DK0591528T3 - Pyrazolo[1,5-a]pyrimidinderivat og antiinflammatorisk middel, der indeholder dette - Google Patents

Pyrazolo[1,5-a]pyrimidinderivat og antiinflammatorisk middel, der indeholder dette

Info

Publication number: DK0591528T3
Authority: DK; Denmark
Prior art keywords: lower alkyl; substituted; hydroxy; phenyl; hydrogen
Prior art date: 1991-04-22

Application number

DK91913666T

Other languages

English (en)

Inventor

Makoto Inoue

Kinji Hashimoto

Toshiko Kuwahara

Yukio Sugimoto

Takuji Uesako

Toshiaki Funato

Original Assignee

Otsuka Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-22

Filing date

1991-08-06

Publication date

1999-08-23

1991-08-06 Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd

1999-08-23 Application granted granted Critical

1999-08-23 Publication of DK0591528T3 publication Critical patent/DK0591528T3/da

Links

LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 title abstract 2
229940121363 anti-inflammatory agent Drugs 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 7
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
-1 hydroxy, carboxyl Chemical group 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004953 trihalomethyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK91913666T 1991-04-22 1991-08-06 Pyrazolo[1,5-a]pyrimidinderivat og antiinflammatorisk middel, der indeholder dette DK0591528T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP9070791		1991-04-22
PCT/JP1991/001043 WO1992018504A1 (fr)	1991-04-22	1991-08-06	DERIVE DE PYRAZOLO[1,5-a]PYRIMIDINE ET AGENT ANTI-INFLAMMATOIRECONTENANT CE DERIVE

Publications (1)

Publication Number	Publication Date
DK0591528T3 true DK0591528T3 (da)	1999-08-23

Family

ID=14006001

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91913666T DK0591528T3 (da)	1991-04-22	1991-08-06	Pyrazolo[1,5-a]pyrimidinderivat og antiinflammatorisk middel, der indeholder dette

Country Status (12)

Country	Link
US (1)	US5688949A (da)
EP (1)	EP0591528B1 (da)
JP (1)	JPH0570353A (da)
KR (1)	KR100191774B1 (da)
AT (1)	ATE174917T1 (da)
AU (1)	AU651986B2 (da)
CA (1)	CA2107479C (da)
DE (1)	DE69130683T2 (da)
DK (1)	DK0591528T3 (da)
ES (1)	ES2126573T3 (da)
TW (1)	TW221434B (da)
WO (1)	WO1992018504A1 (da)

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US7161003B1 (en)	2002-09-04	2007-01-09	Schering Corporation	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7557110B2 (en)	2003-02-28	2009-07-07	Teijin Pharma Limited	Pyrazolo[1,5-A] pyrimidine derivatives
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PE20051089A1 (es) *	2004-01-22	2006-01-25	Novartis Ag	Derivados de pirazolo [1,5-a] pirimidin-7-il-amina como inhibidores de quinasa de proteina
JP2008539047A (ja)	2005-04-28	2008-11-13	プロテウスバイオメディカルインコーポレイテッド	ファーマインフォーマティックスシステム
DE602006016455D1 (de) *	2005-09-09	2010-10-07	Schering Corp	Neue 4-cyano-, 4-amino-, und 4-aminomethylderivative von pyrazoloä1,5-aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h-indazolverbindungen und 5-cyano-, 5-amino- und 5-aminomethylderivative von imidazoä1,2-aüpyridinen, und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase
RU2008117298A (ru)	2005-10-06	2009-11-20	Шеринг Корпорейшн (US)	Пиразолопиримидины как ингибиторы протеинкиназ
AR055206A1 (es) *	2005-10-06	2007-08-08	Schering Corp	Pirazolo[1, 5 - a]pirimidinas como inhibidoras de proteina quinasa, composiciones farmaceuticas y combinaciones con agentes citostaticos que las comprenden y su uso en la fabricacion de un medicamento para el tratamiento del cancer.
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BRPI0719352A2 (pt)	2006-11-29	2017-10-24	Abbott Lab	inibidores de enzima diacilglicerol o-aciltransferase tipo 1
RU2441004C1 (ru)	2007-12-19	2012-01-27	Дженентек, Инк.	5-анилиноимидазопиридины и способы их применения
CN102316902B (zh)	2009-02-20	2014-09-24	to-BBB控股股份有限公司	基于谷胱甘肽的药物递送系统
MY163048A (en)	2009-05-06	2017-08-15	Laboratory Skin Care Inc	Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
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ES2475970T3 (es) *	2009-12-23	2014-07-11	Katholieke Universiteit Leuven	Novedosos compuestos antivirales
WO2012047570A1 (en) *	2010-09-28	2012-04-12	Schering Corporation	Fused tricyclic inhibitors of mammalian target of rapamycin
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
US9132129B2 (en)	2010-11-15	2015-09-15	Katholieke Universiteit Leuven	Antiviral compounds
US8633198B1 (en)	2011-09-20	2014-01-21	Nant Holdings Ip, Llc	Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
JP6415568B2 (ja) *	2013-12-11	2018-10-31	ナントホールディングスアイピー，エルエルシー	Ａ型インフルエンザｒｎａ依存性ｒｎａポリメラーゼの低分子阻害剤
US9963455B2 (en)	2014-01-22	2018-05-08	Curovir Ab	Pyrazolo[1,5-a]pyrimidines as antiviral compounds
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KR20200032751A (ko) *	2017-09-15	2020-03-26	아두로 바이오테크, 인코포레이티드	피라졸로피리미디논 화합물 및 그의 용도
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1991
- 1991-08-06 EP EP91913666A patent/EP0591528B1/en not_active Expired - Lifetime
- 1991-08-06 KR KR1019930703210A patent/KR100191774B1/ko not_active IP Right Cessation
- 1991-08-06 WO PCT/JP1991/001043 patent/WO1992018504A1/ja active IP Right Grant
- 1991-08-06 US US08/133,086 patent/US5688949A/en not_active Expired - Fee Related
- 1991-08-06 AU AU82958/91A patent/AU651986B2/en not_active Ceased
- 1991-08-06 CA CA002107479A patent/CA2107479C/en not_active Expired - Fee Related
- 1991-08-06 AT AT91913666T patent/ATE174917T1/de not_active IP Right Cessation
- 1991-08-06 DK DK91913666T patent/DK0591528T3/da active
- 1991-08-06 DE DE69130683T patent/DE69130683T2/de not_active Expired - Fee Related
- 1991-08-06 ES ES91913666T patent/ES2126573T3/es not_active Expired - Lifetime
- 1991-08-16 TW TW080106516A patent/TW221434B/zh active
1992
- 1992-03-13 JP JP4055370A patent/JPH0570353A/ja active Pending

Also Published As

Publication number	Publication date
EP0591528A1 (en)	1994-04-13
KR100191774B1 (ko)	1999-06-15
AU8295891A (en)	1992-11-17
WO1992018504A1 (fr)	1992-10-29
EP0591528A4 (en)	1995-02-15
TW221434B (da)	1994-03-01
EP0591528B1 (en)	1998-12-23
AU651986B2 (en)	1994-08-11
JPH0570353A (ja)	1993-03-23
US5688949A (en)	1997-11-18
ES2126573T3 (es)	1999-04-01
ATE174917T1 (de)	1999-01-15
DE69130683D1 (de)	1999-02-04
DE69130683T2 (de)	1999-05-06
CA2107479C (en)	1997-12-16
CA2107479A1 (en)	1992-10-23

Publication	Publication Date	Title
DK0591528T3 (da)	1999-08-23	Pyrazolo[1,5-a]pyrimidinderivat og antiinflammatorisk middel, der indeholder dette
CA2311742A1 (en)	1999-06-10	6-amino-9-benzyl-8-hydroxypurine derivatives
ATE206412T1 (de)	2001-10-15	Heterocyclische verbindungen als bradykinin antagonisten
EE03139B1 (et)	1998-12-15	Piperasiiniderivaadid, nende kasutamine ja farmatseutiline kompositsioon
DE60232065D1 (de)	2009-06-04	Indol-, azaindol- und verwandte heterozyklische amidopiperazin-derivate
ATE174596T1 (de)	1999-01-15	Imidazo (1,2-a)pyridine als bradykinin- antagonisten
MY101208A (en)	1991-08-17	Phenyl-piperazine anti-arrhythmia agents.
DK0594636T3 (da)	1998-03-23	3-aminopiperidinderivater og relaterede nitrogenholdige heterocykliske forbindelser
ATE141260T1 (de)	1996-08-15	Indole fungizide
ATE79380T1 (de)	1992-08-15	2-substituierte-e-kondensierte(1,2,4>triazolo(1,5-c>pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
AU2001230564A1 (en)	2001-08-14	Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
NO905519L (no)	1991-02-20	Pyrimidinderivater.
CA2297326A1 (en)	1999-02-04	Heterocyclic compound and antitumor agent containing the same as active component
NO930505L (no)	1993-08-16	Nye azaindoler, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav
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DE69232883D1 (de)	2003-02-06	Substituierte heterocyklische derivate, verwendbar als plättchenaggregationshemmstoffe
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TW360652B (en)	1999-06-11	Acryloyl substituted disstamycin derivatives, process for preparing them, and pharmaceutical composition comprising them
DE69619259D1 (de)	2002-03-21	Amidin- und isothioharnstoffderivate als inhibitoren der stickstoffoxid-synthase
DK0579968T3 (da)	2000-03-27	4-Iminoquinoliner, fremgangsmåde til deres fremstilling og deres anvendelse
DK0486385T3 (da)	1995-06-12	Imidazolderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
NO20053302L (no)	2005-07-05	Imidazolderivater med affinitet for alfa 2-reseptoraktivitet.
DK0582506T3 (da)	1996-07-15	Tetrahydronaphthalenderivater, fremgangsmåde til fremstilling deraf og terapeutisk anvendelse af disse