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CA2327367A1 - Nouveaux composes destines a la transfection d'adn - Google Patents

Nouveaux composes destines a la transfection d'adn Download PDF

Info

Publication number
CA2327367A1
CA2327367A1 CA002327367A CA2327367A CA2327367A1 CA 2327367 A1 CA2327367 A1 CA 2327367A1 CA 002327367 A CA002327367 A CA 002327367A CA 2327367 A CA2327367 A CA 2327367A CA 2327367 A1 CA2327367 A1 CA 2327367A1
Authority
CA
Canada
Prior art keywords
leu
cell
vitro
vivo
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002327367A
Other languages
English (en)
Inventor
Eric Argirios Kitas
Ernst-Jurgen Schlaeger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2327367A1 publication Critical patent/CA2327367A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des conjugués de lipides et de peptides basiques modifiés perturbant la membrane, lesdits conjugués étant caractérisés en ce que les peptides comprennent un squelette amidé inversé. Elle se rapporte en particulier aux composés correspondant à la formule (I) dans laquelle R?1¿ et R?2¿ représentent un groupe fonctionnel hydrocarbyle d'un acide carboxylique saturé ou insaturé à chaîne droite ou ramifiée ou d'un groupe fonctionnel phospholipidique, R?3¿ représentant un peptide basique modifié perturbant la membrane qui possède un squelette amidé inversé, Y représentant alkylène C¿2-10? et X représentant C(O)-NH- ou -S-S-. L'invention se rapporte également aux sels de ces composés.
CA002327367A 1998-04-07 1999-04-07 Nouveaux composes destines a la transfection d'adn Abandoned CA2327367A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP98106302.7 1998-04-07
EP98106302 1998-04-07
EP98124837.0 1998-12-30
EP98124837 1998-12-30
PCT/EP1999/002361 WO1999051629A2 (fr) 1998-04-07 1999-04-07 Nouveaux composes destines a la transfection d'adn

Publications (1)

Publication Number Publication Date
CA2327367A1 true CA2327367A1 (fr) 1999-10-14

Family

ID=26149151

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002327367A Abandoned CA2327367A1 (fr) 1998-04-07 1999-04-07 Nouveaux composes destines a la transfection d'adn

Country Status (5)

Country Link
EP (1) EP1068225A2 (fr)
JP (1) JP2002510706A (fr)
AU (1) AU3706599A (fr)
CA (1) CA2327367A1 (fr)
WO (1) WO1999051629A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19925143A1 (de) * 1999-06-02 2000-12-07 Aventis Pharma Gmbh Neue liposomale Vektorkomplexe und deren Verwendung für die Gentherapie
GB9915074D0 (en) * 1999-06-28 1999-08-25 Cortecs Plc Ligand-binding composition
AU2764801A (en) * 2000-01-07 2001-07-24 University Of Washington Enhanced transport of agents using membrane disruptive agents
CN1313327A (zh) * 2000-03-15 2001-09-19 上海博德基因开发有限公司 一种新的多肽——人接头粘连分子12和编码这种多肽的多核苷酸
EP1182208A3 (fr) * 2000-07-28 2002-05-08 Roche Diagnostics GmbH Composition pour la transfection d'ADN
GB0024428D0 (en) * 2000-10-05 2000-11-22 King S College Absorption enhancers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0784984B1 (fr) * 1996-01-17 2003-07-02 F. Hoffmann-La Roche Ag Molécules compétentes à la transfection

Also Published As

Publication number Publication date
JP2002510706A (ja) 2002-04-09
AU3706599A (en) 1999-10-25
WO1999051629A2 (fr) 1999-10-14
WO1999051629A3 (fr) 1999-12-23
EP1068225A2 (fr) 2001-01-17

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead
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