DK0904110T3 - Nitrogenoxid-afgivende sammensætninger til nedsættelse af lægemidlers toksicitet - Google Patents

Nitrogenoxid-afgivende sammensætninger til nedsættelse af lægemidlers toksicitet

Info

Publication number: DK0904110T3
Authority: DK; Denmark
Prior art keywords: nitric oxide; drug toxicity; reduce drug; releasing compositions; compositions
Prior art date: 1996-02-26

Application number

DK97906115T

Other languages

Danish (da)

English (en)

Inventor

Soldato Piero Del

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-26

Filing date

1997-02-24

Publication date

2002-11-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11373387&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0904110(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-02-24 Application filed by Nicox Sa filed Critical Nicox Sa

2002-11-11 Application granted granted Critical

2002-11-11 Publication of DK0904110T3 publication Critical patent/DK0904110T3/da

Links

MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title abstract 4
239000000203 mixture Substances 0.000 title abstract 2
208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 title 1
206010070863 Toxicity to various agents Diseases 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
UOTMYNBWXDUBNX-UHFFFAOYSA-N 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinolin-2-ium;chloride Chemical compound Cl.C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 UOTMYNBWXDUBNX-UHFFFAOYSA-N 0.000 abstract 1
229910004679 ONO2 Inorganic materials 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
210000003038 endothelium Anatomy 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
150000002484 inorganic compounds Chemical class 0.000 abstract 1
229910010272 inorganic material Inorganic materials 0.000 abstract 1
150000002894 organic compounds Chemical class 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Toxicology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Underground Structures, Protecting, Testing And Restoring Foundations (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK97906115T 1996-02-26 1997-02-24 Nitrogenoxid-afgivende sammensætninger til nedsættelse af lægemidlers toksicitet DK0904110T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT96MI000352A IT1282686B1 (it)	1996-02-26	1996-02-26	Composti in grado di ridurre la tossicita' da farmaci
PCT/EP1997/000873 WO1997031654A1 (fr)	1996-02-26	1997-02-24	Donneurs d'oxyde nitrique capables de diminuer la toxicite de medicaments

Publications (1)

Publication Number	Publication Date
DK0904110T3 true DK0904110T3 (da)	2002-11-11

Family

ID=11373387

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97906115T DK0904110T3 (da)	1996-02-26	1997-02-24	Nitrogenoxid-afgivende sammensætninger til nedsættelse af lægemidlers toksicitet

Country Status (16)

Country	Link
US (1)	US7087588B2 (fr)
EP (2)	EP0904110B1 (fr)
JP (1)	JP2000506133A (fr)
KR (1)	KR19990087113A (fr)
AT (1)	ATE220920T1 (fr)
AU (1)	AU706591B2 (fr)
BR (1)	BR9707739A (fr)
CA (1)	CA2247848C (fr)
DE (1)	DE69714253T2 (fr)
DK (1)	DK0904110T3 (fr)
ES (1)	ES2180938T3 (fr)
HU (1)	HUP9900993A3 (fr)
IT (1)	IT1282686B1 (fr)
PT (1)	PT904110E (fr)
RU (1)	RU2192247C2 (fr)
WO (1)	WO1997031654A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6043232A (en) *	1997-07-23	2000-03-28	Nitromed, Inc.	Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
US5703073A (en) *	1995-04-19	1997-12-30	Nitromed, Inc.	Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
GB9801398D0 (en)	1998-01-22	1998-03-18	Anggard Erik E	Chemical compounds
IT1298338B1 (it) *	1998-03-05	1999-12-20	Nicox Sa	Composizioni farmaceutiche per l'ulcera
JP2002528495A (ja)	1998-10-30	2002-09-03	ニトロメドインコーポレーテッド	ニトロソ化およびニトロシル化された非ステロイド抗炎症性化合物、組成物および使用方法
TWI243672B (en) *	1999-06-01	2005-11-21	Astrazeneca Ab	New use of compounds as antibacterial agents
TWI262791B (en)	1999-10-27	2006-10-01	Nobex Corp	6-methoxy-2-naphthylacetic acid prodrugs
US6436990B1 (en)	1999-10-27	2002-08-20	Nobex Corporation	6-methoxy-2-naphthylacetic acid prodrugs
US6552078B2 (en)	1999-10-27	2003-04-22	Nobex Corp	6-methoxy-2-naphthylacetic acid prodrugs
RU2002119574A (ru)	1999-12-23	2004-01-10	Нитромед, Инк. (Us)	Нитрозированные и нитрозилированные ингибиторы циклооксигеназы-2, композиции на их основе и способы их применения
WO2001054771A2 (fr) *	2000-01-26	2001-08-02	Cedars-Sinai Medical Center	Procede utilisant des agonistes des canaux potassiques pour l'apport d'un medicament jusqu'a une region anormale du cerveau et/ou jusqu'a une tumeur maligne
US7018979B1 (en)	2000-01-26	2006-03-28	Cedars-Sinai Medical Center	Method for using potassium channel agonists for delivering a medicant to an abnormal brain region and/or a malignant tumor
CA2432642A1 (fr)	2000-12-21	2002-08-08	Subhash P. Khanapure	Composes aryle substitues en tant que nouveaux inhibiteurs selectifs de la cyclo-oxygenase-2, compositions et methodes d'utilisation
EP1219306A1 (fr) *	2000-12-29	2002-07-03	Nicox S.A.	Compositions contenant des cyclodextrines et des médicaments libérant le NO
US7211561B2 (en)	2001-10-12	2007-05-01	Cedars-Sinai Medical Center	Method for inducing selective cell death of malignant cells by activation of calcium-activated potassium channels (KCa)
JP2005533013A (ja)	2002-04-19	2005-11-04	イスムリサーチディベロップメントカンパニーオブザヘブライユニバーシティオブエルサレム	一酸化窒素供与基および反応性酸素種捕捉基を含有するβ作用薬化合物、ならびに呼吸障害の治療における該化合物の使用
JP2006501161A (ja)	2002-06-11	2006-01-12	ニトロメッドインク．	ニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物ならびに使用方法
EP1539679A4 (fr)	2002-06-28	2007-07-04	Nitromed Inc	Inhibiteurs a selectivite cyclooxygenase-2 nitrosiles et/ou nitroses contenant une oxime et/ou une hydrazone, compositions et methodes d'utilisation correspondantes
EP1539729A4 (fr)	2002-07-03	2008-02-20	Nitromed Inc	Composes anti-inflammatoires non-steroidiens nitroses, compositions et leur procede d'utilisation
AU2003261281A1 (en)	2002-07-29	2004-02-16	Nicox S.A.	Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
SE0300971D0 (sv) *	2003-04-03	2003-04-03	Aga Ab	Nitric oxide in treatment of inflammation
US20080242722A1 (en) *	2004-01-27	2008-10-02	Claude Dufresne	Combination Therapy for Treating Cyclooxygenase-2 Mediated Diseases or Conditions in Patients at Risk of Thrombotic Cardiovascular Events
EP1778215B1 (fr) *	2004-06-10	2009-12-09	Nippon Kayaku Kabushiki Kaisha	Agent promoteur de l'effet anticancereux
JP2007325501A (ja) *	2004-08-25	2007-12-20	Tottori Univ	非ステロイド性抗炎症薬による動物の消化管副作用の予防・治療方法
EP1888510A4 (fr)	2005-05-27	2013-01-16	Univ North Carolina	Particules liberant de l'oxyde nitrique pour therapie a base d'oxyde nitrique et applications biomedicales
US20100240745A1 (en) *	2009-03-20	2010-09-23	Nicox S.A.	Method of treatment of inflammation in hypertensive patients
CN102695528B (zh)	2009-08-21	2016-07-13	诺万公司	创伤敷料、其使用方法及其形成方法
BR112012003792B1 (pt)	2009-08-21	2020-05-19	Novan Inc	composição tópica, e, uso da composição tópica
US8591876B2 (en)	2010-12-15	2013-11-26	Novan, Inc.	Methods of decreasing sebum production in the skin
WO2012118829A2 (fr)	2011-02-28	2012-09-07	Novan, Inc.	Xérogels libérant de l'oxyde nitrique modifiés par des groupements s-nitrosothiols tertiaires et procédés d'utilisation associés
JO3350B1 (ar)	2011-03-07	2019-03-13	Merck Sharp & Dohme	مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
RU2539630C1 (ru) *	2013-07-09	2015-01-20	Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ")	Способ профилактики ишемии сетчатки в эксперименте

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5570683A (en) *	1990-12-05	1996-11-05	The General Hospital Corporation	Methods and devices for treating pulmonary vasoconstriction and asthma
IT1256345B (it)	1992-08-20	1995-12-01		Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it)	1992-11-26	1995-12-05	Soldato Piero Del	Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
RU2136653C1 (ru)	1993-10-06	1999-09-10	Никокс С.А.	Нитроэфиры, обладающие противовоспалительной и/или анальгетической активностью, способы их получения, фармацевтические композиции
US5861426A (en)	1994-05-10	1999-01-19	Nicox S.A.	Nitro compounds of the formula A-Xi -NO2 and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities
US5597809A (en) *	1994-06-23	1997-01-28	Massachusetts Eye & Ear Infirmary	Treatment of optic neuritis
US5703073A (en)	1995-04-19	1997-12-30	Nitromed, Inc.	Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US5620416A (en)	1995-06-07	1997-04-15	North Carolina State University	Methods of using topical agents with systemically administered active agents

1996
- 1996-02-26 IT IT96MI000352A patent/IT1282686B1/it active IP Right Grant
1997
- 1997-02-24 DE DE69714253T patent/DE69714253T2/de not_active Revoked
- 1997-02-24 BR BR9707739A patent/BR9707739A/pt not_active Application Discontinuation
- 1997-02-24 ES ES97906115T patent/ES2180938T3/es not_active Expired - Lifetime
- 1997-02-24 JP JP9530576A patent/JP2000506133A/ja active Pending
- 1997-02-24 RU RU98117618/14A patent/RU2192247C2/ru not_active IP Right Cessation
- 1997-02-24 KR KR1019980706501A patent/KR19990087113A/ko not_active Ceased
- 1997-02-24 AU AU20924/97A patent/AU706591B2/en not_active Ceased
- 1997-02-24 EP EP97906115A patent/EP0904110B1/fr not_active Revoked
- 1997-02-24 DK DK97906115T patent/DK0904110T3/da active
- 1997-02-24 CA CA002247848A patent/CA2247848C/fr not_active Expired - Fee Related
- 1997-02-24 AT AT97906115T patent/ATE220920T1/de not_active IP Right Cessation
- 1997-02-24 HU HU9900993A patent/HUP9900993A3/hu unknown
- 1997-02-24 PT PT97906115T patent/PT904110E/pt unknown
- 1997-02-24 WO PCT/EP1997/000873 patent/WO1997031654A1/fr not_active Application Discontinuation
- 1997-02-24 EP EP02008079A patent/EP1221326A3/fr not_active Withdrawn
2004
- 2004-07-07 US US10/885,121 patent/US7087588B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BR9707739A (pt)	1999-07-27
KR19990087113A (ko)	1999-12-15
DE69714253D1 (de)	2002-08-29
IT1282686B1 (it)	1998-03-31
EP1221326A3 (fr)	2004-01-14
CA2247848C (fr)	2008-07-15
HUP9900993A2 (hu)	1999-09-28
US20040242651A1 (en)	2004-12-02
EP1221326A2 (fr)	2002-07-10
RU2192247C2 (ru)	2002-11-10
US7087588B2 (en)	2006-08-08
HUP9900993A3 (en)	2000-10-30
JP2000506133A (ja)	2000-05-23
ES2180938T3 (es)	2003-02-16
ITMI960352A1 (it)	1997-08-26
EP0904110B1 (fr)	2002-07-24
DE69714253T2 (de)	2003-03-06
EP0904110A1 (fr)	1999-03-31
WO1997031654A1 (fr)	1997-09-04
ITMI960352A0 (fr)	1996-02-26
AU2092497A (en)	1997-09-16
PT904110E (pt)	2002-12-31
ATE220920T1 (de)	2002-08-15
CA2247848A1 (fr)	1997-09-04
AU706591B2 (en)	1999-06-17

Publication	Publication Date	Title
DK0904110T3 (da)	2002-11-11	Nitrogenoxid-afgivende sammensætninger til nedsættelse af lægemidlers toksicitet
DK0671933T3 (da)	1998-09-23	Hidtil ukendte anvendelser af IL-10
BR9915940A (pt)	2001-09-11	Métodos e composições para restaurar a estabilidade conformacional de uma proteìna da famìlia p53
DE69123795D1 (de)	1997-02-06	Pharmazeutische Zusammensetzung zur rektalen Verabreichung von Wirkstoffen mit topischer medizinischer Wirkung im Dickdarmniveau
ATE309206T1 (de)	2005-11-15	Schwefel-substituierte sulfonylaminocarbonsäure n-arylamide, ihre herstellung, ihre anwendung und diese enthaltende pharmazeutische zusammensetzungen
DE3679920D1 (de)	1991-08-01	Spiro-3-heteroazolidinverbindungen und ihre salze, ihre herstellung und diese enthaltende pharmazeutische mittel.
DE69919179D1 (de)	2004-09-09	Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen
IT1275816B1 (it)	1997-10-17	Composizioni farmaceutiche solide per uso vaginale
SE8404065D0 (sv)	1984-08-10	Novel biologically active compounds
DE3280173D1 (de)	1990-06-21	Superoxid-dismutase, ihre herstellung und dieselbe enthaltende pharmazeutische zusammensetzungen.
BR9908427A (pt)	2000-10-31	Composições farmacêuticas e uso das mesmas
DE3579730D1 (de)	1990-10-25	Eisen-3-hydroxypyron- oder 3-hydroxypyridon-komplexe und diese enthaltende pharmazeutische zusammensetzungen.
DE69706146D1 (de)	2001-09-20	Taxoide, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen
IT1224405B (it)	1990-10-04	Composti attivi sul sistema cardiovascolare
DE69928646D1 (de)	2006-01-05	Derivate des streptogramins, ihre herstellung und sie enthaltende zubereitungen
DE3578597D1 (de)	1990-08-16	4-phenylphthalazin-derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen.
DE69414622D1 (de)	1998-12-24	Streptogramine in gereinigte Form, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
TR199802577T2 (xx)	1999-03-22	Ayr� b�lmelerde iki aktif terkip maddeli transdermik sistemler.
BR9802803A (pt)	2000-03-21	ação e composições farmacêuticas contendo os mesmos.
DE68914700D1 (de)	1994-05-26	Polymere Zusammensetzungen und ihre Herstellung.
ES2155476T3 (es)	2001-05-16	Aril-tio-alquil-tio-piridinas sustituidas.
DE59107240D1 (de)	1996-02-22	Emulgatorfreie Emulsionspolymere in pharmazeutischen Zubereitungen mit verzögerter Wirkstofffreigabe und ihre Herstellung
DE3684756D1 (de)	1992-05-14	Durch (omega-amino)-alkanolgruppen substituierte aromatische derivate mit antimikrobenwirkung und diese enthaltende zusammensetzungen.
ES2126015T3 (es)	1999-03-16	Uso de etofibrato y composiciones farmaceuticas que contienen etofibrato para el tratamiento de la angiopatia y la retinopatia diabeticas.
ES2095554T3 (es)	1997-02-16	Compuestos esteroides 17-fenil-sustituidos con actividad sobre el sistema cardiovascular.