DK0766668T3 - Fremgangsmåde til fremstilling af vandfrie og hydratformer af som antihistaminer anvendelige piperidinderivater, polymorfer og pseudo-morfer deraf - Google Patents

Fremgangsmåde til fremstilling af vandfrie og hydratformer af som antihistaminer anvendelige piperidinderivater, polymorfer og pseudo-morfer deraf

Info

Publication number: DK0766668T3
Authority: DK; Denmark
Prior art keywords: antihistamines; polymorphs; anhydrous; morphs; pseudo
Prior art date: 1994-05-18

Application number

DK95918278T

Other languages

Danish (da)

English (en)

Inventor

Frederick J Mccarty

Daniel R Henton

Susan I Tripp

Jill E Dewitt

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-18

Filing date

1995-04-28

Publication date

2002-10-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26937420&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0766668(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-04-28 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2002-10-28 Application granted granted Critical

2002-10-28 Publication of DK0766668T3 publication Critical patent/DK0766668T3/da

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Peptides Or Proteins (AREA)

DK95918278T 1994-05-18 1995-04-28 Fremgangsmåde til fremstilling af vandfrie og hydratformer af som antihistaminer anvendelige piperidinderivater, polymorfer og pseudo-morfer deraf DK0766668T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US24573194A	1994-05-18	1994-05-18
US41716195A	1995-04-11	1995-04-11
PCT/US1995/004942 WO1995031437A1 (fr)	1994-05-18	1995-04-28	Procedes de preparation de formes anhydres et hydratees de derives de piperidine antihistaminiques, polymorphes et pseudomorphes de ces dernieres

Publications (1)

Publication Number	Publication Date
DK0766668T3 true DK0766668T3 (da)	2002-10-28

Family

ID=26937420

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95918278T DK0766668T3 (da)	1994-05-18	1995-04-28	Fremgangsmåde til fremstilling af vandfrie og hydratformer af som antihistaminer anvendelige piperidinderivater, polymorfer og pseudo-morfer deraf

Country Status (18)

Country	Link
US (12)	US20010012896A1 (fr)
EP (3)	EP2354125A1 (fr)
JP (7)	JPH10500134A (fr)
CN (3)	CN1623985A (fr)
AT (1)	ATE220667T1 (fr)
AU (1)	AU693892B2 (fr)
CA (3)	CA2449419C (fr)
DE (1)	DE69527429T2 (fr)
DK (1)	DK0766668T3 (fr)
ES (1)	ES2176329T3 (fr)
FI (1)	FI964565A0 (fr)
HK (2)	HK1098467A1 (fr)
HU (1)	HU227676B1 (fr)
IL (3)	IL113747A (fr)
MX (1)	MX9605613A (fr)
NO (1)	NO315319B1 (fr)
PT (1)	PT766668E (fr)
WO (1)	WO1995031437A1 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9400555D0 (en) *	1994-01-13	1994-03-09	Short Brothers Plc	Boundery layer control in aerodynamic low drag structures
WO1995031437A1 (fr) *	1994-05-18	1995-11-23	Hoechst Marrion Roussel, Inc.	Procedes de preparation de formes anhydres et hydratees de derives de piperidine antihistaminiques, polymorphes et pseudomorphes de ces dernieres
DK0812195T3 (da) *	1995-02-28	2003-03-03	Aventis Pharma Inc	Farmaceutisk sammensætning til piperidinoalkanolforbindelser
CZ295461B6 (cs) *	1997-08-26	2005-08-17	Aventis Pharmaceuticals Inc.	Farmaceutický prostředek ve formě dvouvrstvé tablety
IN191492B (fr) *	1999-05-25	2003-12-06	Ranbaxy Lab Ltd
US6613906B1 (en)	2000-06-06	2003-09-02	Geneva Pharmaceuticals, Inc.	Crystal modification
CH695216A5 (de)	2001-02-23	2006-01-31	Cilag Ag	Verfahren zur Herstellung eines nicht hydratisierten Salzes eines Piperidinderivats und eine so erhältliche neue kristalline Form eines solchen Salzes.
KR20040012747A (ko) *	2001-04-09	2004-02-11	테바 파마슈티컬 인더스트리즈 리미티드	펙소페나딘 염산염의 다형체
US20030021849A1 (en) *	2001-04-09	2003-01-30	Ben-Zion Dolitzky	Polymorphs of fexofenadine hydrochloride
US7700779B2 (en) *	2001-06-18	2010-04-20	Dr. Reddy's Laboratories Limited	Crystalline forms of fexofenadine and its hydrochloride
EP2261209A1 (fr) *	2001-06-18	2010-12-15	Dr. Reddy's Laboratories Ltd.	Nouvelles formes crystallines d'acide acetique de 4-[4-[4- Hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha, alpha-dimethylbenzene et leur acide chlorhydrique
ATE389405T1 (de) *	2001-07-31	2008-04-15	Texcontor Ets	Fexofenadine hydrochlorid polymorph
US20030158227A1 (en) *	2001-11-08	2003-08-21	Barnaba Krochmal	Polymorphs of fexofenadine base
EP1474392A1 (fr) *	2002-06-10	2004-11-10	Teva Pharmaceutical Industries Ltd.	Forme polymorphe xvi de l'hydrochlorure de fexofenadine
JP3910907B2 (ja) *	2002-10-29	2007-04-25	新光電気工業株式会社	キャパシタ素子及びこの製造方法、半導体装置用基板、並びに半導体装置
WO2005005447A2 (fr) *	2003-07-03	2005-01-20	Teva Pharmaceutical Industries Ltd.	Formes cristallines d'acide zoledronique, formes cristallines de sel de sodium de zoledronate, sel de sodium de zoledronate amorphe et procedes de preparation de ceux-ci
GB0319935D0 (en) *	2003-08-26	2003-09-24	Cipla Ltd	Polymorphs
JP2007532687A (ja) *	2004-04-26	2007-11-15	テバファーマシューティカルインダストリーズリミティド	フェキソフェナジン塩酸塩の結晶形およびその製造方法
ITMI20041143A1 (it)	2004-06-08	2004-09-08	Dipharma Spa	Polimorfi di fexofenadina e procedimento per la loro preparazione
EP1616861A3 (fr) *	2004-06-15	2006-02-08	Dipharma S.p.A.	Procédé de préparation de composés cétoniques
ITMI20041568A1 (it) *	2004-07-30	2004-10-30	Dipharma Spa	"polimorfi di fexofenadina base"
JP2008514641A (ja) *	2004-09-28	2008-05-08	テバファーマシューティカルインダストリーズリミティド	結晶形フェキソフェナジン、およびその調製方法
DOP2006000274A (es) *	2005-12-14	2007-10-15	Sanofi Aventis Us Llc	Formulación de suspensión de fexofenadina
WO2008008434A1 (fr) *	2006-07-11	2008-01-17	Mutual Pharmaceutical Company, Inc.	Formulations à libération controlée
US20090076080A1 (en) *	2007-09-19	2009-03-19	Protia, Llc	Deuterium-enriched fexofenadine
US20090306135A1 (en)	2008-03-24	2009-12-10	Mukesh Kumar Sharma	Stable amorphous fexofenadine hydrochloride
US20100183717A1 (en) *	2009-01-16	2010-07-22	Kristin Arnold	Controlled-release formulations
WO2011054741A2 (fr)	2009-11-06	2011-05-12	Basf Se	Complexes cristallins d'acide 4-hydroxybenzoïque et de pesticides sélectionnés
ES2403130B1 (es)	2010-06-15	2014-09-29	Chemelectiva S.R.L.	Forma polimórfica de clorhidrato de fexofenadina, compuestos intermedios y procedimiento para su preparación
IT1400965B1 (it)	2010-06-15	2013-07-05	Dipharma Francis Srl	Polimorfi di fexofenadina
US9420872B2 (en) *	2010-08-23	2016-08-23	Jason Bird	Apparatus and system for holding game-calling devices
JP2012087100A (ja) *	2010-10-21	2012-05-10	Sumitomo Chemical Co Ltd	形態ｉのフェキソフェナジン一塩酸塩の製造方法
CN104072402B (zh) *	2014-07-16	2016-08-17	昆山龙灯瑞迪制药有限公司	一种新结晶形式的盐酸非索非那定化合物及其制备方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US631375A (en) *	1899-04-12	1899-08-22	Ephraim Musselman	Face-protector.
US3448152A (en) *	1966-11-03	1969-06-03	Jefferson Chem Co Inc	Amine recovery
BE794598A (fr) *	1972-01-28	1973-05-16	Richardson Merrell Inc	Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation
US3878217A (en) *	1972-01-28	1975-04-15	Richardson Merrell Inc	Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3965257A (en) *	1972-01-28	1976-06-22	Richardson-Merrell Inc.	Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
US4285957A (en) *	1979-04-10	1981-08-25	Richardson-Merrell Inc.	1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
US4285958A (en) *	1979-04-10	1981-08-25	Richardson-Merrell Inc.	1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof
US4254129A (en) *	1979-04-10	1981-03-03	Richardson-Merrell Inc.	Piperidine derivatives
US4254130A (en)	1979-04-10	1981-03-03	Richardson-Merrell Inc.	Piperidine derivatives
IL63968A (en) *	1980-10-01	1985-10-31	Glaxo Group Ltd	Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
US4742175A (en) *	1986-05-07	1988-05-03	Merrell Dow Pharmaceuticals Inc.	Preparation of polymorphically pure terfenadine
JPH02213431A (ja) *	1989-02-13	1990-08-24	Kobe Steel Ltd	ＳｉＣウィスカ強化Ａｌ合金複合材料
DE4034218A1 (de) *	1990-10-27	1992-04-30	Merck Patent Gmbh	Verfahren zur herstellung von carebastin
TW198008B (fr) *	1991-04-08	1993-01-11	Green Cross Corp
MX9302076A (es) *	1992-04-10	1994-03-31	Merrell Dow Pharma	Proceso novedoso para preparar derivados de piperidina.
US5631375A (en)	1992-04-10	1997-05-20	Merrell Pharmaceuticals, Inc.	Process for piperidine derivatives
WO1993023047A1 (fr) *	1992-05-11	1993-11-25	Merrell Dow Pharmaceuticals Inc.	Utilisation de derives de terfenadine en tant qu'antihistaminiques chez un patient souffrant de troubles hepatiques
DE69334008T2 (de)	1992-08-03	2006-10-19	Sepracor Inc., Marlborough	Terfenadin-Carboxylat und die Behandlung von allergischen Erkrankungen
US5315016A (en)	1992-10-13	1994-05-24	Nycomed Dak A/S	Process for preparing pure podophyllotoxin
CA2254506C (fr)	1993-06-24	2000-11-28	Albany Molecular Research, Inc.	Derives de la piperidine et methode de preparation
ATE322473T1 (de)	1993-06-24	2006-04-15	Amr Technology Inc	Verfahren zur herstellung von verbindungen geeignet als zwischenprodukte
CA2166059C (fr)	1993-06-25	2005-08-16	Richard Carl Krauss	Nouveaux intermediaires pour la preparation de derives de 4-diphenylmethyl/diphenylmethoxy piperidine, antihistaminiques
US6147216A (en)	1993-06-25	2000-11-14	Merrell Pharmaceuticals Inc.	Intermediates useful for the preparation of antihistaminic piperidine derivatives
WO1995031437A1 (fr) *	1994-05-18	1995-11-23	Hoechst Marrion Roussel, Inc.	Procedes de preparation de formes anhydres et hydratees de derives de piperidine antihistaminiques, polymorphes et pseudomorphes de ces dernieres
US5576610A (en) *	1994-07-05	1996-11-19	Motorola, Inc.	Method and apparatus for determining battery characteristics
IL134772A (en)	1995-02-28	2002-02-10	Aventis Pharma Inc	Pharmaceutical compositions of piperidinoalkanol compounds in solid unit dosage form
DK0812195T3 (da)	1995-02-28	2003-03-03	Aventis Pharma Inc	Farmaceutisk sammensætning til piperidinoalkanolforbindelser
US5574045A (en) *	1995-06-06	1996-11-12	Hoechst Marion Roussel, Inc.	Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
CZ295461B6 (cs) *	1997-08-26	2005-08-17	Aventis Pharmaceuticals Inc.	Farmaceutický prostředek ve formě dvouvrstvé tablety
US6214427B1 (en) *	1998-08-28	2001-04-10	General Electric Company	Method of making an electronic device having a single crystal substrate formed by solid state crystal conversion
US6613906B1 (en) *	2000-06-06	2003-09-02	Geneva Pharmaceuticals, Inc.	Crystal modification
US20020177680A1 (en) *	2000-08-23	2002-11-28	Hubbell Jeffrey A.	Novel polymer compounds
US6475942B1 (en) *	2000-09-05	2002-11-05	General Electric Company	Conversion of polycrystalline alumina to single crystal sapphire using molybdenum doping
KR20040012747A (ko) *	2001-04-09	2004-02-11	테바 파마슈티컬 인더스트리즈 리미티드	펙소페나딘 염산염의 다형체
US7700779B2 (en) *	2001-06-18	2010-04-20	Dr. Reddy's Laboratories Limited	Crystalline forms of fexofenadine and its hydrochloride
US20090211514A1 (en) *	2008-02-26	2009-08-27	Lehigh University	Single crystal conversion process

1995
- 1995-04-28 WO PCT/US1995/004942 patent/WO1995031437A1/fr active IP Right Grant
- 1995-04-28 DE DE69527429T patent/DE69527429T2/de not_active Expired - Lifetime
- 1995-04-28 CN CNA2003101007654A patent/CN1623985A/zh active Pending
- 1995-04-28 CN CN95193122A patent/CN1148849A/zh active Pending
- 1995-04-28 PT PT95918278T patent/PT766668E/pt unknown
- 1995-04-28 AT AT95918278T patent/ATE220667T1/de active
- 1995-04-28 CA CA2449419A patent/CA2449419C/fr not_active Expired - Lifetime
- 1995-04-28 CA CA002189007A patent/CA2189007C/fr not_active Expired - Lifetime
- 1995-04-28 EP EP10180285A patent/EP2354125A1/fr not_active Withdrawn
- 1995-04-28 ES ES95918278T patent/ES2176329T3/es not_active Expired - Lifetime
- 1995-04-28 EP EP01124314A patent/EP1178041A1/fr not_active Withdrawn
- 1995-04-28 JP JP7529654A patent/JPH10500134A/ja not_active Withdrawn
- 1995-04-28 MX MX9605613A patent/MX9605613A/es unknown
- 1995-04-28 EP EP95918278A patent/EP0766668B1/fr not_active Expired - Lifetime
- 1995-04-28 CA CA2585705A patent/CA2585705C/fr not_active Expired - Lifetime
- 1995-04-28 DK DK95918278T patent/DK0766668T3/da active
- 1995-04-28 CN CN2006101031426A patent/CN1907967B/zh not_active Expired - Lifetime
- 1995-04-28 AU AU24265/95A patent/AU693892B2/en not_active Expired
- 1995-04-28 HU HU9603167A patent/HU227676B1/hu unknown
- 1995-05-16 IL IL11374795A patent/IL113747A/en not_active IP Right Cessation
- 1995-05-16 IL IL13491795A patent/IL134917A/en not_active IP Right Cessation
1996
- 1996-11-14 FI FI964565A patent/FI964565A0/fi unknown
- 1996-11-15 NO NO19964859A patent/NO315319B1/no not_active IP Right Cessation
2000
- 2000-03-07 IL IL13491700A patent/IL134917A0/xx unknown
2001
- 2001-03-09 US US09/803,389 patent/US20010012896A1/en not_active Abandoned
- 2001-03-09 US US09/803,476 patent/US20010025106A1/en not_active Abandoned
- 2001-03-09 US US09/803,390 patent/US20010014741A1/en not_active Abandoned
2002
- 2002-03-01 JP JP2002055432A patent/JP4503907B2/ja not_active Expired - Lifetime
- 2002-03-01 JP JP2002055431A patent/JP2002308849A/ja active Pending
- 2002-03-01 JP JP2002055435A patent/JP2002316978A/ja not_active Withdrawn
- 2002-03-01 JP JP2002055434A patent/JP4503909B2/ja not_active Expired - Lifetime
- 2002-03-01 JP JP2002055433A patent/JP4503908B2/ja not_active Expired - Lifetime
- 2002-04-24 US US10/128,926 patent/US20020193600A1/en not_active Abandoned
- 2002-06-03 US US10/160,883 patent/US7135571B2/en not_active Expired - Fee Related
- 2002-06-03 US US10/162,011 patent/US7138524B2/en not_active Expired - Fee Related
- 2002-08-07 US US10/214,262 patent/US20030045721A1/en not_active Abandoned
2003
- 2003-03-10 US US10/386,812 patent/US20040014976A1/en not_active Abandoned
2006
- 2006-09-25 US US11/534,828 patent/US7666881B2/en not_active Expired - Fee Related
- 2006-09-25 US US11/534,839 patent/US7662835B2/en not_active Expired - Fee Related
2007
- 2007-05-04 HK HK07104744.4A patent/HK1098467A1/xx not_active IP Right Cessation
- 2007-10-30 US US11/978,670 patent/US20080167471A1/en not_active Abandoned
- 2007-10-30 US US11/978,669 patent/US20080167469A1/en not_active Abandoned
2010
- 2010-02-05 HK HK10101357.3A patent/HK1137742A1/xx not_active IP Right Cessation
- 2010-02-24 JP JP2010038971A patent/JP2010120969A/ja active Pending

Also Published As

Publication number	Publication date
PT766668E (pt)	2002-11-29
US20080167471A1 (en)	2008-07-10
JP2010120969A (ja)	2010-06-03
US20070021462A1 (en)	2007-01-25
JP4503908B2 (ja)	2010-07-14
EP0766668B1 (fr)	2002-07-17
FI964565L (fi)	1996-11-14
CA2449419C (fr)	2011-09-06
US20040014976A1 (en)	2004-01-22
CA2189007A1 (fr)	1995-11-23
JPH10500134A (ja)	1998-01-06
WO1995031437A1 (fr)	1995-11-23
DE69527429T2 (de)	2003-03-20
IL113747A0 (en)	1995-08-31
DE69527429D1 (de)	2002-08-22
EP1178041A1 (fr)	2002-02-06
EP0766668A1 (fr)	1997-04-09
FI964565A0 (fi)	1996-11-14
EP2354125A1 (fr)	2011-08-10
ATE220667T1 (de)	2002-08-15
JP2002308850A (ja)	2002-10-23
US20010012896A1 (en)	2001-08-09
IL134917A0 (en)	2001-05-20
US20030045721A1 (en)	2003-03-06
CA2585705A1 (fr)	1995-11-23
CA2585705C (fr)	2012-04-17
US20020193603A1 (en)	2002-12-19
IL134917A (en)	2001-07-24
US7666881B2 (en)	2010-02-23
US20010025106A1 (en)	2001-09-27
NO315319B1 (no)	2003-08-18
JP2002316978A (ja)	2002-10-31
AU2426595A (en)	1995-12-05
US7138524B2 (en)	2006-11-21
US20010014741A1 (en)	2001-08-16
IL113747A (en)	2001-05-20
MX9605613A (es)	1998-05-31
JP4503909B2 (ja)	2010-07-14
US20020193601A1 (en)	2002-12-19
NO964859D0 (no)	1996-11-15
US7135571B2 (en)	2006-11-14
CN1148849A (zh)	1997-04-30
US20070021461A1 (en)	2007-01-25
US20020193600A1 (en)	2002-12-19
HU227676B1 (en)	2011-11-28
ES2176329T3 (es)	2002-12-01
HK1098467A1 (en)	2007-07-20
JP4503907B2 (ja)	2010-07-14
JP2002308849A (ja)	2002-10-23
CN1623985A (zh)	2005-06-08
HU9603167D0 (en)	1997-01-28
JP2002255936A (ja)	2002-09-11
US20080167469A1 (en)	2008-07-10
JP2002255935A (ja)	2002-09-11
CN1907967A (zh)	2007-02-07
NO964859L (no)	1996-11-15
CA2449419A1 (fr)	1995-11-23
AU693892B2 (en)	1998-07-09
HUT76134A (en)	1997-06-30
HK1137742A1 (en)	2010-08-06
CN1907967B (zh)	2012-07-04
CA2189007C (fr)	2004-03-02
US7662835B2 (en)	2010-02-16

Publication	Publication Date	Title
DK0766668T3 (da)	2002-10-28	Fremgangsmåde til fremstilling af vandfrie og hydratformer af som antihistaminer anvendelige piperidinderivater, polymorfer og pseudo-morfer deraf
ATE211732T1 (de)	2002-01-15	N-benzylpiperidin- und tetrahydropyridin-derivate
HU9301362D0 (en)	1993-09-28	Method for producing 4-aryl-piperazines and 4-aryl-piperidines
DK0582790T3 (da)	1999-08-23	Ny fremgangsmåde til fremstilling af 7-substituerede-9-[(substitueret glycyl)-amino]-6-demethyl-6-deoxytetracycliner
DE69401817D1 (de)	1997-04-03	Verbesserungen zum herstellen von glasartigem silika
DE69122866D1 (de)	1996-11-28	Herstellung von substituierten piperidinen
NO840048L (no)	1984-07-09	Disubstituerte prolinderivater, fremgangsmaate til deres fremstilling og deres anvendelse
DK0902022T3 (da)	2003-11-24	Hidtil ukendte benzofuranonderivater og fremgangsmåde til deres fremstilling
TW362096B (en)	1999-06-21	Novel piperidine derivatives and the process for preparing the same
DK83789D0 (da)	1989-02-23	Substituerede 1,2,4-triazindioner, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse
DK405884D0 (da)	1984-08-24	Spiro(benzofuran-azalkaner), fremgangsmaade til deres fremstilling og dres anvendelse som laegemidler
DK0483633T3 (da)	1997-09-15	8-Azabicyclo 3,2,1 octylalkylthiazoliddinoner, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler.
HUP0004943A2 (hu)	2001-04-28	Eljárás adott esetben szubsztituált benzofuranon-származékok előállítására
DK244388A (da)	1989-01-13	1-fluor-1-halogen-3,6-dioxabicyclo(4.1.0.)heptanerog fremgangmaade til fremstilling deraf
NO20012328L (no)	2001-05-11	Fluorerte 3,4-dihydrokinolinderivater anvendt som NOS- inhibitorer