DK0797567T3 - Nye aminosyrederivater med forbedret multilægemiddelresistensaktivitet - Google Patents

Nye aminosyrederivater med forbedret multilægemiddelresistensaktivitet

Info

Publication number: DK0797567T3
Authority: DK; Denmark
Prior art keywords: amino acid; acid derivatives; drug resistance; novel amino; enhanced multi
Prior art date: 1994-11-16

Application number

DK95939156T

Other languages

Danish (da)

English (en)

Inventor

Matthew W Harding

Robert E Zelle

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-16

Filing date

1995-11-13

Publication date

2004-06-14

1995-01-23 Priority claimed from US08/377,285 external-priority patent/US5543423A/en

1995-11-13 Application filed by Vertex Pharma filed Critical Vertex Pharma

2004-06-14 Application granted granted Critical

2004-06-14 Publication of DK0797567T3 publication Critical patent/DK0797567T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Peptides Or Proteins (AREA)

DK95939156T 1994-11-16 1995-11-13 Nye aminosyrederivater med forbedret multilægemiddelresistensaktivitet DK0797567T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US34083094A	1994-11-16	1994-11-16
US08/377,285 US5543423A (en)	1994-11-16	1995-01-23	Amino acid derivatives with improved multi-drug resistance activity

Publications (1)

Publication Number	Publication Date
DK0797567T3 true DK0797567T3 (da)	2004-06-14

Family

ID=26992255

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95939156T DK0797567T3 (da)	1994-11-16	1995-11-13	Nye aminosyrederivater med forbedret multilægemiddelresistensaktivitet

Country Status (25)

Country	Link
EP (1)	EP0797567B1 (fr)
JP (1)	JP3921239B2 (fr)
AP (1)	AP781A (fr)
AT (1)	ATE259349T1 (fr)
AU (1)	AU689991B2 (fr)
BR (1)	BR9509698A (fr)
CA (1)	CA2224198A1 (fr)
CZ (1)	CZ298586B6 (fr)
DE (1)	DE69532561T2 (fr)
DK (1)	DK0797567T3 (fr)
ES (1)	ES2216022T3 (fr)
FI (1)	FI972086A7 (fr)
HK (1)	HK1003636A1 (fr)
HU (1)	HU226136B1 (fr)
IL (1)	IL115685A (fr)
MX (1)	MX9703621A (fr)
NO (1)	NO323292B1 (fr)
NZ (2)	NZ296474A (fr)
PL (1)	PL182327B1 (fr)
PT (1)	PT797567E (fr)
RO (1)	RO121113B1 (fr)
SI (1)	SI0797567T1 (fr)
SK (1)	SK282069B6 (fr)
TJ (1)	TJ321B (fr)
WO (1)	WO1996015101A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5846981A (en) *	1993-05-28	1998-12-08	Gpi Nil Holdings Inc.	Inhibitors of rotamase enzyme activity
US5798355A (en) *	1995-06-07	1998-08-25	Gpi Nil Holdings, Inc.	Inhibitors of rotamase enzyme activity
US5859031A (en) *	1995-06-07	1999-01-12	Gpi Nil Holdings, Inc.	Small molecule inhibitors of rotamase enzyme activity
US5696135A (en) *	1995-06-07	1997-12-09	Gpi Nil Holdings, Inc.	Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US5801197A (en) *	1995-10-31	1998-09-01	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US6218424B1 (en)	1996-09-25	2001-04-17	Gpi Nil Holdings, Inc.	Heterocyclic ketone and thioester compounds and uses
US5786378A (en) *	1996-09-25	1998-07-28	Gpi Nil Holdings, Inc.	Heterocyclic thioesters
US5801187A (en) *	1996-09-25	1998-09-01	Gpi-Nil Holdings, Inc.	Heterocyclic esters and amides
US5840736A (en) *	1996-11-13	1998-11-24	Vertex Pharmaceuticals Incorporated	Methods and compositions for stimulating neurite growth
US5811434A (en) *	1996-11-13	1998-09-22	Vertex Pharmacueticals Incorporated	Methods and compositions for stimulating neurite growth
US5780484A (en) *	1996-11-13	1998-07-14	Vertex Pharmaceuticals Incorporated	Methods for stimulating neurite growth with piperidine compounds
US6242468B1 (en) *	1997-02-27	2001-06-05	Jia-He Li	Carbamate and urea compositions and neurotrophic uses
US5846979A (en)	1997-02-28	1998-12-08	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic esters, amides, thioesters, and ketones
US20010049381A1 (en)	1997-06-04	2001-12-06	Gpl Nil Holdings, Inc.,	Pyrrolidine derivative hair growth compositions and uses
US6268384B1 (en)	1997-08-29	2001-07-31	Vertex Pharmaceuticals Incorporated	Compounds possessing neuronal activity
CA2333679A1 (fr) *	1998-06-03	1999-12-09	Gpi Nil Holdings, Inc.	Compositions pour la croissance des cheveux a base de petites molecules de carbamates ou d'urees et utilisation de ces compositions
US6331537B1 (en)	1998-06-03	2001-12-18	Gpi Nil Holdings, Inc.	Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6399648B1 (en)	1998-08-14	2002-06-04	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6384056B1 (en)	1998-08-14	2002-05-07	Gpi Nil Holdings, Inc.	Heterocyclic thioesters or ketones for vision and memory disorders
US6376517B1 (en)	1998-08-14	2002-04-23	Gpi Nil Holdings, Inc.	Pipecolic acid derivatives for vision and memory disorders
US6335348B1 (en)	1998-08-14	2002-01-01	Gpi Nil Holdings, Inc.	Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6333340B1 (en)	1998-08-14	2001-12-25	Gpi Nil Holdings, Inc.	Small molecule sulfonamides for vision and memory disorders
US6339101B1 (en)	1998-08-14	2002-01-15	Gpi Nil Holdings, Inc.	N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6395758B1 (en) *	1998-08-14	2002-05-28	Gpi Nil Holdings, Inc.	Small molecule carbamates or ureas for vision and memory disorders
US6506788B1 (en)	1998-08-14	2003-01-14	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6337340B1 (en)	1998-08-14	2002-01-08	Gpi Nil Holdings, Inc.	Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US7338976B1 (en)	1998-08-14	2008-03-04	Gpi Nil Holdings, Inc.	Heterocyclic esters or amides for vision and memory disorders
US6218423B1 (en)	1998-08-14	2001-04-17	Gpi Nil Holdings, Inc.	Pyrrolidine derivatives for vision and memory disorders
US6462072B1 (en)	1998-09-21	2002-10-08	Gpi Nil Holdings, Inc.	Cyclic ester or amide derivatives
US6300341B1 (en)	1998-09-30	2001-10-09	The Procter & Gamble Co.	2-substituted heterocyclic sulfonamides
US6307049B1 (en)	1998-09-30	2001-10-23	The Procter & Gamble Co.	Heterocyclic 2-substituted ketoamides
WO2000018725A1 (fr) *	1998-09-30	2000-04-06	The Procter & Gamble Company	Cetoamides 2-substitues
AU2407400A (en) *	1999-01-08	2000-07-24	Vertex Pharmaceuticals Incorporated	Process for the formation of intermediates useful for the preparation of pharmaceuticals
JP2001031635A (ja) *	1999-07-14	2001-02-06	Ajinomoto Co Inc	光学活性ｎ−保護−ｎ−メチル−フェニルアラニン誘導体の製造方法
US6693099B2 (en)	2000-10-17	2004-02-17	The Procter & Gamble Company	Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en)	2000-10-17	2002-04-23	The Procter & Gamble Co.	Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US7345068B2 (en) *	2002-02-07	2008-03-18	Hitoshi Endou	Aromatic amino acid derivatives and medicinal compositions
WO2011031926A1 (fr)	2009-09-11	2011-03-17	Vertex Pharmaceuticals Incorporated	Compositions de n-benzyl-3-(4-chlorophényl)-2-[méthyl-[2-oxo-2-(3,4,5-triméthoxyphényl)acétyl]amino]-n-[3-(4-pyridyl)-1-[2-[4-pyridyl)éthyl]propanamide et leurs utilisations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2074061A1 (fr) *	1991-08-26	1993-02-27	Ivo Monkovic	Benzamides, agents d'inversion de la resistance multiple aux anti-cancereux
NZ314207A (en) *	1992-09-28	2000-12-22	Vertex Pharma	1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers
US5744485A (en) *	1994-03-25	1998-04-28	Vertex Pharmaceuticals Incorporated	Carbamates and ureas as modifiers of multi-drug resistance

1995
- 1995-10-19 IL IL11568595A patent/IL115685A/xx not_active IP Right Cessation
- 1995-11-13 HU HU9802168A patent/HU226136B1/hu not_active IP Right Cessation
- 1995-11-13 DK DK95939156T patent/DK0797567T3/da active
- 1995-11-13 JP JP51630696A patent/JP3921239B2/ja not_active Expired - Fee Related
- 1995-11-13 CZ CZ0149197A patent/CZ298586B6/cs not_active IP Right Cessation
- 1995-11-13 NZ NZ296474A patent/NZ296474A/xx not_active IP Right Cessation
- 1995-11-13 PL PL95320227A patent/PL182327B1/pl not_active IP Right Cessation
- 1995-11-13 AU AU41099/96A patent/AU689991B2/en not_active Ceased
- 1995-11-13 PT PT95939156T patent/PT797567E/pt unknown
- 1995-11-13 FI FI972086A patent/FI972086A7/fi not_active Application Discontinuation
- 1995-11-13 BR BR9509698A patent/BR9509698A/pt not_active IP Right Cessation
- 1995-11-13 AT AT95939156T patent/ATE259349T1/de not_active IP Right Cessation
- 1995-11-13 RO RO97-00899A patent/RO121113B1/ro unknown
- 1995-11-13 WO PCT/US1995/014841 patent/WO1996015101A1/fr active IP Right Grant
- 1995-11-13 DE DE69532561T patent/DE69532561T2/de not_active Expired - Lifetime
- 1995-11-13 SI SI9530702T patent/SI0797567T1/xx unknown
- 1995-11-13 SK SK611-97A patent/SK282069B6/sk not_active IP Right Cessation
- 1995-11-13 AP APAP/P/1997/000999A patent/AP781A/en active
- 1995-11-13 ES ES95939156T patent/ES2216022T3/es not_active Expired - Lifetime
- 1995-11-13 CA CA002224198A patent/CA2224198A1/fr not_active Abandoned
- 1995-11-13 TJ TJ97000470A patent/TJ321B/xx unknown
- 1995-11-13 MX MX9703621A patent/MX9703621A/es not_active IP Right Cessation
- 1995-11-13 EP EP95939156A patent/EP0797567B1/fr not_active Expired - Lifetime
1997
- 1997-05-14 NO NO19972217A patent/NO323292B1/no not_active IP Right Cessation
1998
- 1998-04-01 HK HK98102763A patent/HK1003636A1/xx not_active IP Right Cessation
- 1998-12-15 NZ NZ333373A patent/NZ333373A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
AP781A (en)	1999-11-04
FI972086A0 (fi)	1997-05-15
FI972086L (fi)	1997-05-15
PL320227A1 (en)	1997-09-15
NZ333373A (en)	2000-07-28
FI972086A7 (fi)	1997-05-15
AP9700999A0 (en)	1997-07-31
NZ296474A (en)	1999-01-28
RO121113B1 (ro)	2006-12-29
IL115685A (en)	2000-08-31
EP0797567B1 (fr)	2004-02-11
SK61197A3 (en)	1997-11-05
SI0797567T1 (en)	2004-06-30
AU689991B2 (en)	1998-04-09
MX9703621A (es)	1997-08-30
ATE259349T1 (de)	2004-02-15
DE69532561D1 (de)	2004-03-18
SK282069B6 (sk)	2001-10-08
IL115685A0 (en)	1996-01-19
HK1003636A1 (en)	1998-11-06
NO972217D0 (no)	1997-05-14
HU226136B1 (en)	2008-05-28
CZ298586B6 (cs)	2007-11-14
JP3921239B2 (ja)	2007-05-30
CA2224198A1 (fr)	1996-05-23
BR9509698A (pt)	1998-06-30
TJ321B (en)	2001-10-22
WO1996015101A1 (fr)	1996-05-23
ES2216022T3 (es)	2004-10-16
EP0797567A1 (fr)	1997-10-01
NO972217L (no)	1997-06-17
DE69532561T2 (de)	2004-12-23
HUT77977A (hu)	1999-01-28
NO323292B1 (no)	2007-03-05
AU4109996A (en)	1996-06-06
PT797567E (pt)	2004-06-30
JPH10509151A (ja)	1998-09-08
CZ149197A3 (en)	1997-10-15
PL182327B1 (pl)	2001-12-31

Publication	Publication Date	Title
DK0797567T3 (da)	2004-06-14	Nye aminosyrederivater med forbedret multilægemiddelresistensaktivitet
ZA959304B (en)	1996-05-29	Amino acid derivatives with improved multi-drug resistance activity
NO965394D0 (no)	1996-12-13	Nye substituerte purinylderivater med immunomodulerende aktivitet
DE59008394D1 (de)	1995-03-16	Aminosäureamid-Derivate.
PT900210E (pt)	2005-06-30	Derivados azahexano heterociclicos com actividade antviral
NO972525L (no)	1997-12-05	Nye benzimidazolderivater med antihistaminaktivitet
FI901490A7 (fi)	1990-09-29	Aminohappojohdannaiset
NO970088D0 (no)	1997-01-09	Acylazolonderivater med anti-Helicobacteraktivitet
NO983356D0 (no)	1998-07-21	Nye 19-nor-pregnenderivater
FI904360A7 (fi)	1991-03-05	Aminohappojohdannaiset
FI955316A7 (fi)	1995-12-22	Vitamiini D:n amidijohdannaisia
FI954255A7 (fi)	1996-03-16	2,9-diamino- ja 2-amino-8-karbaomyyli-4-hydroksi-alkaanihappoamidijohdannaiset
NO950477D0 (no)	1995-02-09	Aminosyrederivater
NO901759L (no)	1990-10-23	Dipeptid-derivater med enzym-hemmende virkning.
NO970086L (no)	1997-03-10	Heterocykliske azolonderivater med anti-Helicobacteraktivitet
NO960268D0 (no)	1996-01-23	Nye dialkoksypyridinylbenzimidazolderivater
FI901730A7 (fi)	1990-10-06	Aminohappojohdannaisia
FI956016L (fi)	1996-06-17	1,2-silloitettujen 1,4-dihydropyridiinien käyttö lääkeaineina
DE69508700D1 (de)	1999-05-06	Aminosäurederivat mit Anti-CCK-Aktivität
DE59002430D1 (de)	1993-09-30	Cyclopropanoylaminosäureamid-Derivate.
FI901697A7 (fi)	1990-10-05	Aminohappojohdannaisia
FI960119A0 (fi)	1996-01-10	Peptidit, joilla on oksitosiinin vastaista aktiivisuutta
FR2633493B3 (fr)	1990-06-15	Coupe-vent perfectionne
NO920307D0 (no)	1992-01-23	Nye dihydro-isokinolinderivater med farmasoeytisk virkning
SE8903369D0 (sv)	1989-10-13	Motstaandssvetsning med mellanlaegg