DK0975638T3 - Sidekædemodificerede epothiloner - Google Patents

Sidekædemodificerede epothiloner

Info

Publication number: DK0975638T3
Authority: DK; Denmark
Prior art keywords: chain modified; modified epothilones; epothilones; chain; modified
Prior art date: 1997-02-25

Application number

DK98912388T

Other languages

Danish (da)

English (en)

Inventor

Gerhard Hoefle

Michael Sefkow

Original Assignee

Biotechnolog Forschung Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-25

Filing date

1998-02-25

Publication date

2002-11-18

1998-02-25 Application filed by Biotechnolog Forschung Gmbh filed Critical Biotechnolog Forschung Gmbh

2002-11-18 Application granted granted Critical

2002-11-18 Publication of DK0975638T3 publication Critical patent/DK0975638T3/da

Links

HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Silicon Polymers (AREA)
Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Polyesters Or Polycarbonates (AREA)
Epoxy Compounds (AREA)

DK98912388T 1997-02-25 1998-02-25 Sidekædemodificerede epothiloner DK0975638T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19707505		1997-02-25
PCT/EP1998/001060 WO1998038192A1 (fr)	1997-02-25	1998-02-25	Epothilones a chaine laterale modifiee

Publications (1)

Publication Number	Publication Date
DK0975638T3 true DK0975638T3 (da)	2002-11-18

Family

ID=7821415

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98912388T DK0975638T3 (da)	1997-02-25	1998-02-25	Sidekædemodificerede epothiloner

Country Status (25)

Country	Link
US (1)	US6359140B1 (fr)
EP (2)	EP1201666A3 (fr)
JP (1)	JP2001513098A (fr)
KR (1)	KR100494179B1 (fr)
CN (2)	CN1128803C (fr)
AR (1)	AR011878A1 (fr)
AT (1)	ATE221888T1 (fr)
AU (1)	AU736062B2 (fr)
BR (1)	BR9807742B1 (fr)
CA (1)	CA2281105A1 (fr)
CZ (1)	CZ298027B6 (fr)
DE (2)	DE19880193D2 (fr)
DK (1)	DK0975638T3 (fr)
ES (1)	ES2183338T3 (fr)
HK (1)	HK1023774A1 (fr)
HU (1)	HU228851B1 (fr)
IL (1)	IL131343A (fr)
NO (1)	NO327211B1 (fr)
NZ (1)	NZ337195A (fr)
PL (1)	PL190422B1 (fr)
PT (1)	PT975638E (fr)
RU (1)	RU2201932C2 (fr)
TW (1)	TW480263B (fr)
WO (1)	WO1998038192A1 (fr)
ZA (1)	ZA981575B (fr)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
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US6288237B1 (en)	1995-11-17	2001-09-11	Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf)	Epothilons C and D, preparation and compositions
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US6867305B2 (en)	1996-12-03	2005-03-15	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US6204388B1 (en)	1996-12-03	2001-03-20	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
JP4579351B2 (ja)	1996-12-03	2010-11-10	スローン−ケッタリングインスティトュートフォアキャンサーリサーチ	エポチロンの合成とその中間体及びその類似物並びにその使用
US20050043376A1 (en) *	1996-12-03	2005-02-24	Danishefsky Samuel J.	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6660758B1 (en)	1996-12-13	2003-12-09	The Scripps Research Institute	Epothilone analogs
US6380394B1 (en)	1996-12-13	2002-04-30	The Scripps Research Institute	Epothilone analogs
US6441186B1 (en)	1996-12-13	2002-08-27	The Scripps Research Institute	Epothilone analogs
HU228851B1 (en) *	1997-02-25	2013-06-28	Biotechnolog Forschung Gmbh	Process for preparing epothilones with a modified side chain and compounds prepared by this process
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US6320045B1 (en)	1997-12-04	2001-11-20	Bristol-Myers Squibb Company	Process for the reduction of oxiranyl epothilones to olefinic epothilones
US6365749B1 (en)	1997-12-04	2002-04-02	Bristol-Myers Squibb Company	Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6683100B2 (en)	1999-01-19	2004-01-27	Novartis Ag	Organic compounds
US6380395B1 (en)	1998-04-21	2002-04-30	Bristol-Myers Squibb Company	12, 13-cyclopropane epothilone derivatives
US6498257B1 (en)	1998-04-21	2002-12-24	Bristol-Myers Squibb Company	2,3-olefinic epothilone derivatives
DE19826988A1 (de) *	1998-06-18	1999-12-23	Biotechnolog Forschung Gmbh	Epothilon-Nebenkomponenten
DE69804448T2 (de) *	1998-08-05	2002-11-07	Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf)	Epothilon A N-Oxid und/oder Epothilon B N-Oxid enthaltende pharmazeutische Agentien
US6780620B1 (en)	1998-12-23	2004-08-24	Bristol-Myers Squibb Company	Microbial transformation method for the preparation of an epothilone
US6596875B2 (en)	2000-02-07	2003-07-22	James David White	Method for synthesizing epothilones and epothilone analogs
DE19907588A1 (de) *	1999-02-22	2000-08-24	Biotechnolog Forschung Gmbh	C-21 Modifizierte Epothilone
ID29829A (id)	1999-02-22	2001-10-11	Bristol Myers Squibb Co	Epotilon termodifikasi pada c-21
US20020058286A1 (en) *	1999-02-24	2002-05-16	Danishefsky Samuel J.	Synthesis of epothilones, intermediates thereto and analogues thereof
US6291684B1 (en)	1999-03-29	2001-09-18	Bristol-Myers Squibb Company	Process for the preparation of aziridinyl epothilones from oxiranyl epothilones
RU2312860C2 (ru)	1999-04-15	2007-12-20	Бристол-Маерс Сквибб Компани	Циклические ингибиторы протеинтирозинкиназ
US7125875B2 (en)	1999-04-15	2006-10-24	Bristol-Myers Squibb Company	Cyclic protein tyrosine kinase inhibitors
AU772750C (en) *	1999-04-30	2005-02-24	Schering Aktiengesellschaft	6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
AR023792A1 (es) *	1999-04-30	2002-09-04	Bayer Schering Pharma Ag	Derivados 6-alquenilo- y 6-alquinilo-epotilona, los procedimientos para prepararlos y su empleo en productos farmaceuticos
WO2001024763A2 (fr)	1999-10-01	2001-04-12	Immunogen, Inc.	Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques
US6518421B1 (en)	2000-03-20	2003-02-11	Bristol-Myers Squibb Company	Process for the preparation of epothilone analogs
US6593115B2 (en)	2000-03-24	2003-07-15	Bristol-Myers Squibb Co.	Preparation of epothilone intermediates
US6589968B2 (en) *	2001-02-13	2003-07-08	Kosan Biosciences, Inc.	Epothilone compounds and methods for making and using the same
UA75365C2 (en)	2000-08-16	2006-04-17	Bristol Myers Squibb Co	Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon
WO2002058699A1 (fr) *	2001-01-25	2002-08-01	Bristol-Myers Squibb Company	Formes pharmaceutiques d'epothilones pour administration orale
RU2003126171A (ru)	2001-01-25	2005-02-27	Бристол-Маерс Сквибб Компани (Us)	Парентеральный состав, содержащий аналоги эпотилона
YU58203A (sh)	2001-01-25	2006-08-17	Bristol-Myers Squibb Company	Postupci primene epotilonskih analoga za lečenje kancera
US6893859B2 (en) *	2001-02-13	2005-05-17	Kosan Biosciences, Inc.	Epothilone derivatives and methods for making and using the same
EP1368030A1 (fr)	2001-02-20	2003-12-10	Bristol-Myers Squibb Company	Derives d'epothilone destines au traitement de tumeurs refractaires
EP1385529A4 (fr)	2001-02-20	2007-05-09	Bristol Myers Squibb Co	Traitement de tumeurs refractaires a l'aide de derives d'epothilone
IL157312A0 (en) *	2001-02-27	2004-02-19	Biotechnolog Forschung Gmbh	Processes for the preparation of epothilone derivatives and compounds produced thereby
CZ305799B6 (cs)	2001-03-14	2016-03-23	Bristol-Myers Squibb Company	Kombinace analogů epothilonu a chemoterapeutických činidel pro léčení proliferačních nemocí
MXPA03010909A (es)	2001-06-01	2004-02-17	Bristol Myers Squibb Co	Derivados de epotilona.
TW200303202A (en)	2002-02-15	2003-09-01	Bristol Myers Squibb Co	Method of preparation of 21-amino epothilone derivatives
PL371098A1 (en) *	2002-03-08	2005-06-13	Novartis Ag	Combinations comprising epothilone derivatives and alkylating agents
US7211593B2 (en)	2002-03-12	2007-05-01	Bristol-Myers Squibb Co.	C12-cyano epothilone derivatives
EP1483251B1 (fr)	2002-03-12	2009-12-23	Bristol-Myers Squibb Company	Derives de c3-cyano epothilone
TW200403994A (en)	2002-04-04	2004-03-16	Bristol Myers Squibb Co	Oral administration of EPOTHILONES
TW200400191A (en)	2002-05-15	2004-01-01	Bristol Myers Squibb Co	Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives
US7405234B2 (en)	2002-05-17	2008-07-29	Bristol-Myers Squibb Company	Bicyclic modulators of androgen receptor function
US7008936B2 (en)	2002-06-14	2006-03-07	Bristol-Myers Squibb Company	Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
US6921769B2 (en)	2002-08-23	2005-07-26	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
CN1759115A (zh)	2002-08-23	2006-04-12	索隆-基特林癌症研究协会	埃坡霉素(epothilone),合成埃坡霉素的中间体,其类似物及其用途
US7649006B2 (en)	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
GB0221312D0 (en) *	2002-09-13	2002-10-23	Novartis Ag	Organic compounds
EP2287168B1 (fr)	2002-09-23	2013-02-13	Bristol-Myers Squibb Company	Procédés de préparation, isolation et purification d'épothilone B, et structures de cristaux à rayons X d'épothilone B
EP1567487A4 (fr)	2002-11-15	2005-11-16	Bristol Myers Squibb Co	Modulateurs lies a prolyl uree a chaine ouverte de la fonction du recepteur d'androgene
US7820702B2 (en)	2004-02-04	2010-10-26	Bristol-Myers Squibb Company	Sulfonylpyrrolidine modulators of androgen receptor function and method
US7378426B2 (en)	2004-03-01	2008-05-27	Bristol-Myers Squibb Company	Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7696241B2 (en)	2004-03-04	2010-04-13	Bristol-Myers Squibb Company	Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en)	2004-03-04	2009-12-01	Bristol-Myers Squibb Company	Bicyclic modulators of androgen receptor function
DK1817013T3 (da) *	2004-11-18	2008-10-13	Brystol Myers Squibb Company	Enterisk coatet kugle omfattende Ixabepilon
WO2006055742A1 (fr) *	2004-11-18	2006-05-26	Bristol-Myers Squibb Company	Bille enrobee de keratine comprenant de l'epothilone ou un analogue d'epothilone, ainsi que preparation et administration de cette bille
JP4954983B2 (ja)	2005-05-18	2012-06-20	ファーマサイエンス・インコーポレイテッド	Ｂｉｒドメイン結合化合物
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BR112013018534B1 (pt)	2011-01-20	2021-04-06	Board Of Regents, The University Of Texas System	Agente de contraste, seus métodos de preparação, e produto de combinação
RU2617402C2 (ru)	2011-06-10	2017-04-25	Мерсана Терапьютикс, Инк.	Конъюгаты белок-полимер-лекарственное средство
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CN102993239A (zh)	2011-09-19	2013-03-27	陈小平	离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物
US9725477B2 (en)	2012-11-17	2017-08-08	Beijing Fswelcome Technology Development Co., Ltd	Platinum compounds of malonic acid derivative having leaving group containing amino or alkylamino
AU2013359506B2 (en)	2012-12-10	2018-05-24	Mersana Therapeutics, Inc.	Protein-polymer-drug conjugates
EP2931316B1 (fr)	2012-12-12	2019-02-20	Mersana Therapeutics, Inc.	Conjugués hydroxy-polymère-médicament-protéine
EA201600003A1 (ru)	2013-06-11	2016-06-30	Байер Фарма Акциенгезельшафт	КОМБИНАЦИИ ДЛЯ ЛЕЧЕНИЯ РАКА, СОДЕРЖАЩИЕ ИНГИБИТОР Mps-1 КИНАЗЫ И ИНГИБИТОР МИТОЗА
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EP3474901A1 (fr)	2016-06-27	2019-05-01	Tagworks Pharmaceuticals B.V.	Tétrazine clivable utilisée dans l'activation de médicaments bio-orthogonaux
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EP3788032B1 (fr)	2018-05-04	2024-01-24	Tagworks Pharmaceuticals B.V.	Composés comprenant un lieur pour augmenter la stabilité de transcyclooctène
WO2019212356A1 (fr)	2018-05-04	2019-11-07	Tagworks Pharmaceuticals B .V.	Tétrazines pour un rendement élevé de conjugaison de chimie click in vivo et un rendement élevé de libération de chimie click
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CA3230774A1 (fr)	2021-09-06	2023-03-09	Veraxa Biotech Gmbh	Nouveaux variants d'aminoacyl-arnt synthetase pour l'expansion de code genetique dans des eucaryotes
CA3238627A1 (fr)	2021-11-25	2023-06-01	Christine Kohler	Conjugues anticorps-charge utile ameliores (apc) prepares par conjugaison specifique a un site a l'aide d'une expansion de code genetique
EP4186529A1 (fr)	2021-11-25	2023-05-31	Veraxa Biotech GmbH	Conjugués anticorps-charge utile améliorés (apcs) préparés par conjugaison spécifique à un site à l'aide d'une expansion de code génétique
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Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4138042C2 (de) *	1991-11-19	1993-10-14	Biotechnolog Forschung Gmbh	Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
US6288237B1 (en) *	1995-11-17	2001-09-11	Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf)	Epothilons C and D, preparation and compositions
US6441186B1 (en) *	1996-12-13	2002-08-27	The Scripps Research Institute	Epothilone analogs
HU228851B1 (en) *	1997-02-25	2013-06-28	Biotechnolog Forschung Gmbh	Process for preparing epothilones with a modified side chain and compounds prepared by this process

1998
- 1998-02-25 HU HU0002189A patent/HU228851B1/hu unknown
- 1998-02-25 ZA ZA981575A patent/ZA981575B/xx unknown
- 1998-02-25 CN CN98802842A patent/CN1128803C/zh not_active Expired - Fee Related
- 1998-02-25 EP EP02001063A patent/EP1201666A3/fr not_active Ceased
- 1998-02-25 WO PCT/EP1998/001060 patent/WO1998038192A1/fr active IP Right Grant
- 1998-02-25 DE DE19880193T patent/DE19880193D2/de not_active Expired - Lifetime
- 1998-02-25 PT PT98912388T patent/PT975638E/pt unknown
- 1998-02-25 KR KR10-1999-7007773A patent/KR100494179B1/ko not_active Expired - Fee Related
- 1998-02-25 CZ CZ0286599A patent/CZ298027B6/cs not_active IP Right Cessation
- 1998-02-25 IL IL13134398A patent/IL131343A/en not_active IP Right Cessation
- 1998-02-25 AU AU67249/98A patent/AU736062B2/en not_active Ceased
- 1998-02-25 ES ES98912388T patent/ES2183338T3/es not_active Expired - Lifetime
- 1998-02-25 PL PL98335329A patent/PL190422B1/pl unknown
- 1998-02-25 DK DK98912388T patent/DK0975638T3/da active
- 1998-02-25 DE DE59805110T patent/DE59805110D1/de not_active Expired - Lifetime
- 1998-02-25 AT AT98912388T patent/ATE221888T1/de active
- 1998-02-25 CA CA002281105A patent/CA2281105A1/fr not_active Abandoned
- 1998-02-25 RU RU99120378/04A patent/RU2201932C2/ru not_active IP Right Cessation
- 1998-02-25 NZ NZ337195A patent/NZ337195A/en unknown
- 1998-02-25 BR BRPI9807742-2A patent/BR9807742B1/pt not_active IP Right Cessation
- 1998-02-25 JP JP53730098A patent/JP2001513098A/ja not_active Withdrawn
- 1998-02-25 EP EP98912388A patent/EP0975638B1/fr not_active Expired - Lifetime
- 1998-02-25 CN CNA031597866A patent/CN1544436A/zh active Pending
- 1998-02-26 AR ARP980100851A patent/AR011878A1/es unknown
- 1998-05-28 TW TW087102758A patent/TW480263B/zh not_active IP Right Cessation
1999
- 1999-08-17 US US09/376,754 patent/US6359140B1/en not_active Expired - Lifetime
- 1999-08-24 NO NO19994071A patent/NO327211B1/no not_active IP Right Cessation
2000
- 2000-05-19 HK HK00102999A patent/HK1023774A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ286599A3 (cs)	2000-03-15
BR9807742B1 (pt)	2010-12-14
DE59805110D1 (de)	2002-09-12
ATE221888T1 (de)	2002-08-15
IL131343A0 (en)	2001-01-28
DE19880193D2 (de)	2000-08-24
AU736062B2 (en)	2001-07-26
RU2201932C2 (ru)	2003-04-10
PT975638E (pt)	2002-12-31
KR100494179B1 (ko)	2005-06-10
JP2001513098A (ja)	2001-08-28
KR20000075705A (ko)	2000-12-26
CN1544436A (zh)	2004-11-10
PL190422B1 (pl)	2005-12-30
ES2183338T3 (es)	2003-03-16
EP1201666A2 (fr)	2002-05-02
CN1128803C (zh)	2003-11-26
ZA981575B (en)	1998-09-08
HK1023774A1 (en)	2000-09-22
HU228851B1 (en)	2013-06-28
EP0975638A1 (fr)	2000-02-02
AR011878A1 (es)	2000-09-13
CA2281105A1 (fr)	1998-09-03
CZ298027B6 (cs)	2007-05-30
EP1201666A3 (fr)	2003-03-05
NO994071L (no)	1999-10-21
NZ337195A (en)	2001-05-25
NO327211B1 (no)	2009-05-11
PL335329A1 (en)	2000-04-25
BR9807742A (pt)	2000-02-22
CN1248974A (zh)	2000-03-29
HUP0002189A3 (en)	2001-12-28
IL131343A (en)	2004-03-28
WO1998038192A1 (fr)	1998-09-03
AU6724998A (en)	1998-09-18
TW480263B (en)	2002-03-21
HUP0002189A2 (hu)	2001-10-28
EP0975638B1 (fr)	2002-08-07
US6359140B1 (en)	2002-03-19
NO994071D0 (no)	1999-08-24

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DK0975638T3 (da)	2002-11-18	Sidekædemodificerede epothiloner
DE69832294D1 (de)	2005-12-15	Epothilonderivate
DE19810476B4 (de)	2005-10-20	Laryngomaske
ATA93198A (de)	2001-01-15	Fluoxetinpellets
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ID23803A (id)	2000-05-11	Turunan-turunan 2-(4-aril atau heteroaril-piperazin-1-ilmetil)-1h-indola
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DE59804631D1 (de)	2002-08-08	Diketopyrrolopyrrolzusammensetzungen
DE59802506D1 (de)	2002-01-31	Weichspülmittelzusammemsetzung
NO20002555D0 (no)	2000-05-18	Skjøt
DE59801498D1 (de)	2001-10-25	Dioxacycloalkan-8-one
DE59804377D1 (de)	2002-07-18	Kryoventil
DE59710388D1 (de)	2003-08-07	Mikropolarimeter
ATE236897T1 (de)	2003-04-15	3-benzylpiperidine
ATA112597A (de)	1999-03-15	Snowboard - bindung
DE19881798D2 (de)	2001-04-12	Waschtisch
ATA86797A (de)	2002-02-15	Verschleissschuh
DE59800820D1 (de)	2001-07-12	Stiellose kniegelenkendoprothese
ATA46498A (de)	2002-02-15	Kunststoffgleitbahn
BR9701194A (pt)	1998-12-15	Hidrociclo
ATA161897A (de)	1999-10-15	Zielfernrohr
ATA118697A (de)	1999-10-15	Zielfernrohr
KR970018153U (ko)	1997-05-23	세면대
ATE421585T1 (de)	2009-02-15	Motlinhomologe