DK0570518T3 - Fremgangsmåder og apparat til forbedrede elektrokemiluminescens-assays - Google Patents
Fremgangsmåder og apparat til forbedrede elektrokemiluminescens-assaysInfo
- Publication number
- DK0570518T3 DK0570518T3 DK92906820T DK92906820T DK0570518T3 DK 0570518 T3 DK0570518 T3 DK 0570518T3 DK 92906820 T DK92906820 T DK 92906820T DK 92906820 T DK92906820 T DK 92906820T DK 0570518 T3 DK0570518 T3 DK 0570518T3
- Authority
- DK
- Denmark
- Prior art keywords
- electrochemiluminescence
- working electrode
- analyte
- interest
- electrode surface
- Prior art date
Links
- 238000003556 assay Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000012491 analyte Substances 0.000 abstract 2
- 238000005259 measurement Methods 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000000159 protein binding assay Methods 0.000 abstract 1
- 230000001960 triggered effect Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
- G01N21/69—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids, e.g. molten metal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/30—Electrochemically active labels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65242791A | 1991-02-06 | 1991-02-06 | |
| US82726992A | 1992-02-03 | 1992-02-03 | |
| US82727092A | 1992-02-03 | 1992-02-03 | |
| PCT/US1992/000992 WO1992014139A1 (en) | 1991-02-06 | 1992-02-05 | Methods and apparatus for improved luminescence assays |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0570518T3 true DK0570518T3 (da) | 1999-08-02 |
Family
ID=27417877
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92906820T DK0570518T3 (da) | 1991-02-06 | 1992-02-05 | Fremgangsmåder og apparat til forbedrede elektrokemiluminescens-assays |
| DK98200764T DK0877252T3 (da) | 1991-02-06 | 1992-02-05 | Fremgangsmåde og apparat til luminescensassays |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98200764T DK0877252T3 (da) | 1991-02-06 | 1992-02-05 | Fremgangsmåde og apparat til luminescensassays |
Country Status (17)
| Country | Link |
|---|---|
| EP (3) | EP0570518B1 (da) |
| JP (2) | JP3061416B2 (da) |
| KR (1) | KR100226231B1 (da) |
| CN (2) | CN1495425A (da) |
| AT (2) | ATE173542T1 (da) |
| AU (1) | AU668085B2 (da) |
| CA (1) | CA2103674C (da) |
| DE (3) | DE69233703T2 (da) |
| DK (2) | DK0570518T3 (da) |
| ES (3) | ES2291407T3 (da) |
| GR (1) | GR3029446T3 (da) |
| HK (3) | HK1017970A1 (da) |
| IE (1) | IE69060B1 (da) |
| IL (1) | IL100867A (da) |
| NZ (1) | NZ241537A (da) |
| TW (1) | TW316291B (da) |
| WO (1) | WO1992014139A1 (da) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0594766B1 (en) * | 1991-07-10 | 1999-09-08 | Igen International, Inc. | Methods for improved luminescence assays using particle concentration and chemiluminescence detection |
| ZA929351B (en) * | 1991-12-11 | 1993-06-04 | Igen Inc | Electrochemiluminescent label for DNA assays. |
| US5466416A (en) * | 1993-05-14 | 1995-11-14 | Ghaed; Ali | Apparatus and methods for carrying out electrochemiluminescence test measurements |
| ES2143059T3 (es) * | 1994-07-25 | 2000-05-01 | Roche Diagnostics Gmbh | Complejos metalicos hidrofilos. |
| US5744367A (en) * | 1994-11-10 | 1998-04-28 | Igen International, Inc. | Magnetic particle based electrochemiluminescent detection apparatus and method |
| US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
| US6140045A (en) * | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
| US6673533B1 (en) | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
| HUP9801679A3 (en) * | 1995-03-10 | 2001-01-29 | Meso Scale Technologies Llc Co | Process and agent for multi-array, multi-specific electrochemiluminescence testing |
| US6319670B1 (en) | 1995-05-09 | 2001-11-20 | Meso Scale Technology Llp | Methods and apparatus for improved luminescence assays using microparticles |
| US7314711B2 (en) | 1997-05-23 | 2008-01-01 | Bioveris Corporation | Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers |
| JP3366842B2 (ja) * | 1997-08-29 | 2003-01-14 | エーザイ株式会社 | 電気化学発光測定用セル |
| US6200531B1 (en) | 1998-05-11 | 2001-03-13 | Igen International, Inc. | Apparatus for carrying out electrochemiluminescence test measurements |
| US6312896B1 (en) * | 1998-09-17 | 2001-11-06 | Igen Inaternational, Inc. | Assays for measuring nucleic acid binding proteins and enzyme activities |
| US6136268A (en) * | 1999-08-17 | 2000-10-24 | Orion Diagnostica | Method for luminescence measurements |
| EP2405019A1 (en) * | 2001-09-10 | 2012-01-11 | Meso Scale Technologies LLC | Methods, reagents, kits and apparatus for protein function analysis |
| US7497827B2 (en) | 2004-07-13 | 2009-03-03 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20030180814A1 (en) * | 2002-03-21 | 2003-09-25 | Alastair Hodges | Direct immunosensor assay |
| US7553448B2 (en) | 2002-06-20 | 2009-06-30 | Bioveris Corporation | Electrochemiluminescence flow cell and flow cell components |
| WO2004042400A1 (ja) | 2002-11-07 | 2004-05-21 | Mitsubishi Kagaku Iatron, Inc. | 磁性粒子捕集用磁力体及びその利用 |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| KR101076578B1 (ko) | 2004-06-23 | 2011-10-24 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 2입자 착물을 이용한 생물학적 분자의 검출을 위한 방법 및조성물 |
| US20060270922A1 (en) | 2004-07-13 | 2006-11-30 | Brauker James H | Analyte sensor |
| US20060275841A1 (en) * | 2004-12-20 | 2006-12-07 | Martin Blankfard | Assay method and apparatus with reduced sample matrix effects |
| US7300631B2 (en) * | 2005-05-02 | 2007-11-27 | Bioscale, Inc. | Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles |
| US8211279B2 (en) | 2005-06-03 | 2012-07-03 | Board Of Regents Of The University Of Texas System | Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode |
| JPWO2007148762A1 (ja) * | 2006-06-22 | 2009-11-19 | 雅彦 黒田 | ヒトパピローマウイルス（ｈｐｖ）の検出方法、それに用いるプライマーセットおよび検出キット |
| EP2271938B1 (en) | 2008-04-11 | 2014-02-26 | Board of Regents of the University of Texas System | Method and apparatus for nanoparticle electrogenerated chemiluminescence amplification |
| EP2294387B1 (en) | 2008-05-08 | 2017-08-23 | Board of Regents of the University of Texas System | Luminescent nanostructured materials for use in electrogenerated chemiluminescence |
| WO2010036808A1 (en) * | 2008-09-24 | 2010-04-01 | Straus Holdings Inc. | Kits and devices for detecting analytes |
| US20100261292A1 (en) | 2009-04-10 | 2010-10-14 | Meso Scale Technologies, Llc | Methods for Conducting Assays |
| CN103608116B (zh) * | 2011-06-15 | 2017-05-24 | 皇家飞利浦有限公司 | 对生物样本组分的处理 |
| US20150056098A1 (en) * | 2011-12-28 | 2015-02-26 | Hitachi High-Technologies Corporation | Sample analysis device and sample analysis method |
| CN107923911A (zh) | 2015-08-20 | 2018-04-17 | 豪夫迈·罗氏有限公司 | 使用聚乙二醇化分析物特异性结合剂的基于颗粒的免疫测定法 |
| CN108780092A (zh) | 2016-03-07 | 2018-11-09 | 豪夫迈·罗氏有限公司 | 抗p53抗体的检测 |
| JP7039481B2 (ja) * | 2016-03-11 | 2022-03-22 | エフ．ホフマン－ラ ロシュ アーゲー | 電気化学発光検出における分枝鎖アミン |
| WO2018050701A1 (en) | 2016-09-14 | 2018-03-22 | Philip Morris Products S.A. | Aerosol-generating system and method for controlling the same |
| EP3577460B1 (en) | 2017-02-02 | 2021-01-20 | Roche Diagnostics GmbH | Immunoassay using at least two pegylated analyte-specific binding agents |
| DE102017114537A1 (de) * | 2017-06-29 | 2019-01-03 | Endress+Hauser Conducta Gmbh+Co. Kg | Sensormembran, Sensorkappe und optischer Sensor |
| WO2019079125A2 (en) * | 2017-10-19 | 2019-04-25 | Bio-Rad Laboratories, Inc. | DIGITAL AMPLIFICATION TESTS WITH UNCONVENTIONAL AND / OR INVERTED PHOTOLUMINESCENCE CHANGES |
| CN111936522B (zh) | 2018-04-18 | 2024-07-02 | 豪夫迈·罗氏有限公司 | 新型抗胸苷激酶抗体 |
| CA3097748A1 (en) | 2018-04-19 | 2019-10-24 | First Light Biosciences, Inc. | Detection of targets |
| EP3844503B1 (en) | 2018-08-31 | 2024-05-29 | F. Hoffmann-La Roche AG | Thymidine kinase (tk-1) in prognostic indices for dlbcl |
| EP3860452A4 (en) | 2018-10-04 | 2022-11-23 | First Light Diagnostics, Inc. | ANALYSIS INSTRUMENT |
| CN111351781B (zh) * | 2018-12-20 | 2023-11-24 | 麦德龙生物株式会社 | 电化学发光分析装置和使用其分析样品的方法 |
| CN111007593B (zh) * | 2019-05-12 | 2022-05-13 | 桂林电子科技大学 | 基于热扩散融嵌芯毛细管光纤微小粒子输运装置 |
| EP4004552A1 (en) | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | S100a12 as blood biomarker for the non-invasive diagnosis of endometriosis |
| CN114144675A (zh) | 2019-07-22 | 2022-03-04 | 豪夫迈·罗氏有限公司 | S100a9作为血液生物标志物用于子宫内膜异位症的非侵入性诊断 |
| EP4004551A1 (en) | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | Substance p as blood biomarker for the non-invasive diagnosis of endometriosis |
| EP4004555A1 (en) | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | S100a6 as blood biomarker for the non-invasive diagnosis of endometriosis |
| CN114144673A (zh) | 2019-07-22 | 2022-03-04 | 豪夫迈·罗氏有限公司 | S100a8作为血液生物标志物用于子宫内膜异位症的非侵入性诊断 |
| JP2023502360A (ja) | 2019-11-15 | 2023-01-24 | エフ．ホフマン－ラ ロシュ アーゲー | 患者試料における質量分析測定のためのβ－ラクタム抗生物質の誘導体化 |
| CN111693515B (zh) * | 2020-05-07 | 2022-06-17 | 四川轻化工大学 | 一种流式电化学发光实时检测装置及检测方法 |
| CN111693516B (zh) * | 2020-05-07 | 2023-04-21 | 四川轻化工大学 | 一种气液相电化学发光检测装置及检测方法 |
| US20230406909A1 (en) | 2020-11-02 | 2023-12-21 | Roche Diagnostics Operations, Inc. | Sars-cov-2 nucleocapsid antibodies |
| CN113030068A (zh) * | 2021-02-01 | 2021-06-25 | 苏州易莱生物技术有限公司 | 电化学发光的检测设备 |
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| WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
| CN119404103A (zh) | 2022-06-23 | 2025-02-07 | 豪夫迈·罗氏有限公司 | 用于诊断子宫内膜异位症及用于对子宫内膜异位症的分期进行分类的方法 |
| WO2024017985A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| CN119604768A (zh) | 2022-07-22 | 2025-03-11 | 豪夫迈·罗氏有限公司 | 白三烯a4水解酶(lta4h)作为（血液）生物标志物用于诊断多囊卵巢综合征 |
| WO2024017983A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2025017135A1 (en) | 2023-07-20 | 2025-01-23 | F. Hoffmann-La Roche Ag | Screening methods for antibody compositions |
| WO2025026908A1 (en) | 2023-07-28 | 2025-02-06 | Roche Diagnostics Gmbh | Serum epha1 as biomarker for endometriosis |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0030087A1 (en) * | 1979-11-13 | 1981-06-10 | Technicon Instruments Company Limited | Immunoassay method and apparatus and kit for carrying out the method |
| DE3013765A1 (de) * | 1980-04-10 | 1981-10-15 | Philips Patentverwaltung Gmbh, 2000 Hamburg | Detektroranordnung, insbesondere fuer die fluessigkeitschromatografie |
| US4652533A (en) * | 1983-04-28 | 1987-03-24 | Pandex Laboratories, Inc. | Method of solid phase immunoassay incorporating a luminescent label |
| US4628037A (en) * | 1983-05-12 | 1986-12-09 | Advanced Magnetics, Inc. | Binding assays employing magnetic particles |
| CA1272507A (en) * | 1984-07-10 | 1990-08-07 | Simon John Rattle | Method of assay using magnetically held label |
| FI844027A7 (fi) * | 1984-10-12 | 1986-04-13 | Labsystems Oy | Immunologiskt bestaemningsfoerfarande. |
| GB8507706D0 (en) * | 1985-03-25 | 1985-05-01 | Genetics Int Inc | Magnetic nucleic acid sequences |
| DE3751516T2 (de) * | 1986-04-30 | 1996-02-15 | Igen, Inc. (N.D.Ges. D. Staates California), Gaithersburg, Md. | Elektrochemilumineszenz-testverfahren. |
| WO1987007386A1 (en) * | 1986-05-22 | 1987-12-03 | Unilever Plc | Solid phase immunoassay method |
| GB8620893D0 (en) * | 1986-08-29 | 1986-10-08 | Unilever Plc | Assays |
| US5093268A (en) * | 1988-04-28 | 1992-03-03 | Igen, Inc. | Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena |
| EP0757252A3 (en) * | 1988-11-03 | 1997-04-16 | Igen Inc | Electrochemiluminescent test procedure |
| US5061445A (en) * | 1988-11-03 | 1991-10-29 | Igen, Inc. | Apparatus for conducting measurements of electrochemiluminescent phenomena |
| US5068088A (en) * | 1988-11-03 | 1991-11-26 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
| CA2002083C (en) * | 1988-11-03 | 2001-01-09 | Haresh P. Shah | Enhanced electrochemiluminescence |
-
1992
- 1992-02-04 IL IL10086792A patent/IL100867A/en not_active IP Right Cessation
- 1992-02-05 IE IE920380A patent/IE69060B1/en not_active IP Right Cessation
- 1992-02-05 EP EP92906820A patent/EP0570518B1/en not_active Expired - Lifetime
- 1992-02-05 KR KR1019930702344A patent/KR100226231B1/ko not_active Expired - Fee Related
- 1992-02-05 ES ES02022214T patent/ES2291407T3/es not_active Expired - Lifetime
- 1992-02-05 AU AU14206/92A patent/AU668085B2/en not_active Ceased
- 1992-02-05 DK DK92906820T patent/DK0570518T3/da active
- 1992-02-05 EP EP02022214A patent/EP1286164B1/en not_active Expired - Lifetime
- 1992-02-05 JP JP4506644A patent/JP3061416B2/ja not_active Expired - Lifetime
- 1992-02-05 ES ES98200764T patent/ES2281119T3/es not_active Expired - Lifetime
- 1992-02-05 DE DE69233703T patent/DE69233703T2/de not_active Expired - Lifetime
- 1992-02-05 EP EP98200764A patent/EP0877252B1/en not_active Expired - Lifetime
- 1992-02-05 WO PCT/US1992/000992 patent/WO1992014139A1/en active IP Right Grant
- 1992-02-05 AT AT92906820T patent/ATE173542T1/de active
- 1992-02-05 DK DK98200764T patent/DK0877252T3/da active
- 1992-02-05 NZ NZ241537A patent/NZ241537A/en not_active IP Right Cessation
- 1992-02-05 DE DE69233675T patent/DE69233675T2/de not_active Expired - Lifetime
- 1992-02-05 CA CA002103674A patent/CA2103674C/en not_active Expired - Lifetime
- 1992-02-05 ES ES92906820T patent/ES2126591T3/es not_active Expired - Lifetime
- 1992-02-05 AT AT02022214T patent/ATE368224T1/de active
- 1992-02-05 DE DE69227624T patent/DE69227624T2/de not_active Expired - Lifetime
- 1992-02-07 CN CNA021320268A patent/CN1495425A/zh active Granted
- 1992-02-07 CN CN92102540.8A patent/CN1094593C/zh not_active Expired - Lifetime
- 1992-03-19 TW TW081102075A patent/TW316291B/zh active
-
1998
- 1998-07-15 JP JP20086598A patent/JP3182515B2/ja not_active Expired - Lifetime
- 1998-12-23 HK HK98115052A patent/HK1017970A1/xx not_active IP Right Cessation
-
1999
- 1999-02-18 GR GR990400531T patent/GR3029446T3/el unknown
- 1999-03-10 HK HK99100983A patent/HK1015878A1/xx not_active IP Right Cessation
-
2004
- 2004-11-09 HK HK04108800.9A patent/HK1066059A1/xx not_active IP Right Cessation
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