DK0611368T3 - Substituerede aminopyrimidiner som angiotensin II-antagonister - Google Patents
Substituerede aminopyrimidiner som angiotensin II-antagonisterInfo
- Publication number
- DK0611368T3 DK0611368T3 DK92922669.4T DK92922669T DK0611368T3 DK 0611368 T3 DK0611368 T3 DK 0611368T3 DK 92922669 T DK92922669 T DK 92922669T DK 0611368 T3 DK0611368 T3 DK 0611368T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- useful
- angiotensin
- antagonists
- aminopyrimidines
- Prior art date
Links
- 229940123413 Angiotensin II antagonist Drugs 0.000 title 1
- 150000005005 aminopyrimidines Chemical class 0.000 title 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000005007 4-aminopyrimidines Chemical class 0.000 abstract 1
- 102000005862 Angiotensin II Human genes 0.000 abstract 1
- 101800000733 Angiotensin-2 Proteins 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
- 229950006323 angiotensin ii Drugs 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78202691A | 1991-10-24 | 1991-10-24 | |
| US07/900,639 US5336677A (en) | 1991-10-24 | 1992-06-18 | Substituted aminopyrimidines as antihypertensives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0611368T3 true DK0611368T3 (da) | 1996-06-03 |
Family
ID=27119939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92922669.4T DK0611368T3 (da) | 1991-10-24 | 1992-10-22 | Substituerede aminopyrimidiner som angiotensin II-antagonister |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5336677A (da) |
| EP (1) | EP0611368B1 (da) |
| JP (1) | JPH07500598A (da) |
| AT (1) | ATE133944T1 (da) |
| AU (1) | AU2889692A (da) |
| CA (1) | CA2121815A1 (da) |
| DE (1) | DE69208263T2 (da) |
| DK (1) | DK0611368T3 (da) |
| ES (1) | ES2085043T3 (da) |
| GR (1) | GR3019543T3 (da) |
| PT (1) | PT100987B (da) |
| WO (1) | WO1993008169A1 (da) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6034114A (en) * | 1990-12-14 | 2000-03-07 | Smithkline Beecham Plc | Medicament |
| US6028091A (en) * | 1990-12-14 | 2000-02-22 | Smithkline Beecham Plc | Medicament |
| US5283242A (en) * | 1991-10-24 | 1994-02-01 | American Home Products Corporation | Substituted benzimidazoles and quinazolines as antihypertensives |
| GB9217820D0 (en) * | 1992-08-21 | 1992-10-07 | Fujisawa Pharmaceutical Co | New use |
| AU8996698A (en) * | 1997-09-10 | 1999-03-29 | Ono Pharmaceutical Co. Ltd. | Peroxisome proliferator-activated receptor controllers |
| US6440965B1 (en) * | 1997-10-15 | 2002-08-27 | Krenitsky Pharmaceuticals, Inc. | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system |
| US6583148B1 (en) | 1999-04-08 | 2003-06-24 | Krenitsky Pharmaceuticals, Inc. | Neurotrophic substituted pyrimidines |
| AU2001273574A1 (en) | 2000-07-24 | 2002-02-05 | Krenitsky Pharmaceuticals Inc. | Substituted 5-alkynyl pyrimidines having neurotrophic activity |
| AU2005286593A1 (en) * | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyridine compounds, process for their preparation and compositions containing them |
| US8097109B2 (en) * | 2004-12-14 | 2012-01-17 | The Proctor & Gamble Company | Method for the concurrent converting of multiple web materials |
| EP1749828A1 (en) | 2005-08-04 | 2007-02-07 | Farmaprojects S.L. | Process for preparing an angiotensin II receptor antagonist |
| JP5238172B2 (ja) * | 2007-03-22 | 2013-07-17 | 公益財団法人相模中央化学研究所 | パーフルオロアルキル基を有する含窒素六員環化合物およびその製造方法 |
| CA2688161C (en) | 2007-06-04 | 2020-10-20 | Kunwar Shailubhai | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CN101397277B (zh) * | 2008-01-10 | 2012-04-18 | 联化科技股份有限公司 | 一种氨甲基联苯四氮唑及其盐的合成方法、及其中间体及中间体的合成方法 |
| WO2009149279A2 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2009155448A1 (en) * | 2008-06-20 | 2009-12-23 | Ligand Pharmaceuticals Inc. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| JP2011528375A (ja) | 2008-07-16 | 2011-11-17 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB0913636D0 (en) * | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| NZ610315A (en) | 2010-11-15 | 2015-08-28 | Univ Leuven Kath | Antiviral condensed heterocyclic compounds |
| EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| AU2014274812B2 (en) | 2013-06-05 | 2018-09-27 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
| UY35735A (es) | 2013-09-16 | 2015-04-30 | Bayer Pharma AG | Trifluorometilpirimidinonas disustituidas y su uso |
| WO2016113205A1 (de) | 2015-01-13 | 2016-07-21 | Bayer Pharma Aktiengesellschaft | Substituierte pentafluorethylpyrimidinone und ihre verwendung |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5100897A (en) * | 1989-08-28 | 1992-03-31 | Merck & Co., Inc. | Substituted pyrimidinones as angiotensin ii antagonists |
| DE3934153A1 (de) * | 1989-10-12 | 1991-04-18 | Johnson & Johnson Gmbh | Tampon, insbesondere fuer die frauenhygiene, sowie verfahren und vorrichtung zur herstellung desselben |
| EP0435827A3 (en) * | 1989-12-28 | 1991-11-13 | Ciba-Geigy Ag | Diaza compounds |
| IE912956A1 (en) * | 1990-09-10 | 1992-03-11 | Abbott Lab | Angiotensin ii receptor antagonists |
-
1992
- 1992-06-18 US US07/900,639 patent/US5336677A/en not_active Expired - Lifetime
- 1992-10-20 PT PT100987A patent/PT100987B/pt not_active IP Right Cessation
- 1992-10-22 JP JP5507925A patent/JPH07500598A/ja active Pending
- 1992-10-22 ES ES92922669T patent/ES2085043T3/es not_active Expired - Lifetime
- 1992-10-22 AU AU28896/92A patent/AU2889692A/en not_active Abandoned
- 1992-10-22 AT AT92922669T patent/ATE133944T1/de not_active IP Right Cessation
- 1992-10-22 DK DK92922669.4T patent/DK0611368T3/da active
- 1992-10-22 DE DE69208263T patent/DE69208263T2/de not_active Expired - Fee Related
- 1992-10-22 CA CA002121815A patent/CA2121815A1/en not_active Abandoned
- 1992-10-22 EP EP92922669A patent/EP0611368B1/en not_active Expired - Lifetime
- 1992-10-22 WO PCT/US1992/009064 patent/WO1993008169A1/en active IP Right Grant
-
1996
- 1996-04-03 GR GR960400934T patent/GR3019543T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2085043T3 (es) | 1996-05-16 |
| CA2121815A1 (en) | 1993-04-29 |
| US5336677A (en) | 1994-08-09 |
| EP0611368B1 (en) | 1996-02-07 |
| DE69208263D1 (de) | 1996-03-21 |
| WO1993008169A1 (en) | 1993-04-29 |
| PT100987B (pt) | 1999-07-30 |
| DE69208263T2 (de) | 1996-07-18 |
| AU2889692A (en) | 1993-05-21 |
| PT100987A (pt) | 1994-01-31 |
| JPH07500598A (ja) | 1995-01-19 |
| EP0611368A1 (en) | 1994-08-24 |
| ATE133944T1 (de) | 1996-02-15 |
| GR3019543T3 (en) | 1996-07-31 |
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