CL2014001055A1 - Proteina de union biespecifica que se enlaza al factor de necrosis tumoral (tnf) y la interleucina 17 (il-17); acido nucleico que la codifica; vector; celula huesped; metodo de produccion; composicion farmaceutica que la comprende; y su uso. - Google Patents
Proteina de union biespecifica que se enlaza al factor de necrosis tumoral (tnf) y la interleucina 17 (il-17); acido nucleico que la codifica; vector; celula huesped; metodo de produccion; composicion farmaceutica que la comprende; y su uso.Info
- Publication number
- CL2014001055A1 CL2014001055A1 CL2014001055A CL2014001055A CL2014001055A1 CL 2014001055 A1 CL2014001055 A1 CL 2014001055A1 CL 2014001055 A CL2014001055 A CL 2014001055A CL 2014001055 A CL2014001055 A CL 2014001055A CL 2014001055 A1 CL2014001055 A1 CL 2014001055A1
- Authority
- CL
- Chile
- Prior art keywords
- tnf
- interleukin
- binds
- vector
- nucleic acid
- Prior art date
Links
- 102000013691 Interleukin-17 Human genes 0.000 title 1
- 108050003558 Interleukin-17 Proteins 0.000 title 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 title 1
- 102000023732 binding proteins Human genes 0.000 title 1
- 108091008324 binding proteins Proteins 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000003390 tumor necrosis factor Human genes 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/567—Framework region [FR]
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07—ORGANIC CHEMISTRY
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- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Food Science & Technology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550619P | 2011-10-24 | 2011-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014001055A1 true CL2014001055A1 (es) | 2014-08-18 |
Family
ID=47144148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014001055A CL2014001055A1 (es) | 2011-10-24 | 2014-04-24 | Proteina de union biespecifica que se enlaza al factor de necrosis tumoral (tnf) y la interleucina 17 (il-17); acido nucleico que la codifica; vector; celula huesped; metodo de produccion; composicion farmaceutica que la comprende; y su uso. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9655964B2 (es) |
| EP (1) | EP2771361A1 (es) |
| JP (1) | JP6121432B2 (es) |
| KR (1) | KR20140084254A (es) |
| CN (1) | CN104185641A (es) |
| AR (1) | AR088514A1 (es) |
| AU (1) | AU2012328917B2 (es) |
| BR (1) | BR112014009810A2 (es) |
| CA (1) | CA2853114A1 (es) |
| CL (1) | CL2014001055A1 (es) |
| CO (1) | CO7020874A2 (es) |
| CR (1) | CR20140224A (es) |
| DO (1) | DOP2014000084A (es) |
| EC (1) | ECSP14001260A (es) |
| GT (1) | GT201400077A (es) |
| HK (1) | HK1200321A1 (es) |
| IL (1) | IL232207A0 (es) |
| MX (1) | MX2014004980A (es) |
| PE (1) | PE20142245A1 (es) |
| PH (1) | PH12014500903A1 (es) |
| RS (1) | RS20140202A1 (es) |
| RU (1) | RU2014121043A (es) |
| SG (1) | SG11201401796SA (es) |
| TW (1) | TW201323441A (es) |
| UY (1) | UY34410A (es) |
| WO (1) | WO2013063110A1 (es) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102741288B (zh) | 2009-08-29 | 2015-08-19 | Abbvie公司 | 治疗用dll4结合蛋白 |
| CN105037543B (zh) | 2010-03-02 | 2020-11-03 | Abbvie 公司 | 治疗性dll4结合蛋白 |
| MX2012013490A (es) | 2010-05-20 | 2013-01-29 | Ablynx Nv | Materiales biologicos relacionados con her3. |
| KR20130100118A (ko) | 2010-08-03 | 2013-09-09 | 아비에 인코포레이티드 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| UY33679A (es) | 2010-10-22 | 2012-03-30 | Esbatech | Anticuerpos estables y solubles |
| AR084210A1 (es) * | 2010-12-08 | 2013-05-02 | Abbott Lab | PROTEINAS DE UNION AL TNF-a |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| UY34409A (es) | 2011-10-24 | 2013-05-31 | Abbvie Inc | Inmunoenlazadores dirigidos contra el tnf |
| US9217042B2 (en) * | 2012-10-23 | 2015-12-22 | Abbott Cardiovascular Systems Inc. | Method of reducing MACE in diabetic patients subsequent to stent placement |
| WO2014071074A2 (en) | 2012-11-01 | 2014-05-08 | Abbvie Inc. | Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof |
| WO2014144299A2 (en) * | 2013-03-15 | 2014-09-18 | Abbvie Inc. | DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST TNFα |
| HRP20201432T1 (hr) * | 2013-11-18 | 2020-12-11 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Il-17a sredstvo za vezivanje i njegove uporabe |
| AU2015240595B2 (en) | 2014-04-03 | 2020-02-27 | Igm Biosciences, Inc. | Modified J-chain |
| WO2015191760A2 (en) * | 2014-06-10 | 2015-12-17 | Abbvie, Inc. | Compositions and methods for treating rheumatoid arthritis |
| WO2015191783A2 (en) | 2014-06-10 | 2015-12-17 | Abbvie Inc. | Biomarkers for inflammatory disease and methods of using same |
| KR102427097B1 (ko) * | 2014-08-26 | 2022-08-01 | 암젠 케이-에이, 인크. | 항-tnf-알파 항체 요법을 받은 건선 환자의 치료 방법 |
| EP3189153B1 (en) | 2014-09-03 | 2021-06-16 | Boehringer Ingelheim International GmbH | Compound targeting il-23a and tnf-alpha and uses thereof |
| AR102417A1 (es) | 2014-11-05 | 2017-03-01 | Lilly Co Eli | Anticuerpos biespecíficos anti-tnf- / anti-il-23 |
| US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
| GB201500463D0 (en) * | 2015-01-12 | 2015-02-25 | Cresendo Biolog Ltd | Therapeutic molecules |
| US10689449B2 (en) | 2015-01-20 | 2020-06-23 | Igm Biosciences, Inc. | Multimeric death domain-containing receptor-5 (DR5) antibodies and uses thereof |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
| AU2016329197B2 (en) | 2015-09-30 | 2021-01-21 | Igm Biosciences, Inc. | Binding molecules with modified J-chain |
| WO2017059387A1 (en) | 2015-09-30 | 2017-04-06 | Igm Biosciences, Inc. | Binding molecules with modified j-chain |
| AU2016335017A1 (en) * | 2015-10-05 | 2018-03-29 | Galapagos Nv | Antagonists of IL-17C for the treatment and/or prevention of atopic dermatitis |
| EP3389714A4 (en) | 2015-12-14 | 2019-11-13 | MacroGenics, Inc. | BIS-SPECIFIC MOLECULES WITH IMMUNE REACTIVITY WITH PD-1 AND CTLA-4 AND METHOD OF USE THEREOF |
| GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
| GB201522391D0 (en) * | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibody molecules |
| EP3408293A4 (en) * | 2016-01-28 | 2019-09-11 | Janssen Biotech, Inc. | BIS-SPECIFIC ANTI-TNF-ALPHA / IL-17A ANTIBODIES AND ANTI-TNF-ALPHA ANTIBODIES AND METHODS FOR THEIR USE |
| RU2680011C2 (ru) * | 2016-04-29 | 2019-02-14 | Закрытое Акционерное Общество "Биокад" | Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы |
| HRP20210924T1 (hr) | 2016-06-02 | 2021-09-03 | Abbvie Inc. | Agonist glukokortikoidnog receptora i njegovi imunokonjugati |
| WO2018089300A1 (en) * | 2016-11-10 | 2018-05-17 | Merck Sharp & Dohme Corp. | Ilt3 ligand |
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- 2012-10-24 RU RU2014121043/10A patent/RU2014121043A/ru not_active Application Discontinuation
- 2012-10-24 US US13/659,666 patent/US9655964B2/en active Active
- 2012-10-24 MX MX2014004980A patent/MX2014004980A/es unknown
- 2012-10-24 BR BR112014009810A patent/BR112014009810A2/pt not_active IP Right Cessation
- 2012-10-24 RS RS20140202A patent/RS20140202A1/en unknown
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- 2012-10-24 HK HK15100713.9A patent/HK1200321A1/xx unknown
- 2012-10-24 KR KR1020147013797A patent/KR20140084254A/ko not_active Withdrawn
- 2012-10-24 CA CA2853114A patent/CA2853114A1/en not_active Abandoned
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| US20140161804A1 (en) | 2014-06-12 |
| PE20142245A1 (es) | 2015-01-22 |
| RU2014121043A (ru) | 2015-12-10 |
| KR20140084254A (ko) | 2014-07-04 |
| ECSP14001260A (es) | 2015-07-31 |
| AU2012328917B2 (en) | 2017-05-25 |
| SG11201401796SA (en) | 2014-10-30 |
| JP6121432B2 (ja) | 2017-04-26 |
| CO7020874A2 (es) | 2014-08-11 |
| US9655964B2 (en) | 2017-05-23 |
| BR112014009810A2 (pt) | 2017-04-25 |
| AU2012328917A1 (en) | 2014-05-22 |
| US20140079705A1 (en) | 2014-03-20 |
| IL232207A0 (en) | 2014-06-30 |
| TW201323441A (zh) | 2013-06-16 |
| CR20140224A (es) | 2014-09-03 |
| RS20140202A1 (en) | 2014-10-31 |
| DOP2014000084A (es) | 2014-09-15 |
| GT201400077A (es) | 2014-12-23 |
| HK1200321A1 (en) | 2015-08-07 |
| CN104185641A (zh) | 2014-12-03 |
| EP2771361A1 (en) | 2014-09-03 |
| WO2013063110A1 (en) | 2013-05-02 |
| CA2853114A1 (en) | 2013-05-02 |
| MX2014004980A (es) | 2014-09-11 |
| PH12014500903A1 (en) | 2014-06-09 |
| UY34410A (es) | 2013-05-31 |
| JP2015502145A (ja) | 2015-01-22 |
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