DK0577024T3 - - Google Patents

Info

Publication number: DK0577024T3
Authority: DK; Denmark
Prior art keywords: equal; compounds; alk; formula; image
Prior art date: 1992-07-01

Application number

DK93110195.0T

Other languages

Danish (da)

English (en)

Inventor

Andreas Dr Weichert

Hans-Jochen Lang

Wolfgang Dr Scholz

Udo Dr Albus

Florian Prof Dr Lang

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-01

Filing date

1993-06-25

Publication date

1997-02-24

1993-06-25 Application filed by Hoechst Ag filed Critical Hoechst Ag

1997-02-24 Application granted granted Critical

1997-02-24 Publication of DK0577024T3 publication Critical patent/DK0577024T3/da

Links

150000001875 compounds Chemical class 0.000 abstract 3
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
206010002383 Angina Pectoris Diseases 0.000 abstract 1
206010019668 Hepatic fibrosis Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010061216 Infarction Diseases 0.000 abstract 1
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
102000052126 Sodium-Hydrogen Exchangers Human genes 0.000 abstract 1
108091006672 Sodium–hydrogen antiporter Proteins 0.000 abstract 1
230000000879 anti-atherosclerotic effect Effects 0.000 abstract 1
239000003416 antiarrhythmic agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000003293 cardioprotective effect Effects 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
230000001413 cellular effect Effects 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000003176 fibrotic effect Effects 0.000 abstract 1
230000002440 hepatic effect Effects 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000007574 infarction Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 abstract 1
230000035778 pathophysiological process Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
230000002685 pulmonary effect Effects 0.000 abstract 1
208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
201000002793 renal fibrosis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)

DK93110195.0T 1992-07-01 1993-06-25 DK0577024T3 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE4221594		1992-07-01
DE4224107		1992-07-22
DE4244319		1992-12-28

Publications (1)

Publication Number	Publication Date
DK0577024T3 true DK0577024T3 (fr)	1997-02-24

Family

ID=27203913

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93110195.0T DK0577024T3 (fr)	1992-07-01	1993-06-25

Country Status (15)

Country	Link
US (1)	US5693672A (fr)
EP (1)	EP0577024B1 (fr)
JP (1)	JP3490739B2 (fr)
AT (1)	ATE144248T1 (fr)
AU (1)	AU658309B2 (fr)
CA (1)	CA2099445A1 (fr)
DE (1)	DE59304166D1 (fr)
DK (1)	DK0577024T3 (fr)
ES (1)	ES2092729T3 (fr)
FI (1)	FI113367B (fr)
GR (1)	GR3021397T3 (fr)
IL (1)	IL106157A (fr)
NO (1)	NO179673C (fr)
NZ (1)	NZ248013A (fr)
TW (1)	TW328536B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL109570A0 (en) *	1993-05-17	1994-08-26	Fujisawa Pharmaceutical Co	Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4325822A1 (de) *	1993-07-31	1995-02-02	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4412334A1 (de) *	1994-04-11	1995-10-19	Hoechst Ag	Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4417004A1 (de) *	1994-05-13	1995-11-16	Hoechst Ag	Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
IL114670A0 (en) *	1994-08-05	1995-11-27	Fujisawa Pharmaceutical Co	Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
DE4430212A1 (de) *	1994-08-28	1996-02-29	Merck Patent Gmbh	Ortho-substituierte Benzoesäure-Derivate
DE4430213A1 (de) *	1994-08-28	1996-02-29	Merck Patent Gmbh	Arylbenzoylguanidine
DE4430916A1 (de) *	1994-08-31	1996-03-07	Merck Patent Gmbh	Alkyl-benzoylguanidin-Derivate
DE4432101A1 (de) *	1994-09-09	1996-03-14	Hoechst Ag	Aminosäure-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
AU670224B3 (en) *	1994-09-28	1996-07-04	Chain Reaction Sales Promotion Pty Ltd	Signage apparatus
TW372967B (en) *	1994-12-27	1999-11-01	Kanebo Ltd	1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof
DE19531138A1 (de) *	1995-08-24	1997-02-27	Merck Patent Gmbh	Alkenyl-benzoylguanidin-Derivate
DE19540995A1 (de) *	1995-11-03	1997-05-07	Hoechst Ag	Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) *	1995-11-14	1997-05-15	Hoechst Ag	Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) *	1995-11-20	1997-05-26	Hoechst Ag	Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) *	1995-12-14	1997-06-19	Hoechst Ag	Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19622222A1 (de) *	1996-06-03	1997-12-04	Hoechst Ag	Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikament zur Normalisierung der Serumlipide
WO1998039300A1 (fr) *	1997-03-06	1998-09-11	Toa Eiyo Ltd.	DERIVES DE CYCLOALCA[b]PYRIDINE-3-CARBONYLGUANIDINE, LEUR PROCEDE DE PRODUCTION ET MEDICAMENTS LES CONTENANT
US6410563B1 (en)	1999-12-22	2002-06-25	Merck Frosst Canada & Co.	Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
US6639077B2 (en)	2000-03-23	2003-10-28	Merck Frosst Canada & Co.	Tri-aryl-substituted-ethane PDE4 inhibitors
MY123585A (en)	2000-03-23	2006-05-31	Merck Canada Inc	Tri-aryl-substituted-ethane pde4 inhibitors.
AU6196201A (en)	2000-05-25	2001-12-03	Merck Frosst Canada Inc	Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor
US6740666B2 (en)	2000-12-20	2004-05-25	Merck & Co., Inc.	Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
ES2247325T3 (es)	2001-05-24	2006-03-01	MERCK FROSST CANADA & CO.	Inhibidores de 1-biaril-1,8-naftiridin-4-ona fosfodiesterasa-4.
JO2311B1 (en)	2001-08-29	2005-09-12	ميرك فروست كندا ليمتد	Alkyl inhibitors Ariel phosphodiesterase-4
CA2478799C (fr)	2002-03-12	2009-12-29	Merck & Co., Inc.	Modulateurs de tetrazole di-aryle substitues du recepteur 5 de glutamate metabotropique
EP1590338B1 (fr) *	2002-12-04	2009-08-26	Ore Pharmaceuticals Inc.	Modulateurs du recepteur de la melanocortine
US7504401B2 (en)	2003-08-29	2009-03-17	Locus Pharmaceuticals, Inc.	Anti-cancer agents and uses thereof
EP1680109A4 (fr)	2003-10-07	2009-05-06	Renovis Inc	Derives d'amide utilises comme ligands du canal ionique et compositions pharmaceutiques et methodes d'utilisation de ces derives
US7576099B2 (en)	2005-02-28	2009-08-18	Renovis, Inc.	Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
US20080300243A1 (en) *	2005-02-28	2008-12-04	Kelly Michael G	Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
EP1853269A4 (fr) *	2005-02-28	2011-09-07	Renovis Inc	Derives d'amide en tant que ligands de canal ionique, compositions pharmaceutiques et methodes d'utilisation associees
HUE056766T2 (hu) *	2017-07-04	2022-03-28	Sanofi Sa	Etinil-vegyületek, ezek elõállítása és terápiás alkalmazása malária kezelésére

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3247035A (en) *	1962-09-28	1966-04-19	Standard Oil Co	Ammonium nitrate propellants containing a nitro-aminocarboxy-alkali metal phenolate combustion catalyst
US3420874A (en) *	1962-09-28	1969-01-07	Standard Oil Co	Amine addition salts of nitro-carboxyalkali metal phenolates
US3780027A (en) *	1970-04-29	1973-12-18	Merck & Co Inc	Anthranilic acid derivatives
US3728332A (en) *	1971-09-03	1973-04-17	Nat Starch Chem Corp	Preparation of starch esters
US4178387A (en) *	1976-03-30	1979-12-11	William H. Rorer, Inc.	Method for the treatment of arrhythmia
US4251545A (en) *	1979-09-19	1981-02-17	Gaf Corporation	Fungicidal process using 1-(alkoxyaroyl)guanidines
DE3929582A1 (de) *	1989-09-06	1991-03-07	Hoechst Ag	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
US5093194A (en) *	1989-11-01	1992-03-03	Mobil Oil Corporation	Oriented multilayer heat sealable packaging film
ES2089600T3 (es) *	1992-02-15	1996-10-01	Hoechst Ag	Benzoilguanidina sustituida en 3,5, con efecto antiarritmico y efecto inhibidor de la proliferacion de celulas.

1993
- 1993-06-25 DK DK93110195.0T patent/DK0577024T3/da active
- 1993-06-25 AT AT93110195T patent/ATE144248T1/de not_active IP Right Cessation
- 1993-06-25 DE DE59304166T patent/DE59304166D1/de not_active Expired - Lifetime
- 1993-06-25 ES ES93110195T patent/ES2092729T3/es not_active Expired - Lifetime
- 1993-06-25 EP EP93110195A patent/EP0577024B1/fr not_active Expired - Lifetime
- 1993-06-28 IL IL10615793A patent/IL106157A/en not_active IP Right Cessation
- 1993-06-29 NZ NZ248013A patent/NZ248013A/en unknown
- 1993-06-29 FI FI932998A patent/FI113367B/fi not_active IP Right Cessation
- 1993-06-30 JP JP15988693A patent/JP3490739B2/ja not_active Expired - Fee Related
- 1993-06-30 CA CA002099445A patent/CA2099445A1/fr not_active Abandoned
- 1993-06-30 AU AU41635/93A patent/AU658309B2/en not_active Ceased
- 1993-06-30 NO NO932392A patent/NO179673C/no unknown
- 1993-08-23 TW TW082106777A patent/TW328536B/zh active
1995
- 1995-05-26 US US08/451,309 patent/US5693672A/en not_active Expired - Lifetime
1996
- 1996-10-17 GR GR960402615T patent/GR3021397T3/el unknown

Also Published As

Publication number	Publication date
NO932392D0 (no)	1993-06-30
US5693672A (en)	1997-12-02
ES2092729T3 (es)	1996-12-01
AU4163593A (en)	1994-01-06
JPH06116230A (ja)	1994-04-26
NZ248013A (en)	1995-12-21
FI113367B (fi)	2004-04-15
AU658309B2 (en)	1995-04-06
JP3490739B2 (ja)	2004-01-26
EP0577024B1 (fr)	1996-10-16
ATE144248T1 (de)	1996-11-15
DE59304166D1 (de)	1996-11-21
FI932998L (fi)	1994-01-02
EP0577024A1 (fr)	1994-01-05
GR3021397T3 (en)	1997-01-31
FI932998A0 (fi)	1993-06-29
NO179673B (no)	1996-08-19
IL106157A (en)	1999-11-30
NO179673C (no)	1996-11-27
IL106157A0 (en)	1993-10-20
TW328536B (en)	1998-03-21
NO932392L (no)	1994-01-03
CA2099445A1 (fr)	1994-01-02

Publication	Publication Date	Title
DK0577024T3 (fr)	1997-02-24
DE59302959D1 (de)	1996-07-25	3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen
AU7150794A (en)	1995-03-09	Ortho-substituted benzoylguanidines, process for their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
TW250479B (fr)	1995-07-01
HU9403759D0 (en)	1995-02-28	Substituted 1-oxo-1,2-dihydro-isoguino-linoyl- and 1,1-dioxo-2h-1,2-benzothiazinoyl-guanidines, process for producing them, use of them in therapy and pharmaceutical compositions containing them
AU7022394A (en)	1995-02-23	Urea and thiourea-substituted benzoylguanidines, process for their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
AU546719B2 (en)	1985-09-19	Twin-diazonium salt