CO5380035A1 - CHEMICAL DERIVATIVES AND THEIR APPLICATION AS AN ANTITELOMERASA AGENT - Google Patents
CHEMICAL DERIVATIVES AND THEIR APPLICATION AS AN ANTITELOMERASA AGENTInfo
- Publication number
- CO5380035A1 CO5380035A1 CO02025874A CO02025874A CO5380035A1 CO 5380035 A1 CO5380035 A1 CO 5380035A1 CO 02025874 A CO02025874 A CO 02025874A CO 02025874 A CO02025874 A CO 02025874A CO 5380035 A1 CO5380035 A1 CO 5380035A1
- Authority
- CO
- Colombia
- Prior art keywords
- optionally substituted
- alkyl
- cycle
- group
- radical
- Prior art date
Links
- 229910052757 nitrogen Inorganic materials 0.000 abstract 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 4
- XNMYNYSCEJBRPZ-UHFFFAOYSA-N 2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine Chemical compound C1=CC=C2C(OCCN(C)C)=NC(CCCC)=CC2=C1 XNMYNYSCEJBRPZ-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical compound NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 108091081406 G-quadruplex Proteins 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005237 alkyleneamino group Chemical group 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos que fijan la estructura G-cuádruplex de ADN o ARN caracterizados en que responden a la siguiente fórmula general:ciclo aromático nitrogenado - NR3 - repartidor - NRAND#393 - ciclo aromático en la cual? el ciclo aromático nitrogenado representa: ? una quinoleína o isoquinoleína eventualmente sustituida por al menos un radical elegido entre un grupo N(Ra)(Rb) en el cual Ra y Rb, idénticos o diferentes, representan el hidrógeno o un radical alquilo en C1-C4, y un grupo alcoxi o alquilo de cadena corta en C1-C4, o ? una quinoleína o isoquinoleína que posee un átomo de nitrógeno bajo la forma cuaternaria, o ? una benzamidina, o ? una piridina.? El ciclo aromático representa: ? una quinoleína eventualmente sustituida por al menos un radical elegido entre un grupo N(Ra) (Rb) en el cual Ra y Rb, idénticos o diferentes, representan el hidrógeno o un radical alquilo en C1-C4 y un grupo alcoxi o alquilo de cadena corta en C1-C4, o ? una quinoleína que posee un átomo de nitrógeno bajo la forma cuaternaria, o ? una benzamidina, o ? una piridina, o ? un núcleo fenilo eventualmente sustituido por una agrupación halógena; alcoxi en C1-C4; ciano; carbonilamino eventualmente sustituido por uno o varios grupos alquilo en C1-C4; guanilo; alquiltio en C1-C4; amino, alquilamino en C1-C4, dialquilamino en C1-C4 por cada grupo alquilo y cuyas partes alquilo pueden formar conjuntamente un ciclo en C3-C8, nitro; alquilenoamino en C1-C4; alquenilenoamino en C2-C4; ? un núcleo heterociclico mono o bi o triciclico que tiene de 0 a 2 heteroátomos por ciclo siempre y cuando al menos un heteroátomo sea presente en al menos un ciclo eventualmente sustituido por uno o varios grupos alquilo en C1-C4 o por grupos alquileno en C1-C4 o alquenileno en C2-C4.? R3 y RAND#393, idénticos o diferentes, representan independientemente el uno del otro el hidrógeno o un radical alquilo en C1-C4 ? el repartidor representa:- un grupo triacina eventualmente sustituido por un ciclo aromático tal y como está definido anteriormente o por un radical XR1 (R2) en el cual X representa un átomo de nitrógeno N para formar NR1R2, un radical alquilo alineado o ramificado en C1-C6 para formar alkR1R2, un átomo de oxígeno o para formar OR1 o un átomo de azufre S para formar SR1, ...Compounds that fix the G-quadruplex structure of DNA or RNA characterized in that they respond to the following general formula: nitrogen aromatic cycle - NR3 - distributor - NRAND # 393 - aromatic cycle in which? The nitrogen aromatic cycle represents: a quinolein or isoquinoline optionally substituted by at least one radical selected from an N (Ra) (Rb) group in which Ra and Rb, identical or different, represent hydrogen or a C1-C4 alkyl radical, and an alkoxy group or C1-C4 short chain alkyl, or? a quinolein or isoquinoline that possesses a nitrogen atom in the quaternary form, or? a benzamidine, or? a pyridine. The aromatic cycle represents: a quinoline optionally substituted by at least one radical selected from an N (Ra) (Rb) group in which Ra and Rb, identical or different, represent hydrogen or a C1-C4 alkyl radical and an alkoxy or chain alkyl group cut in C1-C4, or? a quinolein that has a nitrogen atom in the quaternary form, or? a benzamidine, or? a pyridine, or? a phenyl core optionally substituted by a halogen cluster; C1-C4 alkoxy; cyano; carbonylamino optionally substituted by one or more C1-C4 alkyl groups; guanil; C1-C4 alkylthio; amino, C1-C4 alkylamino, C1-C4 dialkylamino for each alkyl group and whose alkyl parts may together form a C3-C8 cycle, nitro; C1-C4 alkyleneamino; C2-C4 alkenyleneamino; ? a mono or bi or tricyclic heterocyclic nucleus having 0 to 2 heteroatoms per cycle as long as at least one heteroatom is present in at least one cycle optionally substituted by one or more C1-C4 alkyl groups or C1- alkylene groups C4 or alkenylene in C2-C4. R3 and RAND # 393, identical or different, independently represent each other hydrogen or a C1-C4 alkyl radical? the distributor represents: - a triazine group optionally substituted by an aromatic cycle as defined above or by a radical XR1 (R2) in which X represents a nitrogen atom N to form NR1R2, a C1-aligned or branched alkyl radical -C6 to form alkR1R2, an oxygen atom or to form OR1 or a sulfur atom S to form SR1, ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0103916A FR2822468B1 (en) | 2001-03-23 | 2001-03-23 | CHEMICAL DERIVATIVES AND THEIR APPLICATION AS ANTI-TELOMERASE AGENT |
| FR0110370 | 2001-08-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5380035A1 true CO5380035A1 (en) | 2004-03-31 |
Family
ID=26212933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO02025874A CO5380035A1 (en) | 2001-03-23 | 2002-03-21 | CHEMICAL DERIVATIVES AND THEIR APPLICATION AS AN ANTITELOMERASA AGENT |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1373252A1 (en) |
| JP (1) | JP2004524349A (en) |
| AR (1) | AR034297A1 (en) |
| AU (1) | AU2002251140B2 (en) |
| CA (1) | CA2442012A1 (en) |
| CO (1) | CO5380035A1 (en) |
| IL (2) | IL158056A0 (en) |
| MX (1) | MXPA03008269A (en) |
| MY (1) | MY130957A (en) |
| PE (1) | PE20020959A1 (en) |
| WO (1) | WO2002076975A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004534046A (en) * | 2001-05-28 | 2004-11-11 | アベンティス・ファーマ・ソシエテ・アノニム | Chemical derivatives and their use as anti-telomerase agents |
| US7173032B2 (en) * | 2001-09-21 | 2007-02-06 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| WO2003055866A1 (en) * | 2001-12-21 | 2003-07-10 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
| WO2004001018A2 (en) * | 2002-06-25 | 2003-12-31 | The Center For Blood Research, Inc. | Vacuolins |
| FR2850970B1 (en) * | 2003-02-07 | 2006-07-07 | Aventis Pharma Sa | CHEMICAL DERIVATIVES BINDING VERY SPECIFIC TO G-QUADRUPLEX DNA STRUCTURES AND THEIR APPLICATION AS A SPECIFIC ANTICANCER AGENT |
| AU2004253967B2 (en) | 2003-07-03 | 2010-02-18 | Cytovia, Inc. | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
| WO2006074147A2 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| AU2006246958A1 (en) * | 2005-05-19 | 2006-11-23 | Prometic Biosciences Inc. | Triazine compounds and compositions thereof for the treatment of cancers |
| EP2046763A2 (en) * | 2006-07-31 | 2009-04-15 | Praecis Pharmaceuticals Incorporated | Aurora kinase inhibitors from an encoded small molecule library |
| EP2175933B1 (en) * | 2007-07-25 | 2012-08-22 | Bristol-Myers Squibb Company | Triazine kinase inhibitors |
| FR2948686B1 (en) * | 2009-07-30 | 2011-08-19 | Biomerieux Sa | NEW PEPTIDASE SUBSTRATES |
| US20210024455A1 (en) * | 2018-03-20 | 2021-01-28 | Hiroshima University | Compound which inhibits telomere-binding protein, and telomere-binding protein inhibitor containing same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9206768D0 (en) * | 1992-03-27 | 1992-05-13 | Jarman Michael | New compounds for use in the treatment of cancer |
| JPH1160573A (en) * | 1997-08-22 | 1999-03-02 | Nippon Kayaku Co Ltd | Triazine derivative and telomerase inhibitor |
| US6262053B1 (en) * | 1999-06-23 | 2001-07-17 | Parker Hughes Institute | Melamine derivatives as potent anti-cancer agents |
| JP2003515604A (en) * | 1999-11-29 | 2003-05-07 | アベンテイス・フアルマ・ソシエテ・アノニム | Arylamine derivatives and their use as anti-telomerase agents |
| WO2003066099A1 (en) * | 2002-02-05 | 2003-08-14 | Yamanouchi Pharmaceutical Co., Ltd. | 2,4,6-triamino-1,3,5-triazine derivative |
-
2002
- 2002-03-21 CO CO02025874A patent/CO5380035A1/en not_active Application Discontinuation
- 2002-03-22 PE PE2002000227A patent/PE20020959A1/en not_active Application Discontinuation
- 2002-03-22 AU AU2002251140A patent/AU2002251140B2/en not_active Ceased
- 2002-03-22 JP JP2002576233A patent/JP2004524349A/en not_active Ceased
- 2002-03-22 MX MXPA03008269A patent/MXPA03008269A/en not_active Application Discontinuation
- 2002-03-22 MY MYPI20021036A patent/MY130957A/en unknown
- 2002-03-22 CA CA002442012A patent/CA2442012A1/en not_active Abandoned
- 2002-03-22 AR ARP020101060A patent/AR034297A1/en unknown
- 2002-03-22 EP EP02720068A patent/EP1373252A1/en not_active Withdrawn
- 2002-03-22 WO PCT/FR2002/001005 patent/WO2002076975A1/en active IP Right Grant
- 2002-03-22 IL IL15805602A patent/IL158056A0/en unknown
-
2003
- 2003-09-22 IL IL158056A patent/IL158056A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL158056A0 (en) | 2004-03-28 |
| JP2004524349A (en) | 2004-08-12 |
| MXPA03008269A (en) | 2004-10-15 |
| EP1373252A1 (en) | 2004-01-02 |
| AU2002251140B2 (en) | 2007-03-15 |
| CA2442012A1 (en) | 2002-10-03 |
| AR034297A1 (en) | 2004-02-18 |
| WO2002076975A1 (en) | 2002-10-03 |
| MY130957A (en) | 2007-07-31 |
| IL158056A (en) | 2010-02-17 |
| PE20020959A1 (en) | 2002-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |