DK0533840T3 - Behandling af kronisk nyresvigt med imidazol-angiotensin-II-receptor-antagonister - Google Patents

Behandling af kronisk nyresvigt med imidazol-angiotensin-II-receptor-antagonister

Info

Publication number: DK0533840T3
Authority: DK; Denmark
Prior art keywords: imidazole; angiotensin; renal failure; chronic renal; treatment
Prior art date: 1990-06-22

Application number

DK91912884.3T

Other languages

English (en)

Inventor

David John Carini

John Jonas Vytautas Duncia

Pancras Chor-Bun Wong

Original Assignee

Du Pont

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-22

Filing date

1991-06-07

Publication date

1996-12-30

1991-06-07 Application filed by Du Pont filed Critical Du Pont

1996-12-30 Application granted granted Critical

1996-12-30 Publication of DK0533840T3 publication Critical patent/DK0533840T3/da

Links

208000020832 chronic kidney disease Diseases 0.000 title abstract 2
208000022831 chronic renal failure syndrome Diseases 0.000 title abstract 2
239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
UUPNFNCKGJOLQE-UHFFFAOYSA-N 2-[4-[[2-butyl-4-chloro-5-(hydroxymethyl)imidazol-1-yl]methyl]phenyl]benzoic acid Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C(O)=O)C=C1 UUPNFNCKGJOLQE-UHFFFAOYSA-N 0.000 abstract 1
102000005862 Angiotensin II Human genes 0.000 abstract 1
101800000733 Angiotensin-2 Proteins 0.000 abstract 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
229950006323 angiotensin ii Drugs 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
PSIFNNKUMBGKDQ-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 PSIFNNKUMBGKDQ-UHFFFAOYSA-N 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK91912884.3T 1990-06-22 1991-06-07 Behandling af kronisk nyresvigt med imidazol-angiotensin-II-receptor-antagonister DK0533840T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US54235190A	1990-06-22	1990-06-22

Publications (1)

Publication Number	Publication Date
DK0533840T3 true DK0533840T3 (da)	1996-12-30

Family

ID=24163446

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91912884.3T DK0533840T3 (da)	1990-06-22	1991-06-07	Behandling af kronisk nyresvigt med imidazol-angiotensin-II-receptor-antagonister

Country Status (8)

Country	Link
EP (1)	EP0533840B1 (da)
JP (2)	JPH05509086A (da)
AT (1)	ATE146076T1 (da)
CA (1)	CA2085584C (da)
DE (1)	DE69123582T2 (da)
DK (1)	DK0533840T3 (da)
GR (1)	GR3022035T3 (da)
WO (1)	WO1992000067A2 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2058198A1 (en) *	1991-01-04	1992-07-05	Adalbert Wagner	Azole derivatives, process for their preparation, and their use
JP3810020B2 (ja) *	1993-04-22	2006-08-16	武田薬品工業株式会社	腎疾患の予防または治療剤
FR2719598B1 (fr) *	1994-05-03	1996-07-26	Rhone Poulenc Chimie	Composition élastomère silicone et ses applications, notamment pour l'enduction de sac gonflable, destiné à la protection d'un occupant de véhicule.
AU677702B2 (en) *	1994-10-13	1997-05-01	Takeda Pharmaceutical Company Limited	A prophylactic or therapeutic drug for renal diseases
US6498142B1 (en) *	1996-05-06	2002-12-24	Curis, Inc.	Morphogen treatment for chronic renal failure
DK0980252T3 (da)	1997-05-05	2005-01-31	Curis Inc	Terapier til akut nyresvigt
SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
CA2735267C (en)	2001-01-26	2013-05-07	Chugai Seiyaku Kabushiki Kaisha	Malonyl-coa decarboxylase inhibitors useful as metabolic modulators
EP1377290B1 (en)	2001-01-26	2006-10-04	Chugai Seiyaku Kabushiki Kaisha	Malonyl-coa decarboxylase inhibitors useful as metabolic modulators
EP1353662B1 (en)	2001-01-26	2007-04-18	Chugai Seiyaku Kabushiki Kaisha	Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors
US7709510B2 (en)	2001-02-20	2010-05-04	Chugai Seiyaku Kabushiki Kaisha	Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
NZ526883A (en)	2001-02-20	2005-11-25	Chugai Pharmaceutical Co Ltd	Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators
US7285562B2 (en)	2003-08-01	2007-10-23	Chugai Seiyaku Kabushiki Kaisha	Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors
WO2005011670A1 (en)	2003-08-01	2005-02-10	Chugai Seiyaku Kabushiki Kaisha	Heterocyclic compounds useful as malonyl-coa decarboxylase inhibitors
EP1653957B1 (en)	2003-08-01	2008-07-09	Chugai Seiyaku Kabushiki Kaisha	Piperidine compounds useful as malonyl-coa decarboxylase inhibitors
ES2378418T3 (es)	2003-08-01	2012-04-12	Chugai Seiyaku Kabushiki Kaisha	Compuestos de azol basados en cianoguanidina útiles como inhibidores de malonil-coadescarboxilasa
US8257797B2 (en)	2003-11-03	2012-09-04	Bluestar Silicones France	Silicone composition and process that is useful for improving the tear strength and the combing strength of an inflatable bag for protecting an occupant of a vehicle
ES2559319T3 (es)	2007-06-04	2016-02-11	Synergy Pharmaceuticals Inc.	Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP2011518884A (ja) *	2008-04-29	2011-06-30	セラヴァンス，インコーポレーテッド	二重活性抗高血圧剤
EP2810951B1 (en)	2008-06-04	2017-03-15	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
JPWO2011077712A1 (ja) *	2009-12-22	2013-05-02	興和株式会社	新規な１−（ビフェニル−４−イル−メチル）−１ｈ−イミダゾール誘導体及びこれを含有する医薬
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
JP2016514670A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
AU2014235215A1 (en)	2013-03-15	2015-10-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
HRP20240805T1 (hr)	2013-06-05	2024-09-27	Bausch Health Ireland Limited	Ultra-pročišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i uporabe
EP3478672B1 (en)	2016-06-29	2024-04-10	Université de Montréal	Biarylmethyl heterocycles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5015651A (en) *	1988-01-07	1991-05-14	E. I. Du Pont De Nemours And Company	Treatment of hypertension with 1,2,4-angiotensin II antagonists
ES2142789T3 (es) *	1989-06-14	2000-05-01	Smithkline Beecham Corp	Acidos imidazolil-alquenoicos.
JP2550442B2 (ja) *	1989-06-30	1996-11-06	イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー	置換イミダゾール
CA2032289A1 (en) *	1989-12-29	1991-06-30	Joseph A. Finkelstein	Substituted 5-(alkyl) carboxamide imidazoles

1991
- 1991-06-07 EP EP91912884A patent/EP0533840B1/en not_active Expired - Lifetime
- 1991-06-07 DE DE69123582T patent/DE69123582T2/de not_active Expired - Lifetime
- 1991-06-07 WO PCT/US1991/003906 patent/WO1992000067A2/en active IP Right Grant
- 1991-06-07 DK DK91912884.3T patent/DK0533840T3/da active
- 1991-06-07 AT AT91912884T patent/ATE146076T1/de not_active IP Right Cessation
- 1991-06-07 JP JP3512070A patent/JPH05509086A/ja active Pending
- 1991-06-07 CA CA002085584A patent/CA2085584C/en not_active Expired - Lifetime
1996
- 1996-12-13 GR GR960403462T patent/GR3022035T3/el unknown
1998
- 1998-11-12 JP JP10321761A patent/JPH11228410A/ja active Pending

Also Published As

Publication number	Publication date
DE69123582D1 (de)	1997-01-23
EP0533840B1 (en)	1996-12-11
GR3022035T3 (en)	1997-03-31
WO1992000067A2 (en)	1992-01-09
JPH05509086A (ja)	1993-12-16
JPH11228410A (ja)	1999-08-24
WO1992000067A3 (en)	1993-05-27
CA2085584A1 (en)	1991-12-23
CA2085584C (en)	2003-02-11
ATE146076T1 (de)	1996-12-15
DE69123582T2 (de)	1997-05-15
EP0533840A1 (en)	1993-03-31

Publication	Publication Date	Title
DK0533840T3 (da)	1996-12-30	Behandling af kronisk nyresvigt med imidazol-angiotensin-II-receptor-antagonister
EP0803252A3 (en)	1997-11-26	Treatment of central nervous system disorders with imidazole angiotensin-II receptor antagonists
NO1995004I1 (no)	1995-05-26	Losartan/ 2-butyl-4-klor-1-((2'-(1H-tetrazol-5-yl)-bifenyl-4-yl)-metyl)-5-(hydroksylmetyl)-imidazol
DE69007740D1 (de)	1994-05-05	Substituierte 5-[(Tetrazolyl)alkenyl]-Imidazole.
ATE171447T1 (de)	1998-10-15	Benzimidazole derivate
MX9204737A (es)	1994-02-28	Acidos imidazolil-alquenoicos
DK0403159T3 (da)	2000-08-14	Imidazolylalkensyrer
DE69724246D1 (de)	2003-09-25	Neue substituierte imidazolverbindungen
DE69025473D1 (de)	1996-03-28	Substituierte imidazole und ihre verwendung als hemmmstoff fur angiotensin ii
ES2117014T3 (es)	1998-08-01	Quinazolinonas substituidas en las posiciones 2,3,6 bloqueadoras del receptor de la angiotensina ii.
EP0437103A3 (en)	1991-07-24	Substituted 5-(alkyl)carboxamide imidazoles
BR9708517A (pt)	1999-08-03	Composição farmacêutica processo para prevenir ou tratar doenças mediadas por angiotensina ii em um mamífero e uso de um composto
ATE302205T1 (de)	2005-09-15	Thieno- und furopyrimidin derivate als a2a- rezeptor antagonisten
TR200201057T2 (tr)	2002-09-23	P38 protein kinazı inhibitörleri olarak heteroalkilamino ikameli bisiklik nitrojen heterosaykılları.
NO972324D0 (no)	1997-05-21	Orale blandinger inneholdende Ondansetron
DE60126652D1 (de)	2007-03-29	Indolderivate
RO118870B1 (ro)	2003-12-30	Monometansulfonat de acid (e)-alfa-[2-n-butil-1-[(4-carboxifenil)metil]-1h-imidazol-5-il]metilen-2-tiofenpropionic, procedee de preparare şi compoziţii farmaceutice
FI905481A0 (fi)	1990-11-05	Substituerade n-(imidazolyl) -alkylalaninderivat.
BR9104918A (pt)	1992-06-23	Utilizacao de compostos bloqueadores do receptor de angiotensina-ii,processo para o tratamento da hipertrofia e/ou hiperplasia cardial e vascular,processo para a obtencao de um preparo farmaceutico e composicao farmaceutica
TR199701536T1 (xx)	1998-02-21	Benzimidazollerin, l�seminin tedavisi i�in bir ila� �retilmesinde kullan�m�.
DK1632248T3 (da)	2011-01-24	Anti-interleukin-9-antistof eller anti-interleukin-9-receptor-antistof til behandling af bronkial overfølsomhed
DK1019048T3 (da)	2004-05-03	Anvendelse af en angiotensin II-reseptorantagonist til fremstilling af lægemidler til forøgelse af overlevelsesfrekvensen af nyretransplanterede patienter
DK1287832T3 (da)	2006-05-01	Anvendelse af antagonist af leukæmiinhiberende faktor