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CY1120951T1 - Ανθρωπινα αντισωματα enanti-tau - Google Patents

Ανθρωπινα αντισωματα enanti-tau

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Publication number
CY1120951T1
CY1120951T1 CY181101135T CY181101135T CY1120951T1 CY 1120951 T1 CY1120951 T1 CY 1120951T1 CY 181101135 T CY181101135 T CY 181101135T CY 181101135 T CY181101135 T CY 181101135T CY 1120951 T1 CY1120951 T1 CY 1120951T1
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Cyprus
Prior art keywords
tau
enanti
well
human antibodies
variants
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CY181101135T
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English (en)
Inventor
Feng Chen
Jan Grimm
Jean-Luc Baeriswyl
Roger Nitsch
Christoph Hock
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Biogen Int Neuroscience Gmbh
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Publication date
Application filed by Biogen Int Neuroscience Gmbh filed Critical Biogen Int Neuroscience Gmbh
Publication of CY1120951T1 publication Critical patent/CY1120951T1/el

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
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  • Biophysics (AREA)
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  • Hematology (AREA)
  • Urology & Nephrology (AREA)
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Abstract

Παρέχονται ανθρώπινα tau-ειδικά αντισώματα, όπως επίσης θραύσματα, παράγωγα και παραλλαγές αυτών, όπως επίσης μέθοδοι σχετικές με αυτά. Αποκαλύπτονται επίσης προσδιορισμοί, κιτ και στερεοί φορείς σχετικοί με τα ειδικά για την tau αντισώματα. Το αντίσωμα, αλυσίδα(ες) ανοσοσφαιρίνης, όπως επίσης θραύσματα δέσμευσης, παράγωγα και παραλλαγές αυτού, μπορούν να χρησιμοποιηθούν σε φαρμακευτικές και διαγνωστικές συνθέσεις για tau στοχευόμενη ανοσοθεραπεία και διάγνωση, αντίστοιχα.
CY181101135T 2010-10-11 2018-11-01 Ανθρωπινα αντισωματα enanti-tau CY1120951T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39175110P 2010-10-11 2010-10-11
EP10013494 2010-10-11
PCT/IB2011/002786 WO2012049570A1 (en) 2010-10-11 2011-10-11 Human anti-tau antibodies
EP11797115.0A EP2627672B1 (en) 2010-10-11 2011-10-11 Human anti-tau antibodies

Publications (1)

Publication Number Publication Date
CY1120951T1 true CY1120951T1 (el) 2019-12-11

Family

ID=43602869

Family Applications (1)

Application Number Title Priority Date Filing Date
CY181101135T CY1120951T1 (el) 2010-10-11 2018-11-01 Ανθρωπινα αντισωματα enanti-tau

Country Status (23)

Country Link
US (6) US8940272B2 (el)
EP (1) EP2627672B1 (el)
JP (2) JP2014503178A (el)
CN (1) CN103339146B (el)
AU (1) AU2011315181B2 (el)
BR (1) BR112013008765B8 (el)
CA (1) CA2813493C (el)
CY (1) CY1120951T1 (el)
DK (1) DK2627672T3 (el)
EA (1) EA031698B1 (el)
ES (1) ES2686550T3 (el)
HR (1) HRP20181320T8 (el)
IL (1) IL225670B (el)
LT (1) LT2627672T (el)
MX (1) MX345092B (el)
NZ (1) NZ609984A (el)
PL (1) PL2627672T3 (el)
PT (1) PT2627672T (el)
SG (1) SG189174A1 (el)
SI (1) SI2627672T1 (el)
TR (1) TR201812636T4 (el)
WO (1) WO2012049570A1 (el)
ZA (1) ZA201303175B (el)

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