DK1042297T3 - Carboxylsyresubstituerede heterocykliske forbindelser som metalloproteinaseinhibitorer - Google Patents

Carboxylsyresubstituerede heterocykliske forbindelser som metalloproteinaseinhibitorer

Info

Publication number: DK1042297T3
Authority: DK; Denmark
Prior art keywords: carboxylic acid; acid substituted; substituted heterocyclic; heterocyclic compounds; compounds
Prior art date: 1997-12-19

Application number

DK98964135T

Other languages

Danish (da)

English (en)

Inventor

Kevin Koch

Andreas Termin

John A Josey

Original Assignee

Amgen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-19

Filing date

1998-12-18

Publication date

2003-05-26

1998-12-18 Application filed by Amgen Inc filed Critical Amgen Inc

2003-05-26 Application granted granted Critical

2003-05-26 Publication of DK1042297T3 publication Critical patent/DK1042297T3/da

Links

-1 Carboxylic acid substituted heterocyclic compounds Chemical class 0.000 title 1
239000003475 metalloproteinase inhibitor Substances 0.000 title 1
238000000034 method Methods 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
238000011321 prophylaxis Methods 0.000 abstract 2
230000008354 tissue degradation Effects 0.000 abstract 2
238000011282 treatment Methods 0.000 abstract 2
206010016654 Fibrosis Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical group 0.000 abstract 1
230000004761 fibrosis Effects 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)

DK98964135T 1997-12-19 1998-12-18 Carboxylsyresubstituerede heterocykliske forbindelser som metalloproteinaseinhibitorer DK1042297T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US6820097P	1997-12-19	1997-12-19
US09/213,031 US6335329B1 (en)	1997-12-19	1998-12-16	Carboxylic acid substituted heterocycles, derivatives thereof and methods of use
PCT/US1998/027082 WO1999032452A1 (fr)	1997-12-19	1998-12-18	Composes heterocycliques susbstitues par acide carboxylique en tant qu'inhibiteurs de metalloprotease

Publications (1)

Publication Number	Publication Date
DK1042297T3 true DK1042297T3 (da)	2003-05-26

Family

ID=26748692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98964135T DK1042297T3 (da)	1997-12-19	1998-12-18	Carboxylsyresubstituerede heterocykliske forbindelser som metalloproteinaseinhibitorer

Country Status (14)

Country	Link
US (5)	US6335329B1 (fr)
EP (1)	EP1042297B1 (fr)
JP (1)	JP2001526267A (fr)
KR (1)	KR100446706B1 (fr)
CN (1)	CN1110482C (fr)
AT (1)	ATE233244T1 (fr)
AU (1)	AU746957B2 (fr)
CA (1)	CA2315826C (fr)
DE (1)	DE69811734T2 (fr)
DK (1)	DK1042297T3 (fr)
ES (1)	ES2191986T3 (fr)
HU (1)	HUP0100056A3 (fr)
IL (2)	IL136717A0 (fr)
WO (1)	WO1999032452A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
US7037767B2 (en) *	2003-03-24	2006-05-02	Konica Minolta Holdings, Inc.	Thin-film transistor, thin-film transistor sheet and their manufacturing method
US8177072B2 (en) *	2008-12-04	2012-05-15	Thermogenesis Corp.	Apparatus and method for separating and isolating components of a biological fluid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT72878B (en)	1980-04-24	1983-03-29	Merck & Co Inc	Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
US5455258A (en)	1993-01-06	1995-10-03	Ciba-Geigy Corporation	Arylsulfonamido-substituted hydroxamic acids
US5672598A (en)	1995-03-21	1997-09-30	The Procter & Gamble Company	Lactam-containing hydroxamic acids
DK0821671T3 (da)	1995-04-20	2001-04-23	Pfizer	Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer
KR100475206B1 (ko)	1995-11-13	2005-12-16	훽스트 악티엔게젤샤프트	사이클릭및헤테로사이클릭N-치환된α-이미노하이드록삼산및카복실산
FR2748026B1 (fr)	1996-04-26	1998-06-05	Adir	Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

1998
- 1998-12-16 US US09/213,031 patent/US6335329B1/en not_active Expired - Fee Related
- 1998-12-18 ES ES98964135T patent/ES2191986T3/es not_active Expired - Lifetime
- 1998-12-18 CN CN98813681A patent/CN1110482C/zh not_active Expired - Fee Related
- 1998-12-18 CA CA002315826A patent/CA2315826C/fr not_active Expired - Fee Related
- 1998-12-18 KR KR10-2000-7006449A patent/KR100446706B1/ko not_active Expired - Fee Related
- 1998-12-18 DK DK98964135T patent/DK1042297T3/da active
- 1998-12-18 EP EP98964135A patent/EP1042297B1/fr not_active Expired - Lifetime
- 1998-12-18 WO PCT/US1998/027082 patent/WO1999032452A1/fr active IP Right Grant
- 1998-12-18 HU HU0100056A patent/HUP0100056A3/hu unknown
- 1998-12-18 JP JP2000525389A patent/JP2001526267A/ja not_active Withdrawn
- 1998-12-18 AT AT98964135T patent/ATE233244T1/de not_active IP Right Cessation
- 1998-12-18 AU AU19325/99A patent/AU746957B2/en not_active Ceased
- 1998-12-18 IL IL13671798A patent/IL136717A0/xx not_active IP Right Cessation
- 1998-12-18 DE DE69811734T patent/DE69811734T2/de not_active Expired - Fee Related
2000
- 2000-06-07 US US09/588,978 patent/US6291450B1/en not_active Expired - Fee Related
- 2000-06-12 IL IL136717A patent/IL136717A/en unknown
2001
- 2001-06-22 US US09/887,479 patent/US6593351B2/en not_active Expired - Fee Related
2003
- 2003-06-23 US US10/601,975 patent/US6838454B2/en not_active Expired - Fee Related
2004
- 2004-12-23 US US11/020,751 patent/US7022690B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20050159407A1 (en)	2005-07-21
IL136717A (en)	2007-05-15
WO1999032452A1 (fr)	1999-07-01
CN1284947A (zh)	2001-02-21
JP2001526267A (ja)	2001-12-18
CA2315826C (fr)	2004-09-14
US6593351B2 (en)	2003-07-15
AU1932599A (en)	1999-07-12
IL136717A0 (en)	2001-06-14
EP1042297A1 (fr)	2000-10-11
HK1034964A1 (en)	2001-11-09
US6335329B1 (en)	2002-01-01
KR20010033087A (ko)	2001-04-25
DE69811734T2 (de)	2004-03-18
US7022690B2 (en)	2006-04-04
US6291450B1 (en)	2001-09-18
DE69811734D1 (de)	2003-04-03
ATE233244T1 (de)	2003-03-15
CA2315826A1 (fr)	1999-07-01
AU746957B2 (en)	2002-05-09
KR100446706B1 (ko)	2004-09-01
ES2191986T3 (es)	2003-09-16
US20020065269A1 (en)	2002-05-30
CN1110482C (zh)	2003-06-04
HUP0100056A2 (hu)	2001-07-30
HUP0100056A3 (en)	2002-12-28
US6838454B2 (en)	2005-01-04
US20040029863A1 (en)	2004-02-12
EP1042297B1 (fr)	2003-02-26

Publication	Publication Date	Title
LV12291A (lv)	1999-06-20	Savienojums un farmaceitiskas kompozicijas ar triptazes aktivitates izmainam saistitu slimibu arstesanai
DK0778834T3 (da)	2000-04-17	Bicykliske, heterocykliske diarylforbindelser som inhibitorer af cyclooxygenase-2
DE60118003D1 (de)	2006-05-11	Harnstoffderivate und ihre verwendung
ATE366722T1 (de)	2007-08-15	Substituierte pyridin-derivate als entzündungshemmende mittel
DE60114994D1 (de)	2005-12-22	Blutplättchen-adp-rezeptor-inhibitoren
NO20060278L (no)	2006-03-15	Piperazinderivater og fremgangsmater for anvendelse
ES2191069T3 (es)	2003-09-01	Diaril-2-(5h)-furanonas como inhibidores de cox-2.
DK0828724T3 (da)	2002-03-04	5-oxygenerede diaryl-2-(5H)-furanoner som COX-2-inhibitorer
EA200100971A1 (ru)	2002-02-28	Новые соединения и композиции в качестве ингибиторов протеазы
ATE361288T1 (de)	2007-05-15	N-(3,-dimethylindolin-6-yl)ä2-ä(4-
CA2314154A1 (fr)	1999-07-01	Derives d'azepine et leur utilisation comme produits pharmaceutiques
ES2182035T3 (es)	2003-03-01	Derivados del bisarilciclobuteno como inhibidores de ciclooxigenasa.
DE69819539D1 (de)	2003-12-11	Antithrombotische mittel
EE9800230A (et)	1998-12-15	Difenüülstilbeenid kui COX-2 inhibiitorite eelravimid
DK1042297T3 (da)	2003-05-26	Carboxylsyresubstituerede heterocykliske forbindelser som metalloproteinaseinhibitorer
DE69828522D1 (de)	2005-02-10	Antithrombotische mittel
DE50109320D1 (de)	2006-05-11	Verwendung von 6-dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur therapie der harninkontinenz
DE60008430D1 (de)	2004-03-25	Verbindungen mit antithrombotischer wirkung
LV12459A (lv)	2000-04-20	Savienojums un farmaceitiskas kompozicijas ar triptazes aktivitates izmainam saistitu slimibu arstesanai
ATE355834T1 (de)	2007-03-15	Verwendung von 4-oxo-butansäure derivaten zur behandlung der entzündung