DK0996613T3 - Fremstilling af rent cis-tramadol-hydrochlorid - Google Patents

Fremstilling af rent cis-tramadol-hydrochlorid

Info

Publication number: DK0996613T3
Authority: DK; Denmark
Prior art keywords: cis; preparation; tramadol; tramadol hydrochloride; pure cis
Prior art date: 1997-07-15

Application number

DK98932479T

Other languages

Danish (da)

English (en)

Inventor

Angelo Nikolopoulos

Helmut Schickaneder

Original Assignee

Russinsky Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-15

Filing date

1998-06-26

Publication date

2003-03-03

1998-06-26 Application filed by Russinsky Ltd filed Critical Russinsky Ltd

2003-03-03 Application granted granted Critical

2003-03-03 Publication of DK0996613T3 publication Critical patent/DK0996613T3/da

Links

PPKXEPBICJTCRU-XMZRARIVSA-N (R,R)-tramadol hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-XMZRARIVSA-N 0.000 title abstract 3
TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 abstract 2
239000007818 Grignard reagent Substances 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000004795 grignard reagents Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK98932479T 1997-07-15 1998-06-26 Fremstilling af rent cis-tramadol-hydrochlorid DK0996613T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IE970519		1997-07-15
PCT/IE1998/000051 WO1999003820A1 (fr)	1997-07-15	1998-06-26	Tramadol, sels de ramadol, et procedes d'elaboration

Publications (1)

Publication Number	Publication Date
DK0996613T3 true DK0996613T3 (da)	2003-03-03

Family

ID=11041532

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98932479T DK0996613T3 (da)	1997-07-15	1998-06-26	Fremstilling af rent cis-tramadol-hydrochlorid

Country Status (12)

Country	Link
US (1)	US6469213B1 (fr)
EP (1)	EP0996613B1 (fr)
JP (1)	JP2001510180A (fr)
CN (1)	CN1151122C (fr)
AT (1)	ATE226931T1 (fr)
AU (1)	AU730530B2 (fr)
CA (1)	CA2295884A1 (fr)
DE (1)	DE69809055T2 (fr)
DK (1)	DK0996613T3 (fr)
GB (1)	GB2342352B (fr)
IE (1)	IE980512A1 (fr)
WO (1)	WO1999003820A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9800657D0 (en) *	1998-01-14	1998-03-11	Macfarlan Smith Ltd	Improved purification process
AU4775699A (en) *	1999-06-22	2001-01-09	Grunenthal Gmbh	Method for separating the diastereomer bases of 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-cyclohexanol
DE10049483A1 (de) *	2000-09-29	2002-05-02	Gruenenthal Gmbh	Substituierte 1-Aminobutan-3-ol-Derivate
US6649783B2 (en)	2001-10-03	2003-11-18	Euro-Celtique, S.A.	Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
EP1346978A1 (fr) *	2002-03-21	2003-09-24	Jubilant Organosys Limited	Procédé pour la préparation de tramadol chlorohydrate et/ou de tramadol monohydrate
DE10236510A1 (de) *	2002-08-09	2004-02-19	Grünenthal GmbH	Verfahren zur Herstellung von 2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
US20040248979A1 (en) *	2003-06-03	2004-12-09	Dynogen Pharmaceuticals, Inc.	Method of treating lower urinary tract disorders
BRPI0612802A2 (pt)	2005-07-07	2010-11-30	Farnam Co Inc	composições farmacêuticas de liberação sustentada para medicamentos extremamente hidrossolúveis
EP1785412A1 (fr) *	2005-11-14	2007-05-16	IPCA Laboratories Limited	Procédé de récuperation de Tramadol
US20220372138A1 (en)	2019-07-05	2022-11-24	Iomx Therapeutics Ag	Antibodies binding igc2 of igsf11 (vsig3) and uses thereof
WO2022008027A1 (fr)	2020-07-06	2022-01-13	Iomx Therapeutics Ag	Anticorps de liaison à l'igv d'igsf11 (vsig3) et leurs utilisations

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1199764B (de)	1963-04-02	1965-09-02	Gruenenthal Chemie	Verfahren zur Herstellung von basisch substituierten Phenolaethern
US3652589A (en)	1967-07-27	1972-03-28	Gruenenthal Chemie	1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
MY110317A (en)	1991-09-06	1998-04-30	Mcneilab Inc	Compositions comprising a tramadol material and any of codeine, oxycodone or hydrocodone, and their use.
SG80535A1 (en)	1991-09-06	2001-05-22	Mcneilab Inc	Composition comprising a tramadol material and acetaminophen and its use
US5223541A (en)	1991-09-13	1993-06-29	Mcneilab, Inc.	Tramadol n-oxide material, enantiomers and compositions thereof, and their use
US5516803A (en)	1991-10-30	1996-05-14	Mcneilab, Inc.	Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
IL103096A (en) *	1992-09-08	1996-12-05	Chemagis Ltd	Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts.
IL116281A (en) *	1995-12-07	1999-06-20	Chemagis Ltd	Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts
DE19601745C1 (de) *	1996-01-19	1997-10-09	Gruenenthal Gmbh	Verfahren zur Racematspaltung von Tramadol
IL119121A (en) *	1996-08-22	2000-11-21	Chemagis Ltd	Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride
CA2330142A1 (fr) *	1998-05-22	1999-12-02	Mallinckrodt, Inc.	Synthese et purification perfectionnee de chlorhydrate de (r,r)-2-[ (dimethylamino) methyl]-1-( 3-methoxyphenyl) cyclohexanol

1998
- 1998-06-26 IE IE980512A patent/IE980512A1/en not_active IP Right Cessation
- 1998-06-26 GB GB9929485A patent/GB2342352B/en not_active Expired - Fee Related
- 1998-06-26 AU AU82383/98A patent/AU730530B2/en not_active Ceased
- 1998-06-26 CN CNB988072793A patent/CN1151122C/zh not_active Expired - Fee Related
- 1998-06-26 DK DK98932479T patent/DK0996613T3/da active
- 1998-06-26 CA CA002295884A patent/CA2295884A1/fr not_active Abandoned
- 1998-06-26 EP EP98932479A patent/EP0996613B1/fr not_active Expired - Lifetime
- 1998-06-26 AT AT98932479T patent/ATE226931T1/de not_active IP Right Cessation
- 1998-06-26 JP JP2000503051A patent/JP2001510180A/ja active Pending
- 1998-06-26 DE DE69809055T patent/DE69809055T2/de not_active Expired - Fee Related
- 1998-06-26 WO PCT/IE1998/000051 patent/WO1999003820A1/fr active IP Right Grant
2000
- 2000-01-14 US US09/482,889 patent/US6469213B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2001510180A (ja)	2001-07-31
EP0996613B1 (fr)	2002-10-30
AU8238398A (en)	1999-02-10
DE69809055D1 (de)	2002-12-05
EP0996613A1 (fr)	2000-05-03
GB9929485D0 (en)	2000-02-09
US6469213B1 (en)	2002-10-22
GB2342352B (en)	2002-03-27
IE980512A1 (en)	1999-10-20
WO1999003820A1 (fr)	1999-01-28
GB2342352A (en)	2000-04-12
CN1264363A (zh)	2000-08-23
DE69809055T2 (de)	2003-06-05
AU730530B2 (en)	2001-03-08
CA2295884A1 (fr)	1999-01-28
CN1151122C (zh)	2004-05-26
ATE226931T1 (de)	2002-11-15

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EA200300873A1 (ru)	2003-12-25	Новая соль сукцинат o-десметилвенлафаксина
NO20034931L (no)	2004-01-02	Substituerte 2-pyridin-cykloheksan-1,4-diaminderivater
WO2003103603A3 (fr)	2004-03-25	Nouveau sel de type formiate de o-desmethylvenlafaxine
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