CY1124338T1 - Αναστολεις 3-φωσφογλυκερικης αφυδρογονασης και χρησεις αυτων - Google Patents
Αναστολεις 3-φωσφογλυκερικης αφυδρογονασης και χρησεις αυτωνInfo
- Publication number
- CY1124338T1 CY1124338T1 CY20211100651T CY211100651T CY1124338T1 CY 1124338 T1 CY1124338 T1 CY 1124338T1 CY 20211100651 T CY20211100651 T CY 20211100651T CY 211100651 T CY211100651 T CY 211100651T CY 1124338 T1 CY1124338 T1 CY 1124338T1
- Authority
- CY
- Cyprus
- Prior art keywords
- phosphoglycerate
- dehydrogenation
- inhibitors
- compositions
- methods
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει ενώσεις, συνθέσεις αυτών και μεθόδους χρήσης αυτών.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305930P | 2016-03-09 | 2016-03-09 | |
| PCT/US2017/021420 WO2017156165A1 (en) | 2016-03-09 | 2017-03-08 | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124338T1 true CY1124338T1 (el) | 2022-07-22 |
Family
ID=59789738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100651T CY1124338T1 (el) | 2016-03-09 | 2021-07-19 | Αναστολεις 3-φωσφογλυκερικης αφυδρογονασης και χρησεις αυτων |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10954220B2 (el) |
| EP (2) | EP3884939B1 (el) |
| CY (1) | CY1124338T1 (el) |
| DK (1) | DK3426243T3 (el) |
| ES (2) | ES2883328T3 (el) |
| HR (1) | HRP20211220T1 (el) |
| HU (1) | HUE055197T2 (el) |
| LT (1) | LT3426243T (el) |
| PL (2) | PL3884939T3 (el) |
| PT (1) | PT3426243T (el) |
| RS (1) | RS62271B1 (el) |
| SI (1) | SI3426243T1 (el) |
| WO (1) | WO2017156165A1 (el) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3426243T3 (da) | 2016-03-09 | 2021-07-19 | Raze Therapeutics Inc | 3-phosphoglyceratdehydrogenase-inhibitorer og anvendelser deraf |
| US11014882B2 (en) * | 2016-03-09 | 2021-05-25 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
| US11319295B2 (en) | 2017-10-09 | 2022-05-03 | Merck Sharp & Dohme Corp. | Substituted phenyloxetane and phenyltetrahydrofuran compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors |
| US11498904B2 (en) | 2017-11-14 | 2022-11-15 | Merck Sharp & Dohme Llc | Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| WO2022037585A1 (en) * | 2020-08-18 | 2022-02-24 | Hutchison Medipharma Limited | Pyrimidinone compounds and uses thereof |
| BR112023023420A2 (pt) | 2021-06-16 | 2024-01-30 | Celgene Corp | Compostos de azetidinila compreendendo um grupo ácido carboxílico para o tratamento de doenças neurodegenerativas |
| AU2023412464A1 (en) | 2022-12-19 | 2025-07-31 | Chiesi Farmaceutici S.P.A. | Phosphoglicerate dehydrogenase inhibitors for the treatment of fibrosis |
| WO2025125295A1 (en) | 2023-12-13 | 2025-06-19 | Chiesi Farmaceutici S.P.A. | Thieno-indole amide derivatives as phgdh inhibitors |
| WO2025125290A1 (en) | 2023-12-13 | 2025-06-19 | Chiesi Farmaceutici S.P.A. | Novel phosphoglicerate dehydrogenase inhibitors for the treatment of fibrosis |
| WO2025125293A1 (en) | 2023-12-13 | 2025-06-19 | Chiesi Farmaceutici S.P.A. | Thienopyrimidylamine derivatives as phgdh inhibitors |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| US5639600A (en) | 1994-08-05 | 1997-06-17 | The Regents Of The University Of California | Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement |
| US7087648B1 (en) | 1997-10-27 | 2006-08-08 | The Regents Of The University Of California | Methods for modulating macrophage proliferation using polyamine analogs |
| MXPA01007099A (es) | 1999-01-13 | 2002-03-27 | Univ New York State Res Found | Metodo novedoso para disenar inhibidores de la proteina cinasa. |
| HU229671B1 (en) | 1999-12-10 | 2014-04-28 | Pfizer Prod Inc | Pyrrolo[2,3-d]pirimidine compounds |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| CA2445395C (en) | 2001-04-27 | 2010-03-30 | Zenyaku Kogyo Kabushiki Kaisha | Heterocyclic compound and antitumor agent comprising the same as effective component |
| AR034897A1 (es) | 2001-08-07 | 2004-03-24 | Hoffmann La Roche | Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos |
| CA2464214C (en) | 2001-10-22 | 2011-02-08 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| ATE419865T1 (de) | 2002-08-14 | 2009-01-15 | Silence Therapeutics Ag | Verwendung von protein-kinase-n-beta |
| BRPI0409063A (pt) | 2003-04-03 | 2006-03-28 | Semafore Pharmaceuticals Inc | pró medicamentos de inibidor de pi-3 cinase |
| EP1644363B1 (en) | 2003-05-30 | 2012-02-22 | Gemin X Pharmaceuticals Canada Inc. | Triheterocyclic compounds, compositions, and methods for treating cancer |
| WO2005007623A2 (en) | 2003-07-03 | 2005-01-27 | The Trustees Of The University Of Pennsylvania | Inhibition of syk kinase expression |
| LT1761540T (lt) | 2004-05-13 | 2017-02-27 | Icos Corporation | Chinazolinonai kaip žmogaus fosfatidilinozitol-3-kinazės-delta inhibitoriai |
| AR054183A1 (es) | 2004-12-22 | 2007-06-06 | Astrazeneca Ab | Derivados de piridincarboxamida y su uso como agentes anticancerigenos. procesos de obtencion y composiciones farmaceuticas. |
| WO2006067445A2 (en) | 2004-12-22 | 2006-06-29 | Astrazeneca Ab | Csf-1r kinase inhibitors |
| PT1856135E (pt) | 2005-01-19 | 2010-02-26 | Rigel Pharmaceuticals Inc | Pró-fármacos de compostos 2,4-pirimidinodiamina e suas utilizações |
| CA2606147C (en) | 2005-05-12 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| US7402325B2 (en) | 2005-07-28 | 2008-07-22 | Phoenix Biotechnology, Inc. | Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander |
| WO2007019344A1 (en) | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Imidazo [2,1-b] thiayole derivatives as sirtuin modulating compounds |
| EA024305B1 (ru) | 2005-10-07 | 2016-09-30 | Экселиксис, Инк. | Ингибиторы фосфатидилинозит-3-киназы и их применение |
| WO2007053452A1 (en) | 2005-11-01 | 2007-05-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| PT2455382T (pt) | 2005-12-13 | 2017-01-31 | Incyte Holdings Corp | Pirrolo[2,3-b]piridinas e pirrolo[2,3-b]pirimidinas substituídas por heteroarilo como inibidores de janus quinases |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| DE602007007323D1 (de) | 2006-04-26 | 2010-08-05 | Hoffmann La Roche | Thienoä3,2-düpyrimidin-derivat geeignet als pi3k inhibitor |
| US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| PL2526934T4 (pl) | 2006-09-22 | 2016-09-30 | Inhibitory kinazy tyrozynowej Brutona | |
| AU2007317349B2 (en) | 2006-11-03 | 2011-10-20 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| JP2010520892A (ja) | 2007-03-12 | 2010-06-17 | サイトピア・リサーチ・ピーティーワイ・リミテッド | フェニルアミノピリミジン化合物およびその使用 |
| WO2008118802A1 (en) | 2007-03-23 | 2008-10-02 | Regents Of The University Of Minnesota | Therapeutic compounds |
| PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| US8193194B2 (en) | 2007-05-25 | 2012-06-05 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| SI2288610T1 (sl) | 2008-03-11 | 2016-11-30 | Incyte Holdings Corporation | Derivati azetidina in ciklobutana kot inhibitorji jak |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| HUE035798T2 (en) * | 2008-11-03 | 2018-05-28 | Syntarga Bv | CC-1065 analogues and conjugates |
| US9096579B2 (en) | 2012-04-20 | 2015-08-04 | Boehringer Ingelheim International Gmbh | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments |
| DK3125883T3 (da) * | 2014-04-04 | 2020-10-19 | Iomet Pharma Ltd | Indolderivater til anvendelse i medicin |
| US11014882B2 (en) | 2016-03-09 | 2021-05-25 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
| DK3426243T3 (da) | 2016-03-09 | 2021-07-19 | Raze Therapeutics Inc | 3-phosphoglyceratdehydrogenase-inhibitorer og anvendelser deraf |
-
2017
- 2017-03-08 DK DK17764026.5T patent/DK3426243T3/da active
- 2017-03-08 PL PL21167434.6T patent/PL3884939T3/pl unknown
- 2017-03-08 ES ES17764026T patent/ES2883328T3/es active Active
- 2017-03-08 SI SI201730882T patent/SI3426243T1/sl unknown
- 2017-03-08 PT PT177640265T patent/PT3426243T/pt unknown
- 2017-03-08 HR HRP20211220TT patent/HRP20211220T1/hr unknown
- 2017-03-08 US US16/082,659 patent/US10954220B2/en active Active
- 2017-03-08 EP EP21167434.6A patent/EP3884939B1/en active Active
- 2017-03-08 EP EP17764026.5A patent/EP3426243B1/en active Active
- 2017-03-08 HU HUE17764026A patent/HUE055197T2/hu unknown
- 2017-03-08 LT LTEP17764026.5T patent/LT3426243T/lt unknown
- 2017-03-08 ES ES21167434T patent/ES2965264T3/es active Active
- 2017-03-08 WO PCT/US2017/021420 patent/WO2017156165A1/en not_active Ceased
- 2017-03-08 PL PL17764026T patent/PL3426243T3/pl unknown
- 2017-03-08 RS RS20211023A patent/RS62271B1/sr unknown
-
2021
- 2021-01-15 US US17/150,669 patent/US11634412B2/en active Active
- 2021-07-19 CY CY20211100651T patent/CY1124338T1/el unknown
-
2023
- 2023-03-01 US US18/115,942 patent/US20230312536A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3426243A4 (en) | 2019-07-03 |
| PT3426243T (pt) | 2021-08-19 |
| US11634412B2 (en) | 2023-04-25 |
| DK3426243T3 (da) | 2021-07-19 |
| ES2965264T3 (es) | 2024-04-11 |
| PL3884939T3 (pl) | 2024-02-26 |
| WO2017156165A1 (en) | 2017-09-14 |
| SI3426243T1 (sl) | 2021-11-30 |
| RS62271B1 (sr) | 2021-09-30 |
| EP3426243B1 (en) | 2021-05-19 |
| PL3426243T3 (pl) | 2021-10-04 |
| US20190071431A1 (en) | 2019-03-07 |
| EP3884939C0 (en) | 2023-10-25 |
| US20230009122A1 (en) | 2023-01-12 |
| HRP20211220T1 (hr) | 2021-10-29 |
| US20230312536A1 (en) | 2023-10-05 |
| ES2883328T3 (es) | 2021-12-07 |
| LT3426243T (lt) | 2021-08-10 |
| US10954220B2 (en) | 2021-03-23 |
| HUE055197T2 (hu) | 2021-11-29 |
| EP3884939B1 (en) | 2023-10-25 |
| EP3426243A1 (en) | 2019-01-16 |
| EP3884939A1 (en) | 2021-09-29 |
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