DK1276497T3 - Blanding af defibrotid og G-CSF og anvendelse heraf til aktivering af hæmatopoietiske progenitorceller - Google Patents

Blanding af defibrotid og G-CSF og anvendelse heraf til aktivering af hæmatopoietiske progenitorceller

Info

Publication number: DK1276497T3
Authority: DK; Denmark
Prior art keywords: defibrotide; csf; progenitor cells; mixture; hematopoietic progenitor
Prior art date: 2000-04-18

Application number

DK01931582T

Other languages

Danish (da)

English (en)

Inventor

Laura Ferro

Roberto Porta

Massimo Iacobelli

Alessandro Massimo Gianni

Carmelo Carlo Stella

Original Assignee

Gentium Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-18

Filing date

2001-04-10

Publication date

2006-03-27

2001-04-10 Application filed by Gentium Spa filed Critical Gentium Spa

2006-03-27 Application granted granted Critical

2006-03-27 Publication of DK1276497T3 publication Critical patent/DK1276497T3/da

Links

102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 title abstract 2
108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 title abstract 2
JNWFIPVDEINBAI-UHFFFAOYSA-N [5-hydroxy-4-[4-(1-methylindol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-2-propan-2-ylphenyl] dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C(C(C)C)=CC(C=2N(C(=O)NN=2)C=2C=C3C=CN(C)C3=CC=2)=C1O JNWFIPVDEINBAI-UHFFFAOYSA-N 0.000 title abstract 2
229960004120 defibrotide Drugs 0.000 title abstract 2
210000003958 hematopoietic stem cell Anatomy 0.000 title 1
239000000203 mixture Substances 0.000 title 1
230000003394 haemopoietic effect Effects 0.000 abstract 2
210000000130 stem cell Anatomy 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
210000005259 peripheral blood Anatomy 0.000 abstract 1
239000011886 peripheral blood Substances 0.000 abstract 1
230000002123 temporal effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Hematology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK01931582T 2000-04-18 2001-04-10 Blanding af defibrotid og G-CSF og anvendelse heraf til aktivering af hæmatopoietiske progenitorceller DK1276497T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP00830293A EP1147777A1 (fr)	2000-04-18	2000-04-18	Combinaison de Defibrotide et de G-CSF et son utilisation pour activer les cellules progénitrices haematopoiétiques

Publications (1)

Publication Number	Publication Date
DK1276497T3 true DK1276497T3 (da)	2006-03-27

Family

ID=8175292

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK01931582T DK1276497T3 (da)	2000-04-18	2001-04-10	Blanding af defibrotid og G-CSF og anvendelse heraf til aktivering af hæmatopoietiske progenitorceller
DK05108424.2T DK1621207T3 (da)	2000-04-18	2001-04-10	Mixture of defibrotide and G-CSF, and its use for activating haematopoietic progenitors

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK05108424.2T DK1621207T3 (da)	2000-04-18	2001-04-10	Mixture of defibrotide and G-CSF, and its use for activating haematopoietic progenitors

Country Status (31)

Country	Link
US (1)	US20040131588A1 (fr)
EP (3)	EP1147777A1 (fr)
JP (1)	JP5205668B2 (fr)
KR (1)	KR100849491B1 (fr)
CN (1)	CN1183962C (fr)
AT (2)	ATE310532T1 (fr)
AU (2)	AU2001258322B2 (fr)
BG (1)	BG107203A (fr)
CA (1)	CA2406179C (fr)
CY (1)	CY1104971T1 (fr)
CZ (1)	CZ20023426A3 (fr)
DE (2)	DE60115222T2 (fr)
DK (2)	DK1276497T3 (fr)
EE (1)	EE200200596A (fr)
ES (2)	ES2335776T3 (fr)
HR (1)	HRP20020835A2 (fr)
HU (1)	HUP0300560A3 (fr)
IL (1)	IL152328A (fr)
IS (1)	IS2171B (fr)
MX (1)	MXPA02010346A (fr)
NO (1)	NO20024988L (fr)
NZ (1)	NZ522016A (fr)
PL (1)	PL358100A1 (fr)
PT (1)	PT1621207E (fr)
RO (1)	RO121006B1 (fr)
RU (1)	RU2248216C2 (fr)
SI (1)	SI21079B (fr)
SK (1)	SK14892002A3 (fr)
UA (1)	UA73566C2 (fr)
WO (1)	WO2001078761A2 (fr)
ZA (1)	ZA200208413B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8771663B2 (en)	2000-04-18	2014-07-08	Gentium Spa	Formulation having mobilising activity
EP1656451A2 (fr)	2003-08-13	2006-05-17	Children's Hospital Medical Center	Peptides chimeriques pour regulation de gtpases
US7417026B2 (en)	2003-08-13	2008-08-26	Children's Hospital Medical Center	Mobilization of hematopoietic cells
EP2103689A1 (fr) *	2008-03-19	2009-09-23	Gentium S.p.A.	Oligonucléotides phosphodiesters synthétiques et leurs utilisations thérapeutiques
RU2376985C1 (ru) *	2008-07-17	2009-12-27	Владислав Николаевич Ласкавый	Средство для активации стволовых клеток
ES2694239T3 (es)	2010-11-12	2018-12-19	Gentium S.R.L.	Defibrótido para su uso en profilaxis y/o tratamiento de la enfermedad de Injerto contra huésped (GVHD)
KR102038357B1 (ko)	2012-06-22	2019-10-31	젠티엄 에스알엘	디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법
EP3026122A1 (fr)	2014-11-27	2016-06-01	Gentium S.p.A.	Procédé à base cellulaire pour déterminer la puissance de défibrotide
CN106567694A (zh) *	2016-11-14	2017-04-19	北京国泰通源技术有限公司	智能控水短节
RU2758487C2 (ru) *	2018-01-12	2021-10-28	Селлмиг Биолабс Инк.	Способы получения цитокапсул и цитокапсулярных трубок
KR102749256B1 (ko)	2019-11-13	2025-01-03	후지필름 가부시키가이샤	가식 필름, 성형물, 및 전자 디바이스

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US3899481A (en)	1970-11-03	1975-08-12	Crinos Industria Farmaco	Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs
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IT1206341B (it)	1984-02-16	1989-04-14	Crinos Industria Farmaco	Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.
US4694134A (en)	1985-05-28	1987-09-15	Ajax Magnethermic Corporation	Apparatus for overheating edges of skelp for the production of compression welded pipe
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IT1190313B (it)	1986-04-17	1988-02-16	Crinos Industria Farmaco	Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante
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ATE299030T1 (de) *	1996-07-10	2005-07-15	Meiji Dairies Corp	Verwendung von proteinen aus der mk familie als hämatopoietischer faktor
AU1705599A (en) *	1997-11-26	1999-06-15	Allegheny University Of The Health Sciences	Methods for mobilizing hematopoietic facilitating cells and hematopoietic stem cells into the peripheral blood
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2000
- 2000-04-18 EP EP00830293A patent/EP1147777A1/fr not_active Withdrawn
2001
- 2001-04-10 US US10/432,741 patent/US20040131588A1/en not_active Abandoned
- 2001-04-10 KR KR1020027013967A patent/KR100849491B1/ko not_active Expired - Fee Related
- 2001-04-10 NZ NZ522016A patent/NZ522016A/en unknown
- 2001-04-10 MX MXPA02010346A patent/MXPA02010346A/es active IP Right Grant
- 2001-04-10 HU HU0300560A patent/HUP0300560A3/hu unknown
- 2001-04-10 AT AT01931582T patent/ATE310532T1/de active
- 2001-04-10 SK SK1489-2002A patent/SK14892002A3/sk unknown
- 2001-04-10 RO ROA200201305A patent/RO121006B1/ro unknown
- 2001-04-10 DE DE60115222T patent/DE60115222T2/de not_active Expired - Lifetime
- 2001-04-10 DK DK01931582T patent/DK1276497T3/da active
- 2001-04-10 PL PL01358100A patent/PL358100A1/xx not_active Application Discontinuation
- 2001-04-10 ES ES05108424T patent/ES2335776T3/es not_active Expired - Lifetime
- 2001-04-10 RU RU2002130719/15A patent/RU2248216C2/ru not_active IP Right Cessation
- 2001-04-10 AT AT05108424T patent/ATE443524T1/de active
- 2001-04-10 EP EP05108424A patent/EP1621207B1/fr not_active Expired - Lifetime
- 2001-04-10 IL IL152328A patent/IL152328A/en active IP Right Grant
- 2001-04-10 CA CA2406179A patent/CA2406179C/fr not_active Expired - Fee Related
- 2001-04-10 AU AU2001258322A patent/AU2001258322B2/en not_active Ceased
- 2001-04-10 EP EP01931582A patent/EP1276497B1/fr not_active Expired - Lifetime
- 2001-04-10 PT PT05108424T patent/PT1621207E/pt unknown
- 2001-04-10 DK DK05108424.2T patent/DK1621207T3/da active
- 2001-04-10 CN CNB018082025A patent/CN1183962C/zh not_active Expired - Fee Related
- 2001-04-10 SI SI200120022A patent/SI21079B/sl not_active IP Right Cessation
- 2001-04-10 CZ CZ20023426A patent/CZ20023426A3/cs unknown
- 2001-04-10 JP JP2001576061A patent/JP5205668B2/ja not_active Expired - Fee Related
- 2001-04-10 WO PCT/EP2001/004105 patent/WO2001078761A2/fr active IP Right Grant
- 2001-04-10 ES ES01931582T patent/ES2252227T3/es not_active Expired - Lifetime
- 2001-04-10 DE DE60140015T patent/DE60140015D1/de not_active Expired - Lifetime
- 2001-04-10 EE EEP200200596A patent/EE200200596A/xx unknown
- 2001-04-10 AU AU5832201A patent/AU5832201A/xx active Pending
- 2001-10-04 UA UA2002119177A patent/UA73566C2/uk unknown
2002
- 2002-10-14 IS IS6581A patent/IS2171B/is unknown
- 2002-10-16 NO NO20024988A patent/NO20024988L/no not_active Application Discontinuation
- 2002-10-17 BG BG107203A patent/BG107203A/bg unknown
- 2002-10-17 ZA ZA200208413A patent/ZA200208413B/en unknown
- 2002-10-18 HR HR20020835A patent/HRP20020835A2/xx not_active Application Discontinuation
2006
- 2006-02-08 CY CY20061100179T patent/CY1104971T1/el unknown

Also Published As

Publication number	Publication date
IS6581A (is)	2002-10-14
WO2001078761A3 (fr)	2002-01-24
CN1434719A (zh)	2003-08-06
NO20024988L (no)	2002-12-02
RO121006B1 (ro)	2006-11-30
CY1104971T1 (el)	2010-03-03
KR100849491B1 (ko)	2008-07-31
HRP20020835A2 (en)	2005-10-31
SI21079A (sl)	2003-06-30
UA73566C2 (en)	2005-08-15
ES2252227T3 (es)	2006-05-16
ATE443524T1 (de)	2009-10-15
CZ20023426A3 (cs)	2003-05-14
EP1621207B1 (fr)	2009-09-23
HUP0300560A2 (hu)	2003-06-28
EP1147777A1 (fr)	2001-10-24
AU2001258322B2 (en)	2006-03-16
CA2406179A1 (fr)	2001-10-25
SI21079B (sl)	2006-08-31
EP1276497B1 (fr)	2005-11-23
DE60115222T2 (de)	2006-08-10
HUP0300560A3 (en)	2005-07-28
EP1621207A3 (fr)	2006-11-22
IL152328A0 (en)	2003-05-29
KR20030010603A (ko)	2003-02-05
EP1276497A2 (fr)	2003-01-22
RU2248216C2 (ru)	2005-03-20
PT1621207E (pt)	2009-12-28
RU2002130719A (ru)	2004-03-27
MXPA02010346A (es)	2004-09-06
EE200200596A (et)	2004-04-15
US20040131588A1 (en)	2004-07-08
IL152328A (en)	2009-12-24
DK1621207T3 (da)	2010-02-01
DE60115222D1 (de)	2005-12-29
ES2335776T3 (es)	2010-04-05
NZ522016A (en)	2004-10-29
CN1183962C (zh)	2005-01-12
BG107203A (bg)	2003-05-30
WO2001078761A2 (fr)	2001-10-25
ZA200208413B (en)	2003-10-17
NO20024988D0 (no)	2002-10-16
ATE310532T1 (de)	2005-12-15
IS2171B (is)	2006-11-15
JP5205668B2 (ja)	2013-06-05
DE60140015D1 (de)	2009-11-05
PL358100A1 (en)	2004-08-09
JP2004500437A (ja)	2004-01-08
CA2406179C (fr)	2012-03-27
SK14892002A3 (sk)	2003-06-03
EP1621207A2 (fr)	2006-02-01
AU5832201A (en)	2001-10-30

Publication	Publication Date	Title
AU2001269688A1 (en)	2002-01-14	Combination containing an antifolate and methylmalonic acid lowering agent
EA200300348A1 (ru)	2003-08-28	Спирогетероциклические нитрилы, пригодные для применения в качестве обратимо действующих ингибиторов цистеиновых протеаз
DK1276497T3 (da)	2006-03-27	Blanding af defibrotid og G-CSF og anvendelse heraf til aktivering af hæmatopoietiske progenitorceller
IL119461A0 (en)	1997-01-10	Pyrrolopyrimidines
AR027715A1 (es)	2003-04-09	Composiciones basadas en taxanos y metodos de uso de las mismas
DK0774005T3 (da)	2000-05-22	Overfladeudtrykkelse af enzymer i genorienteret prodrug-terapi
ATE194494T1 (de)	2000-07-15	Kombinierte zelluläre und immunsuppressive therapien
IL158155A0 (en)	2004-03-28	Use of erythropoietin to ameliorate chemotherapy-induced toxicity in vivo
SE8401537D0 (sv)	1984-03-20	Forbettrade analgetiska och anti-inflammatoriska kompositioner innefattande ibuprofen och sett att anvenda dessa
IT8119297A0 (it)	1981-01-23	Procedimento di iniezione e diformazione della miscela, come pure dispositivo per la realizzazione dello stesso.
MC2222A1 (fr)	1993-02-02	Nouveaux retinoides
JPS53127750A (en)	1978-11-08	Optical distrubutor
ES2090167T3 (es)	1996-10-16	Uso topico de glicosaminoglicanos en la prevencion y el tratamiento de enfermedades que afectan al tracto vaginal cervical.
JPS5365816A (en)	1978-06-12	Preparation of dimethylaminoethyl methacrylate
SE8902624D0 (sv)	1989-07-31	New pharmaceutical preparations
YU79802A (sh)	2005-11-28	Formulacija sa aktivnošću mobilizacije
MXPA05012696A (es)	2006-02-22	Formulaciones de agentes antiinflamatorios no esteroides para tratar angiogenesis ocular patologica.
ES2129401T3 (es)	1999-06-16	Uso de un compuesto terapeutico para el tratamiento de bronquitis.
SU644924A1 (ru)	1979-01-30	Армоопалубочный пакет
ECSP003380A (es)	2000-07-21	Derivados de campotecina con actividad antitumoral
ITAL930008V0 (it)	1993-06-02	Modello anello tipo "riviera" con castoni (servono per incassare le pietre) scorrevoli in un binario apribile, formato dalla testa dell'a nello medesimo.
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IT8520654A0 (it)	1985-05-10	Derivato della piridina ad azione terapeutica, in particolare antiflogistica, analgesica e antipiretica; procedimento per prepararlo, uso farmaceutico e composizioni farmaceutiche che lo contengono.
JPS52131737A (en)	1977-11-04	Photoconnector