DK0584118T3 - Nyt konjugat, bestående af et glycoprotein og en nucleinsyrebindende substans - Google Patents

Nyt konjugat, bestående af et glycoprotein og en nucleinsyrebindende substans

Info

Publication number: DK0584118T3
Authority: DK; Denmark
Prior art keywords: glycoprotein; nucleic acid; binding substance; acid binding; conjugates
Prior art date: 1991-05-08

Application number

DK92909423T

Other languages

Danish (da)

English (en)

Inventor

Max L Birnstiel

Matthew Cotten

Ernst Wagner

Original Assignee

Boehringer Ingelheim Int

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-08

Filing date

1992-05-01

Publication date

2001-01-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6431250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0584118(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-05-01 Application filed by Boehringer Ingelheim Int, Genentech Inc filed Critical Boehringer Ingelheim Int

2001-01-29 Application granted granted Critical

2001-01-29 Publication of DK0584118T3 publication Critical patent/DK0584118T3/da

Links

102000003886 Glycoproteins Human genes 0.000 title abstract 6
108090000288 Glycoproteins Proteins 0.000 title abstract 6
102000039446 nucleic acids Human genes 0.000 title abstract 6
108020004707 nucleic acids Proteins 0.000 title abstract 6
150000007523 nucleic acids Chemical class 0.000 title abstract 6
239000000126 substance Substances 0.000 title abstract 4
125000000837 carbohydrate group Chemical group 0.000 abstract 2
108010039918 Polylysine Proteins 0.000 abstract 1
102000004338 Transferrin Human genes 0.000 abstract 1
108090000901 Transferrin Proteins 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
230000008676 import Effects 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
229920000656 polylysine Polymers 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
239000012581 transferrin Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK92909423T 1991-05-08 1992-05-01 Nyt konjugat, bestående af et glycoprotein og en nucleinsyrebindende substans DK0584118T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4115038A DE4115038A1 (de)	1991-05-08	1991-05-08	Neue konjugate, bestehend aus einem glykoprotein und einer nukleinsaeure-bindenden substanz
PCT/EP1992/000953 WO1992019281A2 (fr)	1991-05-08	1992-05-01	Nouveaux conjugues composes d'une glycoproteine et d'une substance liant des acides nucleiques

Publications (1)

Publication Number	Publication Date
DK0584118T3 true DK0584118T3 (da)	2001-01-29

Family

ID=6431250

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92909423T DK0584118T3 (da)	1991-05-08	1992-05-01	Nyt konjugat, bestående af et glycoprotein og en nucleinsyrebindende substans

Country Status (9)

Country	Link
EP (1)	EP0584118B1 (fr)
JP (1)	JP3351524B2 (fr)
AT (1)	ATE196608T1 (fr)
CA (1)	CA2105771A1 (fr)
DE (2)	DE4115038A1 (fr)
DK (1)	DK0584118T3 (fr)
ES (1)	ES2150421T3 (fr)
GR (1)	GR3035006T3 (fr)
WO (1)	WO1992019281A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6022950A (en) *	1984-06-07	2000-02-08	Seragen, Inc.	Hybrid molecules having translocation region and cell-binding region
DE4435087A1 (de) *	1994-09-30	1996-04-04	Deutsches Krebsforsch	Konjugat zur Behandlung von Infektions-, Autoimmun- und Hauterkrankungen
JP3581877B2 (ja) *	1995-05-12	2004-10-27	独立行政法人産業技術総合研究所	機能性分子輸送体
WO1997023608A1 (fr) *	1995-12-22	1997-07-03	Chiron Corporation	Compositions et procedes permettant de doter des vecteurs d'acheminement de genes d'elements de ciblage lies de maniere covalente
GB9908195D0 (en)	1999-04-09	1999-06-02	Microbiological Res Authority	Treatment of intracellular infection
RU2197987C2 (ru) *	2000-07-07	2003-02-10	Закрытое акционерное общество "АСГЛ-Исследовательские Лаборатории"	Носитель чужеродной генетической информации для генной терапии
AU2014262540B2 (en) *	2013-05-10	2016-10-27	Pepsico, Inc.	Taste receptor internalization assay

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1979000515A1 (fr) *	1978-01-16	1979-08-09	Univ Boston	Methode de captage cellulaire de molecules
EP0273085A1 (fr) *	1986-12-29	1988-07-06	IntraCel Corporation	Procédé pour faire entrer des acides nucléiques dans des cellules eucaryotes
DE3727987A1 (de) *	1987-08-21	1989-03-02	Sleytr Uwe B	Pharmazeutische struktur
US5354844A (en) *	1989-03-16	1994-10-11	Boehringer Ingelheim International Gmbh	Protein-polycation conjugates
ES2078521T3 (es) *	1990-05-18	1995-12-16	Boehringer Ingelheim Int	Nuevos conjugados de proteina-polication.

1991
- 1991-05-08 DE DE4115038A patent/DE4115038A1/de not_active Ceased
1992
- 1992-05-01 DK DK92909423T patent/DK0584118T3/da active
- 1992-05-01 EP EP92909423A patent/EP0584118B1/fr not_active Expired - Lifetime
- 1992-05-01 JP JP50853592A patent/JP3351524B2/ja not_active Expired - Fee Related
- 1992-05-01 CA CA002105771A patent/CA2105771A1/fr not_active Abandoned
- 1992-05-01 WO PCT/EP1992/000953 patent/WO1992019281A2/fr active IP Right Grant
- 1992-05-01 ES ES92909423T patent/ES2150421T3/es not_active Expired - Lifetime
- 1992-05-01 DE DE59209869T patent/DE59209869D1/de not_active Expired - Fee Related
- 1992-05-01 AT AT92909423T patent/ATE196608T1/de not_active IP Right Cessation
2000
- 2000-12-06 GR GR20000402697T patent/GR3035006T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0584118A1 (fr)	1994-03-02
JPH06507158A (ja)	1994-08-11
DE59209869D1 (de)	2000-11-02
GR3035006T3 (en)	2001-03-30
WO1992019281A2 (fr)	1992-11-12
WO1992019281A3 (fr)	1993-02-04
EP0584118B1 (fr)	2000-09-27
JP3351524B2 (ja)	2002-11-25
ES2150421T3 (es)	2000-12-01
DE4115038A1 (de)	1992-11-12
CA2105771A1 (fr)	1992-11-09
ATE196608T1 (de)	2000-10-15

Publication	Publication Date	Title
EP0429534B1 (fr)	1996-04-17	Conjugues moleculaires contenant des agents de melange a une membrane cellulaire
US5711944A (en)	1998-01-27	Interferon polymer conjugates
WO1993021331A3 (fr)	1994-01-06	Conjugues et proteines fusionnees se liant aux polysaccharides
DK601786A (da)	1986-12-12	Hidtil ukendte prokoagulationsproteiner
CA2101227A1 (fr)	1994-01-27	Derives de chlorophylle et de bacteriochlorophylle et compositions pharmaceutiques en contenant
DK1175909T3 (da)	2009-07-06	Terapeutiske sammensætninger af antistoffer og antisense-nukleinsyrer mod Serrate
ATE126442T1 (de)	1995-09-15	Neue protein-polykation-konjugate.
WO1999004820A3 (fr)	1999-08-12	Cytolyse orientee de cellules cibles, agents et compostions a l'origine de cette cytolyse et composes pouvant etre utilises pour produire ces agents
EP0339504A3 (fr)	1990-09-12	Virus d'immunodéficience humaine (HIV) peptide env-codé capable de provoquer les anticorps inhibiteurs du HIV dans les mammifères
DK516385A (da)	1985-11-08	Syntetisk vaccine mod hepatitis b virus indeholdende baade t celle og bcelle determinanter
BR9509172A (pt)	1997-11-25	Proteina de via de complemento nativa sequéncia de dna construção de dna conjugado uso de uma proteína processo para reduzir proteina de via de complemento em um mamifero e formulação farmacéutica
DK0584118T3 (da)	2001-01-29	Nyt konjugat, bestående af et glycoprotein og en nucleinsyrebindende substans
NZ333203A (en)	2000-07-28	Tumour antigen proteins, genes thereof, and tumour antigen peptides
ATE202485T1 (de)	2001-07-15	Neue protein-polykation-konjugate
FI902569A0 (fi)	1990-05-23	Producering av till gonorre anslutande pi-proteiner och vaccin.
ATE141415T1 (de)	1996-08-15	Konjugate von antikörpern mit variablen domänen
DK0805204T3 (da)	2007-04-02	Bitestikel - specifikt receptorprotein og anvendelse heraf
DK551786A (da)	1987-09-08	Rekombinant-dna-sekvens, der koder for aminosyresekvenser i et toksin, expressionssystem omfattende samme og vaertsceller transformeret hermed
TR200002611T2 (tr)	2000-12-21	Beta-lipotropin ve kullanımları
RU95101019A (ru)	1996-12-27	Способ получения фактора некроза опухоли, фактор некроза опухоли, днк, клетка, композиция
DK0540560T3 (da)	1995-12-27	Ancrod-lignende proteiner, fremstilling og anvendelse deraf
CA2247998A1 (fr)	1997-09-04	Fragments de recepteur du complement de type 1 et leurs utilisations
Greenfield et al.	1990	Toxin conjugates.
NZ513915A (en)	2003-03-28	Chimeric proteins comprising 6 contiguous amino acids that bind to the GIT fused to a second protein, which may be a drug