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DK0536363T3 - Hidtil ukendte heparinderivater og fremgangsmåde til fremstilling deraf - Google Patents

Hidtil ukendte heparinderivater og fremgangsmåde til fremstilling deraf

Info

Publication number
DK0536363T3
DK0536363T3 DK92908867.2T DK92908867T DK0536363T3 DK 0536363 T3 DK0536363 T3 DK 0536363T3 DK 92908867 T DK92908867 T DK 92908867T DK 0536363 T3 DK0536363 T3 DK 0536363T3
Authority
DK
Denmark
Prior art keywords
heparin
show
equal
new
processes
Prior art date
Application number
DK92908867.2T
Other languages
English (en)
Inventor
Crister Mattsson
Michael Weber
Carl-Magnus Svahn
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Application granted granted Critical
Publication of DK0536363T3 publication Critical patent/DK0536363T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK92908867.2T 1991-04-18 1992-04-14 Hidtil ukendte heparinderivater og fremgangsmåde til fremstilling deraf DK0536363T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9101155A SE9101155D0 (sv) 1991-04-18 1991-04-18 Novel heparin derivatives

Publications (1)

Publication Number Publication Date
DK0536363T3 true DK0536363T3 (da) 1998-01-26

Family

ID=20382487

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92908867.2T DK0536363T3 (da) 1991-04-18 1992-04-14 Hidtil ukendte heparinderivater og fremgangsmåde til fremstilling deraf

Country Status (12)

Country Link
US (2) US6150342A (da)
EP (1) EP0536363B1 (da)
JP (1) JP3278676B2 (da)
AT (1) ATE154614T1 (da)
AU (1) AU642626B2 (da)
CA (1) CA2084301C (da)
DE (1) DE69220442T2 (da)
DK (1) DK0536363T3 (da)
ES (1) ES2104909T3 (da)
GR (1) GR3024757T3 (da)
SE (1) SE9101155D0 (da)
WO (1) WO1992018545A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
US5296471A (en) * 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
WO1995030424A1 (en) * 1994-05-06 1995-11-16 Glycomed Incorporated O-desulfated heparin derivatives, methods of making and uses thereof
WO1996024362A1 (fr) * 1995-02-07 1996-08-15 Shiseido Company, Ltd. Agents anti-inflammatoires
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
WO1999043714A1 (fr) * 1998-02-26 1999-09-02 Seikagaku Corporation Nouveaux derives de polysaccharide, leur procede de production, et compositions medicinales contenant ces nouveaux derives comme principe actif
KR20020032444A (ko) * 1999-06-30 2002-05-03 잭 허쉬 응괴 연관된 응고 인자를 억제하는 헤파린 조성물
US7608246B2 (en) * 2005-09-02 2009-10-27 The Brigham And Women's Hospital, Inc. Apolipoprotein E as an adjuvant for lipid antigens
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
ES2567079T3 (es) * 2007-11-02 2016-04-19 Momenta Pharmaceuticals, Inc. Composiciones de polisacáridos que no son anticoagulantes
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
BR112012026542A2 (pt) 2010-04-16 2016-07-12 Momenta Pharmaceuticals Inc abordagem seletiva de tecido
JP5905455B2 (ja) 2010-06-17 2016-04-20 モメンタ ファーマシューティカルズ インコーポレイテッド 発毛を促進する方法および組成物
WO2014193818A1 (en) 2013-05-28 2014-12-04 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions
GB2515315A (en) * 2013-06-19 2014-12-24 Dilafor Ab New Processes
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4948881A (en) * 1982-12-28 1990-08-14 Sanofi Process for the depolymerization and sulfation of polysaccharides
FR2538404B1 (da) * 1982-12-28 1985-08-23 Anic Spa
US4745098A (en) * 1984-02-24 1988-05-17 The Regents Of The University Of California Compositions and method for improving wound healing
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
SE8702254D0 (sv) * 1987-05-29 1987-05-29 Kabivitrum Ab Novel heparin derivatives
DE3744119A1 (de) * 1987-12-24 1989-07-06 Basf Ag Verwendung von polysulfatierten heparinen
IT1237518B (it) * 1989-11-24 1993-06-08 Renato Conti Eparine supersolfatate

Also Published As

Publication number Publication date
CA2084301C (en) 2005-10-25
JP3278676B2 (ja) 2002-04-30
DE69220442D1 (de) 1997-07-24
ES2104909T3 (es) 1997-10-16
CA2084301A1 (en) 1992-10-19
ATE154614T1 (de) 1997-07-15
EP0536363B1 (en) 1997-06-18
AU1646392A (en) 1992-11-17
DE69220442T2 (de) 1998-01-29
GR3024757T3 (en) 1997-12-31
US6150342A (en) 2000-11-21
EP0536363A1 (en) 1993-04-14
WO1992018545A1 (en) 1992-10-29
JPH05508184A (ja) 1993-11-18
US6326476B1 (en) 2001-12-04
SE9101155D0 (sv) 1991-04-18
AU642626B2 (en) 1993-10-21

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