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DK0565668T3 - Biologisk farvemiddelsammensætning, fremgangsmåde til fremstilling deraf og til anvendelse til aftegning af epitelcancer - Google Patents

Biologisk farvemiddelsammensætning, fremgangsmåde til fremstilling deraf og til anvendelse til aftegning af epitelcancer

Info

Publication number
DK0565668T3
DK0565668T3 DK92921881T DK92921881T DK0565668T3 DK 0565668 T3 DK0565668 T3 DK 0565668T3 DK 92921881 T DK92921881 T DK 92921881T DK 92921881 T DK92921881 T DK 92921881T DK 0565668 T3 DK0565668 T3 DK 0565668T3
Authority
DK
Denmark
Prior art keywords
preparation
dye composition
epithelial cancer
toluidine blue
biological dye
Prior art date
Application number
DK92921881T
Other languages
Danish (da)
English (en)
Inventor
Mark J Malmros
Raymond J Tucci
Pier J Cipriani
Original Assignee
Zila Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zila Inc filed Critical Zila Inc
Application granted granted Critical
Publication of DK0565668T3 publication Critical patent/DK0565668T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Cosmetics (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)
DK92921881T 1991-10-31 1992-10-07 Biologisk farvemiddelsammensætning, fremgangsmåde til fremstilling deraf og til anvendelse til aftegning af epitelcancer DK0565668T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78552091A 1991-10-31 1991-10-31
PCT/US1992/008722 WO1993008847A1 (fr) 1991-10-31 1992-10-07 Composition de coloration biologique, procede de preparation et procede d'utilisation dans le reperage du cancer epithelial

Publications (1)

Publication Number Publication Date
DK0565668T3 true DK0565668T3 (da) 2000-01-31

Family

ID=25135780

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92921881T DK0565668T3 (da) 1991-10-31 1992-10-07 Biologisk farvemiddelsammensætning, fremgangsmåde til fremstilling deraf og til anvendelse til aftegning af epitelcancer

Country Status (12)

Country Link
US (1) US5372801A (fr)
EP (1) EP0565668B1 (fr)
JP (1) JP3549880B2 (fr)
KR (1) KR100242727B1 (fr)
AT (1) ATE181510T1 (fr)
AU (1) AU661727B2 (fr)
CA (1) CA2097695C (fr)
DE (1) DE69229471T2 (fr)
DK (1) DK0565668T3 (fr)
ES (1) ES2133143T3 (fr)
GR (1) GR3031233T3 (fr)
WO (1) WO1993008847A1 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6417003B1 (en) * 1993-01-14 2002-07-09 Zila, Inc. Method and kit for epithelial cancer screening
FI97630C (fi) * 1995-02-23 1997-01-27 Carefibres Oy Kuitumateriaali ja menetelmä sen valmistamiseksi
US5605812A (en) * 1995-05-19 1997-02-25 Charm Sciences, Inc. Test kit and method for the quantitative determination of coliform bacteria and E. coli
ATE198222T1 (de) * 1995-10-05 2001-01-15 Blz Gmbh Verfahren zur herstellung eines schneidwerkzeuges
RU2178565C2 (ru) * 1996-01-16 2002-01-20 Зила Инк. Способы и композиции для обнаружения in vivo оральных злокачественных опухолей и предраковых состояний
AU712732B2 (en) * 1996-01-16 1999-11-11 Zila Biotechnology, Inc. Methods and compositions for in-vivo detection of oral cancers and precancerous conditions
ES2218584T3 (es) * 1996-02-29 2004-11-16 Zila, Inc. Bastoncillo con hisopo preacondicionado para el control del cancer epitelial.
US6083487A (en) * 1997-08-25 2000-07-04 Advanced Photodynamic Technologies, Inc. Methylene blue and toluidene blue mediated fluorescence diagnosis of cancer
US6086852A (en) * 1997-11-13 2000-07-11 Zila, Inc. In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
CA2250731C (fr) 1997-11-13 2006-03-14 Douglas D. Burkett Compose mordant in vivo, procede de fabrication et methodes d'identification de tissu dysplastique
WO1999025388A1 (fr) * 1997-11-13 1999-05-27 Zila, Inc. Composition de colorants in vivo, son procede d'obtention et des procedes d'utilisation en vue d'une identification d'un tissu dysplasique
US6194573B1 (en) * 1997-11-13 2001-02-27 Zila, Inc. Process for manufacture of in vivo stain composition
JP2003520816A (ja) * 2000-01-31 2003-07-08 ジラ・インコーポレーテッド インビボ染色化合物および異形成組織を同定するための使用法
US6649144B1 (en) * 2000-02-28 2003-11-18 Zila, Inc. Method for detecting and killing epithelial cancer cells
AU2000237154A1 (en) * 2000-02-28 2001-09-12 Zila, Inc. Method for detecting and killing epithelial cancer cells
CA2383194A1 (fr) * 2000-06-30 2002-01-10 Zila, Inc. Agent diagnostic a base de bleu de methylene et methodes diagnostiques pour la detection d'un cancer epithelial
JP2004501982A (ja) * 2000-06-30 2004-01-22 ジラ・インク 上皮癌の検出のためのローダミン診断薬および診断方法
US6967015B1 (en) * 2000-07-20 2005-11-22 Zila, Inc. Diagnostic method for detecting dysplastic epithelial tissue
US20040146919A1 (en) * 2002-05-18 2004-07-29 Burkett Douglas D. Method for early prediction of the onset of invasive cancer
EP1322339A4 (fr) * 2000-09-26 2004-05-26 Zila Inc Procede de depistage precoce de l'apparition d'un cancer de type envahissant
EP1463838A4 (fr) * 2001-12-14 2006-06-07 Zila Inc Analyse moleculaire effectuee au moyen d'un colorant en vue du pronostic et du diagnostic du cancer
US20030017158A1 (en) * 2002-03-08 2003-01-23 Bernal Samuel D. Method for detecting and killing epithelial cancer cells
US20060110326A1 (en) * 2002-06-04 2006-05-25 Zila, Inc. Toluidine blue o drug substance and use thereof for in vitro staining and chemotherapeutic treatment of dysplastic tissues
MXPA04012031A (es) * 2002-06-04 2005-03-07 Zila Biotechnology Inc Sustancia farmacologica azul de toluidina o y su uso para tincion in vivo y quimioterapia de tejidos displasicos.
US7910531B2 (en) 2004-06-17 2011-03-22 C2C Technologies Llc Composition and method for producing colored bubbles
AT501919B1 (de) * 2005-06-14 2008-09-15 Erber Ag Probiotischer, gesundheits- bzw. leistungsfördernder futtermittel- und/oder trinkwasserzusatz für tiere sowie seine verwendung
WO2008106646A2 (fr) * 2007-03-01 2008-09-04 Introgen Therapeutics, Inc Procédés et formulations pour une thérapie génique topique
US20090023138A1 (en) * 2007-07-17 2009-01-22 Zila Biotechnology, Inc. Oral cancer markers and their detection
IT1398643B1 (it) 2010-03-04 2013-03-08 Cosmo Technologies Ltd Composizione solida per la somministrazione orale di coloranti, e utilizzo diagnostico della stessa
CN102221526A (zh) * 2011-03-09 2011-10-19 叶欣 用于筛选口腔内膜细胞早期病变的组合试剂及其使用方法
PT106082A (pt) * 2012-01-04 2013-07-04 Fernando Jorge Neves Ferreira Composição fixadora para citologia, método de fixação de células e suas aplicações
RU2700680C1 (ru) * 2019-03-14 2019-09-18 Федеральное государственное автономное образовательное учреждение высшего образования "Дальневосточный федеральный университет" (ДВФУ) Способ хирургического лечения меланомы кожи
IT202100018434A1 (it) * 2021-07-13 2023-01-13 Diapath S P A Composizioni coloranti per campioni biologici, citologici, istologici e autoptici.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2571593A (en) * 1950-10-16 1951-10-16 Abbott Lab Preparation of stable leuco toluidine blue o solutions
US3743088A (en) * 1971-01-18 1973-07-03 R Henkin Diagnostic device and method of treatment
US4181128A (en) * 1975-11-28 1980-01-01 Massachusetts Institute Of Technology Virus inactivation applicator and the like
US4321251A (en) * 1979-12-19 1982-03-23 The United States Of America As Represented By The Department Of Health And Human Services Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse
US4977177A (en) * 1985-04-30 1990-12-11 Nippon Petrochemicals Company, Ltd. Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
JP2681053B2 (ja) * 1989-02-27 1997-11-19 三井サイテック株式会社 紙の製造法
US5018531A (en) * 1989-09-07 1991-05-28 Hartman William B Skin blemish measuring and recording system and method

Also Published As

Publication number Publication date
EP0565668A4 (en) 1994-09-07
JPH06507419A (ja) 1994-08-25
AU2778892A (en) 1993-06-07
EP0565668B1 (fr) 1999-06-23
WO1993008847A1 (fr) 1993-05-13
AU661727B2 (en) 1995-08-03
ATE181510T1 (de) 1999-07-15
GR3031233T3 (en) 1999-12-31
DE69229471D1 (de) 1999-07-29
DE69229471T2 (de) 1999-11-25
CA2097695A1 (fr) 1993-05-01
CA2097695C (fr) 2000-08-08
KR930703022A (ko) 1993-11-29
US5372801A (en) 1994-12-13
EP0565668A1 (fr) 1993-10-20
KR100242727B1 (ko) 2000-03-02
JP3549880B2 (ja) 2004-08-04
ES2133143T3 (es) 1999-09-01

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