DK1353948T3 - Oplöselige biologiske analoge til bata-amyloidpeptid - Google Patents

Oplöselige biologiske analoge til bata-amyloidpeptid

Info

Publication number: DK1353948T3
Authority: DK; Denmark
Prior art keywords: beta; amyloid peptide; soluble biological; biological analogs; analogs
Prior art date: 2001-01-13

Application number

DK01990584T

Other languages

English (en)

Inventor

Herwig Brunner

Afroditi Kapurniotu

Juergen Bernhagen

Original Assignee

Fraunhofer Ges Forschung

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-13

Filing date

2001-12-21

Publication date

2006-02-27

2001-12-21 Application filed by Fraunhofer Ges Forschung filed Critical Fraunhofer Ges Forschung

2006-02-27 Application granted granted Critical

2006-02-27 Publication of DK1353948T3 publication Critical patent/DK1353948T3/da

Links

DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title 1
230000003941 amyloidogenesis Effects 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK01990584T 2001-01-13 2001-12-21 Oplöselige biologiske analoge til bata-amyloidpeptid DK1353948T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10101430A DE10101430B4 (de)	2001-01-13	2001-01-13	Lösliche cyclische Analoga zur Modulation der Amyloidogenese

Publications (1)

Publication Number	Publication Date
DK1353948T3 true DK1353948T3 (da)	2006-02-27

Family

ID=7670511

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01990584T DK1353948T3 (da)	2001-01-13	2001-12-21	Oplöselige biologiske analoge til bata-amyloidpeptid

Country Status (10)

Country	Link
US (2)	US7342091B2 (da)
EP (1)	EP1353948B1 (da)
JP (1)	JP4079775B2 (da)
AT (1)	ATE307143T1 (da)
AU (1)	AU2002229677A1 (da)
CA (1)	CA2433687A1 (da)
DE (2)	DE10101430B4 (da)
DK (1)	DK1353948T3 (da)
ES (1)	ES2250509T3 (da)
WO (1)	WO2002055552A2 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10303974A1 (de)	2003-01-31	2004-08-05	Abbott Gmbh & Co. Kg	Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
EP1676859A1 (en) *	2004-12-30	2006-07-05	Pevion Biotech Ltd.	Immunogenic compositions of cyclic peptides derived from the beta-amyloid peptide
KR20140087058A (ko)	2005-11-30	2014-07-08	애브비 인코포레이티드	아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도
EP1954718B1 (en)	2005-11-30	2014-09-03	AbbVie Inc.	Anti-a globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
US8455626B2 (en)	2006-11-30	2013-06-04	Abbott Laboratories	Aβ conformer selective anti-aβ globulomer monoclonal antibodies
WO2008104386A2 (en)	2007-02-27	2008-09-04	Abbott Gmbh & Co. Kg	Method for the treatment of amyloidoses
NZ590324A (en) *	2008-07-01	2012-08-31	Nederlanden Staat	Vaccine against amyloid folding intermediate
US20110092445A1 (en) *	2008-07-25	2011-04-21	Abbott Laboratories	Amyloid ß peptide analogues, oligomers thereof, processes for preparing and composi-tions comprising said analogues or oligomers, and their uses
EP2558494B1 (en)	2010-04-15	2018-05-23	AbbVie Inc.	Amyloid-beta binding proteins
CA2808187A1 (en)	2010-08-14	2012-02-23	Abbvie Inc.	Amyloid-beta binding proteins
US10774120B2 (en)	2015-11-09	2020-09-15	The University Of British Columbia	Anti-amyloid beta antibodies binding to a cyclic amyloid beta peptide
WO2017079835A1 (en)	2015-11-09	2017-05-18	The University Of British Columbia	Amyloid beta epitopes and antibodies thereto
US20180125920A1 (en)	2016-11-09	2018-05-10	The University Of British Columbia	Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions
US12286469B2 (en)	2017-07-18	2025-04-29	The University Of British Columbia	Humanized antibodies binding to amyloid-beta (A-beta)
JP2024520061A (ja)	2021-05-26	2024-05-21	リゲインセラピューティクススウェーデンアー・ベー	プロテイノパチーの治療および／または予防のための組成物および方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5262332A (en) *	1989-04-05	1993-11-16	Brigham And Women's Hospital	Diagnostic method for Alzheimer's disease: examination of non-neural tissue
DE69621607T2 (de) *	1995-03-14	2003-01-02	Praecis Pharmaceuticals Inc., Waltham	VERBINDUNGEN MIT AGGREGATIONS-MODULIERENDEN WIRKUNG AUF DAS AMYLOiD PROTEIN
DE19725619A1 (de)	1997-06-17	1998-12-24	Fraunhofer Ges Forschung	Peptide als Agonisten und/oder Inhibitoren der Amyloidbildung und Zytotoxizität sowie der Verwendung bei Alzheimer'schen Krankheit, beim Typ II Diabetes mellitus und bei spongiformen Encephalopathien
CN1636011A (zh) *	1998-12-24	2005-07-06	杜邦药品公司	作为Aβ蛋白产生抑制剂的琥珀酰氨基苯并二氮杂䓬
WO2001034631A2 (en) *	1999-11-05	2001-05-17	Axonyx, Inc.	PEPTIDE ANALOGS AND MIMETICS SUITABLE FOR IN VIVO USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL PROTEIN FOLDING INTO AMYLOID, AMYLOID-LIKE DEPOSITS OR β-SHEET RICH PATHOLOGICAL PRECURSOR THEREOF

2001
- 2001-01-13 DE DE10101430A patent/DE10101430B4/de not_active Expired - Fee Related
- 2001-12-21 AU AU2002229677A patent/AU2002229677A1/en not_active Abandoned
- 2001-12-21 DK DK01990584T patent/DK1353948T3/da active
- 2001-12-21 EP EP01990584A patent/EP1353948B1/de not_active Expired - Lifetime
- 2001-12-21 CA CA002433687A patent/CA2433687A1/en not_active Abandoned
- 2001-12-21 US US10/250,581 patent/US7342091B2/en not_active Expired - Fee Related
- 2001-12-21 DE DE50107777T patent/DE50107777D1/de not_active Expired - Lifetime
- 2001-12-21 WO PCT/EP2001/015181 patent/WO2002055552A2/de active IP Right Grant
- 2001-12-21 JP JP2002556620A patent/JP4079775B2/ja not_active Expired - Fee Related
- 2001-12-21 AT AT01990584T patent/ATE307143T1/de not_active IP Right Cessation
- 2001-12-21 ES ES01990584T patent/ES2250509T3/es not_active Expired - Lifetime
2008
- 2008-01-09 US US11/971,695 patent/US20080146508A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1353948B1 (de)	2005-10-19
EP1353948A2 (de)	2003-10-22
JP4079775B2 (ja)	2008-04-23
CA2433687A1 (en)	2002-07-18
DE10101430B4 (de)	2008-10-02
US20080146508A1 (en)	2008-06-19
US7342091B2 (en)	2008-03-11
US20040116337A1 (en)	2004-06-17
WO2002055552A2 (de)	2002-07-18
ES2250509T3 (es)	2006-04-16
JP2004526693A (ja)	2004-09-02
ATE307143T1 (de)	2005-11-15
DE10101430A1 (de)	2002-08-01
DE50107777D1 (de)	2005-11-24
AU2002229677A1 (en)	2002-07-24
WO2002055552A3 (de)	2003-04-24

Publication	Publication Date	Title
DK1353948T3 (da)	2006-02-27	Oplöselige biologiske analoge til bata-amyloidpeptid
CO5611160A2 (es)	2006-02-28	Conjugados de agentes terapeuticos o citotoxicos y peptidos biologicamente activos
CR8012A (es)	2009-01-07	Clavo endomedular destinado al tratamiento de fracturas de femur proximal
ATE318590T1 (de)	2006-03-15	Arzneimittelkombinationen (z.b. chlorpromazin und pentamidin) zur therapie von neoplastischen erkrankungen
DK1206474T3 (da)	2004-10-04	Sulfonylphenylpyrazolforbindelser anvendelige som cox-2-inhibitorer
YU9404A (sh)	2006-08-17	Multimerna, usmerena kontrastna sredstva na bazi peptida
ECSP045520A (es)	2005-03-10	Metodos de tratamiento con inhibidores de la ptec y agentes antihipertensivos
ATE425253T1 (de)	2009-03-15	Tribonektine
ATE308324T1 (de)	2005-11-15	Zolpidem hemitartrat
PT1147420E (pt)	2004-12-31	Inibidor de tripsina urinario para o diagnostico da sida
IT1306165B1 (it)	2001-05-30	Impiego di inibitori della sostanza p per il trattamento degliadenocarcinomi.
IL158186A0 (en)	2004-03-28	Pharmaceutically active compounds and methods of use
NO20005548L (no)	2000-12-04	Mykobakterieinhibitorer
AP2781A (en)	2013-10-31	Oxidized proteins, their biological activity, and therapeutic and diagnostic measures, which are derived from the active mechansim, from the use of these porteins or from the inhibition thereof
DE60215219D1 (de)	2006-11-16	Verwendung von darifenacin zur behandlung des harndrangs
ATE473295T1 (de)	2010-07-15	Nukleotidträger zur diagnose und therapie oraler erkrankungen
ATE328082T1 (de)	2006-06-15	Verkürztes bard1 protein und dessen diagnostische und therapeutische anwendungen
SE0002417D0 (sv)	2000-06-27	Promoter sequences
ATE443695T1 (de)	2009-10-15	Doppelester
WO2002097119A3 (de)	2003-05-30	Verwendung des nachweises der expression von splice-varianten von gen21 für die diagnose und therapie von tumorerkrankungen
UA28113C2 (uk)	2000-10-16	Спосіб експрес-тестування ефективності реабілітації здоров'я людини
ITRM20030219A1 (it)	2004-11-07	Uso della liquerizia per la prevenzione e la cura di aids e sars.