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DK0996621T3 - Triazolo[4,5-d]pyrimidin-derivater som anti-trombotiske midler - Google Patents

Triazolo[4,5-d]pyrimidin-derivater som anti-trombotiske midler

Info

Publication number
DK0996621T3
DK0996621T3 DK98934107T DK98934107T DK0996621T3 DK 0996621 T3 DK0996621 T3 DK 0996621T3 DK 98934107 T DK98934107 T DK 98934107T DK 98934107 T DK98934107 T DK 98934107T DK 0996621 T3 DK0996621 T3 DK 0996621T3
Authority
DK
Denmark
Prior art keywords
triazolo
pyrimidine derivatives
thrombotic agents
thrombotic
agents
Prior art date
Application number
DK98934107T
Other languages
Danish (da)
English (en)
Inventor
Simon Guile
Anthony Ingall
Brian Springthorpe
Paul Willis
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26663042&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0996621(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE9702775A external-priority patent/SE9702775D0/xx
Priority claimed from SE9702773A external-priority patent/SE9702773D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK0996621T3 publication Critical patent/DK0996621T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DK98934107T 1997-07-22 1998-07-15 Triazolo[4,5-d]pyrimidin-derivater som anti-trombotiske midler DK0996621T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9702775A SE9702775D0 (sv) 1997-07-22 1997-07-22 Novel compounds
SE9702773A SE9702773D0 (sv) 1997-07-22 1997-07-22 Novel compounds
PCT/SE1998/001393 WO1999005143A1 (fr) 1997-07-22 1998-07-15 Nouveaux composes

Publications (1)

Publication Number Publication Date
DK0996621T3 true DK0996621T3 (da) 2004-02-02

Family

ID=26663042

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98934107T DK0996621T3 (da) 1997-07-22 1998-07-15 Triazolo[4,5-d]pyrimidin-derivater som anti-trombotiske midler

Country Status (31)

Country Link
EP (1) EP0996621B1 (fr)
JP (1) JP4187406B2 (fr)
KR (2) KR100535837B1 (fr)
CN (1) CN1154650C (fr)
AR (2) AR017014A1 (fr)
AT (1) ATE251161T1 (fr)
AU (1) AU745381B2 (fr)
BR (1) BR9810802B1 (fr)
CA (1) CA2296665C (fr)
CZ (1) CZ302629B6 (fr)
DE (1) DE69818668T2 (fr)
DK (1) DK0996621T3 (fr)
EE (1) EE04193B1 (fr)
EG (1) EG24412A (fr)
ES (1) ES2207846T3 (fr)
HK (1) HK1026421A1 (fr)
HU (1) HU230074B1 (fr)
IL (2) IL133959A0 (fr)
IS (1) IS2236B (fr)
MY (1) MY123196A (fr)
NO (1) NO315854B1 (fr)
NZ (1) NZ502381A (fr)
PL (1) PL200325B1 (fr)
PT (1) PT996621E (fr)
RU (1) RU2225407C2 (fr)
SA (1) SA98190487B1 (fr)
SK (1) SK284199B6 (fr)
TR (1) TR200000197T2 (fr)
TW (1) TW530058B (fr)
UA (1) UA66801C2 (fr)
WO (1) WO1999005143A1 (fr)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) * 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9903290D0 (sv) * 1999-09-15 1999-09-15 Astra Pharma Prod Novel compounds
SE9904129D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
SE9904128D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
GB0013487D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Novel process
GB0013407D0 (en) 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
GB0013488D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
AR028110A1 (es) * 2000-06-02 2003-04-23 Astrazeneca Ab Nuevo proceso
IT1317049B1 (it) 2000-06-23 2003-05-26 Sigma Tau Ind Farmaceuti Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv.
SE0004098D0 (sv) 2000-11-09 2000-11-09 Astrazeneca Ab Novel compounds
SE0004099D0 (sv) * 2000-11-09 2000-11-09 Astrazeneca Ab Novel compounds
GB0219746D0 (en) 2002-08-23 2002-10-02 Inst Of Ex Botany Ascr Azapurine derivatives
US7335648B2 (en) 2003-10-21 2008-02-26 Inspire Pharmaceuticals, Inc. Non-nucleotide composition and method for inhibiting platelet aggregation
US7504497B2 (en) 2003-10-21 2009-03-17 Inspire Pharmaceuticals, Inc. Orally bioavailable compounds and methods for inhibiting platelet aggregation
WO2005040174A1 (fr) 2003-10-21 2005-05-06 Inspire Pharmaceuticals, Inc. Composes tetrahydro-furo[3,4d]dioxole, et compositions et procede pour inhiber une agregation plaquettaire
US7749981B2 (en) 2003-10-21 2010-07-06 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound
SE0401001D0 (sv) 2004-03-31 2004-03-31 Astrazeneca Ab Chemical process
US7932376B2 (en) 2005-05-05 2011-04-26 Inspire Pharmaceuticals, Inc. Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation
GB0615620D0 (en) 2006-08-05 2006-09-13 Astrazeneca Ab A process for the preparation of optically active intermediates
JP2010508350A (ja) 2006-10-31 2010-03-18 ヤンセン ファーマシューティカ エヌ．ベー． Ａｄｐｐ２ｙ１２レセプターアンタゴニストとしてのトリアゾロピリミジン誘導体
UA100864C2 (uk) * 2007-12-03 2013-02-11 Астразенека Аб Спосіб лікування або запобігання аневризмі черевної аорти
KR101669297B1 (ko) 2008-09-09 2016-10-25 아스트라제네카 아베 [1Ｓ-[1-알파,2-알파,3-베타(1Ｓ*,2Ｒ*),5-베타]]-3-[7-[2-(3,4-디플루오로페닐)-사이클로프로필아미노]-5-(프로필티오)-3Ｈ-1,2,3-트리아졸로[4,5-ｄ]피리미딘-3-일]-5-(2-하이드록시에톡시)사이클로펜탄-1,2-디올의 제조 방법 및 그 중간체
WO2010043721A1 (fr) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Inhibiteurs d’oxydases et leur utilisation
WO2010084160A1 (fr) 2009-01-21 2010-07-29 Oryzon Genomics S.A. Dérivés de phénylcyclopropylamine et leur utilisation médicale
US8389580B2 (en) 2009-06-02 2013-03-05 Duke University Arylcyclopropylamines and methods of use
EP2305376A1 (fr) 2009-09-23 2011-04-06 Lonza Ltd. Procédé et catalyseur pour l'hydrogénation catalytique de composés de nitro aromatiques et hétéro-aromatiques
KR101736218B1 (ko) 2009-09-25 2017-05-16 오리존 지노믹스 에스.에이. 라이신 특이적 디메틸라아제-1 억제제 및 이의 용도
US8946296B2 (en) 2009-10-09 2015-02-03 Oryzon Genomics S.A. Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use
CA2781182A1 (fr) 2009-12-03 2011-06-09 Astrazeneca Ab Co-cristaux d'un inhibiteur d'agregation plaquettaire a base de triazolo [4,5-d] pyrimidine
ES2550033T3 (es) 2009-12-23 2015-11-04 Ratiopharm Gmbh Forma de dosificación farmacéutica sólida de ticagrelor
EP2536695A1 (fr) 2010-02-16 2012-12-26 Actavis Group Ptc Ehf Procédés améliorés pour préparer un intermédiaire de ticagrelor, la 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine
US9186337B2 (en) 2010-02-24 2015-11-17 Oryzon Genomics S.A. Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
WO2011106105A2 (fr) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibiteurs destinés à une utilisation antivirale
WO2011131697A1 (fr) 2010-04-19 2011-10-27 Oryzon Genomics S.A. Inhibiteurs de la déméthylase-1 spécifiques de la lysine, et leur utilisation
WO2011132083A2 (fr) 2010-04-20 2011-10-27 Actavis Group Ptc Ehf Nouveau procédé de préparation de dérivés de phénylcyclopropylamine par utilisation de nouveaux intermédiaires
AU2011273101A1 (en) 2010-06-30 2013-01-17 Actavis Group Ptc Ehf Novel processes for the preparation of phenylcyclopropylamine derivatives and use thereof for preparing ticagrelor
WO2012013727A1 (fr) 2010-07-29 2012-02-02 Oryzon Genomics S.A. Dérivés de cyclopropylamine utiles en tant qu'inhibiteurs de lsd1
US9181198B2 (en) 2010-07-29 2015-11-10 Oryzon Genomics S.A. Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use
WO2012045883A1 (fr) 2010-10-08 2012-04-12 Oryzon Genomics S.A. Inhibiteurs d'oxydases de cyclopropylamine
WO2012063126A2 (fr) 2010-11-09 2012-05-18 Actavis Group Ptc Ehf Procédés améliorés de préparation de (3ar,4s,6r,6as)-6-amino-2,2-diméthyltétrahdro-3ah-cyclopenta[d] [1,3]-dioxol-4-ol pur et son matériau de départ clé
WO2012072713A2 (fr) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Inhibiteurs de la déméthylase spécifique de la lysine pour des maladies et troubles liés aux flaviviridés
RU2013133879A (ru) 2010-12-20 2015-01-27 Актавис Груп Птс Ехф НОВЫЕ СПОСОБЫ ПОЛУЧЕНИЯ ТРИАЗОЛО[4, 5-d]ПИРИМИДИНА, ЕГО ПРОИЗВОДНЫЕ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ
EP2712315B1 (fr) 2011-02-08 2021-11-24 Oryzon Genomics, S.A. Inhibiteurs de lysine déméthylase pour des troubles myéloprolifératifs
CN102731510B (zh) * 2011-04-07 2015-12-16 博瑞生物医药（苏州）股份有限公司 替卡格雷的衍生物、制备方法及其药物用途
CN103764149A (zh) 2011-06-01 2014-04-30 阿斯利康(瑞典)有限公司 新型替卡格雷共晶
CA2839057A1 (fr) 2011-06-15 2012-12-20 Actavis Group Ptc Ehf Procede ameliore de preparation de derives de cyclopentanamine et de leurs intermediaires
CN102924457A (zh) * 2011-08-12 2013-02-13 上海恒瑞医药有限公司 三唑并嘧啶类衍生物、其制备方法及其用途
MY187638A (en) 2011-10-20 2021-10-06 Oryzon Genomics Sa (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
KR102139537B1 (ko) 2011-10-20 2020-07-31 오리존 지노믹스 에스.에이. Lsd1 억제제로서 (헤테로)아릴 사이클로프로필아민 화합물
US9469614B2 (en) * 2011-10-27 2016-10-18 Lek Pharmaceuticals D.D. Synthesis of triazolopyrimidine compounds
EP2589587A1 (fr) 2011-11-04 2013-05-08 Chemo Ibérica, S.A. Synthèse de cyclopropanes à substitution azote
EP2785716A1 (fr) 2011-11-30 2014-10-08 Actavis Group PTC EHF Nouvelle forme cristalline du ticagrelor et procédé pour sa préparation
US20130178520A1 (en) 2011-12-23 2013-07-11 Duke University Methods of treatment using arylcyclopropylamine compounds
US9233966B2 (en) 2012-04-05 2016-01-12 Dr. Reddy's Laboratories Limited Preparation of ticagrelor
CN102675321B (zh) * 2012-05-11 2014-12-10 上海皓元化学科技有限公司 一种替卡格雷的制备方法
CN103626743B (zh) * 2012-08-23 2018-06-08 广东东阳光药业有限公司 替卡格雷的新型中间体及其制备方法
CZ2012705A3 (cs) 2012-10-16 2014-04-23 Zentiva, K.S. Pevná orální farmaceutická formulace obsahující ticagrelor
WO2014083139A1 (fr) 2012-11-29 2014-06-05 Actavis Group Ptc Ehf Nouvelle forme amorphe de ticagrelor
CN103965198A (zh) * 2013-02-05 2014-08-06 郝聪梅 替卡格雷的中间体及其制备方法以及利用该中间体制备替卡格雷的方法
CN103183679A (zh) * 2013-03-20 2013-07-03 西藏海思科药业集团股份有限公司 抗凝血化合物及其应用
CN104098553B (zh) * 2013-04-10 2017-11-28 江苏恒瑞医药股份有限公司 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法
EP3003276A1 (fr) 2013-05-29 2016-04-13 ratiopharm GmbH Forme posologique pharmaceutique solide
WO2014206187A1 (fr) 2013-06-24 2014-12-31 苏州明锐医药科技有限公司 Procédé de préparation du ticagrelor et de ses intermédiaires
CN103588751B (zh) * 2013-11-07 2014-12-17 苏州明锐医药科技有限公司 替格瑞洛中间体的制备方法
WO2015162630A1 (fr) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Nouveaux procédés de préparation de triazolo[4,5-d]-pyrimidines, dont le ticagrelor, via de nouveaux intermédiaires et une nouvelle voie de synthèse
EP3157907B1 (fr) 2014-06-18 2018-08-29 Flamma S.P.A. Procédé pour la préparation de composés de triazolo[4,5-d]pyrimidine cyclopentane
CN105272985B (zh) * 2014-06-24 2017-11-21 珠海联邦制药股份有限公司 三唑并[4,5‑d]嘧啶化合物及其合成方法、用途、组合物
CA2963166C (fr) 2014-10-01 2023-10-03 Medimmune Limited Anticorps a ticagrelor et procedes de leur utilisation
WO2016116942A1 (fr) 2015-01-20 2016-07-28 Anlon Chemical Research Organization Nouveaux composés pharmaceutiques comprenant du ticagrélor avec des sels d'aspirine
CN105985346B (zh) * 2015-03-06 2019-10-18 苏州朗科生物技术股份有限公司 一种新的替格瑞洛化合物制备方法及其中间体化合物
TR201601835A2 (tr) 2016-02-12 2017-08-21 Ali Raif Ilac Sanayi Ve Ticaret Anonim Sirketi Ti̇kagrelor i̇çeren formülasyonlar i̇çi̇n üreti̇m yöntemi̇
CN109153649B (zh) 2016-03-22 2022-04-19 默沙东公司 烟碱乙酰胆碱受体的变构调节剂
WO2018167447A1 (fr) 2017-03-14 2018-09-20 University Of Sheffield Aspirine à faible dose (1-50 mg) conjointement avec des antiagrégants plaquettaires de type ticagrelor d'anticoagulants
CN107141298A (zh) * 2017-07-24 2017-09-08 苏州信恩医药科技有限公司 一种替格瑞洛的合成方法
TWI641327B (zh) * 2017-09-30 2018-11-21 双邦實業股份有限公司 Socks that are comfortable and comfortable to wear
EP3527571A1 (fr) * 2018-02-14 2019-08-21 Université de Liège Dérivés de pyrimidine pour la prévention et le traitement d'infections bactériennes
CN117003756A (zh) * 2022-05-04 2023-11-07 华东师范大学 芳香稠环化合物作为trek-1激活剂的用途、包含其的药物组合物、镇痛剂
CN114805367B (zh) * 2022-05-24 2023-04-07 郑州大学 一种三氮唑并嘧啶类衍生物及其制备方法和应用
CN115710275B (zh) * 2022-11-21 2024-02-02 河南中医药大学 一种嘧啶-tcp类化合物、制备方法和医药用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742064A (en) * 1985-09-10 1988-05-03 Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
DE3924424A1 (de) * 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
TR199800019T1 (xx) * 1995-07-11 1998-05-21 Astra Pharmaceuticals Limited Trombosit topaklanmas�n� �nleyici yeni maddeler.
JP4125790B2 (ja) * 1996-12-20 2008-07-30 アストラゼネカ・アクチエボラーグ トリアゾロ［４，５−ｄ］ピリミジニル誘導体および医薬としてのその使用

Also Published As

Publication number Publication date
HK1026421A1 (en) 2000-12-15
HU230074B1 (hu) 2015-06-29
NO315854B1 (no) 2003-11-03
MY123196A (en) 2006-05-31
EE04193B1 (et) 2003-12-15
CA2296665A1 (fr) 1999-02-04
NO20000312D0 (no) 2000-01-21
IS5354A (is) 2000-01-20
CN1270590A (zh) 2000-10-18
UA66801C2 (uk) 2004-06-15
NZ502381A (en) 2001-12-21
ES2207846T3 (es) 2004-06-01
SA98190487B1 (ar) 2006-08-20
CZ302629B6 (cs) 2011-08-10
ATE251161T1 (de) 2003-10-15
AU745381B2 (en) 2002-03-21
AR077553A2 (es) 2011-09-07
BR9810802A (pt) 2000-09-12
IS2236B (is) 2007-05-15
KR20050084540A (ko) 2005-08-26
KR100535837B1 (ko) 2006-01-12
EE200000044A (et) 2000-10-16
RU2225407C2 (ru) 2004-03-10
DE69818668D1 (de) 2003-11-06
BR9810802B1 (pt) 2010-10-19
HUP0004333A3 (en) 2001-11-28
EG24412A (en) 2009-05-25
DE69818668T2 (de) 2004-08-12
IL133959A (en) 2007-10-31
KR20010022083A (ko) 2001-03-15
NO20000312L (no) 2000-03-21
PT996621E (pt) 2004-02-27
CA2296665C (fr) 2008-06-10
AR017014A1 (es) 2001-08-22
HUP0004333A2 (hu) 2001-04-28
EP0996621B1 (fr) 2003-10-01
CZ2000233A3 (cs) 2000-07-12
JP4187406B2 (ja) 2008-11-26
AU8370698A (en) 1999-02-16
CN1154650C (zh) 2004-06-23
IL133959A0 (en) 2001-04-30
PL200325B1 (pl) 2008-12-31
WO1999005143A1 (fr) 1999-02-04
TW530058B (en) 2003-05-01
JP2001510842A (ja) 2001-08-07
SK188199A3 (en) 2000-10-09
SK284199B6 (sk) 2004-10-05
EP0996621A1 (fr) 2000-05-03
PL338516A1 (en) 2000-11-06
TR200000197T2 (tr) 2000-06-21

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