CL2007003565A1 - Compuestos derivados de piperidinas sustituidas; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una infeccion vih. - Google Patents
Compuestos derivados de piperidinas sustituidas; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una infeccion vih.Info
- Publication number
- CL2007003565A1 CL2007003565A1 CL200703565A CL2007003565A CL2007003565A1 CL 2007003565 A1 CL2007003565 A1 CL 2007003565A1 CL 200703565 A CL200703565 A CL 200703565A CL 2007003565 A CL2007003565 A CL 2007003565A CL 2007003565 A1 CL2007003565 A1 CL 2007003565A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- piperidins
- treat
- replaced
- pharmaceutical composition
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- 208000031886 HIV Infections Diseases 0.000 title 1
- 208000037357 HIV infectious disease Diseases 0.000 title 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87467306P | 2006-12-13 | 2006-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2007003565A1 true CL2007003565A1 (es) | 2008-07-04 |
Family
ID=39381919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200703565A CL2007003565A1 (es) | 2006-12-13 | 2007-12-10 | Compuestos derivados de piperidinas sustituidas; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una infeccion vih. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7998969B2 (es) |
| EP (1) | EP2089384B1 (es) |
| JP (1) | JP5415957B2 (es) |
| KR (1) | KR101475091B1 (es) |
| CN (1) | CN101553483B (es) |
| AR (1) | AR064221A1 (es) |
| AU (1) | AU2007332654B2 (es) |
| BR (1) | BRPI0720436A2 (es) |
| CA (1) | CA2671478C (es) |
| CL (1) | CL2007003565A1 (es) |
| ES (1) | ES2550152T3 (es) |
| IL (1) | IL199152A (es) |
| MX (1) | MX2009005881A (es) |
| PE (1) | PE20081509A1 (es) |
| RU (1) | RU2469032C2 (es) |
| TW (1) | TW200833681A (es) |
| WO (1) | WO2008071587A2 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2718858A1 (en) | 2008-03-20 | 2009-09-24 | Boehringer Ingelheim International Gmbh | Selective synthesis of substituted pyrimidines |
| UY31714A (es) | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
| TW201024281A (en) | 2008-11-24 | 2010-07-01 | Boehringer Ingelheim Int | New compounds |
| TWI491605B (zh) | 2008-11-24 | 2015-07-11 | Boehringer Ingelheim Int | 新穎化合物 |
| US8334297B2 (en) * | 2009-01-14 | 2012-12-18 | Rigel Pharmaceuticals Inc. | 2,4-pyrimidinediamine compounds for treatment of inflammatory disorders |
| AR076024A1 (es) * | 2009-04-03 | 2011-05-11 | Schering Corp | Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos |
| WO2011017079A1 (en) | 2009-07-27 | 2011-02-10 | Teva Pharmaceutical Industries Ltd. | Process for the preparation and purification of etravirine and intermediates thereof |
| JP5539518B2 (ja) * | 2009-08-14 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ２−アミノ−５−トリフルオロメチルピリミジン誘導体の位置選択的調製 |
| US8933227B2 (en) * | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| GR1007010B (el) | 2009-10-08 | 2010-10-07 | Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), | Ινσουλινοειδη πεπτιδια |
| CN101723904B (zh) * | 2009-11-26 | 2012-02-08 | 复旦大学 | 4-氰基二芳基嘧啶类衍生物及其制备方法和用途 |
| CA2802308C (en) * | 2010-07-02 | 2018-08-28 | Lianhong Xu | Napht-2-ylacetic acid derivatives to treat aids |
| PT2588455T (pt) | 2010-07-02 | 2018-06-29 | Gilead Sciences Inc | Derivados de ácido 2-quinolinil-acético como compostos antivirais para vih |
| PE20141066A1 (es) | 2011-04-21 | 2014-09-05 | Gilead Sciences Inc | Compuestos de benzotiazol |
| CN102285969B (zh) * | 2011-06-28 | 2013-06-19 | 山东大学 | N-1-取代哌啶-4-芳胺类衍生物及其制备方法与应用 |
| CN102382062B (zh) * | 2011-08-01 | 2014-08-13 | 复旦大学 | 一种环烷基芳基嘧啶类衍生物及其制备方法和用途 |
| US20130123498A1 (en) | 2011-10-19 | 2013-05-16 | Maja Sepelj MAJER | Process for the preparation of etravirine and intermediates in the synthesis thereof |
| WO2013062028A1 (ja) | 2011-10-25 | 2013-05-02 | 塩野義製薬株式会社 | Ｈｉｖ複製阻害剤 |
| WO2013103738A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Napthalene acetic acid derivatives against hiv infection |
| WO2013103724A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids |
| KR20150002573A (ko) | 2012-04-20 | 2015-01-07 | 길리애드 사이언시즈, 인코포레이티드 | 벤조티아졸-6-일 아세트산 유도체 및 ｈｉｖ 감염을 치료하기 위한 이의 용도 |
| JP6213475B2 (ja) * | 2012-10-26 | 2017-10-18 | 旭硝子株式会社 | ジフルオロエステル化合物の製造方法 |
| CN102964295B (zh) * | 2012-12-17 | 2014-08-20 | 寿光富康制药有限公司 | 一种2-取代-4-（哌啶基甲基）吡啶的制备方法 |
| TW201441197A (zh) | 2013-01-31 | 2014-11-01 | Shionogi & Co | Ｈｉｖ複製抑制劑 |
| CN103523533A (zh) * | 2013-07-25 | 2014-01-22 | 上海董奥机械科技有限公司 | 一种用于pet空瓶气流输送的装置 |
| CN110066273A (zh) * | 2019-06-05 | 2019-07-30 | 山东大学 | 一种含三氮唑环的单芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用 |
| CN110407812B (zh) * | 2019-07-31 | 2020-08-25 | 武汉工程大学 | 一种吲唑哌啶嘧啶类衍生物及其制备方法和用途 |
| CN111285859B (zh) * | 2020-04-02 | 2021-07-02 | 山东大学 | 一类以hiv-1逆转录酶为靶点的2,4,5-三取代嘧啶类化合物及其制备方法与应用 |
| EP4242203A4 (en) * | 2020-11-06 | 2024-12-25 | Pelemed Co., Ltd. | NEW CAPSIDIC ASSEMBLY INHIBITOR |
| MX2023008854A (es) * | 2021-01-28 | 2023-10-17 | Carmot Therapeutics Inc | Agonistas del receptor acoplado a proteinas g (gpcr), composiciones farmaceuticas que los comprenden y metodos para su uso. |
| US12084453B2 (en) | 2021-12-10 | 2024-09-10 | Incyte Corporation | Bicyclic amines as CDK12 inhibitors |
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| CN101027829B (zh) | 2004-09-28 | 2012-07-18 | Nxp股份有限公司 | 电流式受控dc-dc转换器 |
| RU2403244C2 (ru) | 2004-09-30 | 2010-11-10 | Тиботек Фармасьютикалз Лтд. | Вич-ингибирующие 5-карбо- или гетероциклические замещенные пиримидины |
| BRPI0516746A (pt) | 2004-09-30 | 2008-09-23 | Tibotec Pharm Ltd | 5-heterociclil pirimidinas para inibição de hiv |
| CN101048410B (zh) | 2004-10-29 | 2010-06-23 | 泰博特克药品有限公司 | 抑制hiv的双环嘧啶衍生物 |
| BRPI0607811B8 (pt) | 2005-02-18 | 2021-05-25 | Janssen R & D Ireland | derivados de óxido de pirimidina de 2-(4-cianofenilamino) inibidores de hiv, composição farmacêutica compreendendo os mesmos, processo para preparar a referida composição e uso |
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-
2007
- 2007-12-04 KR KR1020097014458A patent/KR101475091B1/ko not_active Expired - Fee Related
- 2007-12-04 EP EP07847731.2A patent/EP2089384B1/en not_active Not-in-force
- 2007-12-04 BR BRPI0720436-1A patent/BRPI0720436A2/pt not_active IP Right Cessation
- 2007-12-04 RU RU2009126624/04A patent/RU2469032C2/ru not_active IP Right Cessation
- 2007-12-04 AU AU2007332654A patent/AU2007332654B2/en not_active Ceased
- 2007-12-04 WO PCT/EP2007/063224 patent/WO2008071587A2/en active Application Filing
- 2007-12-04 ES ES07847731.2T patent/ES2550152T3/es active Active
- 2007-12-04 CA CA2671478A patent/CA2671478C/en not_active Expired - Fee Related
- 2007-12-04 CN CN2007800455630A patent/CN101553483B/zh not_active Expired - Fee Related
- 2007-12-04 MX MX2009005881A patent/MX2009005881A/es active IP Right Grant
- 2007-12-04 JP JP2009540713A patent/JP5415957B2/ja not_active Expired - Fee Related
- 2007-12-10 CL CL200703565A patent/CL2007003565A1/es unknown
- 2007-12-11 AR ARP070105525A patent/AR064221A1/es unknown
- 2007-12-12 TW TW096147347A patent/TW200833681A/zh unknown
- 2007-12-12 PE PE2007001776A patent/PE20081509A1/es not_active Application Discontinuation
- 2007-12-13 US US12/001,947 patent/US7998969B2/en not_active Expired - Fee Related
-
2009
- 2009-06-04 IL IL199152A patent/IL199152A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2671478C (en) | 2015-02-17 |
| AU2007332654A1 (en) | 2008-06-19 |
| AU2007332654B2 (en) | 2013-06-20 |
| US20080146595A1 (en) | 2008-06-19 |
| EP2089384B1 (en) | 2015-08-05 |
| TW200833681A (en) | 2008-08-16 |
| ES2550152T3 (es) | 2015-11-04 |
| RU2009126624A (ru) | 2011-01-20 |
| EP2089384A2 (en) | 2009-08-19 |
| JP2010513240A (ja) | 2010-04-30 |
| AR064221A1 (es) | 2009-03-18 |
| MX2009005881A (es) | 2009-06-12 |
| KR101475091B1 (ko) | 2014-12-22 |
| WO2008071587A2 (en) | 2008-06-19 |
| KR20090087512A (ko) | 2009-08-17 |
| BRPI0720436A2 (pt) | 2014-01-07 |
| JP5415957B2 (ja) | 2014-02-12 |
| PE20081509A1 (es) | 2008-10-24 |
| WO2008071587A3 (en) | 2008-07-31 |
| IL199152A (en) | 2015-11-30 |
| CN101553483A (zh) | 2009-10-07 |
| US7998969B2 (en) | 2011-08-16 |
| RU2469032C2 (ru) | 2012-12-10 |
| CN101553483B (zh) | 2013-04-17 |
| CA2671478A1 (en) | 2008-06-19 |
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| CL2008001002A1 (es) | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. | |
| CL2008001003A1 (es) | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. | |
| CL2007003686A1 (es) | Compuestos derivados de indol con anillo unido en las posiciones 4,5; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para tratar una infeccion viral. | |
| CL2007003685A1 (es) | Compuestos derivados de indol con un anillo unido en las posiciones 4 y 5; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion viral. | |
| CL2007003684A1 (es) | Compuestos derivados de indol con un anillo unido en las posiciones 5 y 6; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion viral. | |
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| CL2008000403A1 (es) | Compuestos derivados de pentafluorotiobenzamido-acetonitrilo; composicion farmaceutica; y uso para tratar una infestacion por parasitos. | |
| CL2007001392A1 (es) | Compuestos derivados de quinolina o benzopirano inhibidores de la replicacion del hiv; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de una infeccion por vih | |
| CL2017001847A1 (es) | Una formulación sólida de dosificación farmacéutica | |
| CL2007003645A1 (es) | Compuestos parasiticidas derivados de aril-pirazoles sustituidos; compuestos intermediarios; composicion farmaceutica; y uso para tratar una infeccion parasitaria. | |
| CL2007002916A1 (es) | Compuestos derivados de pirazoliltienopiridinas; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en la inhibicion de escaras. | |
| BRPI0716171A2 (pt) | composto, composiÇço farmacÊutica e uso de um composto. | |
| CL2007003232A1 (es) | Compuestos derivados de 5-hidroximetil oxazolidin-2-ona; composicion farmaceutica que contiene a dichos compuestos; y su uso para tratar y prevenir infecciones bacterianas. | |
| CL2007001992A1 (es) | Compuestos derivados de pirimidilciclopentanos; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de una enfermedad inflamatoria, hiperproliferante, cardiovascular, neurodege | |
| CL2008001983A1 (es) | Compuestos derivados de ftalazinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades vasculares, shock septico, lesiones isquemicas, neurotoxicidad, shock hemorragico, infecciones virales, entre otras. | |
| CL2008003406A1 (es) | Compuestos derivados de quinolina; composicion farmaceutica que los comprende; y uso en el tratamiento de una infeccion por vih. | |
| CL2007003299A1 (es) | Compuestos derivados de macrociclos, inhibidores del virus de la hepatitis c; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la hepatitis c. | |
| CL2008000585A1 (es) | Compuestos derivados de nicotinamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una enfermedad mediada por prostaglandina d2 producida por h-pgds. | |
| CL2012000573A1 (es) | Compuestos derivados de bifenil-pirrolidinil-imidazol; composicion farmaceutica que los comprende; su uso en el tratamiento de una infeccion viral por hcv. | |
| BRPI0814593A2 (pt) | Composto, composição farmacêutica que o contém e uso do composto. | |
| CL2007003470A1 (es) | Compuestos derivados de urea; composicion farmaceutica que comprende a dichos compuestos; y su uso como antibacterianos. | |
| CL2007000918A1 (es) | Compuestos derivados de enfumafungina, inhibidores de (1,3)-beta-d-glucanosintetasa; composicion farmaceutica; y uso para tratar una infeccion fungica. | |
| CL2008002319A1 (es) | Compuestos derivados de pirrolopirimidina; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer. |