DK0636119T3 - Phenylsubstituerede cycloalkylhydroxyurinstofderivater som hæmmer lipoxygenase - Google Patents

Phenylsubstituerede cycloalkylhydroxyurinstofderivater som hæmmer lipoxygenase

Info

Publication number: DK0636119T3
Authority: DK; Denmark
Prior art keywords: alkyl; halosubstituted; phenylthio; phenoxy; phenyl
Prior art date: 1992-04-17

Application number

DK93905957.2T

Other languages

Danish (da)

English (en)

Inventor

Rodney W Stevens

Kazunari Nakao

Akiyoshi Kawai

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-17

Filing date

1993-02-18

Publication date

1997-12-22

1993-02-18 Application filed by Pfizer filed Critical Pfizer

1997-12-22 Application granted granted Critical

1997-12-22 Publication of DK0636119T3 publication Critical patent/DK0636119T3/da

Links

102000003820 Lipoxygenases Human genes 0.000 title 1
108090000128 Lipoxygenases Proteins 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 8
125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 5
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 4
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
206010027654 Allergic conditions Diseases 0.000 abstract 1
102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 1
108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
239000005977 Ethylene Chemical group 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
-1 tri-substituted phenyl Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
- C07C323/47—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK93905957.2T 1992-04-17 1993-02-18 Phenylsubstituerede cycloalkylhydroxyurinstofderivater som hæmmer lipoxygenase DK0636119T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP4098150A JPH05294921A (ja)	1992-04-17	1992-04-17	新規なフェニル置換シクロアルキル尿素誘導体および組成物

Publications (1)

Publication Number	Publication Date
DK0636119T3 true DK0636119T3 (da)	1997-12-22

Family

ID=14212150

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93905957.2T DK0636119T3 (da)	1992-04-17	1993-02-18	Phenylsubstituerede cycloalkylhydroxyurinstofderivater som hæmmer lipoxygenase

Country Status (10)

Country	Link
EP (1)	EP0636119B1 (fr)
JP (1)	JPH05294921A (fr)
AT (1)	ATE159933T1 (fr)
CA (1)	CA2133218C (fr)
DE (1)	DE69315069T2 (fr)
DK (1)	DK0636119T3 (fr)
ES (1)	ES2108266T3 (fr)
FI (1)	FI944848L (fr)
GR (1)	GR3025692T3 (fr)
WO (1)	WO1993021149A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW448144B (en) *	1993-08-19	2001-08-01	Pfizer	Phenoxyphenyl cyclopentenyl hydroxyureas
WO1995017379A1 (fr) *	1993-12-22	1995-06-29	Pfizer Inc.	Hydroxyurees de cycloalcenyle phenylthiophenyle utilisees comme inhibiteurs de la lypoxygenase
US6832204B1 (en) *	1999-12-27	2004-12-14	Ge-Harris Railway Electronics, Llc	Train building planning method
CN1968932A (zh)	2004-06-18	2007-05-23	惠氏公司	制备6－烷基－5－芳基磺酰基－二氢菲啶的方法
ATE530519T1 (de) *	2005-06-03	2011-11-15	Abbott Lab	Cyclobutylaminderivate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5120752A (en) *	1989-12-28	1992-06-09	Abbott Laboratories	Cyclopropyl derivative lipoxygenase inhibitors
DE69122759T2 (de) *	1990-07-25	1997-05-15	Abbott Lab	Acetylenderivate mit lipoxygenase inhibitorischer wirkung
GB9025514D0 (en) *	1990-11-23	1991-01-09	Wellcome Found	Anti-inflammatory compounds
JP3007138B2 (ja) *	1990-11-27	2000-02-07	ファイザー製薬株式会社	新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物
US5283361A (en) *	1991-04-23	1994-02-01	Eli Lilly And Company	N-hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]ureas as lipoxygenase inhibitors
JP2989951B2 (ja) *	1991-10-25	1999-12-13	ファイザー製薬株式会社	新規なシクロアルキル尿素誘導体および組成物
US5187192A (en) *	1992-03-13	1993-02-16	Abbott Laboratories	Cyclobutyl derivatives having lipoxygenase inhibitory activity

1992
- 1992-04-17 JP JP4098150A patent/JPH05294921A/ja active Pending
1993
- 1993-02-18 AT AT93905957T patent/ATE159933T1/de not_active IP Right Cessation
- 1993-02-18 CA CA002133218A patent/CA2133218C/fr not_active Expired - Fee Related
- 1993-02-18 WO PCT/US1993/001341 patent/WO1993021149A1/fr active IP Right Grant
- 1993-02-18 DK DK93905957.2T patent/DK0636119T3/da active
- 1993-02-18 ES ES93905957T patent/ES2108266T3/es not_active Expired - Lifetime
- 1993-02-18 DE DE69315069T patent/DE69315069T2/de not_active Expired - Fee Related
- 1993-02-18 EP EP93905957A patent/EP0636119B1/fr not_active Expired - Lifetime
1994
- 1994-10-14 FI FI944848A patent/FI944848L/fi unknown
1997
- 1997-12-16 GR GR970403342T patent/GR3025692T3/el unknown

Also Published As

Publication number	Publication date
JPH05294921A (ja)	1993-11-09
ES2108266T3 (es)	1997-12-16
FI944848A0 (fi)	1994-10-14
CA2133218A1 (fr)	1993-10-28
DE69315069T2 (de)	1998-02-26
DE69315069D1 (en)	1997-12-11
FI944848L (fi)	1994-10-14
GR3025692T3 (en)	1998-03-31
EP0636119A1 (fr)	1995-02-01
CA2133218C (fr)	2002-07-09
EP0636119B1 (fr)	1997-11-05
WO1993021149A1 (fr)	1993-10-28
ATE159933T1 (de)	1997-11-15

Publication	Publication Date	Title
MY107341A (en)	1995-11-30	Novel hydroxamic acid and n-hydroxyurea derivatives and their use
ATE278402T1 (de)	2004-10-15	Arylpiperidinol und arylpiperidin-derivate und sie enthaltende arzneimittel
NL350030I2 (nl)	2006-10-02	Fungicide preparaten.
DK0420762T3 (da)	1993-08-16	Heterocyklisk forbindelse
DK0636119T3 (da)	1997-12-22	Phenylsubstituerede cycloalkylhydroxyurinstofderivater som hæmmer lipoxygenase
TW222627B (fr)	1994-04-21
DK0561882T3 (da)	1994-10-03	Hydroxamsyrederivater, som inhiberer lipoxygenase
CA2160140A1 (fr)	1994-10-13	Cycloalkylhydroxyurees et leur utilisation comme inhibiteurs de la lipoxygenase
AU2983792A (en)	1993-06-10	Diaminomethyleneamino substituted substituted phenyl thiazoles
DK0651743T3 (da)	1998-02-02	Indolinyl-N-hydroxyurinstof- og N-hydroxamsyrederivater som lipoxygenaseinhibitorer
DK0625140T3 (da)	1996-12-30	Cyclopropyl-N-hydroxyurinstof og -N-hydroxyacetamider, som inhiberer lipoxygenase