
UA (1)	UA81403C2 (da)
UY (1)	UY27602A1 (da)
WO (1)	WO2003054002A1 (da)
ZA (1)	ZA200405514B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CU23225A1 (es) *	2001-12-20	2007-08-30	Ct Ingenieria Genetica Biotech	PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES
CU23431B6 (es)	2005-05-12	2009-10-16	Ct Ingenieria Genetica Biotech	Método para la inhibición de la proliferación de células tumorales y el tratamiento del cáncer
GB2433740A (en) *	2005-12-23	2007-07-04	Rapid Biosensor Systems Ltd	Detection of tuberculosis infection
CU23511B6 (es)	2006-02-28	2010-04-13	Biorec B V	Combinación farmacéutica para el tratamiento y/o quimiosensibilización de tumores refractarios a drogas anticancerígenas
GB2441131A (en) *	2006-08-24	2008-02-27	Univ Dundee	Modulation of binding of CK2a to NDPK
CN100522992C (zh) *	2007-02-12	2009-08-05	中国科学院昆明动物研究所	一种环状小肽ba
EP2133083A4 (en)	2007-03-27	2012-02-15	Taiko Pharmaceutical Co Ltd	THERAPEUTIC FOR SKIN OR MOLECULE INFECTIONS
US20110305706A1 (en)	2009-02-23	2011-12-15	Scott Thomas Brady	Compositions and Methods for Treating a Disease Mediated by Soluble Oligomeric Amyloid Beta
CA2755245A1 (en) *	2009-03-13	2010-09-16	Egen, Inc.	Compositions and methods for the delivery of biologically active rnas
CA3010056A1 (en)	2015-12-30	2017-07-06	Kodiak Sciences Inc.	Antibodies and conjugates thereof
CU20200103A7 (es) *	2020-12-18	2022-07-08	Ct Ingenieria Genetica Biotecnologia	Péptido sintético para la inducción de inmunidad antitumoral y antiviral
CU20210058A7 (es)	2021-07-09	2023-02-13	Ct Ingenieria Genetica Biotecnologia	Péptidos lineales que inhiben la fosforilación mediada por ck2 y composiciones que los comprenden
CN118370805B (zh) *	2024-04-29	2025-02-14	广州中科佰氏健康产业有限公司	一种抑菌妇科凝胶及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE902820A1 (en) *	1989-08-07	1991-02-27	Merck & Co Inc	Peptide inhibitors of human papilloma virus protein binding¹to retinoblastoma gene proteins
EP0531080A3 (en) *	1991-09-04	1993-12-29	Merck & Co Inc	Peptide inhibitors of human papilloma virus protein binding to retinoblastoma gene protein
GB9313556D0 (en) *	1993-07-01	1993-08-18	British Tech Group	Synthetic peptides of human papillomavirus
US5625031A (en) *	1994-02-08	1997-04-29	Bristol-Myers Squibb Company	Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein
ATE235509T1 (de) *	1998-06-30	2003-04-15	Deutsches Krebsforsch	Peptide zur inhibition von hpv e7 proteinen
WO2001064835A2 (en) *	2000-02-28	2001-09-07	Hyseq, Inc.	Novel nucleic acids and polypeptides
US6641994B2 (en) *	1999-08-25	2003-11-04	Pharmacia & Upjohn Company	Methods of identifying anti-viral agents
CU23225A1 (es) *	2001-12-20	2007-08-30	Ct Ingenieria Genetica Biotech	PéPTIDOS PARA EL TRATAMIENTO DEL CáNCER ASOCIADO AL VIRUS PAPILOMA HUMANO (VPH) Y DE OTROS TUMORES EPITELIALES

2001
- 2001-12-20 CU CU20010309A patent/CU23225A1/es unknown
2002
- 2002-04-12 UA UA20040705927A patent/UA81403C2/uk unknown
- 2002-12-04 MX MXPA04005832A patent/MXPA04005832A/es active IP Right Grant
- 2002-12-04 JP JP2003554718A patent/JP4056476B2/ja not_active Expired - Fee Related
- 2002-12-04 DK DK02796490.7T patent/DK1491553T3/da active
- 2002-12-04 HR HRP20040663AA patent/HRP20040663B1/hr not_active IP Right Cessation
- 2002-12-04 RU RU2004122084/13A patent/RU2290410C2/ru active
- 2002-12-04 US US10/499,458 patent/US7374767B2/en not_active Expired - Lifetime
- 2002-12-04 PT PT02796490T patent/PT1491553E/pt unknown
- 2002-12-04 WO PCT/CU2002/000010 patent/WO2003054002A1/es active IP Right Grant
- 2002-12-04 ES ES02796490T patent/ES2371239T3/es not_active Expired - Lifetime
- 2002-12-04 AT AT02796490T patent/ATE520704T1/de active
- 2002-12-04 EP EP02796490A patent/EP1491553B1/en not_active Expired - Lifetime
- 2002-12-04 BR BRPI0215213A patent/BRPI0215213C1/pt not_active IP Right Cessation
- 2002-12-04 NZ NZ534170A patent/NZ534170A/en not_active IP Right Cessation
- 2002-12-04 KR KR1020047009771A patent/KR100642437B1/ko not_active Expired - Fee Related
- 2002-12-04 CA CA2471110A patent/CA2471110C/en not_active Expired - Lifetime
- 2002-12-04 IL IL16263302A patent/IL162633A0/xx active IP Right Grant
- 2002-12-04 EP EP11168526A patent/EP2383282A1/en not_active Ceased
- 2002-12-04 CN CNB028282698A patent/CN100368431C/zh not_active Expired - Lifetime
- 2002-12-04 SI SI200230967T patent/SI1491553T1/sl unknown
- 2002-12-04 AU AU2002361922A patent/AU2002361922B2/en not_active Ceased
- 2002-12-11 MY MYPI20024638A patent/MY133530A/en unknown
- 2002-12-13 AR ARP020104844A patent/AR037825A1/es not_active Application Discontinuation
- 2002-12-17 DO DO2002000548A patent/DOP2002000548A/es unknown
- 2002-12-19 HN HN2002000377A patent/HN2002000377A/es unknown
- 2002-12-20 UY UY27602A patent/UY27602A1/es active IP Right Grant
2003
- 2003-01-06 PE PE2003000006A patent/PE20030861A1/es not_active Application Discontinuation
2004
- 2004-06-04 CR CR7361A patent/CR7361A/es unknown
- 2004-06-15 MA MA27740A patent/MA27868A1/fr unknown
- 2004-06-16 IS IS7320A patent/IS2906B/is unknown
- 2004-06-17 TN TNP2004000114A patent/TNSN04114A1/en unknown
- 2004-06-20 IL IL162633A patent/IL162633A/en not_active IP Right Cessation
- 2004-07-12 ZA ZA2004/05514A patent/ZA200405514B/en unknown
- 2004-07-20 NO NO20043112A patent/NO333259B1/no not_active IP Right Cessation
2008
- 2008-04-08 US US12/099,646 patent/US7947287B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR20050002811A (ko)	2005-01-10
WO2003054002A1 (es)	2003-07-03
EP1491553B1 (en)	2011-08-17
CA2471110C (en)	2017-01-31
DOP2002000548A (es)	2003-06-30
UA81403C2 (en)	2008-01-10
KR100642437B1 (ko)	2006-11-06
US7374767B2 (en)	2008-05-20
MXPA04005832A (es)	2004-09-13
HN2002000377A (es)	2003-04-10
CA2471110A1 (en)	2003-07-03
BR0215213A (pt)	2004-12-07
NZ534170A (en)	2006-08-31
IL162633A (en)	2011-02-28
ZA200405514B (en)	2005-03-30
HRP20040663B1 (hr)	2013-05-31
IS2906B (is)	2014-11-15
CN100368431C (zh)	2008-02-13
NO20043112L (no)	2004-07-20
CN1620464A (zh)	2005-05-25
MA27868A1 (fr)	2006-05-02
AR037825A1 (es)	2004-12-09
HRP20040663A2 (en)	2005-08-31
BRPI0215213B1 (pt)	2018-09-11
ATE520704T1 (de)	2011-09-15
US20090005294A1 (en)	2009-01-01
EP1491553A1 (en)	2004-12-29
ES2371239T3 (es)	2011-12-28
PT1491553E (pt)	2011-11-25
IL162633A0 (da)	2005-11-20
RU2004122084A (ru)	2005-03-27
IS7320A (is)	2004-06-16
NO333259B1 (no)	2013-04-22
PE20030861A1 (es)	2003-12-02
JP4056476B2 (ja)	2008-03-05
TNSN04114A1 (en)	2006-06-01
UY27602A1 (es)	2003-04-30
MY133530A (en)	2007-11-30
BRPI0215213C1 (pt)	2021-05-25
HK1068901A1 (en)	2005-05-06
CR7361A (es)	2005-02-18
JP2005525090A (ja)	2005-08-25
RU2290410C2 (ru)	2006-12-27
AU2002361922A1 (en)	2003-07-09
US20060233742A1 (en)	2006-10-19
EP2383282A1 (en)	2011-11-02
AU2002361922B2 (en)	2007-04-05
US7947287B2 (en)	2011-05-24
CU23225A1 (es)	2007-08-30
SI1491553T1 (sl)	2011-12-30

Publication	Publication Date	Title
DK1491553T3 (da)	2011-12-05	Peptider til behandling af cancer forbundet med human papillomavirus (HPV) og andre epitheliale tumorer
FR20C1016I1 (da)	2020-06-12
IS7426A (is)	2004-09-15	Veirulíkar agnir af mennskri vörtuveiru
WO2006075245A3 (en)	2007-11-15	Systems, methods, and compositions for detection of human papilloma virus in biological samples
ATE508635T1 (de)	2011-05-15	Virusvektoren und ihre verwendung bei therapeutischen methoden
DK1292328T3 (da)	2008-06-16	Kimære humant papillomvirus- (HPV) - molekyler og deres anvendelse
NO2012016I2 (no)	2012-10-08	Kombinasjon av HPV16 og HPV18 L1 viruslignende partikler
MXPA02005639A (es)	2004-09-10	Induccion de respuestas celulares iinmunologicas al virus de papiloma humano y utilizacion de composiciones de peptidos y acidos nucleico.
WO1999033868A3 (en)	1999-09-16	Human papillomavirus vaccine
IS7133A (is)	2004-01-29	Afleiða beta-amyloid - T-frumu-mótefnavísisbóluefni
DK2204374T3 (da)	2012-09-10	Nucleosidphosphonater og analoge deraf til behandling af HPV-infektioner
DK1021547T3 (da)	2007-04-23	Vaccineformuleringer indeholdende papillomviruskapsomer og fremgangsmåder til anvendelse heraf
WO2003034992A3 (en)	2003-11-13	Diindolylmethane for the treatment of hpv infection
AU2002349727A1 (en)	2003-07-24	Hepatitis E virus monoclonal antibodies or the binding fragments of it and the use thereof
IS2811B (is)	2012-11-15	Notkun á HPV16 og HPV18 veirulíkum ögnum gegn einni eða fleiri af æxlisvaldandi HPV gerðum 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68
DK1531843T3 (da)	2011-12-12	Fremgangsmåde til behandling af cervixcancer
DK1381382T3 (da)	2009-02-02	Fremgangsmåder og præparater til behandling af öjensygdomme
WO2004002416A3 (en)	2005-02-03	Methods and materials for treating human papillomavirus infections
IL161138A0 (en)	2004-08-31	Treatment of hepatitis b virus infection with human monoclonal antibodies
EP1765330A4 (en)	2007-10-17	PYRANOINDOLE DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF DISEASE OR INFECTION CAUSED BY HEPATITIS C VIRUS
NO20006358L (no)	2001-02-13	Anvendelse av optisk ren (-)-norcisaprid ved behandling av apné, bulimi og andre sykdommer
WO2004098497A3 (en)	2005-03-10	Cd4+ human papillomavirus (hpv) epitopes
NO20024325D0 (no)	2002-09-10	Rensede hepatitt C-viruskappeproteiner for diagnostisk og terapeutisk anvendelse
AU2003287216A1 (en)	2004-05-13	Gb virus c and methods of treating viral infections
SI1572233T1 (sl)	2011-07-29	Uporaba HPV16 in HPV18 kot cepivo proti enemu ali več onkogenih HPV tipa 31,33,35,39,45,51,52,56,58,59,66,68